CAS No. 104040-78-0

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ACTIVITY: Herbicide (sulfonylurea)

CAS Name: N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-3-(trifluoromethyl)-2-pyridinesulfonamide


Adverse Effects:


Regulatory Information
(only comprehensive for the US)
US EPA Registered: Pending
Registered use in
(includes only a limited list of countries) 
Hungary, Japan, New Zealand, Taiwan
Japan's Maximum Residue Levels (MRLs) Grape, Grapefruit, Lemon, Lime, Natsudaidai (whole), Orange, Other Citrus fruits, Sugarcane, Unshu orange  
Other Information
Molecular Formula: C13H12 F3 N5O5S 
Entry Year: 1989 
Inventing Company: ISK Biosciences 
Other Names: Flazasulfuron 25 WG
Katana 25% WG
Technical Flazasulfuron Herbicide 
Of special interest:
PAN Data 
March 10, 2004. EU: Commission Directive 2004/30/EC of 10 March 2004 amending Council Directive 91/414/EEC to include benzoic acid, flazasulfuron and pyraclostrobin as active substances (Text with EEA relevance). Official Journal L 077 , 13/03/2004 P. 0050 - 0053.
2004 - Trial information. Control of Broadleaf Weeds with Flazasulfuron in Texas. University of Georgia Coop Ext Service.
Initiation Date: 5-27-2004. Planned Completion Date: 7-26-2004.
November 27, 2003. EU: Review report for the active substance flazasulfuron. SANCO/ 3051/99/-Final. List of uses supported by available data: Citrus, Grapes, Olives. COMMISSION WORKING DOCUMENT - DOES NOT NECESSARILY REPRESENT THE VIEWS OF THE COMMISSION SERVICES.
February 18, 2002 - European Commission decision to extend provisional authorisation granted for new active substances which included flazasulfuron
October 2001 - Glossary of Pesticide Chemicals, A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 

Federal Register
Date Published Docket No. Details
Nov 10, 2004 OPP-2004-0353 

ISK Biosciences Corp. Product registration application for new active ingredient not included in any previously registered products.

1. File Symbol: 71512-RR. Applicant: ISK Biosciences Corporation,
7470 Auburn Road, Suite A, Concord, OH 44077. Product Name: Technical Flazasulfuron Herbicide. Active ingredient: Flazasulfuron at 96.9%.
Proposed classification/Use: None. For manufacturing use only.

2. File Symbol: 71512-RE. Applicant: ISK Biosciences Corp. Product Name: Flazasulfuron 25 WG. Active ingredient: Flazasulfuron at 25%. Proposed classification/Use: None. For use as a selective herbicide on professionally managed turf.


Ecotoxicol Environ Saf. 2003 Jul;55(3):271-277.

Pigments as biomarkers of exposure to the vineyard herbicide flazasulfuron in freshwater algae.

Couderchet M, Vernet G.

Laboratoire d'Eco-Toxicologie, Unite de Recherches Vigne et Vin de Champagne (URVVC), UPRES EA 2069, Universite de Reims Champagne-Ardenne, BP 1039, F-51687 Cedex 02, Reims, France

Abstract: Weed control in Champagne vineyards has long relied on the use of diuron and substituted triazines; these compounds are now being replaced by flazasulfuron, a sulfonylurea that is used at a much lower dosage. The vineyards of Champagne are planted on steep slopes and runoff is important, and even though low doses of these herbicides are used, they may present some potential risk for freshwater ecosystems. Therefore, the effects of the sulfonylurea herbicide, flazasulfuron (formulated as Katana) was investigated on the unicellular green alga Scenedesmus obliquus. The pigment content of the algal suspensions was followed as a biomarker of exposure to the herbicide. The results demonstrate that flazasulfuron induced a reduction in chlorophyll content at concentrations of 10&mgr;g/L, while the increase of pigment content in the culture was reduced with the lowest concentration tested (0.1&mgr;g/L). Among the three pigments tested, chlorophyll a appeared to be the most sensitive biomarker. In the algal medium, flazasulfuron was slowly degraded (DT(50) approximately 8 days) in a compound that was tentatively identified. The toxicity of this herbicide for the algae was comparable to that of older herbicides which are used at a much higher rate. Therefore, we may speculate that even if flazasulfuron comes into contact with freshwater ecosystems, its effects on algae will be less deleterious than that of traditional herbicides.

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