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|
| Order
No. |
Title |
Keywords |
NTIS/OTS0538106
EPA/OTS;
Doc #88-920007049 |
1992
- INIT SUB: NEUROTOXICITY STUDIES WITH NAK 1654 IN HENS
WITH COVER LETTER DATED 09-10-92
BAYER
AG |
MILES
INC
NAK 1654
HEALTH EFFECTS
NEUROTOXICITY
BIRDS
ORAL
GAVAGE
CAS Registry Numbers: 75867-00-4
|
NTIS/OTS0555590
EPA/OTS;
Doc #88-920010108 |
1992
-
INITIAL SUBMISSION: ACUTE AND SUBACUTE TOXICITY STUDIES
OF NAK 1654 WITH COVER LETTER DATED 08/17/92
Corporate Name: INSTITUT FUR TOXIKOLOGIE |
MILES
INC
NAK 1654
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
DIET
MICE
DOGS
PARENTERAL
INTRAPERITONEAL
SUBCUTANEOUS
DERMAL
INHALATION
SUBCHRONIC TOXICITY
PRIMARY DERMAL IRRITATION
RABBITS
PRIMARY EYE IRRITATION
NEUROTOXICITY
BIOCHEMISTRY
TISSUE CONCENTRATION
CAS Registry Numbers: 75867-00-4
|
From
Toxline at TOXNET
PESTICIDE
SCIENCE; 52 (1). 1998.
3-20.
Research
into fluorinated pyrethroid alcohols: An episode in
the history of pyrethroid discovery.
NAUMANN
K
Landwirtschaftszentrum Monheim, Bayer AG, D-51368
Leverkusen, Germany.
Abstract: BIOSIS COPYRIGHT: BIOL ABS. An account of
pyrethroid research from 1975 to 1985 at Bayer AG
is given. The exploitation of fluorine chemistry for
this purpose led to increased activity of known 3-phenoxybenzyl
pyrethroid esters and to the commercialization of
the broad-spectrum insecticide cyfluthrin, the particularly
tick-toxic flumethrin
and the rapid-acting household insecticides fenfluthrin
and transfluthrin. The last two constituted in 1976
a novel type of pyrethroid, based on polyfluorinated
benzyl alcohols, off the mainstream of published pyrethroid
research. Transfluthrin, the single isomer (1R)trans-permethric
acid ester of 2,3,5,6-tetrafluorobenzyl alcohol has
just been introduced to the market. The history of
its discovery and structure-activity data as well
as resistance considerations regarding cyfluthrin,
are presented.
|
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10810595&dopt=Abstract
J Commun
Dis 1999
Jun;31(2):91-9
Evaluation
of cyfluthrin and fenfluthrin for their insecticidal activity
against three vector mosquitoes.
Mohapatra R, Ranjit MR, Dash AP.
Regional Medical Research Centre, Bhubaneswar, Orissa, India.
The EC50/EC90 concentrations of cyfluthrin and fenfluthrin
were tested for their activity against different developmental
stages of three important vector mosquitoes viz., Anopheles
stephensi Liston, Aedes aegypti (Linn.) and Culex quinquefasciatus
Say. The EC90 concentrations of both cyfluthrin and fenfluthrin
showed ovicidal effect on An. Stephensi and Ae. aegypti whereas
EC90 of cyfluthrin checked the hatching of eggs completely
in Cx. quinquefasciatus. Fenfluthrin
at EC50 concentration reduced the percentage of hatching significantly
(p < 0.05) only in An. stephensi. Both the compounds were
more active against the fourth larval instars of all mosquito
species and cyfluthrin in culicines (17.3% Ae. aegypti = 9.1%)
and fenfluthrin in anophenlines (An. stephensi = 36.8%) brought
about maximum inhibition in adult emergence. Various types/degrees
of morphogenetic aberrations were induced in all mosquito
species on treatment with these compounds. Cyfluthrin treated
female mosquitoes showed reduced fecundity rates in An. stephensi
(p < 0.05), Cx. quinquefasciatus (p < 0.001) and fenfluthrin
treated in An. stephensi (p < 0.5) and Ae. aegypti (p <
0.05). The fertility rates of all the mosquito species were
significantly reduced (p < 0.001) by both the compounds.
PMID: 10810595 [PubMed - indexed for MEDLINE]
From
Toxline at TOXNET
PESTIC
BIOCHEM PHYSIOL; 39 (3). 1991.
210-218
Phenylpyrazoles,
a new class of pesticides: An electrophysiological investigation
into basic effects.
KLIS
S FL VIJVERBERG H PM VAN DEN BERCKEN J
Res. Inst.
Toxicology, Univ. Utrecht, P.O. Box 80.176, NL-3508 TD Utrecht,
Netherlands.
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. Phenylpyrazoles constitute a newly
developed class of pesticides that may exert direct excitatory
effects on the nervous system. Basic electrophysiological
effects were investigated in vitro in the sciatic nerve and
the lateral-line sense organ of the clawed frog, Xenopus laevis,
by recording nerve activity extracellularly. In the slowly
adapting stretch receptor organ of the crayfish, Astacus sp.,
effects on the membrane potential of the neurone were recorded
using intracellular microelectrodes. Both in the sciatic nerve
and in the lateral-line sense organ the main effect of phenylpyrazoles
was to decrease the survival time of the isolated preparation.
In the isolated crayfish stretch receptor organ a similar
decrease of the survival time was accompanied by a depolarization
of the stetch receptor neurone membrane. The depolarizing
effect of the phenylpyrazoles is not caused by a modification
of the tetrodotoxin-sensitive voltage-dependent Na+ channels,
nor by an effect
CAS
Registry Number: 75867-00-4
From
Toxline at TOXNET
Toxicology
and Applied Pharmacology, Vol. 103, No. 3, page 528-538, 43
references,1990
Characteristics
of the Prolonged Inhibition Produced by a Range of Pyrethroids
in the Rat Hippocampus
Joy
RM, Lister T, Ray DE, Seville MP
1990 Abstract:
The effects of eight different synthetic pyrethroids were
determined on the excitability of hippocampal granule cells
in urethane anesthetized rats. Electrodes were stereotactically
placed in the brain of male LAC-Porton-rats. Square wave pulses
0.1 millisecond in duration were used as stimuli. The pyrethroids
tested were fenfluthrin (75867004),
cismethrin (35764591), NRDC-108 (18877899), cyphenothrin (39515407),
fenproponate, RU-26941 (67670671), fenvalerate (51630581),
and deltamethrin (52918635). The depression of granule cell
excitability that follows stimulation of the major synaptic
input, the perforant path, was prolonged by all eight compounds.
The class to which the pyrethroid belonged determined the
magnitude of this effect. The depression of granule
cell excitability was prolonged by type-I pyrethroids for
shorter periods than type-II pyrethroids or pyrethroids producing
a mixed type of intoxication. Cismethrin, a type-I pyrethroid,
was tested over a dose range of 1.5 to 24 times the conscious
rat intravenous median lethal dose to determine whether the
difference observed between type-I and type-II pyrethroids
was the result of the selection of doses. The prolongation
even at the highest dose remained well below that produced
by type-II pyrethroids. Deltamethrin caused an effect which
was consistent with the production or potentiation of a surmountable
inhibitory response. This action of deltamethrin was antagonizable
by mephenesin and lidocaine, but not by picrotoxin or halothane.
This type of effect, its time course,
and the antagonism data suggest that type-II pyrethroids enhance
inhibition in the dentate gyrus. This action does not
appear to be mediated by GABA-A receptors.
Defintions:
Dentate gyrus - one of the
two interlocking gyri composing the hippocampus, the other
one being the Ammon horn.
Gyrus.
gen and pl. gyri
- one ot the prominent rounded elevations from the cerebral
hemispheres, each consisting of an exposed superficial portion
and a portionhidden from view in the wall and floor of the
sulcus.
Sulcus
- 1. one of the g rooves or furrows on the surface of the
brain, bounding the several convolutions or gyri; a fissure.
2. any long narrow groove, furrow, or slight depression.
3. a groove or depression in the oral cavity or on the surface
of a tooth.
Ref:
Stedman's
Concise Medical Dictionary for the Health Proessions. Illustrated
4th Edition. Ed. JH Dirckx. Lippincott Williams & Wilkins.
A Wolters Kluwer Company.
| CAS
Registry Numbers: |
51630-58-1
- Fenvalerate |
|
75867-00-4 - Fenfluthrin
|
39515-40-7
- Cyphenothrin |
|
67670-67-1 - Fenproponate, RU-26941 |
35764-59-1
- Cismethrin |
| 52918-63-5
- Deltamethrin |
18877-89-9
- NRDC-108 |
From
Toxline at TOXNET
PESTIC
BIOCHEM PHYSIOL; 34 (2). 1989.
164-173.
EFFECTS OF PYRETHROIDS
ON NEUROTRANSMITTER-OPERATED ION CHANNELS IN CULTURED MOUSE
NEUROBLASTOMA CELLS
OORTGIESEN
M VAN KLEEF R G DM VIJVERBERG H PM
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM ALLETHRIN IR-CIS CYPHENOTHRIN
IR-CIS FENFLUTHRIN INSECTICIDE
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3238775&dopt=Abstract
Trop Anim
Health Prod 1988 Nov;20(4):267-8
No
Abstract available
Pyrethroid
impregnated ear tags in trypanosomiasis control.
Dolan RB, Sayer PD, Alushula H, Heath
BR.
Kenya Trypanosomiasis Research Institute, Kikuyu.
PMID: 3238775 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3376131&dopt=Abstract
Toxicology
1988 May;49(2-3):271-6
Effects
of pyrethroids on the acoustic startle reflex in the rat.
Hijzen TH, De Beun R, Slangen JL.
Department of Psychophysiology, State University of Utrecht,
The Netherlands.
The effects of NAK 1901 (Pentafluorbenzyl
(1R, cis)-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-carboxylate)
and cypermethrin ((S,R)-alpha-cyano-3-phenoxybenzyl-2,2-dimethyl
(1R, 1S, cis, trans)-3-(2,2-dichlorovinyl) cyclopropane-carboxylate)
(RU 24 501) on amplitude and prepulse inhibition of the acoustic
startle reflex were studied in male Wistar rats. NAK 1901
(0, 1, 2.5, 4 mg/kg p.o.) enhanced the amplitude of the startle
reflex in a dose-dependent way. Startle latency was not affected.
Cypermethrin (0, 0.5, 1, 2 mg/kg p.o.) had no effect on the
amplitude or the latency of the startle reflex. Both NAK 1901
and cypermethrin administration produced a dose-dependent
increase in toxic signs and a dose-dependent increase in weight
loss during the experimental session. None of the pyrethroids
affected prepulse inhibition of the startle reflex. Because
the neural substrate of the inhibitory processes involved
in prepulse inhibition are probably of supraspinal origin,
it is suggested that these substrates are not affected by
pyrethroids.
PMID: 3376131 [PubMed - indexed for MEDLINE]
From
Toxline at TOXNET
Toxicology
Letters, Vol. 40, No. 2, pages 141-152, 18 references, 1988
Effects of Type
I and Type II Pyrethroids on the Startle Response in Rats
Hijzen
TH, Slangen JL
Abstract:
The effects of type-I and type-II pyrethroids on the startle
response of male Wistar-rats were studied in three experiments.
Type-I and type-II compounds were distinguished by the absence
or presence of a cyanophenoxybenzyl moiety. In experiment
one, male rats were fed 30, 60 or 90mg/kg cis-permethrin (61949766)
(type-I) or 60, 90 or 120mg/kg cis,trans-cypermethrin (type-II),
and were startled before and after treatment by pulses of
a pure tone of 9 kilohertz (kHz) with an intensity of 120
decibels (dB). Three weeks later the animals were given the
same doses and subjected to pulses of a tone of 4kHz, 70dB.
Startle amplitude, measured as displacement of the floor of
a hanging cage, increased as a function of dose, with similar
results for both the first and second sets of treatments.
Overt behavior and habituation of the startle response were
not affected. In experiment two, rats received 0, 2, 4 and
6mg/ml deltamethrin (52918635) (type-II) or 0, 1, 2.5 and
4mg/kg fenfluthrin (75867004)
(NAK-1901, type-I). Each rat was exposed to each of the doses
and to tone and light shock stimuli. Deltamethrin had no effect
on startle, while fenfluthrin resulted
in a dose dependent increase in the startle amplitude,
and neither compound affected potentiation of the startle
reflex. In experiment three, each rat received each of doses
of 0, 2, 4 and 6mg/kg deltamethrin and the startle intensity
was 120dB. Two hundred startle stimuli were presented at each
session, and blocks of the first, middle and last 30 trials
were analyzed. The startle amplitude decreased significantly
in successive trial blocks, demonstrating the effect of habituation.
The authors conclude that the effects
of type-II pyrethroids on startle amplitude are mediated by
an indirect metabolic effect and a direct effect at the site
of the muscle, and also that supraspinal mechanisms are not
influenced by the doses of pyrethroids administered.
From
Toxline at TOXNET
PESTIC
BIOCHEM PHYSIOL; 30 (1). 1988.
79-86.
CLASSIFICATION
OF THE ACTIONS OF TEN PYRETHROID INSECTICIDES IN THE RAT USING
THE TRIGEMINAL REFLEX AND SKELETAL MUSCLE AS TEST SYSTEMS
WRIGHT
C DP FORSHAW PJ RAY DE
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM SENSORY GANGLION MOTOR NUCLEUS
DIAPHRAGM MUSCLE MEMBRANE ELECTROPHYSIOLOGY
| CAS
Registry Numbers |
68085-85-8
Cyhalothrin |
64312-66-9
Cyclopropanecarboxylic acid, 3-(2,2-dimethylethenyl)-2,2-dimethyl-,
cyano(3-phenoxyphenyl)methyl ester, (1R-(1-alpha(S*),3-alpha))-
|
35764-59-1
Cismethrin |
75867-00-4
Fenfluthrin
|
67890-40-8
Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-,cyano(3-phenoxyphenyl)methyl
ester, (R*,R*)- |
64257-84-7
Fenpropathrin |
18877-89-9
NRDC-108
|
68359-37-5
Cyfluthrin |
67670-66-0
Fluorocyphenothrin |
52918-63-5
Deltamethrin |
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2449265&dopt=Abstract
Brain
Res 1987 Dec 29;437(2):309-22
Increase
of sodium current after pyrethroid insecticides in mouse neuroblastoma
cells.
Ruigt GS, Neyt HC, Van der Zalm JM,
Van den Bercken J.
Department of Veterinary Pharmacology, Pharmacy and Toxicology,
University of Utrecht, The Netherlands.
The effects of 4 different pyrethroid insecticides on sodium
channel gating in internally perfused, cultured mouse neuroblastoma
cells (N1E-115) were studied using the suction pipette, voltage
clamp technique. Pyrethroids increased the amplitude of the
sodium current, sometimes by more than
200%. Activation of the sodium current occurred at
more hyperpolarized potentials than under control conditions.
The declining phase of the sodium current during depolarization
was markedly slowed down and after repolarization of the membrane
a large, slowly decaying sodium tail current developed. Pyrethroids
did not affect the sodium current reversal potential, steady-state
sodium inactivation or recovery from sodium channel inactivation.
The amplitude of the pyrethroid-induced slow tail current
was always proportional to the sodium current at the end of
the preceding depolarizing pulse. The rate of decay of the
slow tail current strongly depended on pyrethroid structure
and increased in the order deltamethrin, cyphenothrin, fenfluthrin
and phenothrin. The rate of decay further depended on membrane
potential and temperature. Below -85 m V the instantaneous
current-voltage relationship of the slow tail current showed
a negative slope conductance. The tail current decayed more
slowly at low temperatures. Arrhenius plots indicated that
the relaxation of open sodium channels to a closed state involved
a higher energy barrier for pyrethroid-affected than for normal
channels. The energy barrier was higher after deltamethrin
than after the non-cyano pyrethroid fenfluthrin.
It is concluded that in mammalian neuronal membrane pyrethroids
selectively reduce the rate of closing of sodium channels
both during depolarization and after repolarization of the
nerve membrane.
PMID: 2449265 [PubMed - indexed for MEDLINE]
From
Toxline at TOXNET
J COMP
PHYSIOL A SENS NEURAL BEHAV PHYSIOL; 159 (1). 1986.
43-54.
PRONOUNCED REPETITIVE
ACTIVITY INDUCED BY THE PYRETHROID INSECTICIDE FENFLUTHRIN
IN THE SLOWLY ADAPTING STRETCH RECEPTOR NEURON OF THE CRAYFISH
RUIGT
G SF KLIS J FL VAN DEN BERCKEN
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM DDT TETRODOTOXIN FENFLUTHRIN
REPRESSOR SODIUM-POTASSIUM PUMP SPIKE TRIGGER ZONE ELECTROPHYSIOLOGY
ACTION POTENTIAL AXON SOMA NEUROTOXIN
From
Toxline at TOXNET
FORD,
M. G., ET AL. (ED.). ELLIS HORWOOD SERIES IN BIOMEDICINE:
NEUROPHARMACOLOGY AND PESTICIDE ACTION; NEUROTOX '85, BATH,
ENGLAND, 1985. 512P. VCH PUBLISHERS, INC.: NEW YORK, NEW YORK,
USA; WEINHEIM, WEST GERMANY; ELLIS HORWOOD LTD.: CHICHESTER,
ENGLAND (DIST. IN THE USA AND CANADA BY VCH PUBLISHERS: DEERFIELD
BEACH, FLORIDA, USA) ILLUS. ISBN 0-89573-424-9; ISBN 3-527-26340-3.;
0 (0). 1986. 267-286.
THE EFFECT OF
PYRETHROID STRUCTURE ON THE INTERACTION WITH THE SODIUM CHANNEL
IN THE NERVE MEMBRANE
VIJVERBERG
H PM DE WEILLE JR RUIGT G SF VAN DEN BERCKEN J
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM FROG MOUSE NEUROBLASTOMA CELL
INSECTICIDE STRUCTURE-ACTIVITY RELATIONSHIP MODE OF ACTION
| CAS
Registry Numbers: |
57731-67-6
Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-,
ethynyl(3-phenoxyphenyl)methyl ester |
52315-07-8 |
39515-40-7
Cyphenothrin |
10453-86-8
Resmethrin |
102407-97-6
(no info found) |
52918-63-5
Deltamethrin |
51630-58-1
Fenvalerate |
35764-59-1
Cismethrin |
584-79-2
Bioallethrin |
75867-00-4
Fenfluthrin
|
52645-53-1
Permethrin |
39515-41-8
|
26002-80-2
Phenothrin |
- |
From
Toxline at TOXNET
INTERNATIONAL
SYMPOSIUM ON NEUROPHARMACOLOGY AND PESTICIDE ACTION HELD AT
NEUROTOX '85, BATH, ENGLAND, MAR. 31-APR. 4, 1985.
PESTIC
SCI; 16 (5). 1985. 545-546.
INVESTIGATION
OF THE RELATIONSHIP BETWEEN THE NEUROPHYSIOLOGICAL EFFECTS
OF TWO STRUCTURALLY RELATED PYRETHROIDS AND THEIR IN-VIVO
TOXICITY
BUCKLEY
DS, LEAKE LD, FORD MG
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM ABSTRACT MUSCA-DOMESTICA HIRUDO-MEDICINALIS
STRUCTURE-ACTIVITY RELATIONSHIP KNOCKDOWN INSECTICIDE MODE
OF ACTION
| CAS
Registry Numbers: |
75867-00-4
Fenfluthrin
|
52918-63-5
Deltamethrin |
28434-00-6
S-Bioallethrin |
From
Toxline at TOXNET
190TH
AMERICAN CHEMICAL SOCIETY NATIONAL MEETING, CHICAGO, ILL.,
USA, SEPT. 8-13, 1985. ABSTR PAP AM CHEM SOC; 190 (0). 1985.
NO PAGINATION.
SYNTHESIS
AND ARTHROPODICIDAL PROPERTIES OF HIGHLY
POTENT FLUORINATED PYRETHROIDS
ARLT
D, BEHRENZ D, FOERSTER H, FUCHS R, HAMANN I, HARTMANN W, HEINE
HG, HOFFMANN H, JAUTELAT M, ET AL
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM ABSTRACT LEVO-1R-TRANS
FENFLUTHRIN CYFLUTHRIN FLUMETHRINE HYGIENE AGRICULTURE
VETERINARY USE
From
Toxline at TOXNET
KIEL MILCHWIRTSCH
FORSCHUNGSBER; 37 (2). 1985.
125-212.
STUDIES ON BOVINE
SUMMER MASTITIS
TOLLE
A, REICHMUTH J, FRANKE V, BEIMGRABEN J
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM MOUSE HAEMATOBIA-STIMULANS
PEPTOCOCCUS-INDOLICUS CORYNEBACTERIUM-PYOGENES BACTEROIDES
HYDROTAEA-IRRITANS HAEMATOBIA-IRRITANS ANTIBIOTIC TREATMENT
FENFLUTHRIN INSECTICIDE PYOGENIC
MASTITIS VACCINATION GRAZING ENVIRONMENT FLY CONTROL
From
Toxline at TOXNET
ANZ SCHAEDLINGSKD
PFLANZENSCHUTZ UMWELTSCHUTZ; 58 (2). 1985.
30-35.
CYFLUTHRIN AND
FENFLUTHRIN 2 NEW PYRETHROIDS FOR THE CONTROL OF HYGIENE PESTS
BEHRENZ
W, ELBERT A
Abstract:
BIOSIS COPYRIGHT: BIOL ABS. RRM COCKROACH BEDBUG MOSQUITO
FLY PENTAFLUOROPHENYLMETHYL-1R 3R-3-2 2-DICHLOROETHENYL-2
2-DIMETHYLCYCLOPROPANECARBOXYLATE CYANO-4-FLUORO-3-PHENOXYPHENYLMETHYL-3-2
2-DICHLOROETHENYL-2 2-DIMETHYLCYCLOPROPANECARBOXYLATE TOXICITY
KNOCK DOWN ACTION
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4054972&dopt=Abstract
Indian
J Med Res 1985 Jul;82:1-8
No
Abstract available
Evaluation
of fenfluthrin (OMS 2013), a
synthetic pyrethroid for insecticidal efficacy against mosquito
vectors.
Mariappan T, Kalyanasundaram M, Panicker
KN, Balakrishnan N, Tyagi BK, Das PK.
PMID: 4054972 [PubMed - indexed for MEDLINE]
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to Fenfluthrin Index Page
