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| Order
No. |
Date/Title |
Keywords/Abstract |
| NTIS/OTS0545185
EPA/OTS;
Doc #88-920006586 |
1992.
INITIAL SUBMISSION: A TERATOLOGY STUDY WITH ETHALFLURALIN
IN DUTCH-BELTED RABBITS WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO |
Ethalfluralin
(CAS# 55283-68-6) was evaluated for developmental toxicity.
The test material was administered orally to 14, 13, 15, and
13 inseminated Dutch-Belted rabbits in doses of 0, 250, 500,
and 750 mg/kg/day, respectively, on days 6-18 of gestation.
Four, 9, and 7 rabbits of the 250, 500, and 750 mg/kg/day
groups, respectively, aborted and were killed. Abortions
were preceded by extended periods of anorexia and weight loss.
Anorexia and substantial weight loss were observed during
dosing at 250 mg/kg/day and above. Decreased
live litter size and an increase in resorption incidence occurred
at 500 and 750 mg/kg/day. No live fetuses were recovered at
750 mg/kg/day. No effects on sex distribution or weight
were observed. No treatment related skeletal or visceral defects
were observed. The authors concluded that maternal
toxicity was observed at all dose levels. No teratogenicity
was observed at any dose level. |
| NTIS/OTS0545147
EPA/OTS;
Doc #88-920006548 |
1992.
INITIAL SUBMISSION: A TERATOLOGY STUDY WITH ETHALFLURALIN
ADMINISTERED ORALLY TO DUTCH-BELTED RABBITS WITH COVER LETTER
DATED 08-21-92
ELI
LILLY & CO |
Ethalfluralin
(CAS# 55283-68-6) was evaluated for developmental toxicity.
The test material was administered orally to 20 inseminated
Dutch-Belted rabbits in doses of 0, 25, 75, 150, or 300 mg/kg/day
on days 6-18 of gestation. At 150 and 300 mg/kg/day, maternal
toxicity was indicated by abortions which followed anorexia
and marked body weight loss. Absolute and relative
liver weight were elevated at 300 mg/kg/day. Prenatal
reproduction parameters, fetal body weights, and developmental
variations or abnormalities were not treatment-related. The
no-effect level for maternal toxicity was 75 mg/kg/day. |
NTIS/OTS0545074
EPA/OTS;
Doc #88-920006475 |
1992.
INITIAL SUBMISSION: A PILOT TERATOLOGY STUDY WITH ETHALFLURALIN
IN DUTCH-BELTED RABBITS WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO |
Ethalfluralin
(CAS# 55283-68-6) was evaluated for developmental toxicity.
Two, 4, 3, and 3 Dutch-Belted rabbits were dosed with 0, 250,
500, and 1000mg/kg/day, respectively, on days 6-18 of gestation.
At 1000 mg/kg/day, all rabbits aborted and were killed.
At 500 mg/kg/day, one rabbit aborted and was also killed.
Markedly reduced food consumption was observed in all rabbits
at 1000 mg/kg/day and in 1/3 at 500 mg/kg/day. Body
weight was also reduced in these rabbits. Reproduction
data (implantations, corpora lutea) in all groups were similar
to controls. No resorptions were observed at any dose level.
All fetuses were normal grossly.
This study was briefly summarized. |
| NTIS/OTS0545085
EPA/OTS;
Doc #88-920006486 |
1992.
INITIAL SUBMISSION: A TERATOLOGY STUDY WITH ETHALFLURALIN
IN DUTCH-BELTED RABBITS WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO |
Ethalfluralin
(CAS# 55283-68-6) was evaluated for developmental toxicity.
Fourteen, 11, and 14 pregnant Dutch-Belted rabbits were administered
0, 75, and 250 mg/kg/day of the test substance respectively,
on days 6-18 of gestation. An increase
in the number of anorectic rabbits occurred at 250 mg/kg/day.
Four and 3 rabbits of the 75 and 250
mg/kg/day dose group, respectively, died or aborted. The
abortions were preceded by anorexia and weight loss. Nine,
9, and 12 rabbits of the 0, 75, and 250 mg/kg/day dose groups
were available for evaluation. Live litter size, resorption
occurrence, fetal viability, and sex distribution were unaffected
by treatment. Mean fetal weights of
the treatment groups were lower than controls but the
differences were not statistically significant. An
increase in the incidence of skeletal abnormalities, including
cleft palate and crooked ribs, was observed at 250 mg/kg/day.
No treatment related visceral abnormalities were observed.
The 250 mg/kg/day dose was maternally
toxic but not teratogenic since the increased incidence of
fetal defects was associated with anorexic dams. The
75 mg/kg/day dose was a no-effect level. |
| NTIS/OTS0545118
EPA/OTS;
Doc #88-920006519 |
1992.
INITIAL SUBMISSION: A TWO-YEAR DIETARY EVALUATION WITH ETHALFLURALIN
IN FISCHER 344 RATS WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO
|
ETHALFLURALIN
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET
CAS No. 55283-68-6 |
NTIS/OTS0545090
EPA/OTS;
Doc #88-920006491 |
1992.
INITIAL SUBMISSION: A ONE-YEAR DIETARY TOXICITY STUDY WITH
ETHALFLURALIN IN RATS WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO
|
ETHALFLURALIN
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET
CAS No. 55283-68-6 |
NTIS/OTS0555145
EPA/OTS;
Doc #88-920008647 |
1992.
INITIAL SUBMISSION: DERMAL SENSITIZATION OF ETHALFLURALIN
IN THE GUINEA PIG WITH COVER LETTER DATED 08/18/92
ELI
LILLY & CO
|
ETHALFLURALIN
HEALTH EFFECTS
PRIMARY DERMAL SENSITIZATION
MAMMALS
GUINEA PIGS
DERMAL
CAS No. 55283-68-6 |
NTIS/OTS0544604
EPA/OTS;
Doc #88-920005947 |
1992.
INITIAL
SUBMISSION: ACUTE RAT ORAL STUDY WITH ETHALFLURALIN AND
LINURON WITH COVER LETTER DATED 08-03-92
ELI
LILLY & CO
|
ETHALFLURALIN
AND LINURON
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
CAS No. 55283-68-6 |
NTIS/OTS0543399
EPA/OTS;
Doc #88-920005936 |
1992.
INITIAL
SUBMISSION: LETTER FROM ELI LILLY & CO TO USEPA SUBMITTING
RESULTS ON AN ACUTE INHALATION STUDY WITH ETHALFLURALIN
AND FLURIDONE IN RATS WITH ATTACHMENTS
ELI
LILLY & CO |
ETHALFLURALIN
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
CAS Nos.
55283-68-6
59756-60-4 |
NTIS/OTS0544603
EPA/OTS;
Doc #88-920005946 |
1992.
INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH ETHALFLURALIN
WITH COVER LETTER DATED 08-03-92
ELI
LILLY & CO
|
ETHALFLURALIN
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
CAS Registry Numbers:
330-55-2
55283-68-6 |
NTIS/OTS0544933
EPA/OTS;
Doc #88-920006096 |
1992. INITIAL SUBMISSION: ACUTE
RAT INHALATION STUDY WITH FLURIDONE & ETHALFLURALIN
WITH COVER LETTER DATED 08-03-92
ELI
LILLY & CO |
FLURIDONE
& ETHALFLURALIN
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
CAS Registry Numbers:
55283-68-6
59756-60-4 |
NTIS/OTS0543304
EPA/OTS;
Doc #88-920005843 |
1992.
INITIAL
SUBMISSION: LETTER FROM ELI LILLY & CO TO USEPA SUBMITTING
RESULTS ON AN ACUTE INHALATION STUDY WITH ETHALFLURALIN
IN RATS WITH ATTACHMENTS
ELI
LILLY & CO |
ETHALFLURALIN
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
CAS Registry Numbers:
55283-68-6 |
NTIS/OTS0545116
EPA/OTS;
Doc #88-920006517 |
1992.
INITIAL SUBMISSION: A TWO-YEAR DIETARY EVALUATION WITH ETHALFLURALIN
IN B6C3F1 MICE WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO |
ETHALFLURALIN
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
MICE
ORAL
DIET
CAS Registry Numbers:
55283-68-6 |
NTIS/OTS0545236
EPA/OTS;
Doc #88-920006698 |
1992.
INITIAL SUBMISSION: A ONE-YEAR DIETARY TOXICITY STUDY WITH
ETHALFLURALIN IN B6C3F1 MICE WITH COVER LETTER DATED 08-21-92
ELI
LILLY & CO |
ETHALFLURALIN
HEALTH EFFECTS
CHRONIC TOXICITY
MAMMALS
MICE
ORAL
DIET
CAS Registry Numbers:
55283-68-6 |
NTIS/OTS0543330
EPA/OTS;
Doc #88-920005868 |
1992.
INITIAL SUBMISSION: LETTER FROM ELI LILLY & CO TO USEPA
SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH R-O-66-83
IN RATS WITH ATTACHMENTS
ELI
LILLY & CO
|
R-O-66-83
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
CAS Registry Numbers:
55283-68-6 |
NTIS/OTS0570719
EPA/OTS;
Doc #88-920008437 |
1992.
INITIAL
SUBMISSION: DERMAL SENSITIZATION OF BENZENAMINE, N-ETHYL-N-(2-METHYL-2-PROPENYL)-2,6-DINITRO-4-(TRIFLUOROMETHYL)-
IN GUINEA PIGS WITH COVER LETTER DATED 08-18-92
ELI
LILLY & CO
|
BENZENEAMINE,
N-ETHYL-N-(2-METHYL-2-PROPENYL)-2,6-DINITRO-4-
HEALTH EFFECTS
PRIMARY DERMAL SENSITIZATION
MAMMALS
GUINEA PIGS
DERMAL
CAS Registry Numbers:
55283-68-6 |
| NTIS/OTS0570822
EPA/OTS;
Doc #88-920008537 |
1992.
INITIAL
SUBMISSION: ORAL PILOT TERATOLOGY STUDY OF BENZENAMINE,
N-ETHYL-N-(2-METHYL-2-PROPENYL)-2,6-DINITRO-4-(TRIFLUOROMETHYL)-
IN RABBITS WITH COVER LETTER DATED 08-18-92
ELI
LILLY & CO |
BENZENAMINE,
N-ETHYL-N-(2-METHYL-2-PROPENYL)-2,6-DINITRO-4-*
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
ORAL
GAVAGE
CAS Registry Numbers:
55283-68-6 |
NTIS/OTS0516618
EPA/OTS;
Doc #88-890000001 |
1988.
LETTER FROM ELI LILLY AND COMPANY TO USEPA REGARDING CASE
STUDIES OF MONOLINURON EXPOSURE WITH ATTACHMENTS.
ELI
LILLY & CO
|
MONOLINURON
& ETHAFLURALIN
HEALTH EFFECTS
CASE REPORT
MAMMALS
HUMANS
CAS Registry Numbers:
1746-81-2
55283-68-6 |
NTIS/PB82-156035
21p |
1982.
The Determination
of Dinitroaniline Pesticides in Industrial and Municipal Wastewater:
Method 627
Pressley T, Longbottom JE
Environmental
Monitoring and Support Lab.-Cincinnati, OH.
|
This
is a gas chromatographic (GC) method applicable to the determination
of selected pesticides in municipal and industrial discharges
as provided under 40CFR 136.1. A sample is solvent extracted
with methylene chloride using a separatory funnel. The extract
is exchanged to hexane during concentration. GC conditions
are described which permit measurement with an electron capture
detector. The compounds included in the method scope are:
benfluralin; ethalfluralin; isopropalin;
profluralin; and trifluralin. Final
rept. |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15621183&query_hl=2
Chemosphere. 2005 Feb;58(6):693-703.
Atmospheric concentrations and dry and
wet deposits of some herbicides currently used on the Canadian
Prairies.
Waite DT, Bailey P, Sproull JF, Quiring
DV, Chau DF, Bailey J, Cessna AJ.
Environment Canada, 300-2365 Albert Street, Regina, Sask., Canada
S4P 4K1. don.waite@ec.gc.ca
High volume air sampling in the Canadian Prairies was used to
characterize atmospheric concentrations for 10 herbicides (alachlor,
atrazine, ethalfluralin, metolachlor,
2,4-D, dicamba, bromoxynil, MCPA, trifluralin, and triallate)
along a 500-km north-south transect. Atmospheric concentration
measurements at various altitudes identified that of the six herbicides
present in the highest concentrations, triallate was strongly
influenced by local sources, while 2,4-D, dicamba, bromoxynil,
MCPA and trifluralin were dominated by regional atmospheric transport.
Concentrations of the herbicides measured at various altitudes
were compared with dry deposition rates measured using a dry/wet
deposition sampler and used to calculate deposition velocities
V(d). The primary atmospheric transport mechanism for MCPA and
bromoxynil was shown to be adsorption to particles dispersed in
the atmosphere, with the same mechanism also confirmed for 2,4-D
and dicamba, while trifluralin was shown to be transported mainly
in the gas phase. This method of calculation indicated that transportation
of triallate was influenced by particle adsorption. Weekly maximum
atmospheric loadings of the major herbicides present in the Prairies
were estimated to range from 73 kg for trifluralin to 541 kg for
2,4-D.
PMID: 15621183 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15366828&query_hl=2
J Agric Food Chem. 2004 Sep 22;52(19):5828-35.
Analysis of pesticides in honey by solid-phase
extraction and gas chromatography-mass spectrometry.
Albero B, Sanchez-Brunete C, Tadeo JL.
Departamento de Medio Ambiente, INIA, Ctra de la Coruna Km 7,
28040 Madrid, Spain.
An analytical method for the simultaneous determination of 51
pesticides in commercial honeys was developed. Honey (10 g) was
dissolved in water/methanol (70:30; 10 mL) and transferred to
a C(18) column (1 g) preconditioned with acetonitrile and water.
Pesticides were subsequently eluted with a hexane/ethyl acetate
mixture (50:50) and determined by gas chromatography with electron
impact mass spectrometric detection in the selected ion monitoring
mode (GC-MS-SIM). Spiked blank samples were used as standards
to counteract the matrix effect observed in the chromatographic
determination. Pesticides were confirmed by their retention times,
their qualifier and target ions, and their qualifier/target abundance
ratios. Recovery studies were performed at 0.1, 0.05, and 0.025
microg/g fortification levels for each pesticide, and the recoveries
obtained were >86% with relative standard deviations of <10%.
Good resolution of the pesticide mixture was achieved in approximately
41 min. The detection limits of the method ranged from 0.1 to
6.1 microg/kg for the different pesticides studied. The developed
method is linear over the range assayed, 25-200 microg/L, with
determination coefficients of >0.996. The proposed method was
applied to the analysis of pesticides in honey samples, and low
levels of a few pesticides (dichlofluanid,
ethalfluralin, and triallate) were
detected in some samples.
PMID: 15366828 [PubMed - indexed for MEDLINE]
JOURNAL OF CHROMATOGRAPHY B; 714 (2). 1998.
205-213.
Headspace solid-phase microextraction
and gas chromatographic determination of dinitroaniline herbicides
in human blood, urine and environmental water.
GUAN F, WATANABE K, ISHII A, SENO H. KUMAZAWA
T, HATTORI H, SUZUKI O
Dep. Legal Med., Hamamatsu Univ. Sch. Med., 3600 Handa-cho, Hamamatsu
431-3192, Japan.
BIOSIS COPYRIGHT: BIOL ABS. Solid-phase microextraction (SPME)
is a unique extraction and sampling technique, and it has been
used for separation of volatile organics from water or other simple
matrices. In this study, we have used SPME to separate dinitroaniline
herbicides from complicated matrices of human urine and blood
in order to broaden its application to biomedical analysis. The
SPME conditions were optimized for water, urine and blood samples,
in terms of pH, salt additives, extraction temperature, and fiber
exposure time. Urine or water (1.0 ml) spiked with herbicides
and 0.28 g of anhydrous sodium sulfate was preheated at 70C for
10 min, and a polydimethylsiloxane-coated fiber for SPME was exposed
to the headspace at 70C for another 30 min; while spiked blood
(0.5 ml) diluted with water (0.5 ml) was treated at 90C in the
same way. The herbicides were extractable under these conditions,
and could be determined by gas chromatography-electron capture
detector (GC-ECD). The recoveries of [abstract truncated]
CAS Registry Numbers: (fluorinated pesticides
in red)
55283-68-6 - Ethalfluralin
40487-42-1 - Pendimethalin
33820-53-0 - Isopropalin
33245-39-5 - Fluchloralin
29091-21-2 - Prodiamine
26399-36-0 - Profluralin
1861-40-1 - Benefin (Benfluralin)
J ENVIRON SCI HEALTH PART B PESTIC FOOD CONTAM AGRIC WASTES; 27
(6). 1992. 695-709.
Effect of some herbicides on activities
of microorganisms and enzymes in soil.
TU CM
London Res. Centre, Agric. Canada, 1400 Western Rd., London, Ontario,
Canada N6G 2V4.
BIOSIS COPYRIGHT: BIOL ABS. Laboratory tests were conducted with
eight herbicides, atrazine, butylate, ethalfluralin,
imazethapyr, linuron, metolachlor, metribuzin and trifluralin,
applied to a loamy sand at rate of 10 mug/g to determine if these
materials caused any serious effects on microbial and enzymatic
activities related to soil fertility. Some herbicides showed an
effect on bacteria and fungi for the first week of incubation,
but, subsequently, the populations returned to levels similar
to those obtained in the controls. After several herbicide treatments
there appeared to cause a slight depression of nitrification.
Sulfur oxidation was better than that obtained with untreated
soil in all treatments. Oxygen consumption was increased significantly
after 96 hr incubation with atrazine. The
soil dehydrogenase and amylase activities were inhibited by ethalfluralin
treatment respectively for 1 wk and 1 day, and p-nitrophenol
liberation was inhibited for 2 hrs by all herbicide treatments.
Result
CAN J SOIL SCI; 72 (3). 1992. 255-262.
The relative persistence of trifluralin
(545 EC and 5 G) and ethalfluralin in prairie soils.
GERWING PD , MCKERCHER RB
Gulf Canada Resources Ltd., Calgary, Alberta T2P 2H7, Can.
BIOSIS COPYRIGHT: BIOL ABS. The persistence in soil of trifluralin
545 EC, trifluralin 5 G, and ethalfluralin 360 EC was studied
over a 2-yr period at three different sites in Saskatchewan (Canada).
At two of the three sites both formulations of trifluralin were
more persistent than ethalfluralin when a canola crop was grown
in the treated soil. In the high organic matter soil at the third
site the persistance of trifluralin and ethalfluralin was similar
under both fallow and cropped conditions. Crop response data gathered
from wheat, oat and millet stands plus gas chromatographic analysis
of soil extracts indicated that trifluralin 545 EC and trifluralin
5 G persisted in soil for comparable lengths of time when applied
at rates between 0.85 and 1.40 kg a.i. ha-1. At recommended application
rates to summerfallowed fields, the amount of herbicide remaining
in the different soils at seeding time the following season was
least for ethalfluralin 360 EC. The average amount of trifluralin
545 EC, triflur [abstract truncated]
J AGRIC FOOD CHEM; 39 (4). 1991. 700-704.
GC and LC/MS determination of 20 pesticides
for which dietary oncogenic risk has been estimated./DIAGNOSIS
MATTERN GC, LIU C-H, LOUIS JB, ROSEN JD
Dep. Food Sci., Cook College, Rutgers Univ., New Brunswick, N.J.
08903.
BIOSIS COPYRIGHT: BIOL ABS. The National Research Council has
estimated dietary oncogenic risk for 28 pesticides registered
for use in the United States. We report a rapid analytical procedure
for 20 of these pesticides in a variety of crops based on a single
extraction step and the use of mass spectrometry for detection
and quantification. Recovery and sensitivity studies were performed
in various commodities (apples, peaches, potatoes, tomatoes, peppers,
spinach, lettuce, snap beans, and sweet corn) for the suspected
oncogenes acephate, alachlor, azinphos-methyl, captafol, captan,
chlordimeform, chlorothalonil, cypermethrin, diclofopmethyl, ethanfluralin,
metolachlor, oxadiazon, parathion, permethrin, pronamide, o-phenylphenol
terbutryne, folpet, linuron, and oryzalin. All pesticides were
determined by gas chromatography/chemical ionization mass spectrometry
(GC) except the last three, for which high-performance liquid
chromatography/mass spectrometry (HPLC/MS) was used. Average recoveries
at th [abstract truncated]
CAS Registry Numbers:
55283-68-6
55283-68-6
52645-53-1
52315-07-8
51338-27-3
51218-45-2
30560-19-1
23950-58-5
19666-30-9
19044-88-3
15972-60-8
6164-98-3
2425-06-1
1897-45-6
886-50-0
330-55-2
133-07-3
133-06-2
90-43-7
86-50-0
56-38-2
J AGRIC FOOD CHEM; 39 (10). 1991. 1781-1785.
Using fluorine-19 NMR for trace analysis
of fluorinated pesticides in food products.
MORTIMER RD, DAWSON BA
Food Res. Div., Bureau Chemical Safety, Food Directorate, Health
Protection Branch, Health Welfare Canada, Ottawa, Ontario, Canada
K1A 0L2.
BIOSIS COPYRIGHT: BIOL ABS. Fluorine nuclear magnetic resonance
spectroscopy is sufficiently sensitive for the analysis of fluorinated
pesticides in food sample extracts at the low parts per billion
level without manipulation of large samples and lengthy instrument
time. This sensitivity also permits the direct analysis of fluorine-containing
compounds in liquid food products such as vegetable oil and wine
at \ 1.0 mg with a 5 mm diameter probe.
CAS Registry Numbers:
82657-04-3 - Bifenthrin
69806-50-4 - Fluazifop-butyl
69409-94-5 - Fluvalinate
55283-68-6 - Ethalfluralin
53780-34-0 - Mefluidide
52756-25-9 - Flamprop-methyl
42874-03-3 - Oxyfluorofen
35367-38-5 - Diflubenzuron
27314-13-2 - Norflurazon
1582-09-8 - Trifluralin
1085-98-9 - Dichlofluanid
Teratology 1990 May;41(5):542
Developmental toxicity of dinitroanilines.
II. Ethalfluralin.
Byrd RA, Adams ER, Robinson K, Markham JK
Lilly Research Laboratories, Eli Lilly
and Co., Greenfield, Indiana.
Ethalfuralin [N-ethyl-N-(-methyl-2-propenyl)-2,6-dinitro-4-(trifluoromethyl)
benzenamine] is the active ingredient in the herbicides SONALAN
and EDGE. The potential developmental toxicity of ethalfluralin
was evaluated in rats and rabbits. Pregnant rats and rabbits were
dosed once daily by gavage on gestation days 6-15 and 6-18, respectively.
Doses for rats were 0, 50, 250, and 1000 mg/kg; doses for rabbits
were 0, 25, 75, 150, and 300 mg/kg. Cesarean sections were performed
on rats and rabbits on gestation days 20 and 28, respectively.
In rats, maternal toxicity was indicated at the 1000-mg/kg dose
level by depression of body weight gain and food consumption.
Fetal viability, weight, and morphology were not adversely affected
at any dose level. The NOELs for maternal and developmental toxicity
in the rat were 250 and 1000 mg/kg, respectively. The A/D ratio
in rats was less than 1. In rabbits, maternal toxicity was indicated
at the 150- and 300-mg/kg dose levels by abortions
in conjunction with depression of food consumption. Fetal
viability, weight, and morphology were not adversely affected
by ethalfluralin. The NOELs for maternal and developmental toxicity
in the rabbit were 75 and 300 mg/kg, respectively. The A/D ratio
in rabbits was less than 1. Based on these data, ethalfluralin
did not exhibit selective toxicity toward the developing conceptus.
CAN J SOIL SCI; 65 (3). 1985. 587-592.
DINITROANILINE HERBICIDE PERSISTENCE IN
SOIL IN SOUTHWESTERN ONTARIO CANADA
GAYNOR JD
No absract available
SZEGI, J. (ED.). SOIL BIOLOGY AND CONSERVATION OF THE BIOSPHERE,
VOLS. 1. AND 2; 8TH MEETING OF THE SOIL BIOLOGY SECTION OF THE HUNGARIAN
SOCIETY FOR SOIL SCIENCE, GODOLLO, HUNGARY, AUG. 26-28, 1981.
XV+460P.(VOL. 1); XII+439P.(VOL. 2). AKADEMIAI KIADO: BUDAPEST,
HUNGARY. ILLUS. ISBN 963-05-3700-1(VOLS. 1 AND 2).; 0 (0). 1984.
239-250.
EFFECT OF HERBICIDE COMBINATIONS CONTAINING
ETHALFLURALIN ON THE SOIL MICROFLORA AND THE NITROGEN-FIXING CAPACITY
OF AZOTOBACTER-CHROOCOCCUM
HELMECZI B, NAGY M, KATAI J, BESSENYEI M
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7426803&query_hl=2
Bull Environ Contam Toxicol. 1980
Sep;25(3):508-11.
Comparison of the persistence of ethalfluralin
and trifluralin in Saskatchewan field soils.
Hayden BJ, Smith AE.
No abstract available
PMID: 7426803 [PubMed - indexed for MEDLINE]
Toxicol. Appl. Pharmacol. 48(1): A7 1979
The biotransformation and biliary excretion
of ethalfluralin in male rats.
Hanasono GK, Moss CL
Toxicol. Div., Lilly Res. Lab.,
Greenfield, IN
PESTAB. Ethalfluralin (E), N-ethyl- N-(2-methyl- 2-propenyl)-
2,6-dinitro- 4-(tri fluoromethyl) benzenamine, a dinitroaniline
herbicide, is rapidly metabolized by rats. The peak plasma concentration
of E (150 ng/ml) 2 hr after a single 100-mg/kg oral dose of ring-labeled
[14C]E represented less than 2% of the total plasma radiocarbon
content. Peak tissue concentrations of radioactivity
at 8 hr in liver > fat > kidney were all 2- to 3-fold higher
than in plasma. Bile-fistula rats excreted about one-third
of the radiolabeled dose of E in the bile as metabolites during
a 24-hr period. Almost half of the biliary radioactivity collected
was characterized as glucuronide conjugates. GC-MS and NMR analyses
showed that a diol metabolie of E, N-ethyl-
N-(2-methyl- 2,3-dihydroxy propyl)- 2,6-dinitro- 4-(tri fluoromethyl)
benzenamine, was a major glucuronide metabolite in bile.
Approximately half of the biliary radioactivity infused into the
duodena of bile-fistula rats underwent enterohepatic circulation
and reappeared in the 24-hr bile collection. [Abstract #14 of
the 1979 annual meeting of the Society of Toxicology.] (Author
abstract by permission)
Toxicol. Appl. Pharmacol. 45(1): 321 1978
The metabolism and disposition of ethalfluralin,
a dinitroaniline herbicide, in male rats.
Hanasono GK , Occolowitz JL, Wollen RL
Toxicol. Div., Lilly Res. Lab.,
Greenfield, IN
PESTAB. The excretion, biotransformation, and enterohepatic circulation
of ring-labeled [14C] ethalfuralin [N-ethyl- N- (2-methyl- 2-propenyl)-
2,6-dinitro- 4(trifluro methyl) benzeamine] was investigated in
male rats given single oral doses (100 mg/kg). The 7-day urinary
and fecal excretion of radiolabeled materials by intact animals
accounted for 24 and 71%, respectively, of the administered radioactivity.
Three urinary metabolites of ethalfluralin were identified by
GC-MS and by high-resolution mass spectrometry. A
major urinary metabolite (ca. 25% of urinary 14C) was identified
as 2-(hydroxymethyl)- 3-[2,6-dinitro- 4-(trifluoro- methyl) phenylamine]
propanoic acid. Animals with biliary fistulas excreted
32% of the radiocarbon dose into the bile by 24 hr and 41% by
48 hr. When bile containing 14C-labeled metabolites of ethalfluralin
was infused into the duodenum of other bile duct-cannulated rats,
45% of the administered radioactivity reappeared in the 24-hr
bile collection. This indicated that an appreciable portion of
the labeled materials excreted into the bile undergoes enterohepatic
circulation. [Presented at the 17th Annu. Mtg. of the Soc. of
Toxicol.] (Author abstract by permission)
PHYTOPARASITICA; 4 (2). 1976; 149
ETHALFLURALIN A NEW RESIDUAL HERBICIDE
IN COTTON
KOREN E, DAHAN C, MARMELSTEIN M
