CAS No. 135319-73-2 or 133855-98-8 (formerly 106325-08-0)

Return to Epoxiconazole Adverse Effects

ACTIVITY: Fungicide (Triazole)

CAS Name: rel -1-[[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole


Adverse Effects:

Body Weight Decrease
Carcinogenic: LIVER

Endocrine: Adrenal
Endocrine: Ovary
Endocrine: Pituitary
-Adrenal axis
Endocrine: Suspected Disruptor


Environmental Effects:

1997. European Commission: Banned.
Low degradability, toxic to water-living organisms and endocrine effects.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Import Tolerances Established
US EPA Chemical Code: 123909
US Tolerances: 40 CFR §180.619
FDA LMS Code: B53
Note: Norway: Banned
- also, see box below
US Tolerances: Import tolerances for banana and coffee.
Registered use in
(includes only a limited list of countries)

Germany, Hungary, Netherlands, New Zealand, Vietnam, South Africa, UK
Other Information
Molecular Formula: C17H13C1 F N3O
Entry Year: 1995 
Manufacturers: BASF
Other Names: BAS 480F, Opus® Fungicide, Opal® 7.5 EC Fungicide
Of special interest:
PAN Data
August 2006. US EPA Pesticide Fact Sheet.
April 26, 2006. Chemicals Evaluated for Carcinogenic Potential by the Office of Pesticide Programs. From: Jess Rowland, Chief Science Information Management Branch Health Effect Division (7509C) Office of Pesticide Programs, USEPA.
April 7, 2006. Too good to be true: The pesticide scam. By Mike Abram. Farmers Weekly (UK).

Epoxiconazole ranked number 14 for "Most Widely used pesticides in the UK (by Area Treated)"

Rank Formulation Method Area treated (ha) Weight applied (kg ai)
14 Epoxiconazole Spray 710,744 46,860

Ref: April 29, 2000. UK Department for Environment, Food & Rural Affairs in the online report, "Design of a Tax or Charge Scheme for Pesticides. " Annex C3: Overview of Pesticide Industry

June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role
in endocrine disruption. During 2000, a candidate list of 553 man-made substances
and 9 synthetic/natural hormones has been identified."
Organofluorine pesticides in this list include:

Substances included on the Endocrine Disruptor Liist CAS No. Substances included on the Endocrine Disruptor Liist CAS No.
Bifenthrin 82657-04-3 Flutriafol 76674-21-0
Cyhalothrin (@Karate) 91465-08-6 Fluvalinate 69409-94-5
Diflubenzuron 35367-38-5 Prodiamine 29091-21-2
Epoxiconazole 135319-73-2 Stannane, tributylfluoro [Tributyltin fluoride] 1983-10-4
Fipronil - Thiazopyr -
Fluazifop-butyl 69806-50-4 Trifluralin - 

April 2002 Beer in the UK: 23 organofluorine pesticides approved for use on malting barley. Published by the British Beer and Pubs Association and Brewing Research International.
October 2001 Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. Also available at: http://vm.cfsan.fda.gov/~acrobat/pestglos.pdf
August 2001 IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes Epoxiconazole.

US Federal Register
Date Published Docket Identification Number Details
September 13, 2006 EPA-HQ-2005-0071 BASF. Pesticide Tolerance. FINAL RULE.
This regulation establishes tolerances for residues of epoxiconazole in or on
-- Banana* at 0.5 ppm
-- Coffee* at 0.05 ppm
*No U.S. Registration as of August 4, 2006
Feb 15, 2006


PP 0E6128

BASF - Pesticide petition to establish tolerance. Pesticide Petition (PP 0E6128) to establish a tolerance for residues of the fungicide epoxiconazole, (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane in or on food commodity coffee bean at 0.05 ppm. Epoxiconazole residues are extracted from coffee beans with methanol-water. After filtration and precipitation of the interfering matrix components with calcium hydroxide, epoxiconazole is extracted from the aqueous mixture with hexane and chromatographed on silica gel. The samples are then analyzed by GC/ECD. Average recovery from fortified control samples is 90 ± 8% (n=22).
Sept 22, 2000 PF-961

BASF - Petition to Establish Tolerances for residues in or on bananas at 0.5 ppm and in or on banana pulp at 0.2 ppm.

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