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Activity: Fungicide (strobin)
Structure:

Adverse Effects:
Body Weight Decrease
Bone
Endocrine: Testicular

Body Weight Decrease (click on for all fluorinated pesticides)

-- Short term toxicity. Target / critical effect: No specific target organ toxicity (rat, dog) Reduced bodyweight and food consumption/ utilisation efficiency at highest dose tested. Lowest relevant oral NOAEL / NOEL: 90-d & 1-yr dietary, dog: 4.3 mg/kg bw/d. Lowest relevant dermal NOAEL / NOEL: 28-d, rat: >1000 mg/kg bw/d (limit dose)
-- Reproductive toxicity. Target / critical effect - Reproduction: No effects on reproductive performance; reduced body weights of offspring at the end of the lactation period at parentally toxic doses (750 ppm). Lowest relevant reproductive NOAEL / NOEL: 2-gen, rat: >750 ppm (78.2 mg/kg bw/d), this being the highest dose tested; 200 ppm (parent rats) Target / critical effect - Developmental toxicity: Ossification delay and increased incidence of skeletal variants at maternally toxic doses. Lowest relevant developmental NOAEL / NOEL: rat: 30 mg/kg bw/day rabbit: 25 mg/kg bw/day
-- Long term toxicity and carcinogenicity. Target / critical effect: No significant target organ toxicity. Reduced bodyweight and food consumption at the highest dose tested (750 ppm). Lowest relevant NOAEL: 2-yr, rat: 200 ppm (12.2 mg/kg bw/d). Carcinogenicity: No evidence of carcinogenicity
-- Other toxicological studies. o-phthalic acid (Metabolite 15, grain): Survey of published literature (November 2000) Acute oral LD50, rat: 7500-8400 mg/kg bw In-vitro genotoxicity (Ames test & cytogenetic assay in CHO cells): negative. Dominant lethal test: questionable positive test result involving reduced male fertility and abnormal sperm morphology. Non-carcinogenic in rats and mice according to NTP carcinogenicity programme. Reduced foetal body weight and retarded ossification in rats at maternal toxic doses
Ref: July 2003 - Review report for the active substance picoxystrobin. Picoxystrobin SANCO/10196/2003-Final. 3 June 2003. Finalised in the [European Commission] Standing Committee on the Food Chain and Animal Health at its meeting on 4 July 2003 in view of the inclusion of picoxystrobin in Annex I of Directive 91/414/EEC/.
http://www.fluorideaction.org/pesticides/picoxystrobin.eu.june.2003.pdf

Bone (click on for all fluorinated pesticides)

-- Reproductive toxicity. Target / critical effect - Reproduction: No effects on reproductive performance; reduced body weights of offspring at the end of the lactation period at parentally toxic doses (750 ppm). Lowest relevant reproductive NOAEL / NOEL: 2-gen, rat: >750 ppm (78.2 mg/kg bw/d), this being the highest dose tested; 200 ppm (parent rats) Target / critical effect - Developmental toxicity: Ossification delay and increased incidence of skeletal variants at maternally toxic doses. Lowest relevant developmental NOAEL / NOEL: rat: 30 mg/kg bw/day rabbit: 25 mg/kg bw/day
-- Other toxicological studies. o-phthalic acid (Metabolite 15, grain): Survey of published literature (November 2000) Acute oral LD50, rat: 7500-8400 mg/kg bw In-vitro genotoxicity (Ames test & cytogenetic assay in CHO cells): negative. Dominant lethal test: questionable positive test result involving reduced male fertility and abnormal sperm morphology. Non-carcinogenic in rats and mice according to NTP carcinogenicity programme. Reduced foetal body weight and retarded ossification in rats at maternal toxic doses
Ref: July 2003 - Review report for the active substance picoxystrobin. Picoxystrobin SANCO/10196/2003-Final. 3 June 2003. Finalised in the [European Commission] Standing Committee on the Food Chain and Animal Health at its meeting on 4 July 2003 in view of the inclusion of picoxystrobin in Annex I of Directive 91/414/EEC/.
http://www.fluorideaction.org/pesticides/picoxystrobin.eu.june.2003.pdf

Endocrine: Testicular (click on for all fluorinated pesticides)

-- Other toxicological studies. o-phthalic acid (Metabolite 15, grain): Survey of published literature (November 2000) Acute oral LD50, rat: 7500-8400 mg/kg bw In-vitro genotoxicity (Ames test & cytogenetic assay in CHO cells): negative. Dominant lethal test: questionable positive test result involving reduced male fertility and abnormal sperm morphology. Non-carcinogenic in rats and mice according to NTP carcinogenicity programme. Reduced foetal body weight and retarded ossification in rats at maternal toxic doses
Ref: July 2003 - Review report for the active substance picoxystrobin. Picoxystrobin SANCO/10196/2003-Final. 3 June 2003. Finalised in the [European Commission] Standing Committee on the Food Chain and Animal Health at its meeting on 4 July 2003 in view of the inclusion of picoxystrobin in Annex I of Directive 91/414/EEC/.
http://www.fluorideaction.org/pesticides/picoxystrobin.eu.june.2003.pdf