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Activity: Herbicide
(Anilide)
Structure:
Adverse Effects:
Eye
Kidney
•
As of October 11, 2003: Very little tox info available.
Many animal studies performed in the 1980's were found to
be unacceptable.
See:
Mefluidide,
diethanolamine salt: Summary of Toxicology Data. 1986. California
EPA, Department of Pesticide Regulation, Medical Toxicology
Branch.
http://www.fluoridealert.org/pesticides/mefluidide.ca.epa.1986.pdf
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Eye
(click
on for all fluorinated pesticides)
The studies reviewed
below were conducted with either the free acid or the diethanolamine
salt of mefluidide. The diethanolamine salt is the registered
active ingredient in California. Possible toxicological differences
between the free acid and diethanolamine salt were not considered
in the following reviews. The free acid and diethanolamine salt
have been grouped by the US EPA (Morris, 10/5/93)...
-- 386-004 987263, "Two Year Feeding study in Rats", (International
Research and Development Corporation, Mattawan, MI, study no.
102-208, report no. 225, 6/14/79). Mefluidide (MBR 12325) technical,
purity 93%, fed in the diet to 50/sex/group at 0, 600, 1800 or
6000 ppm over two (2) years starting at in utero from a reproductive
study. ADVERSE EFFECT: retinal degeneration.
Eye effect NOEL = 600 ppm.
Ref: Summary of Toxicology Data. 1986. California
EPA, Department of Pesticide Regulation, Medical Toxicology Branch.
http://www.fluoridealert.org/pesticides/mefluidide.ca.epa.1986.pdf
Kidney
(click
on for all fluorinated pesticides)
The studies reviewed
below were conducted with either the free acid or the diethanolamine
salt of mefluidide. The diethanolamine salt is the registered
active ingredient in California. Possible toxicological differences
between the free acid and diethanolamine salt were not considered
in the following reviews. The free acid and diethanolamine salt
have been grouped by the US EPA (Morris, 10/5/93)...
-- ** 386-026 037397, "Twelve Month Diet Feeding Study of MBR-12325
in Dogs", (Riker Laboratories, experiment no. 0280CD0021, 11/1/82).
Technical MBR-12325 (Mefluidide), purity 93% and 91% at pre-study
and post-study, respectively, fed at 0, 60, 600 or 6000 ppm in
the diet to Beagle dogs, 6/sex/group for one year. Positive
for adverse effects on kidney at high dose. NOEL kidney
= 600 ppm; body weight = 60 ppm. Nephrosis
or degeneration of proximal convoluted renal tubular epithelium
in 4/12 at high dose. Record 059988 contains the diet analyses
for content, stability and homogeneity. ACCEPTABLE. (Gee, 3/17/86
and 7/14/88). EPA one-liner: Minimum. NOEL = 60 ppm (weight loss);
LEL = 600 ppm (cortical nephrosis). EPA one-liner: Minimum. NOEL
= 60 ppm (weight loss); LEL = 600 ppm (cortical nephrosis).
Ref: Mefluidide, diethanolamine salt: Summary
of Toxicology Data. 1986. California EPA, Department of Pesticide
Regulation, Medical Toxicology Branch.
http://www.fluoridealert.org/pesticides/mefluidide.ca.epa.1986.pdf
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