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Activity:
Intermediate
for herbicides (eg, Fluometron
and Norflurazon).
Intermediate for pharmaceuticals. Breakdown product.
Structure:
Adverse
Effects:
Blood
Genotoxic
Lung
•
Little toxicologic information available
•
See studies below submitted to US EPA
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Manufacturers: Diaz Chemical Corp, Hq, 40 Jackson St, PO
Box 194, Holley, NY 14470, (716) 638-6321;
Production site: Holley, NY 14470
[SRI. 1992 Directory of Chemical Producers-United States
of America. Menlo Park, CA: SRI International, 1992. 458]
Ref:
Hazardous Substances Data Bank for M-(TRIFLUOROMETHYL)ANILINE
CASRN: 98-16-8.
http://www.fluorideaction.org/pesticides/3-trifluoromethyl.an.toxnet.htm
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Blood
(click
on for all fluorinated pesticides)
--
HEMATOLOGIC. ACUTE EXPOSURE. Methemoglobinemia
is a possibility with exposure to m-trifluoroaniline.
-- CHRONIC EXPOSURE. Methemoglobin
was evident in rats exposed to m-trifluoromethylaniline for five
months... No reproductive studies were found. Methemoglobin inducers
are considered especially dangerous to the fetus.
-- ACUTE EXPOSURE. m-Trifluoromethylaniline is toxic by the oral,
inhalation, dermal, or IP routes.
Ref: TOXNET profile from Hazardous Substances
Data Bank.
http://www.fluoridealert.org/pesticides/3-Trifluoromethyl.an.TOXNET.htm
Abstract: Conclusions
of this criteria document: 3-trifluoromethylaniline has been show
to irritate the skin and mucous membranes.
Animal experiments show it to be a strong, indirect methaemoglobin-forming
agent.
Ref: Monograph
title: 3-Trifluoromethylaniline (3-trifluoromethylbenzeneamine).
Corporate
Name: Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee
on Existing chemicals of Environmental Relevance (BUA).
Source: VCH Verlagsgesellschaft mbH, D-W-6940 Weinheim, Germany,
1991. 43p. Bibl.ref. Language: English.
As cited on Toxline at Toxnet.
Genotoxic
(click
on for all fluorinated pesticides)
--
GENOTOXICITY. m-Trifluoromethylaniline
induced dominant lethal mutations in flies.
-- ACUTE EXPOSURE. m-Trifluoromethylaniline is toxic by the oral,
inhalation, dermal, or IP routes.
-- Non-Human Toxicity Excerpts: WHEN ADDED TO FOOD OF LARVAL &
IMAGO DROSOPHILA, M-TRIFLUOROMETHYLANILINE INCR
INCIDENCE OF DOMINANT LETHAL MUTATIONS AMONG OFFSPRING & INCR
PERCENTAGE OF UNFERTILIZED EGGS.
[ILICHKINA AG ET AL; MOL MEKH GENET PROTSESSOV 291 (1976)].
Ref: TOXNET profile from Hazardous Substances
Data Bank.
http://www.fluoridealert.org/pesticides/3-Trifluoromethyl.an.TOXNET.htm
Lung
(click
on for all fluorinated pesticides)
--
RESPIRATORY. ACUTE EXPOSURE. m-Trifluoroaniline is expected to
be a severe respiratory irritant
because of its corrosive properties. Pulmonary
edema is possible. Cyanosis has been reported in experimental
animals.
-- HEMATOLOGIC. ACUTE EXPOSURE. Methemoglobinemia
is a possibility with exposure to m-trifluoroaniline.
-- CHRONIC EXPOSURE. Methemoglobin
was evident in rats exposed to m-trifluoromethylaniline for five
months... No reproductive studies were found. Methemoglobin inducers
are considered especially dangerous to the fetus.
-- GENOTOXICITY. m-Trifluoromethylaniline induced dominant lethal
mutations in flies.
-- ACUTE EXPOSURE. m-Trifluoromethylaniline is toxic by the oral,
inhalation, dermal, or IP routes.
-- Non-Human Toxicity Excerpts: WHEN ADDED TO FOOD OF LARVAL &
IMAGO DROSOPHILA, M-TRIFLUOROMETHYLANILINE INCR INCIDENCE OF DOMINANT
LETHAL MUTATIONS AMONG OFFSPRING & INCR PERCENTAGE OF UNFERTILIZED
EGGS. [ILICHKINA AG ET AL; MOL MEKH GENET PROTSESSOV 291 (1976)].
Ref: TOXNET profile from Hazardous Substances
Data Bank.
http://www.fluoridealert.org/pesticides/3-Trifluoromethyl.an.TOXNET.htm
Note
from FAN: If anyone has copies of the following reports,
please share them with us. Thanks. EC.
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1992.
INITIAL
SUBMISSION: LETTER SUBMITTING 4 STUDIES ON M-AMINOBENZOTRIFLUORIDE
AND 3-NITRO-4-CHLOROBENZOTRIFLUORIDE (FINAL REPORT)
Corporate Name: HAZLETON
LABS
Source:
EPA/OTS; Doc #88-920001174
Order
Number: NTIS/OTS0537071
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1987.
INITIAL SUBMISSION: LETTER FROM OCCIDENTAL CHEM CORP TO
USEPA REGARDING ACUTE TOXICITY STUDIES OF 3-(TRIFLUOROMETHYL)ANILINE
WITH ATTACHMENTS, DATED
5/22/87
Corporate Name: HAZLETON
LABORATORIES
Source: EPA/OTS; Doc #FYI-OTS-0794-1036
Order
Number: NTIS/OTS0001036
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1985.
Benzenamine, 3-(trifluoromethyl)-
Authors:
ANON
Source: In:
EPA Chemical Profiles, United States Environmental Protection
Agency, Washington D.C. 20460, USA, Dec. 1985.
4p.
Abstract:
Aspects covered in this data sheet: chemical identity; exposure
limits; physicochemical properties; fire and explosion hazards;
reactivity; health hazards; uses; handling of spills or
releases.
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3-Trifluoromethylaniline
(3-trifluoromethylbenzeneamine)
Corporate Name:
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee
on Existing chemicals of Environmental Relevance (BUA)
Source: VCH
Verlagsgesellschaft mbH, D-W-6940 Weinheim, Germany, 1991.
43p. Bibl.ref.
Abstract:
Conclusions of this criteria document:
3-trifluoromethylaniline has been show to irritate the skin
and mucous membranes. Animal experiments show it to be a
strong, indirect methaemoglobin-forming agent. Ecotoxicological
data are also provided.
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1991.
3-Trifluoromethylaniline (Trifluoromethylbenzeneamine)
Authors: Anonymous
Source:
TA:Beratergremium
fuer umweltrelevante Altstoffe (BUA) PG:47 p YR:1991
IP: VI:44
Abstract:
Ecological aspect: In a standard test (Zahn-Wellens-Test
- test for inherent biodegradability) trifluoromethylaniline
is biologically degraded. After 28 days, the value for biological
degradability was 74%. 3-Trifluoromethylaniline emitted
into the air is subjected to a photochemical-oxidative degradation
by reaction with photo-chemically formed OH radicals, where
a half-life value of approximately 10 hours was estimated.
On the basis of log Pow = 2.39 only a slight bioaccumulation
of 3-trifluoromethylaniline is to be expected. The bacterial
toxicity (EC 50) in an oxygen consumption inhibition test
(OECD 209) is greater than 1400 mg/l; the EC 0 was determined
as 174 mg/l. In a test procedure for measurement of algae
fluorescence a toxic threshold concentration of 0.67 mg/l
was determined for 3-trifluoromethylaniline. Growth inhibition
in algae was observed at 1.9 mg/ml. Acute studies with daphniae
revealed no harmful effects at 0.3 mg/ml. The EC 50 values
after 24 and 48 hours were 6.6 mg/ml and 2.7 mg/l respectively.
The fish toxicity (Brachydanio rerio) was determined as
35 mg/l (48 and 96 hours). The LC 0 was 25 mg/l and the
LC 100 50 mg/l. Toxicological aspect: 3-Trifluoromethylaniline
is a strong, indirect methaemo-globinforming agent. 3-Trifluoromethylaniline
irritates the skin and mucous membranes. Indications of
blood picture changes, disturbances of the renal and hepatic
function and morphological changes of the nervous system
are given in an insufficiently documented chronic inhalation
study. In mutagenicity studies (Ames-test, DNA repair assay,
Drosophila test) no mutagenic effects were detected. Cancerogenicity
and reproduction toxicity data are not available.
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