Note: This is not an exhaustive list.
When time allows more information will be added.

Diabetes

Sodium fluoride - Insecticide, Wood preservative, US EPA List 4B Inert - CAS No. 7681-49-4

Summary: Wistar rats were given 20 ppm fluroide in drinking water, or single administration of 115 mg/kg alloxan i.m. to induce diabetes, or single administraiton of 115 mg/kg alloxan i.m. followed by 20 ppm fluoride for 31 days. Blood sugar level increased in rats given alloxan and alloxan + fluoride. Body weight gain in rats given alloxan + fluoride decreased significantly compared to other groups. Decrease in haemoglobin and glutamic oxaloacetate transaminase (GOT) was seen only in rats given alloxan + fluoride. In this group alkaline phosphatase, the target enzyme in fluoride toxicosis, increased considerably. The toxicity of fluoride in diabetic rats was further reflected in organ weight data. This investigation shows that fluoride toxicity is greater in diabetic rats.
Ref: Fluoride 1997; 30(1):43-50. Toxicity of fluoride to diabetic rats; by Priya CATB, Anitha K, Mohan EM, Pillai KS, Murthy PB

Triphenyltin fluoride - Antifoulant, Algaecide, Herbicide - CAS No. 379-52-2

Abstract: ...Recently we found that a single oral administration of triphenyltin fluoride to rabbits induces transient diabetes and diabetic lipemia by inhibiting insulin secretion from morphologically normal pancreatic B-cells...
Ref: Recent progress in the study of analytical methods, toxicity, metabolism and health effects of organotin compounds by Wada O, Manabe S, Iwai H, Arakawa Y. Sangyo Igaku 1982 Jan;24(1):24-54.

Abstract: ... These findings suggest that TPTF inhibits insulin release from rabbit islets, subsequently inducing diabetic lipemia due to the insulin deficiency. Furthermore, it is possible to provide a new animal model for diabetes and diabetic lipemia by administration of TPTF to rabbits.
Ref: Triphenyltin fluoride (TPTF) as a diabetogenic agent. TPTF induces diabetic lipemia by inhibiting insulin secretion from morphologically intact rabbit B-cell by Manabe S, Wada O. Diabetes 1981 Dec;30(12):1013-21.

Abstract: . Phenyltin compounds have been used as agricultural chemicals and marine antifoulants and studied from the stand-point of toxicity. The in vivo mechanisms of toxicity and metabolism are not understood. Oral administration of 100 mg/kg body wt of tripheyltin fluoride (TPTF) to rabbits evoked hypertriglyceridemia. The mechanism of TPTF-induced hypertriglyceridemia was studied by following the time course of fasting blood glucose (FBS), glucose tolerance tests, serum IRI (immunoreactive insulin), serum lipids and lipoprotein lipase (LPL) activity and by determining the influence of insulin on TPTF-induced hypertriglyceridemia. The pancreatic islets, liver and kidney of the rabbits were also examined histologically. After TPTF administration, FBS and plasma triglyceride concentration were elevated significantly (P < 0.02) forma postheparin lipolytic activity) and LPL in adipose tissue decreased (P < 0.02), while chyromicron and VLDL (very low density lipoproteins) increased. Insulin treatment for 1 or 2 days increased LPL activity to the normal level but withdrawal of insulin from the insulin-treated rabbits again resulted in a decrease in LPL activity. A single oral dose of TPTF evoked diabetic lipemia and glucose intolerance due to insulin deficiency. The IRI level decreased before and even after glucose infusion during these periods. Microscopic examinations revealed no remarkable changes in the pancreas islets, liver and kidney. Pancreatic B-cells contained normal amounts of granules at the maximal hyperlipemic stage. TPTF interfered with insulin release from rabbit beta-cells and/or TPTF decreased the sensitivity of islets to release insulin in response to increasing levels of blood glucose.
Ref: MANABE S and WADA O (1981). Transient diabetic lipemia and reversible glucose intolerance in rabbits after a single dose of triphenyltin fluoride. J JPN DIABETIC SOC; 24 (6). 669-677.

Tributyltin fluoride - Antifoulant, Fungicide, Microbiocide - CAS No. 1983-10-4

Pub Med abstract: ... These results suggest that hyperlipidemia induced in rabbits by tributyltin fluoride is due to decreased LPL [Lipoprotein lipase] activity. The decrease in LPL activity seems to be related to the inhibition of insulin release from islets by TBTF.
Ref: [Properties and mechanism of hyperlipidemia induced in rabbits by tributyltin fluoride] by Matsui H, Wada O, Manabe S, Ono T, Iwai H, Fujikura T. Sangyo Igaku 1982 Mar;24(2):163-71.
• Hyperlipidemia = High Cholesterol

Hydroureter

Fluazifop-butyl - Herbicide - CAS No. 69806-50-4

-- Fetotoxicity (delayed ossification and eye opacities) was also demonstrated in New Zealand White rabbits (the LOEL was 30 mg/kg/day; the NOEL was 10 mg/kg/day). EPA believes that there is sufficient evidence for listing fluazifop butyl on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available hepatic and developmental toxicity data for this chemical.
-- In a teratogenicity study in Sprague-Dawley rats exposed via oral gavage, delayed ossification and an increased incidence of hydroureter were observed in fetuses (the fetotoxic LOEL was 5 mg/kg/day; the NOEL 1 mg/kg/day) and a teratogenic LOEL of 200 mg/kg/day (the NOEL was 10 mg/kg/day) was determined based on the incidence of diaphragmatic hernia.
Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993). As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

In a teratogenicity study in Sprague-Dawley rats exposed via oral gavage, delayed ossification and an increased incidence of hydroureter were observed in fetuses (the fetotoxic LOEL was 5 mg/kg/day; the NOEL 1 mg/kg/day) and a teratogenic LOEL of 200 mg/kg/day (the NOEL was 10 mg/kg/day) was determined based on the incidence of diaphragmatic hernia.
Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

Triphenyltin fluoride - Antifoulant, Algaecide, Herbicide - CAS No. 379-52-2

2. Comment. American Hoechst Corporation disagrees with the Agency's [US EPA] position that TPTH produces teratogenic effects and that a NOAEL has not been determined in the two previously reviewed rat teratogenicity studies [Refs. 5 and 46]. American Hoechst and M&T Chemicals had the rat teratology study by Battelle Columbus Laboratories [Ref. 3] peer reviewed by two independent sources and submitted the results of those reviews. One reviewer found that 2.8 mg/ kg/day was clearly a NOAEL for teratogenicity while the second reviewer was unable to identify a no effect level from the data available. In addition, American Hoechst submitted the results of a teratology study of triphenyltin fluoride (TPTF) that had been previously submitted to EPA. The NOAEL for this study was 3.0 mg/kg/day.
Response. The submissions from American Hoechst Corporation do not satisfactorily eliminate concerns regarding the teratogenicity of TPTH because no new information was presented to the Agency. Although these studies provided sufficient data to assure that TPTH is not teratogenic in rats at dose levels up to and including 8.0 mg/kg/day, these studies did result in developmental and maternal toxicity. Second, the registrant did not provide new information indicating that a NOAEL exists in the two rat studies. Third, the teratology study with TPTF also indicated hydroureter as a fetal lesion. The initial reviewer of this study classified this compound as a teratogen.
Ref: Federal Register: October 20, 2000. Triphenyltin Hydroxide; Proposed Determination To Terminate
Special Review. Proposed Determination to Terminate Special Review.
http://www.epa.gov/EPA-PEST/2000/October/Day-20/p27036.htm

Immunological

Flucarbazone-sodium - Herbicide - CAS No. 181274-17-9

SUBCHRONIC/CHRONIC TOXICITY
-- Study # 870.3100. 28-Day oral toxicity in rodents (rats) NOAEL = 27 mg/kg/day in males and 25 mg/kg/day in females. LOAEL = 266 mg/kg/day in males and 251 mg/kg/day in females based on immunological changes in both sexes.
-- Study # 870.3100. 90-Day oral toxicity in rodents (rats) NOAEL = 73.5 mg/kg/day in males and 102 mg/kg/day in females LOAEL = 287 mg/kg/day in males and 358 mg/kg/day in females based on immunological findings in both sexes
-- Study # 870.4300. 2-Year Chronic toxicity/carcinogenicity in rats NOAEL = 125 mg/kg/day in males and females LOAEL = 1,000 mg/kg/day in males and females based on decreased body weight and increased food consumption in females, thickened mucosa of the glandular stomach in both sexes, inflammatory infiltrates (males), vacuolation of the squamous epithelium in the fore-stomach (females) and immunological effects in males. no evidence of carcinogenicity
Ref: US EPA Pesticide Fact Sheet for Flucarbazone-sodium. September 29, 2000. http://www.epa.gov/opprd001/factsheets/flucarbazone.pdf

Ringing in Ears

1,1,1,2-Tetrafluoroethane (HFC-134a) - Propellant; Inert - CAS No. 811-97-2

-- The adverse events observed during the exposures to HFC-134a and HFC-227ea were unexpected and inconsistent with the published data. Based on the published data on HFC-134a and HFC-227ea, no adverse effects should have been observed at the 0.4% v/v and 0.6% levels, respectively, used in this study.
-- Subject #3 reported problems with dizziness and balance following the exposure. At the time of this report (6 weeks post exposure), both the dizziness and balance problems still persisted. Subject #5 reported chest tightness and a headache with associated dizziness immediately following the exposure. The headache subsided by the time the subject woke up the day following the exposure. The day following the exposure, subject #5 reported unusual feelings in the chest resembling "flutters". The chest tightness was reported to subside within 3 days of the exposure and the "flutters" within 2 weeks of the exposure. As with subject #3, subject #5 was still experiencing dizziness and balance problems at the time of this report (6 weeks post exposure). Subject #5 also reported persistent ringing in the ears which was still present at the time of this report.
-- The presence of HFC-134a in the blood 1 hour after exposure was unexpected.
-- In summary, all 7 human volunteers completed the Halon 1301 exposures without incident while both the HFC-134a and HFC-227ea exposures were terminated due to the adverse effects described in this report.
Ref: 1997. Human Inhalation of Halon 1301, HFC-134a and HFC-227ea for Collection of Pharmacokinetic Data. 19 Aug 97.
http://www.fluoridealert.org/pesticides/1.1.1.2.3.3.3-hep.97.report.htm