Gastrointestinal Tract - Adverse Effects
Fluorinated and Fluoride Pesticides

The use of high doses increases the likelihood that potentially significant toxic effects will be identified. Findings of adverse effects in any one species do not necessarily indicate such effects might be generated in humans. From a conservative risk assessment perspective however, adverse findings in animal species are assumed to represent potential effects in humans, unless convincing evidence of species specificity is available.

-- Food and Agricultural Organization of the United Nations

Note: This is not an exhaustive list.
When time allows more information will be added.

Fuazifop-butyl - Herbicide - CAS No. 69806-50-4

**411-083 069476 Virgo, D. M., "Fluazifop-butyl: 55 week oral toxicity study in beagle dogs," Life Science Research, Stock, Essex, England, 10/15/82. LSR Report No. 81/ILK019/620. Six dogs/sex/group were dosed for 55 weeks with Fluazifop-butyl, 99.6% purity, by gelatin capsules at dose levels of 0, 5, 25, and 125 mg/kg/day in a chronic study. Test article within capsules was dissolved in 0.4 ml/kg corn oil vehicle. NOEL = 5 mg/kg/day... All other noteworthy findings were limited to the high dose group, as follows. Seven 125 mg/kg/day dogs (5 M, 2 F) were killed in extremis prior to term, generally after at least 29 weeks on study. Fluazifop-butyl caused ulcerations in the g.i. tract, specifically in the tongue, lip, mouth lining, stomach pylorus, or cecum. Ulcerations may have contributed to low RBC parameters in both sexes (reduced HCT, Hb levels, and RBC counts, particularly in males)...
Ref: May 20, 2002. SUMMARY OF TOXICOLOGY DATA FLUAZIFOP-P-BUTYL. California EPA. Department of Pesticide Regulation. Medical Toxicology Branch.

Fluosilicic acid - Wood Preservative - CAS No. 16961-83-4

-- Rats, oral; 430 mg/ kg (LD 50 ; 2.98 mmol/ kg); Somnolence and/ or general depressed activity was observed. RTECS* (2000)
-- Rats, Sprague- Dawley albino, oral (via stomach tube); single doses of 215, 464, 1000, and 2100 mg/ kg (1.49, 3.22, 6.939, and 14.57 mmol/ kg) dissolved in water. Animals were observed for 14 days and then necropsied. With 464 mg/ kg, 3 out of 5 rats died; at 1000 mg/ kg, 100% mortality was observed. At 464 mg/ kg, acute depression was observed. Necropsy showed that animals in the low- dose group were "grossly normal" and that dead rats had massive hemorrhages in the entire gastrointestinal tract. Rhone- Poulenc Inc. (1971)
Ref: Review of Toxicological Literature. October 2001. Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4]. Prepared for Scott Masten, Ph.D. National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709. Contract No. N01-ES-65402. Submitted by Karen E. Haneke, M.S. (Principal Investigator) Bonnie L. Carson, M.S. (Co-Principal Investigator) Integrated Laboratory Systems P.O. Box 13501 Research Triangle Park, North Carolina 27709.

Fluorouracil - Former insect Chemosterilant; now used as a pharmaceutical - CAS No. 51-21-8

A major use of fluorouracil is in the palliative treatment of carcinoma of the colon, rectum, breast, stomach, and pancreas that is not amenable to surgery or irradiation. The major toxic effects of fluorouracil are on the normal, rapidly proliferating tissues particularly of the bone marrow and lining of the gastrointestinal tract. Leukopenia, predominantly of the granulocytopenic type, thrombocytopenia, and anemia occur commonly with intravenous fluorouracil therapy at doses ranging from 6 to 12 mg/kg. Pancytopenia and agranulocytosis also have occurred.
Ref: USEPA/OPPT. Support Document for the Health and Ecological Toxicity Review of TRI Expansion Chemicals. U. S. Environmental Protection Agency, Washington, DC (1993). As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

POTENTIAL ADVERSE EFFECTS ON FETUS: Exposure in first trimester resulted in skeletal abnormalities; hypoplasia of aorta, lungs, thymus, and gastrointestinal tract; and urinary tract abnormalities. Fetus exposed in third trimester had cyanosis and clonus.
Ref: TOXNET profile from Hazardous Substances Data Base.

Tetraconazole - Fungicide - CAS No. 112281-77-3

Metbolism nd Toxicokinetics. Tetraconazole was broadly distributed to all organs and tissues tested, with the highest level detected in the liver, followed by kidneys, gonads, brain and bones. Low residual levels were still detected in the liver and gastrointestinal tract (sometimes bones) at 72 hr.
Ref: August 2005 - Evaluation of Tetraconazole in the product Domark 40ME Fungicide. Australian Pesticides and Veterinary Medicines Authority.

Triflusulfuron-methyl - Herbicide - CAS No. 126535-15-7

Groups of 20 artificially inseminated female rabbits were treated by gavage with 0, 15, 90, 270 or 800 mg/kg bw/d DPX-66037-24 (95.6% purity) on days 719 of gestation. The NOEL for maternal toxicity was 15 mg/kg bw/d. At 90 mg/kg bw, body-weight gains were lower than controls at the beginning of the treatment period. Clinical signs of toxicity were observed at 270 mg/kg bw/d (stool absent or reduced, small stool), abortions and evidence of gastrointestinal effects were found at gross necropsy (ulceration of gastric mucosa, gaseous distension). Food consumption was also lower than controls in the 270 and 800 mg/kg bw/d groups...
Ref: Dec 3, 1999 - Report on Triflusulfuron methyl. Regulatory Note REG99-03. Pest Management Regulatory Agency, Health Canada, Ottawa.

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