Pesticide
CAS
No. |
Cancer
detail |
Cancer
site |
Activity |
US
Approved on Food Commodities |
Registered
use:
(includes a very limited number of countries) |
| |
Acifluorfen
50594-66-6 |
Carcinogen |
•
Liver (Mice)
|
Herbicide |
NO |
Canada,
Taiwan |
Acifluorfen,
sodium
62476-59-9 |
US EPA:
"Probable Human Carcinogen" |
•
Liver (Mice) |
Herbicide |
YES
US:
permitted in or on 5 food commodities:
Peanut,
Rice, grain,
Rice, straw,
Soybean,
Strawberry
See
food
tolerances |
Australia,
Hungary, US |
Bifenthrin
82657-04-3
(Cis);
83322-02-5
(Trans) |
US EPA:
"Possible Human Carcinogen" |
•
Urinary bladder
(Mice, male)
•
Lung
(Mice, female) |
Acaricide
Insecticide |
YES
US:
As of Feb 11, 2005, permitted in or
on 198 food commodities.
See
food
tolerances
Also,
a tolerance of 0.05 ppm in or on all
food/feed items (other than those covered by a higher
tolerance as a result of use on growing crops) in food/feed
handling establishments. |
Australia,
Hungary, Japan, New Zealand, Portugal, South Africa, Taiwan,
Tanzania, Uganda, UK, US |
Chlorfenapyr
122453-73-0 |
US EPA:
"Suggestive
Evidence of Carcinogenicity, but Not Sufficient to Assess
Human Carcinogenic Potential''
based on significant trends in liver
tumors (adenomas and combined adenomas/ carcinomas), malignant
histiocytic sarcomas, and testicular cell tumors in male rats
and uterine polyps in female rats seen at the highest dose." |
•
Liver
•
Testicular
•
Uterine
•
Bone: Histiocytic sarcomas |
Acaricide
Insecticide |
YES
US
Sept
26, 2003:
1 ppm in or on several raw vegetables
See
food
tolerances
US
Jan 26, 2005:
A tolerance of 0.01 ppm was established for residues of chlorfenapyr
in or on all food commodities as a result of application of
chlorfenapyr to crack, crevice and spot applications in food/feed
handling areas where food/feed products are prepared,
held, processed, or served. |
Australia,
Japan, Philippines, South Africa, Taiwan, Tanzania, US, Vietnam |
1-Chloro-1,1-difluoroethane
75-68-3 |
Potentially
carcinogenic to animals. |
na |
Solvent
EPA List 2 Inert |
YES
US
- Because this is an "Inert", the public is not
allowed to know which crops it is used on. |
US |
Chlorodifluoromethane
75-45-6 |
US EPA:
Squamous
cell carcinoma and fibrosarcoma of the stomach were reported
in 92% of exposed males and 94% of exposed females
Chlorofluoromethane
was found to be a highly active mutagen in the Salmonella
reverse mutation assay, and to induce transformation of BHK21
cells in vitro
A computerized
analysis of structure-activity relationships based on a set
of rules generated by US EPA experts (Oncologic, version 1.0)
finds that chlorofluoromethane is of
high-to-moderate concern. (This is the
highest level of concern noted for chemicals which are not
included in the database of carcinogenicity bioassay results
from which the program rules are derived.)
IARC:
In the inhalation study in rats, males receiving the high
dose had increased incidences of fibrosarcomas and Zymbal-gland
tumours
|
•
Stomach
|
Insecticide
Fungicide
Propellant
EPA
List 2 Inert |
YES
US
- Because this is an "Inert", the public is not
allowed to know which crops it is used on. |
US |
Chlorofluoromethane
593-70-4 |
Potent
carcinogen (to the rat stomach) |
•
Stomach
(rat) |
EPA
List 3 Inert |
YES
US
- Because this is an "Inert", the public is not
allowed to know which crops it is used on. |
US |
Clodinafop-propargyl
105512-06-9
|
US EPA:
Likely to be carcinogenic to humans. |
•
Prostate (Rats)
• Ovary (Rats)
•
Liver (Mice, both sexes)
•
Blood vessel tumors (Mice, female) |
Herbicide |
YES
US
- Wheat
(forage, grain, hay, straw)
See
food
tolerances |
Australia,
Canada, Denmark, Hungary, India, Netherlands, New Zealand, South
Africa, UK, US |
Cyhalofop-butyl
122008-85-9 |
Carcinogenicity |
•
Kidney
(Mice, female) |
Herbicide |
YES
US:
Rice (Grain, Straw)
See
food
tolerances |
Japan,
Phillipines, Taiwan, US, Vietnam |
Dichlofluanid
1085-98-9 |
May be mutagenic and/or carcinogenic for exposed humans |
na |
Wood
Preservative
Antifoulant
Fungicide
Acaricide |
NO |
Australia,
Denmark, Germany, Hungry, Japan, New Zealand, Portugal, South
Africa, Taiwan, UK |
Dichlorofluoromethane
75-43-4 |
Carcinogen |
na |
EPA
List 2 Inert
Propellant
|
YES
US
- Because this is an "Inert", the public is not
allowed to know which crops it is used on. |
US |
Dichlorotetrafluoroethane
76-14-2 |
Carcinogen |
na |
Propellant
Former EPA List 2 Inert |
NO |
- |
Diflubenzuron
35367-38-5 |
...
Notwithstanding diflubenzuron is negative in in vivo
long-term carcinogenicity studies, its
co-mutagenic potential may be of concern in the presence of
ubiquitous premutagens (e.g. diet, environmental pollutants).
Furthermore, the ability of these insecticides to act as homeostatic
disruptors should not be underestimated.
The minor
metabolite, 4-chloroaniline,
was shown to be positive in several in vitro mutagenicity
assays using various endpoints. It is
carcinogenic in rats and mice. The neoplastic lesions
related to administration of 4-chloroaniline were benign
and malignant mesenchymal tumours in the spleens of male rats
and haemangiomas and haemangiosarcomas,
primarily in the spleen and liver of male mice.
Effects
on humans. The diflubenzuron metabolite, 4-chloroaniline,
has been reported to cause methaemoglobinaemia
in exposed workers and in neonates inadvertently exposed. |
• Co-mutagenic
potential
•
Liver (Rat, male) - attributed to non-fluorinated metabolite
•
Spleen (Rat, male)
attributed to non-fluorinated metabolite |
Insecticide
Acaricide |
YES
US
- Permitted
in or on over 400 food commodities,
including:
Artichoke, Egg, Grapefruit, Pasture rangeland), Milk, Mushroom,
Pear, Rice, Soybean, Tangerine, Walnut, Cattle, Goat, Horse,
Hog, Poultry, Sheep
See
food
tolerances |
Australia,
Canada, Denmark, Finland, Hungary, India, Japan, Netherlands,
New Zealand, Portugal, Taiwan, UK, US
Africa: Burkina Faso, Cape Verde, Chad, Gambia, Gunina-Bissau,
Madagascar, Mali, Mauritania, Niger, Senegal, South Africa,
Tanzania |
Ethalfluralin
55283-68-6 |
US EPA:
"Possible Human Carcinogen"
Increased mammary gland fibroadenomas and adenomas/fibroadenomas
combined in female rats. The tumor incidences were statistically
significant at both the mid and high
dose, and exceeded of the upper range of historical controls
Exposure
to ethalfluralin from food is estimated to result in a lifetime
cancer risk of 7.11 x 10-7. Cancer risks of less than 1 x
10-6 are generally considered to be negligible. |
•
Breast
(Rat, female) |
Herbicide |
YES
US
- Permitted
in or on 26 food commodities,
including:
Bean (dry, seed), Canola (seed), Peanut, Pea (dry, seed),
Safflower (seed), Soybean, Sunflower (seed), Cantaloupe, Cucumber,
Melon, Muskmelon, Watermelon
See
food
tolerances |
Canada,
Hungary, US |
| |
Fipronil
120068-37-3 |
US EPA:
"Possible Human Carcinogen" |
•
Thyroid (Rat,
both sexes) |
Acaracide
Insecticide |
YES
US
- permitted in or on 18 food commodities,
including:
Cattle, Corn, Egg, Goat, Hog, Horse, Milk, Poultry, Rice,
Sheep
See
food
tolerances |
Australia,
Denmark, Finland, Hungary, India, Japan, Netherlands, New Zealand,
Philippines, Taiwan, US
Africa: Burkina Faso, Cape Verde, Chad, Gambia, Guinea-Bissau,
Madagascar, Mali, Mauritania, Niger, Senegal, South Africa,
Tanzania, Uganda |
Fluazinam
79622-59-6 |
US EPA:
Clear
evidence of carcinogenicity (hepatocellular tumors) in male
mice, but not in females.
Some
evidence of carcinogenicity (thyroid gland follicular cell
tumors) in male rats, but not in females.
Equivocal/some
evidence of carcinogenicity (hepatocellular tumors) in male
mice, but not in females, |
•
Liver (Mice,
male)
•
Thyroid (Rat,
male) |
Fungicide |
YES
US
- Peanuts, Potatoes, Grape (wine)
See
food
tolerances |
Australia,
Denmark, Finland, Germany, Hungary, Japan, Netherlands, New
Zealand, Philippines, Portugal, Taiwan, UK, US |
Flucythrinate
70124-77-5 |
Suggestive
evidence that this substance can act as tumour promoter. |
•
Tumor promoter |
Acaricide
Insecticide |
NO (Revoked) |
India,
Japan, Portugal, Taiwan |
Fludioxonil
131341-86-1 |
Statistically
significant trend for malignant lymphomas |
•
Lymphomas
(Rat, female) |
Fungicide |
YES
US:
Permitted in or on 948 food commodities
See
food
tolerances |
Australia,
Canada, Denmark, Finland, Germany, Hungary, India, Japan, Netherlands,
New Zealand, South Africa, Taiwan, UK, US |
Fluometuron
2164-17-2 |
US EPA:
"Possible Human Carcinogen" |
•
Liver (Mice, male) |
Herbicide |
NO
Registered
in US for Cotton,
undelinted seed
See
tolerances
|
Australia,
India, US
Africa: Burkina Faso, Cape Verde, Chad, Gambia, Guinea-Bissau,
Mali, Mauritania, Niger, Senegal, South Africa, Tanzania |
Fluorine
7782-41-4 |
The
high incidence of cancer among hospital personnel repeatedly
exposed to fluorine-containing general anesthetics raises a
fundamental need to examine other fluorocarbon-exposed workers
for similar effects. |
Fluthiacet-methyl
117337-19-6 |
US EPA:
"likely to be a human carcinogen" |
•
Pancreatic tumors (Rats, male)
•
Liver
(Mice, both sexes) |
Herbicide |
YES
US
- permitted in or on 9 food commodities, including:
Corn, Soybean seed
See
food
tolerances |
US |
Fomesafen
72178-02-0 |
US EPA:
"Possible Human Carcinogen" |
•
Liver (Mice,
both sexes) |
Herbicide |
NO
In 2003,
the Code of Federal Regulations listed both Fomesafen and
the Sodium salt of fomesafen with a tolerance of 0.05 ppm
on Soybean. |
Canada,
France, Hungary, Italy, South Africa, Tanzania, UK |
Fomesafen
sodium
108731-70-0
|
Possible
Carcinogen |
•
Liver (Rats
and/or Mice) |
Herbicide |
YES
US: Soybean
and Temporary tolerances for Snap beans and Dry beans
See
food
tolerances |
US |
| |
Haloxyfop-etotyl
87237-48-7 |
Carcinogenic
effects in mice even at very low doses. |
na |
Herbicide |
NO |
Denmark,
Madagascar |
Haloxyfop-methyl
69806-40-2 |
US
EPA:
Probable Human Carcinogen |
•
Liver (Rats/and or Mice)
|
Herbicide |
NO |
India |
Hexafluoropropene,
polymer with tetrafluoroethylene
25067-11-2 |
IARC:
"Tetrafluoroethylene
is possibly carcinogenic to humans (Group 2B)." |
•
Liver (Rats,
both sexes) |
EPA
List 3 Inert |
YES
Because
this is an "Inert", the public is not allowed to
know which crops it is used on. |
Not
Known |
Hexaflurate
17029-22-0 |
Arsenic
is a
Carcinogen
As F6
K (INORGANIC-Arsenic) |
na |
Herbicide
Wood
Preservative |
NO |
Australia |
Hydramethylnon
67485-29-4 |
US
EPA:
Possible Human Carcinogen |
•
Lung (Mice, female) |
Insecticide
|
YES
US:
Grass (pasture & rangeland)
Grass hay (pasture & rangeland)
Pineapple
See
food
tolerances |
Australia,
Canada, India, Netherlands, New Zealand, Philippines, South
Africa, Tanzania, US |
Isoxaflutole
141112-29-0 |
US
EPA:
Likely to be carcinogenic to humans |
•
Liver
(Rats, both sexes)
•
Thyroid (Rats,
male) |
Herbicide |
YES
US
and Canada:
Cattle, Corn, Egg, Goat, Hog, Horse, Milk, Poultry, Sheep
US
- permitted in or on 28 food commodities
See
food
tolerances |
Australia,
Canada, Germany, Hungary, Netherlands, Portugal, US
Africa:
Burkina Faso, Cameroon, Cape Verde, Chad, Gambia, Guinea-Bissau,
Mali, Mauritania, Niger, Senegal, South Africa |
Lactofen
77501-63-4 |
US
EPA:
1987:
Probable Human Carcinogen
2004:
Likely to be carcinogenic to humans |
•
Liver (Rodents) |
Herbicide |
YES
US:
Beans, snap, succulent (excluding limas)
Cotton, gin byproducts
Cotton, undelinted seed
Peanut
Soybean, seed
See
food
tolerances |
India,
US, Vietnam |
Norflurazon
27314-13-2 |
US
EPA:
Possible Human Carcinogen |
•
Liver (Mice,
male) |
Herbicide |
YES
US
- permitted in or on 59 food commodities
See
food
tolerances |
Australia,
New Zealand, South Africa, US |
Oxyfluorfen
42874-03-3 |
US
EPA:
Possible Human Carcinogen |
•
Liver (Mice) |
Herbicide |
YES
US
- permitted in or on 91 food commodities
See
food
tolerances |
Australia,
Canada, Hungary, India, New Zealand, Philippines, Portugal,
South Africa, Taiwan, US |
Penoxsulam
219714-96-2 |
US
EPA:
Suggestive Evidence of Carcinogenicity But
not sufficient to assess human carcinogenic potential and,
therefore, quantification of human cancer risk is not required. |
•
Leukemia (Rats,
male) |
Herbicide
|
YES
US
-
Rice, grain
Rice, straw
See
food
tolerances |
US
|
Prodiamine
29091-21-2 |
US
EPA:
Possible Human Carcinogen |
•
Thyroid |
Herbicide |
NO
US:
There are 96 Active products containing this herbicide, which
is used mainly on lawns |
US,
Australia |
Profluralin
26399-36-0 |
US
EPA:
Profluralin has been evaluated as a carcinogen
The
human carcinogen potency factor (q(l)*) for profluralin is
.028 (mg/kg bw/day)-1 for oral exposure. |
na |
Herbicide |
NO
Revoked
for use by EPA - was used on several food commodities |
believed
obsolete or
discontinued |
Pyraflufen-ethyl
129630-19-9 |
US
EPA:
Likely to be Carcinogenic to Humans'' by the oral route |
•
Liver
|
Herbicide |
YES
US:
13 tolerances for: Corn, Cotton, Potato, Soybean
See
food
tolerances |
Japan,
US
Japan:
Apple, Barley, Chestnut, Grape, Grapefruit, Japanese persimon,
Lemon, Lime, Mume plum, NATSUDAIDAI (whole), Orange (including
Navel), Other citrus fruits, Peach, Pear, Rice, UNSHU orange,
Wheat |
| |
Silafluofen
105024-66-6 |
Tumor-promoting |
na |
Insecticide
Termiticide
Wood
preservative |
NO |
India,
Japan, Taiwan, Vietnam
Japan:
Apple, Pear, Persimon, Rice, Tea
Taiwan:
Drupe, Rice, Small berries |
Sodium
fluoride
7681-49-4 |
A
1992 New Jersey Department of Health report: "Between
the years 1970 and 1989, the rate of osteosarcoma (among 10-19
year old males) was found to be 3.5 to 6.3 times greater in
the fluoridated versus unfluoridated areas." |
•
Bladder (Cryolite workers)
•
Lung (Cryolite workers)
•
Osteosarcoma
(Young boys; male rats)
•
Uterine cancer |
Wood
preservative
EPA
List 4B Inert |
YES
US
- Because this is an "Inert", the public is not
allowed to know which crops it is used on. |
Australia,
Canada, New Zealand, US, Vietnam |
Tetraconazole
112281-77-3 |
US
EPA:
Likely
to be carcinogenic to humans |
•
Liver |
Fungicide |
YES
US:
Cattle, Milk, Sugarbeets,
Sugarbeet-related commodities
See
food
tolerances |
Brazil,
Hungary, Japan, Portugal, South Africa, Taiwan, UK, US |
Thiazopyr
117718-60-2 |
US
EPA:
PossibleHuman
Carcinogen |
•
Thyroid |
Herbicide |
YES
US:
Grapefruit,
Orange
See
food
tolerances |
Australia,
US |
Tolylfluanid
731-27-1 |
US
EPA:
Likely
to be carcinogenic to humans |
•
Thyroid |
Fungicide
|
YES
US
approved
tolerances:
On Imported: Apple, Grape, Tomato, Hop
See
food
tolerances |
Australia,
Denmark, Finland, Germany, Hungary, New Zealand, Tanzania,
UK, US |
Trifluralin
1582-09-8
|
US
EPA:
Possible
Human Carcinogen |
•
Urinary bladder tumors in females
•
Renal pelvis carcinomas in male rats
•
Thyroid (males)
•
Non-Hodgkin's Lymphoma |
Herbicide |
YES
US
- permitted in or on 129 food commodities
See
food
tolerances |
Australia,
Canada, Finland, Germany, Hungary, Japan, India, New Zealand,
Portugal, South Africa, Taiwan, UK, US, Vietnam |
Triflusulfuron-methyl
126535-15-7 |
US
EPA: Possible
Human Carcinogen |
•
Liver
•
Testicular |
Herbicide |
YES
US:
Beet (sugar, roots & tops), Chicory root
See
food
tolerances |
Canada,
Denmark, Finland, Germany, Netherlands, UK, US |
|
