Dithiopyr
CAS No. 97886-45-8
 
 

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Adverse Effects
Abstracts

ACTIVITY: Herbicide (pyridine)

CAS Name: S,S?-dimethyl 2-(difluoromethyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3,5-pyridinedicarbothioate

Structure:

Adverse Effects:

Body Weight Decrease
Endocrine: Adrenal
Endocrine: Ovary
Endocrine: Testicular
Endocrine: Thymus
Endocrine: Thyroid
Endocrine: Uterus
Kidney
Liver
Lung
Spleen

Environmental Effects:

Fish: Moderately to Highly Toxic

Zooplankton: Highly Toxic

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
US EPA PC Code: 128994
California Chemical Code 2308
US EPA Permit Date
and Registrant:
1991, Monsanto 
Registered use in
(includes only a limited list of countries)

Australia, Canada, US
Other Information
Molecular Formula: C15H16 F5 NO2S2
Entry Year: 1987 
Inventing Company: Monsanto
Manufacturers: Monsanto
Rohm & Haas
Other Names: Dimension, Stakeout,
MON-7200,
MON-15100
 
Manufacture site: US:
Rohm & Haas, Tyrone,
Pennsylvania 16686
Of special interest:
PAN Data
Material Safety Data Sheets & Labels
2005 - New Jersey: "On April 22, parents of Toms River High School East students received a letter notifying them that the athletic fields were going to be sprayed with pesticides today, during spring break. The letter stated that the fields will be treated with Dithiopyr, dimethylamine and glyphosate and this warning follows: "harmful if swallowed, inhaled or absorbed through the skin, avoid contact with eyes or clothing."
It goes on to warn that the Office of Pesticide Programs of the Environmental Protection Agency has stated: "Where possible, persons who potentially are sensitive, such as pregnant women, infants and children, should avoid any unnecessary exposure." ...
Letter in the Asbury Park Press 4/27/05.
February 1993 - Summary of Toxicology Studies With Dithiopyr. Dennis P. WARD, Toxicology Department, The Agricultural Grop, A Unit of Monsanto Company.
Rohm and Haas - Canadian Material Safety Data Sheet for Dimension herbicide (1999).
Abstracts
1988 - 1992 - US EPA Office of Cleared Reviews, 1988 to 1992.
June 2002 - In Australia when Dithiopyr is used for "Treatment of turf where grazing by, or feeding to, livestock including poultry will not occur" no maximum residue levels are required. Ref: June 2002. Table 5. Uses of substances where maximum residue limits are not necessary. Australian National Registration Authority for Agricultural Veterinary Chemicals. The MRL Standard. Maximum residue limits in food and animal feedstuff. http://www.nra.gov.au/residues/mrl5.pdf

Rationale for US EPA to add Dithiopyr to the Toxic Release Inventory

In a 2-generation rat reproduction study, decreased body weight, diffuse hepatocellular swelling, and ``white spots'' on the livers were observed in the offspring of rats administered greater than or equal to 16.4 mg/kg/day. The NOEL values were 1.7 mg/kg/day. In a 13-week rat feeding study, the LOEL of 6.62 mg/kg/day produced diffuse hepatocellular swelling. The NOEL was 0.662 mg/kg/day. In a 13-week dog feeding study, increased alkaline phosphatase, discolored livers, and cholestasis was observed at 10 mg/kg/day (LOEL). The NOEL was 1 mg/kg/day. In addition, at 30 mg/kg/day, increased serum glutamic-pyruvic transaminase and serum glutamic oxaloacetic transaminase, increased liver and kidney weights, and decreased cholesterol and albumin were observed. EPA believes that there is sufficient evidence for listing dithiopyr on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available hepatic and renal toxicity data.

Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

Note:
Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know. Final Rule.
Dithiopyr was included in the deferral of 40 chemicals: EPA is deferring final action on 40 chemicals and one chemical category until a later date. These chemicals and the comments received on them raised particularly difficult technical or policy issues which will require additional time to address. The Agency does not believe that it would be in the spirit of community right-to-know to delay final action on the remaining 286 chemicals and chemical categories, pending completion of work on the more limited group. In a future rulemaking, EPA will make a final determination as to whether these chemicals should be added to EPCRA section 313. The public comment that has been received specific to these deferred chemicals will be addressed as part of the future rulemaking discussed above.


US Federal Register

Date Published Docket Identification Number Details
August 17, 2005 OPP-2005-0222

Requests to Voluntarily Cancel Certain Pesticide Registrations.

Registration no. Product Name Chemical Name Registrants Requesting Voluntary Cancellation
010404-00097 Superstar Plus Mini Fertilizer Dithiopyr Lesco Inc., 1301 E. 9th Street,
Suite 1300, Clevela, OH
441141849.
December 13, 1999 OPP-300939

Clomazone; Pesticide Tolerances for Emergency Exemptions. Final Rule.
... Clomazone is a member of the pyridazones/pyridinones class of herbicides. Other members of this class include purazon, norflurazon, fluridone, oxadiazon, fluorochloridone, amitrol, and dithiopyr. EPA does not have, at this time, available data to determine whether clomazone has a common mechanism of toxicity with other substances or how to include this pesticide in a cumulative risk assessment...

November 6, 1996

40 CFR Part 455

[FRL-5630-9]
RIN 2040-AC21

Pesticide Chemicals Category, Formulating, Packaging and Repackaging Effluent Limitations Guidelines, Pretreatment Standards, and New Source Performance Standards. Final Rule.

Table 10 to Part 455.--List of Appropriate Pollution Control Technologies \1\
PAI name \2\ Shaughnessy code \4\ Structural group \5\ Treatment technology
Dithiopyr (ANSI) 128994 Pyridine Activated Carbon

\1\ The 272 Pesticide Active Ingredients (PAIs) are listed first, by PAI code, followed by the non-272 PAIs from the 1988 FIFRA and TSCA Enforcement System (FATES) Database, which are listed in Shaughnessy code order. PAIs that were exempted or reserved from the PFPR effluent guidelines are not listed in the table.

\2\ The non-272 PAI names are taken directly from the 1988 FATES database. Several of the PAI [pesticide active ingredient] names are truncated because the PAI names listed in the FATES database are limited to 60 characters.

\4\ All Shaughnessy codes are taken from the 1988 FATES database. Some of the 272 PAIs are not listed in the 1988 FATES database; therefore, no Shaughnessy codes are listed for these PAIs.

\5\ Structural groups are based on an analysis of the chemical structures of each PAI.

November 30, 1994 OPPTS-400082B7

Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know. Final Rule.

EPA is deferring final action on 40 chemicals and one chemical category until a later date. These chemicals and the comments received on them raised particularly difficult technical or policy issues which will require additional time to address. The Agency does not believe that it would be in the spirit of community right-to-know to delay final action on the remaining 286 chemicals and chemical categories, pending completion of work on the more limited group. In a future rulemaking, EPA will make a final determination as to whether these chemicals should be added to EPCRA section 313. The public comment that has been received specific to these deferred chemicals will be addressed as part of the future rulemaking discussed above. These chemicals follow:
dithiopyr

Jan 12, 1994 OPPTS-400082 EPA's proposal to add 41 fluorine and organofluorine chemicals to the Toxics Release Inventory (TRI). See excerpt in box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm
 
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