Return to
Adverse Effects
ACTIVITY: Herbicide,
Plant Growth Regulator (Aryloxyphenoxy propionic
acid)
CAS Name for Clodinafop:
(R)-2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propanoic acid
Structure for Clodinafop:
Adverse
Effects:
Anemia
Bladder (ureter)
Blood
Body Weight Decrease
Bone
Cancer: Likely
to be carcinogenic to humans - PROSTATE, OVARIAN, LIVER, BLOOD
Clastogenicity
Dermal
Endocrine: Ovary
Endocrine: Prostate
Endocrine: Thymus
Kidney
Liver
Tremors |
Environmental
Effects:
Highly
Toxic to Freshwater Fish
The
major degradate, CGA-193469, is persistent and has the potential
to contaminate drinking water. |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes |
US
EPA PC Code: |
125203 |
US
Tolerances: |
CFR
180.559 |
FDA
LMS Code: |
B38 |
Registered
use in
(includes only a limited list
of countries)
|
Australia,
Canada, Denmark, Hungary, India, Netherlands, New Zealand, South
Africa, UK, US |
US
Maximum Residue Levels permitted
in food commodities
|
US:
Wheat (forage, grain, hay, straw) |
Other
Information |
Molecular
Formula: |
C17H13Cl
F NO4 |
Inventing Company: |
Ciba
Geigy |
Entry Year: |
1989 |
Manufacturers: |
Syngenta
(Ciba Geigy),
Novartis |
Other
Names: |
Banvel
Celio
CGA-184927
Clarity
Discover,
Harmony
Horizon (Novartis)
Mondak
Platinum
Topik |
Manufacture
sites: |
SWITZERLAND:
Novartis, Monthey
UK: Novartis,
Grimsby,
NE Lincolnshire |
Of special interest: |
PAN
BAD ACTOR (Carcinogen) |
Material
Safety Data Sheets & Labels |
2006: April 12. Commission
Directive 2006/39/EC, ameding Council Directive to include clodinafop
as an active substance. |
2006: January 27.
Final
review report fo the active substance clodinafop. European
Commission, Health & Consumer Protection Directorat -General.
SANCO/10530/2005 - rev. 3. |
2005: August 10.
Conclusion
regarding the peer review of the pesticide risk assessment of
the active substance clodinafop. EFSA Scientific Report
34, 1-78. |
2005:
July 30. Peer Review Report
on Clodinafop (based on the variant clodinafop-propargyl).
European Food Safety Authority (EFSA). |
2005:
May. Classification
of clodinafop-propargyl with R48/22. The Netherlands. |
2005:
May 23. U.S. Congressman Lee Terry (R-NE) introduced
a bill "to suspend temporarily the duty on Formulations
of Clodinafop-propargyl" up to December 31, 2008. The bill
was referred to the House Committee on Ways and Means. |
2004: November. "Pesticide
Info". British Columbia Ministry of Agriculture, Food
& Fisheries. |
2000:
June 6. Conditional
Registration; US EPA Fact Sheet |
US
Federal Register |
Date Published |
Docket
Identification Number |
Details |
August
3, 2005 |
OPP-2005-0201 |
Cancellation
of Pesticides for Non-payment of Year 2005 Registration Maintenance
Fees.
Section
24(c) Registrations canceled for non-payment of the
2005
maintenance fee are shown in the following Table 1:
Table
1.--Section 24(c) Registrations Canceled for Non-Payment
of Maintenance Fee |
SLN no. |
Product
Name |
000100
OR-01-0007 |
Discover
Herbicide |
|
June
22, 2000 |
OPP-301009 |
Pesticide
Tolerance for Wheat (forage, grain, hay) 0.1 ppm; Wheat (straw)
at 0.5 ppm. - FINAL RULE. |
April
26, 2000 |
PF-938 |
NOVARTIS
- Pesticide
Tolerance Petition in or on Wheat (grain, forage, hay) at
0.1 ppm; Straw at 0.5 ppm. |
Sept
25, 1998 |
OPP-30460 |
NOVARTIS
- Application
to register pesticide: Clodinafop 2E Herbicide. Active
ingredient: Clodinafop-propargyl at 22.3%. For use in wheat
(including Durum) to control wild oats, green and yellow foxtail,
and Persian darnel. US EPA File Symbol: 100-ONT. |
June
5, 1998 |
PF-807 |
NOVARTIS
- Pesticide
Tolerance Petition; in or on wheat grain at 0.02 ppm and wheat
straw at 0.05 ppm. |
Novartis.
May 9, 2000.
Form 20-F/A. US Securities
& Exhange Commission.
New pesticide products in development: Butafenacil,
Clodinafop, Fludioxonil (Apron), Fluthiacet,
Metolachlor, Trifloxystrobin, Trifloxysulfuron.
Note: "The Company was created by the merger of Sandoz
AG and CIBA-Geigy AG (the "Merger") in December
1996. Prior to the Merger, Sandoz AG and CIBA-Geigy AG were
each global participants in the pharmaceutical and agrochemical
industries. The predecessor companies of the Company merged
to realize sales, cost and cross-sector synergies, and to
create a combined entity with the resources and ability to
compete in the long term in an increasingly competitive global
environment. The Boards of the Company and AstraZeneca announced
on December 2, 1999, that they each agreed to spin off and
merge NovartisÕ Crop Protection and Seeds businesses and Zeneca
Agrochemicals to create the worldÕs first dedicated agribusiness
company with pro forma combined sales in 1998 of approximately
$7.9 billion. The new company will be named Syngenta AG ("Syngenta"),
headquartered in Basel, Switzerland (p 5)...
In Crop Protection, the major production sites for the active
ingredients are located in India, Switzerland, the UK and
the U.S., with the major production sites for formulation
and packaging in Brazil, China, France, South Korea, Switzerland
and the U.S. (p 36)... Agribusiness. On September 1, 1998,
Novartis acquired a production plant and related operating
assets from Oriental Chemicals Industries, South Korea for
CHF 196 million (p F-13)."
Also available at: http://www.novartis.com/downloads/corporate_publications/form20f_e.pdf
|
Syngenta
AG. June 8, 2001.
Form 20-F. US Securities and Exchange
Commission.
"Divestments.
Novartis, AstraZeneca and Syngenta made several divestments
in order to satisfy conditions imposed by the FTC and the
European Commission in connection with the formation of
Syngenta. The divestments completed in 2000 included ...
and the divestment to Makhteshim Agan Ltd. of its former
Novartis cereal fungicide product range in Denmark, Sweden
and Finland (p 9)."... Active Substances. Herbicides:...
Clodinafop (Topik,
Horizon, Celio, Banvel, Mondak, Clarity)... Nature
of operations. Syngenta AG ("Syngenta", the "Company"...)
is a world leading crop protection and seeds business that
is involved in the discovery, development, manufacture and
marketing of a range of agricultural products designed to
improve crop yields and food quality. Syngenta is headquartered
in Basel, Switzerland and was formed by Novartis AG ("Novartis")
and AstraZeneca PLC ("AstraZeneca") through an
agreement to spin off and merge the Novartis crop protection
and seeds businesses with the Zeneca agrochemicals business
to create a dedicated agribusiness company whose shares
were then the subject of a global offering (the "Transactions").
The Transactions were completed on November 13, 2000 (the
"Transaction Date"). In this annual report, for
periods prior to November 13, 2000, we refer to the businesses
contributed by Novartis as the "Novartis agribusiness";
and we refer to the businesses contributed to Syngenta by
AstraZeneca as the "Zeneca agrochemicals business"
(p i)." Also
available at:
http://www.syngenta.com/en/downloads/Syngenta_2000_Form_20-F1.pdf
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