Chlorodifluoromethane (Freon 22)
CAS No. 75-45-6

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Adverse Effects
NTIS Reports

ACTIVITY: Insecticide, Fungicide, Propellant, EPA List 2 Inert (Halogenated organic)


Adverse Effects:

Body Weight Decrease
limited evidence, fibrosarcomas

Endocrine: Adrenal
Endocrine: Pituitary
Eye -
Microphthalmia and Anophthalmia
Mutagenic (Eye)
Salivary Glands
Spinal Cord

Environmental Effects:

Dangerous for the ozone layer

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes.
US EPA List 2 Inert.
US EPA PC Code: 000015
California Chemical Code 3104
Other Information
Manufacturers: DuPont
Elf Atochem
Other Names:

Algeon 22; Algofrene 22;
Algofrene type 6; Arcton 4;
Arcton 22; CFC 22;
Chlorodifluoromethane (ACGIH);
Daiflon 22;
Dymel 22;
Electro - CF 22;
Eskimon 22;
F 22; Flugene 22;
Fluorocarbon - 22;
Forane 22;
Freon 22; Frigen 22;
Genetron 22; Haltron 22;
HFA - 22; Isceon 22;
Isotron 22; Khaladon 22;
Propellant 22; R - 22;
R 22 (refrigerant); Racon 22;
Refrigerant R 22; Ucon 22

Of special interest:
PAN BAD ACTOR (Carcinogen)
TOXNET profile from Hazardous Substances Data Base
Abstracts - updated
See the long list of health studies and other reports concerning ozone and greenhouse effects from chlorodifluoromethane that are available from the National Technical Information Service (NTIS).
2000 - Toxic Release Inventory. Brief Summary.
Updated July 2000 - The Registry of Toxic Effects of Chemical Substances. Methane, chlorodifluoro - RTECS #: PA6390000. NIOSH - National Institute for Occupational Safety and Health. Also available at
May 1998 - IRIS - Integrated Risk Information System - US EPA
1996 - Material Safety Data Sheet for Freon 22. DuPont.
1998 - In this report Chlorodifluoromethane was identified as: "Dangerous for the ozone layer." The report, entitled Examples of substances requiring particular attention, was issued by the Swedish National Chemicals Inspectorate in collaboration with the Swedish Environmental Protection Agency and the Swedish National Board of Occupational Safety and Health. NATIONAL CHEMICALS INSPECTORATE. Order No 510 622. Second, revised edition, 1998. See list of the specific Fluorine and organofluorine pesticides cited in the report.
1986 - IARC - Summary of data

US EPA List of Inerts. This substance is on List 2

Note: US EPA allows so-called "Inert" ingredients to be commonly mixed with the "active" pesticidal ingredient to create a formulated pesticide product. According to EPA, "The term `inert' is not intended to imply nontoxicity; the ingredient may or may not be chemically active." "Inert" ingredients include solvents, emulsifiers, spreaders, and other substances mixed into pesticide products to increase the effectiveness of the active ingredients, make the product easier to apply, or to allow several active ingredients to mix in one solution. Both US EPA and California Department of Pesticide Regulation require pesticide manufacturers to identify inert ingredients in their products but do not disclose this information to the general public because the pesticide industry considers product formulations trade secrets, protected by law and by the US EPA. The US EPA category of Inerts (as of September 2003):

List 1 - Of Toxicological Concern
List 2 - Potentially Toxic / High Priority for Testing
List 3 - Of Unknown Toxicity
List 4A - Generally Regarded as Safe
List 4B - EPA states it has Sufficient Information to Reasonably Conclude that the Current Use Pattern in Pesticide Products will not Adversely Affect Public Health or the Environment
List 4 (all)

See good report: Toxic Secrets": "Inert" Ingredients in Pesticides 1987-1997, published by Northwest Coalition for Alternatives to Pesticides.

US Federal Register
Date Published Docket Identification Number Details
June 21, 2001 RSPA-2000-7702 (HM-215D) Hazardous Materials Regulations for Fluoride/fluorinated substances. Harmonization of international shipment of Dangerous Goods.- FINAL RULE.
June 24, 1998 OPP- 36192 US EPA List 2 Inert; Ingredient in Pesticide Products.
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