CAS Name: Cyclopropanecarboxylic acid,
3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano (4-fluoro-3-phenoxyphenyl)methyl
Note: CAS No.
68359-37-5 for cyfluthrin and
beta-cyfluthrin is the same
Structure for Cyfluthrin:
toxic to Fish, Aquatic Invertebrates.
risk to Honey Bees and other Arthropod species.
(only comprehensive for the US)
EPA PC Code:
(includes only a limited list
Denmark, Finland, Germany, Hungary, Madagascar, New Zealand,
South Africa, Tanzania, Uganda, US (See
Residue Levels permitted
in food commodities
also, Bay, Bulldock, Ducat,
FCR 4545, OMS 3051
Mirfield West Yorkshire
|Of special interest:
Safety Data Sheets & Labels
- US EPA CHEERS study in Jacksonville, Duval County, Florida.
This 2-year study of children's exposure to selected pesticides
and chemicals has ignited enormous controversy. Cyfluthrin
II, III, IV, total)
one of 16 pesticides selected to be monitored in children
(ages 0-3 years). See FAN's
updates on this study. Also, 4-fluoro-3-phenoxybenzoic
acid, (CAS No. 77279-89-1), a
breakdown product of Cyfluthrin, will be analyzed in
biological media. It's molecular structure is
the CDC's "Third National Report on Human Exposure to
Environmental Chemicals," expected to be released sometime
in 2005, includes 4-fluoro-3-phenoxybenzoic
acid in its list of chemicals.
report for the active substance beta-cyfluthrin Finalised
in the Standing Committee on the Food Chain and Animal Health
at its meeting on 3 December 2002 in view of the inclusion of
beta-cyfluthrin in Annex I of Directive 91/414/EEC. EUROPEAN
COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE- Also available
2002 - beta-cyfluthrin:
In Australia when Beta-cyfluthrin is used "As the active
constituent in contained bait stations used in orange, mandarin,
mango, lychee, carambola and persimmon trees, where direct contact
will not occur with the fruit" no maximum residue levels
are required. Ref: June 2002. Table 5. Uses of substances
where maximum residue limits are not necessary. Australian National
Registration Authority for Agricultural Veterinary Chemicals.
The MRL Standard. Maximum residue limits in food and animal
17, 2002. Bayer's
acquistion of Aventis. Discussion
of beta-cyfluthrin and cyfluthrin.
European Commission press release.
10, 2001 - beta-cyfluthrin / cyfluthrin. Australia: "Current
List. RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS."
Sci. 2006 Jan;89(1):271-7.
Relative potencies for acute effects of pyrethroids
on motor function in rats.
MJ, Gennings C, Crofton KM.
Research Council, Research Triangle Park, North Carolina
prevalence of pyrethroids in insecticide formulations has
increased in the last decade. A common
mode-of-action has been proposed for pyrethroids based on
in vitro studies, which includes alterations in sodium channel
dynamics in nervous system tissues, consequent disturbance
of membrane polarization, and abnormal discharge in targeted
neurons. The objective of this work was to characterize
individual dose-response curves for in vivo motor function
and calculate relative potencies for eleven commonly used
pyrethroids. Acute oral dose-response functions were determined
in adult male Long Evans rats for five Type I (bifenthrin,
S-bioallethrin, permethrin, resmethrin, tefluthrin), five
Type II (beta-cyfluthrin, lambda-cyhalothrin,
cypermethrin, deltamethrin, esfenvalerate) and one mixed
Type I/II (fenpropathrin) pyrethroids (n = 8-18 per dose;
6-11 dose levels per chemical, vehicle = corn oil, at 1
ml/kg). Motor function was measured using figure-8 mazes.
Animals were tested for 1 h during the period of peak effects.
All pyrethroids, regardless of structural
class, produced dose-dependent decreases in motor activity.
Relative potencies were calculated based on the computed
ED30s. Deltamethrin, with an ED30 of 2.51 mg/kg, was chosen
as the index chemical. Relative potency ratios ranged from
0.009 (resmethrin) to 2.092 (esfenvalerate). Additional
work with environmentally-based mixtures is needed to test
the hypothesis of dose-additivity of pyrethroids.
Of the pesticides cited above, the following are fluorinated:
bifenthrin, tefluthrin, beta-cyfluthrin,
FAO Specificiations and Evaluations for Plant Protection Products.
is an insecticide, acting as a contact and stomach poison. It
combines a rapid knock-down effect with long lasting efficacy.
It is not systemic in plants. It is used in agriculture, horticulture
(field and protected crops) and viticulture. It is also used
against migratory locusts and grasshoppers and in public health
products - partial
and cyfluthrin have the same toxicological profile. Beta-cyfluthrin
has an approximately 2 to 5 times higher acute toxicity
than cyfluthrin. The NOELs of subacute and subchronic
studies are in the same range.
Ref: December 2002 - Beta-cyflutrin:
Review report for the active substance beta-cyfluthrin Finalised
in the Standing Committee on the Food Chain and Animal Health
at its meeting on 3 December 2002 in view of the inclusion
of beta-cyfluthrin in Annex I of Directive 91/414/EEC. EUROPEAN
COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL
|November 8, 2006
of Receipt of Requests to Voluntarily Cancel Certain
|EPA Registration Number
||Bayer Cropscience LP
2 T.W. Alexander Drive, Research
Triangle Park NC 27709
Longitudinal Study of Young Children's Exposures in their
Homes to Selected Pesticides, Phthalates, Brominated Flame
Retardants, and Perfluorinated Chemicals
(A Children's Environmental Exposure Research Study--CHEERS).
Abstract: The U.S. EPA's Office of Research and Development's
National Exposure Research Laboratory proposes to conduct
a two-year longitudinal field measurement study of young children's
(aged 0 to 3 years) potential exposures to current-use pesticides
and selected phthalates, polybrominated diphenyl ethers, and
perfluorinated compounds that may be found in residential
environments. The study will be conducted in Duval County,
Jacksonville, Florida over a two-year period from 2004 to
2006. Sixty young children will be recruited into this study
in two cohorts: (1) infants recruited into the study soon
after birth, and, (2) children recruited into the study at
approximately 12 months of age.
A: Supporting Statement
- EPA ICR Number: 2126.01 - 61 pages
From Table 2:
• Of 16 pesticides included in this study, 4 are
Bifenthrin, Fipronil, lamda-Cyhalothrin,
and Cyfluthrin I, II, III, IV,
Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate
Table 3: List of chemicals to be analyzed in biological
• one is fluorinated: 4-fluoro-3-phenoxybenzoic
• Perfluorooctanoic acid/Perfluorooctane sulfonate
on CHEERS study