Integrated In-silico and In-vivo Assessments of Betaine’s Effect on the Hypothalamic-Pituitary-Testicular (HPT) Axis in Fluoride-Treated Rats.

Serum calcium improves the relationship between fluoride exposure and hypothalamic-pituitary-testicular axis hormones levels in males-a cross-sectional study on farmers in the lower reaches of the Yellow River.

Research links excessive fluoride use to pituitary gland malfunction

The initial findings of a groundbreaking study conducted by a group of leading medical institute researchers recently on animal models shows that high levels of fluoride exposure may disrupt the pituitary gland’s hormone production and release mechanisms. While this study contributes valuable insights into the potential hazards of consuming excessive fluoride, experts stress the necessity […]

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats.

References   Abd El Tawab AM, Shahin NN, AbdelMohsen MM. 2014. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Chem.-Biol. Interact. 224: 196-205 Crossref, Medline, ISI, Google Scholar.   Adedara IA, Ojuade TJD, Olabiyi BF, Idris UF, Onibiyo EM, Ajeigbe OF, Farombi EO. 2017. Taurine ameliorates renal oxidative damage and thyroid dysfunction […]

[Indices of the pituitary-thyroid system in residents of cities with various fluorine concentrations in drinking water].

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats.

Fluoride exposure, follicle stimulating hormone receptor gene polymorphism and hypothalamus-pituitary-ovarian axis hormones in chinese women

Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride.

Discussion The objective of this study was to investigate the effects of F oral exposure on T [testosterone] biosynthesis and the neuroendocrine regulation of the HPT axis in male mice. T is one of the endpoint parameters inHTP axis. In this study, reduced serum T concentration replicates our prior report of F-induced decrease in T […]

Fluoride exposure changed the structure and the expressions of reproductive related genes in the hypothalamus-pituitary-testicular axis of male mice

The effects of fluoride on cell migration, cell proliferation, and cell metabolism in GH4C1 pituitary tumour cells.