Triphenyltin fluoride
CAS No. 379-52-2
 
 

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Adverse Effects
Abstracts

ACTIVITY: Antifoulant, Algaecide, Herbicide (Organotin)

Structure:

Adverse Effects:

Blood
Body Weight Decrease
Diabetes

Eye
Lung
Pancreas

Teratogen

Environmental Effects:

Severe marine pollutant.

Fish: Highly to Very Highly Toxic

Zooplankton: Very Highly Toxic

Molluscs: Very Higly Toxic

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No
US EPA PC Code: 083602 
(Old US EPA PC Code = 496900 )
California Chemical Code 2212 
US EPA Permit Date
and Registrant:
1975, M & T 
Registered use in
(includes only a limited list of countries)

Netherlands 
Other Information
Molecular Formula: C18H15 F Sn  
Manufacturers: Hempel Coatings (USA)
Atofina
 
Other Names:

Synonyms
Biomet 204
Caswell No. 896H
EINECS 206-833-8
Fluorotriphenylstannane
TPTF
Tin, fluorotriphenyl-

Systematic Names
Fentin fluoride
Stannane, fluorotriphenyl-
 

Of special interest:
PAN BAD ACTOR - Acute Toxicity 
Material Safety Data Sheet
INITIAL SUBMISSION: ACUTE TOXICITY STUDY OF TRIPHENYLTIN FLUORIDE IN EMBRYOS OF CRASSOSTREA VIRGINICA WITH COVER LETTER DATED 07/24/92
Corporate Name: EG&G BIONOMICS
Source: EPA/OTS; Doc #88-920008707
Order Number: NTIS/OTS0555205

THE ENVIRONMENTAL CHEMISTRY OF THREE ORGANOTIN CHEMICALS
Year of Publication: 2000
Corporate Name:
M & T CHEM INC
Source: EPA/OTS; Doc #40+7863020
Order Number: NTIS/OTS0509272

DISSIPATION AND DETOXIFICATION OF ORGANOTINS IN THE ENVIRONMENT
Year of Publication: 2000
Corporate Name: M & T CHEM INC
Source: EPA/OTS; Doc #40+7863021
Order Number: NTIS/OTS0509273

California EPA list of products.  
Abstracts 
In Japan: Listed since Dec 27, 1989, as a Class 2 specified chemical substance. A substance which, either in itself or one of its degradation products, is not easily degradable and which may be harmful to human health when ingested continuously and which is considered to cause or expected to cause harm to human health due to significant residues of the substance in a wide range of areas. A person who manufactures or imports this substance or who imports product in which this substance is contained shall submit a notification on planned manufacturing or import quantities. Authorities concerned may order a change of the amount in order to prevent damage to human health by environmental pollution. Ref: Division of Chem-Bio Informatics, National Institute of Health Sciences, Japan. (Online as of Dec 2, 2001). 

Federal Register

Date Published Docket No. Details
Oct 20, 2000 OPP-30000/42A Triphenyltin Hydroxide; Proposed Determination To Terminate Special Review.
2. Comment. American Hoechst Corporation disagrees with the Agency's [US EPA] position that TPTH produces teratogenic effects and that a NOAEL has not been determined in the two previously reviewed rat teratogenicity studies [Refs. 5 and 46]. American Hoechst and M&T Chemicals had the rat teratology study by Battelle Columbus Laboratories [Ref. 3] peer reviewed by two independent sources and submitted the results of those reviews. One reviewer found that 2.8 mg/ kg/day was clearly a NOAEL for teratogenicity while the second reviewer was unable to identify a no effect level from the data available. In addition, American Hoechst submitted the results of a teratology study of triphenyltin fluoride (TPTF) that had been previously submitted to EPA. The NOAEL for this study was 3.0 mg/kg/day.
Response. The submissions from American Hoechst Corporation do not satisfactorily eliminate concerns regarding the teratogenicity of TPTH because no new information was presented to the Agency. Although these studies provided sufficient data to assure that TPTH is not teratogenic in rats at dose levels up to and including 8.0 mg/kg/day, these studies did result in developmental and maternal toxicity. Second, the registrant did not provide new information indicating that a NOAEL exists in the two rat studies. Third, the teratology study with TPTF also indicated hydroureter as a fetal lesion. The initial reviewer of this study classified this compound as a teratogen.
 
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