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Trichlorofluoromethane (CAS No. 75-69-4) Abstracts.
Also known as Freon 11

For more abstracts search PubMed and Toxnet


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11516020&dopt=Abstract

Environ Monit Assess 2001 Jul;70(1-2):47-56

Background monitoring and long-range transport of atmospheric CFC-11 and CFC-12 at Kosan, Korea.

Kim J, Oh SN, Cho HM, Park MK, Kim KR, Elkins JW.

Applied Meteorology Research Laboratory, Meterological Research Institute, Seoul, Korea. jykim@metri.re.kr


The background concentrations of atmospheric CFC-11 and CFC-12 were monitored to assess their impact on stratospheric ozone depletion and global warming from September 1995 to March 1999 at Kosan, Korea, located at eastern margin of the Asian Continent. The concentrations of atmospheric CFC-11 at Kosan have decreased slightly, at a rate of -2.5 pptv yr(-1), over the period in response to the Montreal Protocol. The CFC-12 mixing ratio at Kosan continues to increase in the atmosphere at a rate of 5.7 pptv yr(-1) despite international regulations, because of its extreme atmosphere persistence. Recent trends of these two chlorofluorocarbons at Kosan, Korea were concordant with those of the northern hemispheric background monitored unit at Mauna Loa, Hawaii. The maximum seasonal mean mixing ratios of CFC-11 and CFC-12 at Kosan, Korea, were 270 +/- 4 pptv in the spring and 538 +/- 9 pptv in the winter, and the corresponding seasonal minima were 267 +/- 7 and 529 +/- 12 pptv. This occurred in the summer and was due to southeasterly winds from the northwestern Pacific Ocean. By performing a three-day isentropic backward trajectory analysis, it was shown that air masses at Kosan, and with the exception of summer, mainly originated from central and northern China. In particular, the mixing ratios of these two contaminant species are closely related with their air mass trajectories.

PMID: 11516020 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8006631&dopt=Abstract

J Forensic Sci 1994 May;39(3):871-6

A fatal case of trichlorofluoromethane (Freon 11) poisoning. Tissue distribution study by gas chromatography-mass spectrometry.

Groppi A, Polettini A, Lunetta P, Achille G, Montagna M.

Institute of Legal Medicine, University of Pavia, Italy.

A case of lethal poisoning due to trichlorofluoromethane (FC11) inhalation is described. The fluorocarbon was determined in biological tissues by headspace gas chromatography-mass spectrometry. FC11 was detected in all the examined tissues, with decreasing levels in heart, lung, brain, liver, blood, kidney, and spleen. The highest concentration measured in heart could be related to the mode of toxic action of fluorocarbons postulated by many authors, characterized by the sensitization of the myocardium to the catecholamines producing arrhythmia and cardiac arrest. Nevertheless the aspecific picture of the anatomo-pathological and histological findings does not exclude that the described accidental fatality may have been caused by the combination of direct from toxicity with hypoxemic asphyxiation, due to the saturation of the atmosphere by FC11 in the closed environment in which the intoxication occurred.

PMID: 8006631 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8349485&dopt=Abstract

J Am Osteopath Assoc 1993 Jun;93(6):714-8

Unexpected adverse effects of Freon 11 and Freon 12 as medication propellants.

Oenbrink RJ.

Metered-dose inhalers are frequently used in treating pulmonary diseases associated with bronchoconstriction, chiefly asthma and chronic bronchitis. These aerosolized medications are not without the potential for adverse effects. The author describes two patients who likely had adverse reactions to the Freon propellants used in the inhalers. These reactions are reported in order to alert physicians to their possible occurrence and to suggest a rational treatment approach.


PMID: 8349485 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1537550&dopt=Abstract

FEMS Microbiol Lett 1992 Jan 1;69(2):201-4

Dehalogenation of trichlorofluoromethane (CFC-11) by Methanosarcina barkeri.

Krone UE, Thauer RK.

Laboratorium fur Mikrobiologie der Philipps-Universitat, Marburg, F.R.G.

Methanobacterium barkeri was found to catalyze the reductive dehalogenation of trichlorofluoromethane (CFC-11), also known as FREON 11. Products detected were CHFCl2, CH2FCl, CO and fluoride.

PMID: 1537550 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=871444&dopt=Abstract

Br J Ind Med 1977 May;34(2):130-6

Effects of fluorocarbon propellants on respiratory flow and ECG.

Valic F, Skuric Z, Bantic Z, Rudar M, Hecej M.

Ten subjects were exposed to the propellants freon 11, freon 12, freon 114, to two mixtures of freon 11 and 12 and to a mixture of freon 12 and 114. The length of exposure was 15, 45 or 60 seconds. Maximum expiratory flow-volume (MEF) curves and ECG were recorded before, and intermittently up to 1 hour after, exposure. Breathing level concentrations of propellants during exposure were determined by gas chromatography. All freons induced biphasic reduction of ventilatory capacity on inhalation. The first fall occurred within a few minutes of exposure while the second was delayed 13-30 minutes after exposure. The effects of mixtures were greater than those of individual freons. The relative fall in MEF 75% was more pronounced than that in MEF 50%. No clear-cut pathological changes in ECG were found. Nevertheless, most subjects developed variations in heart rate exceeding those noted before exposure. In a few cases inversion of the T wave, and in one case atrioventricular block, were observed.


Publication Types:

PMID: 871444 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=803403&dopt=Abstract

Can J Microbiol 1975 Feb;21(2):221-6

Comparison of the effects of three fluorocarbons on certain bacteria.

Van Auken OW, Healy J, Kaufmann AJ.

Three fluorocarbons were tested to determine their effect on bacterial growth. Freon 11 and 21 in various concentrations had an inhibitory effect on selected test organisms, but Freon 22 had no effect. Both aerobic and anaerobic microorganisms, as well as gram-positive and gram-negative species, were included among the bacteria tested. Freon 11 and 21 caused a similar response with Freon 11 being more inhibitory to some species and Freon 21 more inhibitory to others. Inhibition was dependent on the concentration of the halocarbon and resulted in decreased respiration rates at all concentrations tested. Results reported here indicate that the action of the fluorocarbons tested is bactericidal rather than bacteriostatic, Serratia marcescens and Clostridium botulinum were the species most sensitive to the halocarbons tested.


PMID: 803403 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1147700&dopt=Abstract

Arch Environ Health 1975 Jul;30(7):353-60

Concentrations of fluoroalkanes associated with cardiac conduction system toxicity.

Flowers NC, Hand RC, Horan LG.

When respiratory alterations associated with the inhalation of aerosol propellants were eliminated, it was demonstrated that a ten-minute exposure to trichloromonofluoromethane (Freon 11) at concentrations below 15% never caused death. Rarely, at a concentration of exactly 15% minimal sinus slowing occurred (change less than 10% the base line rate). At concentrations between 15% and 17%, nine animals survived while seven succumbed. Ranges between 17.5% and 21% resulted in seven survivors of 19 animals, while no animal survived a ten-minute exposure to a concentration in excess of 21%.The mode of death was most commonly and ultimate asystole. Concentrations of dichlorodifluoromethane (Freon 12) greater than 95% were necessary to produce death in ten minutes, and severe oxygen deficit was evident.


PMID: 1147700 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5867244&dopt=Abstract

No Abstract available

Trans Assoc Ind Med Off 1965 Jul;15(3):105-6

Narcotic effects of acute exposure to trichlorofluoromethane (Freon 11).

Thomas G.

PMID: 5867244 [PubMed - indexed for MEDLINE]