Tributyltin fluoride (TBTF)
CAS No. 1983-10-4

 
 

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Adverse Effects
Abstracts

ACTIVITY: Antifoulant, Fungicide, Microbiocide (Organotin)

Structure:

Adverse Effects:

Brain
Developmental / Reproductive
Diabetes
Eye

Endocrine: Suspected Disruptor

Environmental Effects:

Acute Aquatic Toxicity Values

Very Highly Toxic to Amphibians

Very Highly Toxic to Fish

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No 
US EPA PC Code: 083112 
California Chemical Code 1030 
Registered use in
(includes only a limited list of countries)

Canada 
Other Information
Molecular Formula: C12H27FSn  
Manufacturers: Atochem 
Other Names:

Poly Cop Blue.
EPA product Reg.#s:
5204-19, 5204-61, 5204-64

BRN 4125568
Caswell No. 867C
EINECS 217-847-9
Fluorotributylstannane
Fluorotributyltin
NSC 179737
NSC 195319
Stannane, fluorotributyl-
Tin, tributyl-, fluoride
Tin, tributylfluoro-
Tri-n-butylstannyl fluoride
Tributylfluorostannane
Tributylstannane fluoride

Of special interest:
PAN Data
A little history...
In the early 1960s, both tributyltin oxide (TBTO) and TBT fluoride were tested, mainly in Africa, as molluscicides against several freshwater snail species that are vectors of the disease schistosomiasis, the snails being the intermediate hosts of the trematode parasite. This use led to the introduction of TBT, during the mid 1960s, as an antifouling paint on boats. At the same time TBT compounds were being registered as wood preservatives (the first registration was in 1958).
Ref: Tributyltin Compounds. Environmental Health Criteria Report Number 116. World Health Organization. International Programme on Chemical Safety.
2005 - Schedule for Reregistration & Tolerance Reassessment (RED) for "tbt-containing compounds" is expected to be September 2008. Contact at EPA: Rebecca Miller (703) 305-0012; miller.rebecca@epa.gov . According to EPA:
Through the pesticide reregistration and tolerance reassessment programs, EPA is assessing risks and making risk management decisions for older pesticides. These decisions are summarized in documents known as REDs, IREDs, and TREDs. By making decisions according to the schedule below, EPA will meet its statutory deadlines for completing reregistration and tolerance reassessment.
Some of the decision dates presented in the schedule may change due to the dynamic nature of the review process. Any pesticide decisions that are not completed during the current fiscal year will be rescheduled for the following year. EPA is committed to meeting its reregistration and tolerance reassessment deadlines.
http://www.epa.gov/pesticides/reregistration/decision_schedule.htm
In Japan: Listed since Sept 12, 1990, as a Class 2 specified chemical substance. A substance which, either in itself or one of its degradation products, is not easily degradable and which may be harmful to human health when ingested continuously and which is considered to cause or expected to cause harm to human health due to significant residues of the substance in a wide range of areas. A person who manufactures or imports this substance or who imports product in which this substance is contained shall submit a notification on planned manufacturing or import quantities. Authorities concerned may order a change of the amount in order to prevent damage to human health by environmental pollution. Ref: Division of Chem-Bio Informatics, National Institute of Health Sciences, Japan. (Online as of Dec 2, 2001). 
In Japan: Listed as a "Deleterious Substance" under the "Poisonous and and Deleterious Substances Control Law" by the National Institute of Health Sciences, Japan. (Online as of Dec 2, 2001).
Pesticide products - partial list
Abstracts 

Rationale for US EPA to add Tributyltin Fluoride to the Toxic Release Inventory

Aquatic acute toxicity values for tributyltin fluoride include a bleak fish 96-hour LC
50 of 2.3 ppb, an algae 72-hour EC50 of 9.3 ppb, and a Harpacticoid copepod 96-hour LC 50 of 0.8 ppb. EPA believes that there is sufficient evidence for listing tributyltin fluoride on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C) based on the available environmental toxicity data.

Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.


Table 9 Organotin compounds suspected of being endocrine disruptors.
Common name CAS-no. Y /g l 1 log P ow
Bis(tributyltin)oxide 56-35-9 8000 10 000 3.62
Triphenyltinhydroxide 76-87-9 400 -
Tributyltin fluoride 1983-10-4 - -
Ysat :Water solubility in seawater at 22 C.
P ow :Partition coefficient octanol/water.
Ref: Endocrine Disruptors in the Environment (IUPAC Technical Report). Prepared for publication by J.LINTELMANN et al. INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY. Pure Appl.Chem.,Vol.75,No.5,pp.631 681,2003. 2003 IUPAC. Full report available at
http://www.iupac.org/publications/pac/2003/pdf/7505x0631.pdf

June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified." Organofluorine pesticides in this list include:

Substances included on the Endocrine Disruptor Liist CAS No. Substances included on the Endocrine Disruptor Liist CAS No.
Bifenthrin 82657-04-3 Flutriafol 76674-21-0
Cyhalothrin (@Karate) 91465-08-6 Fluvalinate 69409-94-5
Diflubenzuron 35367-38-5 Prodiamine 29091-21-2
Epoxiconazole - Stannane, tributylfluoro [Tributyltin fluoride] 1983-10-4
Fipronil - Thiazopyr -
Fluazifop-butyl 69806-50-4 Trifluralin -


US Federal Register
Nov 30, 1994 ATOCHEM - Cancellation Order. This Order, issued pursuant to section 6(f)(1) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), 7 U.S.C. 136 et seq., announces EPA's cancellation of the registrations for ELF ATOCHEM North America, Inc. (``Atochem'') products containing Tributyltin Fluoride (TBTF). Further, this Order announces the Agency's decision prohibiting Atochem's sale, distribution and use of existing stocks of its TBTF products as of this date.
Jan 12, 1994 EPA's proposal to add 41 fluorine and organofluorine chemicals to the Toxics Release Inventory (TRI). See excerpt in box above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm
 
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