Thiazopyr
CAS No. 117718-60-2

 
 

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Adverse Effects
Abstracts

ACTIVITY: Herbicide (Pyridine carboxylic acid)

CAS Name: methyl 2-(difluoromethyl)-5-(4,5-dihydro-2-thiazolyl)-4-(2-methylpropyl)-6-(trifluoromethyl)-3-pyridinecarboxylate

Structure:

Adverse Effects:

Amyloidosis
Blood
Body Weight Decrease
Bone
Cancer: Likely to be a Human Carcinogen - THYROID, KIDNEY
Cholesterol
Endocrine: Pituitary (disruption of the thyroid-pituitary hormonal feedback mechanism)
Endocrine: Suspected Disruptor
Endocrine: Thyroid
Eye
Kidney
Liver

Environmental Effects:

Very Highly Toxic to nontarget terrestrial and aquatic plants, algae and diatoms

Moderate to High Toxicity to Martine Invertebrates

Persistent in soil

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 129100 
California Chemical Code 3984 
US Tolerances: CFR 180.496 
FDA LMS Code: B12 
European Commission:

Not allowed to be used as an active ingredient after July 25, 2003.

Registered use in
(includes only a limited list of countries)

Australia, US 
US Maximum Residue Levels permitted in food commodities
Grapefruit, Orange
Other Information
Molecular Formula: C16H17 F5 N2O2S 
Entry Year: 1989 
Inventing Company: Monsanto 
Manufacturers: Rohm & Haas 
Other Names: Visor
RH-123652
Mandate
MON 13200
MON 13211
13211-A
13211-B
707-EUP-136
 
Thiazophyr
Visor
Manufacture site: US:
Rohm & Haas, Dayton,
Ohio 45418
 
Of special interest:
PAN Data
February 1997 - US EPA Fact Sheet.
November 26, 2002 - European Commission: Thiazopyr is one of 320 pesticides to be withdrawn in July 2003. "Some 320 substances used in plant protection products (PPPs) including insecticides, fungicides and herbicides are to be withdrawn from the market by 25 July 2003 as part of the European Commission's new approach to the evaluation of active substances in plant protection products. This aims to improve safeguards to ensure that all such products in use are safe for the environment and human health. Users, wholesalers and retailers of plant protection products will need to be aware of whether the products they use or sell are likely to be withdrawn, so as to prevent them being left with stocks of unusable material. Those concerned should contact their national authority to check the authorisation status for any particular product. The Regulation (n 2076/2002 of 20 November 2002), with the list of the 320 substances, has now been published in the Offical Journal. Ref: MIDDAY EXPRESS. News from the Press and Communication Service's midday briefing. 
Abstracts
August 2001 - IR-4: New Products/Transitional Solution List -This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Thiazopyr
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  
April 2000 - Food and Drug Administration Pesticide Residue Monitoring. - Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring. 

June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified." Organofluorine pesticides in this list include:

Substances included on the Endocrine Disruptor Liist CAS No. Substances included on the Endocrine Disruptor Liist CAS No.
Bifenthrin 82657-04-3 Flutriafol 76674-21-0
Cyhalothrin (@Karate) 91465-08-6 Fluvalinate 69409-94-5
Diflubenzuron 35367-38-5 Prodiamine 29091-21-2
Epoxiconazole - Stannane, tributylfluoro [Tributyltin fluoride] 1983-10-4
Fipronil - Thiazopyr 117718-60-2-
Fluazifop-butyl 69806-50-4 Trifluralin -


US Federal Register
Date Published Docket Identification Number Details
Aug 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
March 5, 1997 OPP-300455

ROHM & HAAS - Pesticide Tolerances.- FINAL RULE. This document establishes tolerances for residues of the herbicide thiazopyr and its metabolites in or on the raw agricultural commodities orange and grapefruit at 0.05 ppm. In the Federal Register of October 21, 1993 (58 FR 54354), EPA issued a notice announcing the filing of a pesticide tolerance petition by Monsanto. The petition requested that 40 CFR part 180 be amended by adding a regulation for tolerances for combined residues of the herbicide thiazopyr and its metabolites in or on the raw agricultural commodities: Citrus, whole fruit at 0.05 ppm; cotton seed at 0.05 ppm and cotton forage at 0.2 ppm. In the Federal Register of August 24, l994 (59 FR 43580) EPA issued a notice of an amendment to the petition. The tolerances requested were changed to residues of thiazopyr and its metabolites in or on citrus whole fruit at 0.05 ppm, cotton seed at 0.05 ppm and cotton forage at 0.2 ppm. Monsanto Co. requested the petition be amended to read: tolerances of 0.05 ppm for orange, whole fruit and 0.05 for grapefruit, whole fruit.

April 2, 1997 na
  • MONSANTO - Approval of Pesticide Product Registrations:
  • Thiazopyr Technical Herbicide. EPA Reg. No. 707-250
  • Visor 2E Herbicide to control annual grasses and broadleaf weeds in grapefruit and oranges. EPA Reg. No. 707-251
  • NOTE: EPA issued a notice, published the FR of June 10, 1993 (58 FR 32533; FRL-4582-6), which announced that Monsanto had submitted applications to register the pesticide products MON 13211-A Citrus Herbicide and Thiazopyr Technical (MON 13200) (EPA File Symbols 524-UAG and 524-UAE) containing the active ingredient Thiazopyr
Nov 22, 1996 PF-673

ROHM & HAAS - Pesticide Tolerance Petition for residues of the herbicide in or on the raw agricultural commodity orange (whole fruit) and grapefruit (whole fruit) at 0.05 ppm.

Nov 13, 1996 na

ROHM & HAAS - Issuance of Experimental Use Permit (707-EUP-136). This experimental use permit allows the use of 565.0 pounds of the herbicide on 800 acres of tree nuts and 660 acres of peanuts to evaluate the preemergence control of various annual grasses and broadleaf weeds. The program is authorized only in the States of California, Georgia, New Mexico, Oregon, and Texas for the tree nut program and in the States of Alabama, Georgia, North Carolina, Oklahoma, Texas, and Virginia for the peanut program. The experimental use permit is effective from July 25, 1996 to July 25, 1998.

1993 na

MONSANTO - Request for residues in or on citrus whole fruit at 0.05 ppm, cotton seed at 0.05 pm, and cotton forage at 0.2 ppm. This was announced by USDA. The Federal Register for 1993 is not online.


Thiazopyr product: VISOR 2E HERBICIDE
US EPA Registration No: 707- 251-AA
Status as of August 2002: Active
Ingredients found: 22.3% of THIAZOPYR
77.7% of INERT INGREDIENTS
Use: ALMOND (3001) || APRICOT (5001) || CHERRY (5002) || CITRUS FRUITS (ALL OR UNSPEC) (2000) || GRAPEFRUIT (2002) || GRAPES (ALL OR UNSPEC) (1014) || GRAPES, WINE (29143) || NECTARINE (5003) || NUT CROPS, NUT TREES (ALL OR UNSPEC) (3000) || ORANGE (ALL OR UNSPEC) (2006) || PEACH (5004) || PESTICIDE PRODUCTS FOR TANK MIXES (99003) || PISTACHIO (PISTACHE NUT) (3011) || PLUM (INCLUDES WILD PLUMS FOR HUMAN CONSUMPTION) (5005) || PRUNE (5006) || WALNUT (ENGLISH WALNUT, PERSIAN WALNUT) (3009) || WEEDS, ANNUAL BROADLEAF (TARGET PEST) (29638) || WEEDS, BROADLEAF (UNSPECIFIED) (29637) ||
Company: ROHM & HAAS COMPANY
PHILADELPHIA PA 19106-2399
 
Fluoride Action Network | Pesticide Project | 315-379-9200 | pesticides@fluoridealert.org