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| Order
No. |
Title |
Keywords |
CAS
Nos. |
| NTIS/PB95-270963,
14p. |
1995
-
Pesticide Fact Sheet: Prosulfuron.
US
EPA Office of Pesticide Programs. |
Abstract:
This document contains up-to-date
chemical information, including a summary of the Agency's
regulatory position and rationale, on a specific pesticide
or group of pesticides. A Fact Sheet is issued after registration
of a new chemical. |
94125-34-5
|
NTIS/OTS0529902-3
EPA/OTS;
Doc #89-950000124 |
1995
- SUPPORT: LETTER FROM CIBA GEIGY
CORP TO USEPA REGARDING TOXICOLOGICAL STUDIES OF CGA-152005
WITH ATTACHMENTS DATED 02-02-95 |
CIBA
GEIGY CORP
CGA-152005
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
DOGS
ORAL
DIET
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
RABBITS
GAVAGE
MICE
NEUROTOXICITY
RATS |
94125-34-5
|
NTIS/OTS0529902-3
EPA/OTS;
Doc #8EHQ-0494-1104 |
1994
-
SUPPORT: LETTER FROM CIBA GEIGY CORP
TO USEPA RE: TWO-YEAR DIETARY CHRONIC TOXICITY/ONCOGENICITY
STUDY WITH CGA-152005 TECHNICAL IN RATS WITH ATTACHMENTS
DATED 04-08-94 |
CIBA
GEIGY CORP
CGA-152005
HEALTH EFFECTS
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET |
94125-34-5
|
NTIS/OTS0529902-4
EPA/OTS;
Doc #89920000360D |
1994
- SUPPORT: LETTER FROM CIBA-GEIGY CORP TO USEPA RE: 1-(4-METHOXY-6-
METHYLTRIAZIN-2-YL)-3-[2-(3,3,3-
TRIFLUOROPROPYL)PHENYLSULFONYL]UREA, DATED 09/21/1992
(DECLASSIFIED) |
CIBA-GEIGY
CORP
1-(4-METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-
(3,3,3-TRIFLUOROPRO*
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET |
94125-34-5
|
NTIS/OTS0529902-4
EPA/OTS;
Doc #89910000273D |
1991
- METHYLTRIAZIN-2-YL)-3-[2-(3,3,3-
TRIFLUOROPROPYL)PHENYLSUFONYL]
UREA, DATED 09/03/1991 (DECLASSIFIED)
|
CIBA-GEIGY
CORP
1-(4-METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-
(3,3,3-TRIFLUOROPRO*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
DOGS
ORAL
DIET |
94125-34-5
|
| NTIS/OTS0529902-4
EPA/OTS;
Doc #89910000154D |
1991
- SUPPORT: LETTER FROM CIBA-GEIGY
CORP TO USEPA RE: 1-(4-METHOXY-6-
METHYLTRIAZIN-2-YL)-3-[2-(3,3,3-
TRIFLUOROPROPYL)PHENYLSULFONYL]
UREA, DATED 05/30/1991 (DECLASSIFIED)
|
CIBA-GEIGY
CORP
1-(4-METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-
(3,3,3-TRIFLUOROPRO*
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
MICE
ORAL
DIET |
94125-34-5
|
NTIS/OTS0529902-4
EPA/OTS;
Doc #89910000026D |
1991
-
SUPPORT: LETTER FROM CIBA-GEIGY CORP
TO USEPA RE: 1-(4-METHOXY-6-
METHYLTRIAZIN-2-YL)-3-[2-(3,3,3-
TRIFLUOROPROPYL)PHENYLSULFONYL]
UREA, DATED 01/02/1991 (DECLASSIFIED)
|
CIBA-GEIGY
CORP
1-(4-METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-
(3,3,3-TRIFLUOROPRO*
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
ORAL |
94125-34-5
|
NTIS/OTS0529902-4
EPA/OTS;
Doc #88910000017D |
1990
- INITIAL SUBMISSION: LETTER FROM CIBA-GEIGY
CORP TO USEPA RE: 1-(4-
METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-(3,3,3-
TRIFLUOROPROPYL)PHENYLSULFONYL]UREA, DATED 10/19/1990
(DECLASSIFIED) |
CIBA-GEIGY
CORP
1-(4-METHOXY-6-METHYLTRIAZIN-2-YL)-3-[2-
(3,3,3-TRIFLUOROPRO*
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
ORAL
SUBCHRONIC TOXICITY
DOGS |
94125-34-5 |
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12769518&dopt=Abstract
J Agric
Food Chem. 2003 Jun 4;51(12):3525-7.
Soil transformation
of prosulfuron.
Menniti
C, Cambon JP, Bastide J.
Centre de
Phytopharmacie, FRE CNRS 2605, Universite de Perpignan, 52 Avenue
de Villeneuve, 66860 Perpignan Cedex, France.
The transformation
of prosulfuron [1-(4-methoxy-6-methyltriazine-2-yl)-3-[2-(3,3,3-trifluropropyl)phenylsulfonyl]urea]
in three soils at different pH values (sterilized and unsterilized)
was studied, and it was shown that the rate of transformation
was high in acidic soil. From the results obtained in sterile
soils, it is shown that the mechanism of dissipation was mainly
chemical in acidic soils. A new metabolite,
2-(3,3,3-trifluoropropyl)phenylsulfonic acid, was identified.
PMID: 12769518
[PubMed - in process]
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12009993&dopt=Abstract
J Agric
Food Chem. 2002 May 22;50(11):3236-43.
Effects of soil
pH and soil water content on prosulfuron dissipation.
Hultgren
RP, Hudson RJ, Sims GK.
Department
of Natural Resources and Environmental Sciences, University
of Illinois, Urbana, Illinois 61801, USA. hultgren@ecn.purdue.edu
The sulfonylurea
herbicide prosulfuron, 1-(4-methoxy-6-methyltriazin-2-yl)-3-[2-(3,3,3-trifluoropropyl)phenylsulfonyl]urea,
is used for the selective control of broadleaf weeds in corn,
sorghum, and cereal grains. To investigate its fate in soils,
this study examined the effects of soil pH and water content
on the rates of dissipation processes and the products formed
under aerobic conditions. Radiometry and chromatography analyses
were used to quantify the degradation products and bound residues
formed in incubations of 10 different soils. The pH-dependent
hydrolysis of the sulfonylurea bridge to form phenyl sulfonamide
was the primary transformation process. Significant microbial
degradation of prosulfuron occurred in 2 of the 10 soils, yielding
(14)CO(2) and desmethyl prosulfuron among the major products.
The time required for 50% dissipation of the herbicide (DT(50))
was determined for each soil and water content treatment. At
equivalent water contents, prosulfuron DT(50) values were positively
correlated with soil pH (P < 0.0001), varying from 6.5 days
at pH 5.4 to 122.9 days at pH 7.9. Soil pH and water content
strongly influence the fate of sulfonylurea herbicides in agricultural
fields. Differences in the effect of soil water content on dissipation
kinetics in a comparison of two soils were attributed to differences
in soil pH, texture, and the ability of indigenous microorganisms
to transform the herbicide.
PMID: 12009993
[PubMed - indexed for MEDLINE]
From Toxline at Toxnet
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY; 45 (5). 1997.
1940-1945.
Hydrolytic dissipation of four sulfonylurea
herbicides.
DINELLI G, VICARI A, BONETTI A, CATIZONE
P
Dep. Agronomy, Univ. Bologna, Via Filippo Re 6/8, 40126 Bologna,
Italy.
BIOSIS COPYRIGHT: BIOL ABS. The fate of prosulfuron, primisulfuron
methyl, rimsulfuron, and thifensulfuron methyl in aqueous solutions
was investigated, using capillary electrophoresis (CE) for herbicide
detection. The hydrolysis of the four sulfonylureas followed
first-order kinetics and was pH dependent and accelerated at
higher temperature. Rimsulfuron and thifensulfuron methyl showed
fast degradation in water, with half-lives from 12 to 0.06 days
in the pH range from 2 to 8.5 at 25êC. The
degradation rate of prosulfuron and primisulfuron methyl resulted
relatively slow, with half-lives from 49 to 399 days in the
pH range from 5 to 7.5, at 25êC. The hydrolysis
of the four sulfonylureas as a function of temperature and pH
was mathematically combined. The resulting complex equations
represent simple and useful models to predict the hydrolytic
dissipation of these sulfonylureas. The complex equations of
prosulfuron and primisulfuron methyl suggest that once these
herbicides reach the groundwater, [abstract truncated]
From Toxline at Toxnet
PESTICIDE SCIENCE; 51 (1). 1997.
56-64.
Hydrolysis of prosulfuron at pH 5: Evidence
for a resonance-stabilized triazine cleavage product.
BRAY LD, HEARD NE, OVERMAN MC, VARGO JD,
KING DL, LAWRENCE LJ, PHELPS AW
Dep. Environ. Fate Effects, Ciba-Geigy
Corp., 410 Swing Road, Greensboro, NC 27419, USA.
BIOSIS COPYRIGHT: BIOL ABS. Prosulfuron is a herbicide for
the selective control of broadleaf weeds in corn. In order to
examine the effect of pH on the stability of prosulfuron in
aqueous solution, a hydrolysis experiment was conducted in buffer
at pH 5, 7 and 9 utilizing (phenyl-14C) and (triazine-14C)prosulfuron.
Prosulfuron was found to be stable under neutral and basic conditions
and hydrolytically unstable under acidic
conditions (T1/2 5 involved hydrolysis of the sulfonylurea
bridge to yield the corresponding phenyl- and triazine-cleavage
products and minor amounts of desmethyl-prosulfuron and dihydroxymethyltriazine.
In addition to these hydrolysis products, an
unknown species was observed at significant levels after 30
days ( 20% of the applied dose). A large-scale experiment
was subsequently performed to generate additional material for
the spectroscopic characterization and identification of this
unknown degradate. A thorough spectral evaluation of this unknown
revealed a resonance-sta [abstract truncated]
From Toxline at Toxnet
Order No. NTIS/PB95-270963,
14p.
1995 - Pesticide Fact
Sheet: Prosulfuron.
US EPA Office of Pesticide Programs.
This document contains up-to-date chemical
information, including a summary of the Agency's regulatory
position and rationale, on a specific pesticide or group of
pesticides. A Fact Sheet is issued after registration of a new
chemical.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8820859&dopt=Abstract
Drug Metabol
Drug Interact. 1995;12(3-4):317-27.
Induction of cytochrome
P450 genes by ethanol in maize.
Potter
S, Moreland DE, Kreuz K, Ward E.
Ciba
Agricultural
Biotechnology, Research Triangle Park, NC 27709, USA.
Ethanol
treatment of etiolated maize seedlings led to a marked enhancement
in metabolism of the herbicides metolachlor and prosulfuron.
cDNA clones representing eight genes that encode putative cytochrome
P450 enzymes were isolated from maize. They fall into three
families and are designated CYP71C5, CYP73A6, A7, and A8, and
CYP81A1, A2, A3, and A4. Ethanol treatment induced the CYP81A
subfamily at the mRNA level in both roots and shoots of etiolated
seedlings.
PMID: 8820859
[PubMed - indexed for MEDLINE]
From Toxline at Toxnet
PESTICIDE SCIENCE; 41 (3). 1994.
259-267.
Key chemical inputs to new herbicides:
Intermediates, processes and mechanistic investigations.
DINGHWALL JG
CIBA Plant Prot., R and D Weed
Control, CH-4002 Basel, SWI.
BIOSIS COPYRIGHT: BIOL ABS. The key chemical inputs that led
to the discovery of the three herbicides CGA 215 684 (a cyclohexanedione),
CGA 244 126 (a substituted pyridine) and CGA 152 005 (sulfonylurea)
and the plant-growth regulant CGA 163 935 (a cyclohexanedione)
are described.
CAS Registry Numbers:
95266-40-3
94125-34-5 - Prosulfuron
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