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ACTIVITY:
Herbicide (2,6-Dinitroaniline)
CAS Name:
2,4-dinitro-N3,N3-dipropyl-6-(trifluoromethyl)-1,3-benzenediamine
Structure:
Reports
available from The National Technical Information Service
(NTIS)
- see http://www.ntis.gov/ |
| Order
No. |
Title |
Keywords |
CAS
No. |
| NTIS/PB92-145416
(14p) |
1992
- Pesticide Fact Sheet Number 231: Prodiamine.
Environmental
Protection Agency, Washington, DC. Office of Pesticide
Programs.
The
document contains up-to-date chemical information, including
a summary of the Agency's regulatory position and rationale,
on prodiamine. A Fact Sheet is issued for the following
action--registration of a new chemical. |
Pesticides
Toxic substances
Registration
Chemical Information Fact Sheet
Prodiamine |
29091-21-2 |
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9681970&dopt=Abstract
Environ
Health Perspect 1998 Aug;106(8):437-45
Mode of
carcinogenic action of pesticides inducing thyroid follicular
cell tumors in rodents.
Hurley PM.
Office of Prevention, Pesticides
and Toxic Substances, U.S. Environmental Protection
Agency, Washington, DC 20460 USA.
Of 240 pesticides screened for carcinogenicity by the
U.S. Environmental Protection Agency Office of Pesticide
Programs, at least 24 (10%) produce thyroid follicular
cell tumors in rodents. Thirteen of the thyroid carcinogens
also induce liver tumors, mainly in mice, and 9 chemicals
produce tumors at other sites. Some mutagenic data are
available on all 24 pesticides
producing thyroid tumors. Mutagenicity does not
seem to be a major determinant in thyroid carcinogenicity,
except for possibly acetochlor;
evidence is less convincing for
ethylene thiourea and etridiazole. Studies on thyroid-pituitary
functioning, including indications of thyroid cell growth
and/or changes in thyroxine, triiodothyronine, or thyroid-stimulating
hormone levels, are available on 19 pesticides. No such
antithyroid information is available for etridiazole,
N-octyl bicycloheptene dicarboximide,
terbutryn,
triadimefon, and
trifluralin. Of the studied
chemicals, only bromacil lacks antithyroid activity
under study conditions. Intrathyroidal and extrathyroidal
sites of action are found: amitrole,
ethylene thiourea, and mancozeb are thyroid peroxidase
inhibitors; and acetochlor, clofentezine, fenbuconazole,
fipronil,
pendimethalin, pentachloronitrobenzene,
prodiamine,
pyrimethanil, and thiazopyr
seem to enhance the hepatic metabolism and excretion
of thyroid hormone. Thus, with 12 pesticides that mode
of action judgments can be made, 11 disrupt thyroid-pituitary
homeostasis only; no chemical is mutagenic only; and
acetochlor may have both antithyroid and some mutagenic
activity. More information is needed to identify other
potential antithyroid modes of thyroid carcinogenic
action.
PMID: 9681970 [PubMed - indexed for
MEDLINE]
|
From
Toxline at Toxnet
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY; 21 (4). 1999.
263-270.
Neutrophil function in workers exposed
to organophosphate and carbamate insecticides.
QUEIROZ M LS, FERNANDES MD, VALADARES
MC
Department of Pharmacologyemocenter, Faculty of Medical Sciences,
UNICAMP, CEP 113084-100, Campinas, SP, Brazil.
BIOSIS COPYRIGHT: BIOL ABS. Neutrophil function in 40 workers
occupationally exposed to carbamate and organophophate insecticides
were examined and compared to those of non-exposed individuals.
Phagocytosis and intracellular killing of Candida albicans and
Candida pseudotropicalis by neutrophils were studied. Two species
of Candida were used since in individuals with myeloperoxidase
deficiency neutrophils are unable to kill Candida albicans,
while Candida pseudotropicalis can be effectively lysed.
Phagocytosis of both anti hese results demonstrate that exposure
to carbamates and organophophates insecticides may lead to changes
in neutrophil function even in workers presenting no impairment
in the cholinesterase activity.
CAS Registry Numbers:
29091-21-2
29091-21-2
15263-53-3
10265-92-6
22259-30-9
33089-61-1
333-41-5
62-73-7
56-38-2
From
Toxline at Toxnet
ENVIRONMENTAL SCIENCE
& TECHNOLOGY; 31 (9). 1997.
2445-2454.
Fluorinated
organics in the biosphere.
KEY
BD, HOWELL RD, CRIDDLE CS
Dep. Civil Environ.
Eng., Mich. State Univ., East Lansing, MI 48824, USA.
BIOSIS COPYRIGHT: BIOL ABS. The use of organofluorine compounds
has increased throughout this century, and they are now ubiquitous
environmental contaminants. Although generally viewed as recalcitrant
because of their lack of chemical reactivity, many
fluorinated organics are biologically active. Several
questions surround their distribution, fate, and effects. Of
particular interest is the fate of perfluoroalkyl substituents,
such as the trifluoromethyl group. Most evidence to date suggest
that such groups resist defluorination, yet they can confer
significant biological activity. Certain volatile fluorinated
compounds can be oxidized in the troposphere yielding nonvolatile
compounds, such as trifluoroacetic acid. In addition, certain
nonvolatile fluorinated compounds can be transformed in the
biosphere to volatile compounds. Research is needed to assess
the fate and effects of nonvolatile fluorinated organics, the
fluorinated impurities present in commercial formulations, and
the transformation
CAS Registry Numbers:
137938-95-5 - na
112839-33-5 - chlorazifop [C14H11Cl2NO4]
112839-32-4 - chlorazifop [ C14H11Cl2NO4]
106917-52-6 - flusulfamide [C13H7Cl2F3N2O4S]
104040-78-0 - flazasulfuron [C13H12F3N5O5S]
102130-93-8 - 4-Fluorothreonine [ C4-H8-F-N-O3
]
101463-69-8 - flufenoxuron [C21H11ClF6N2O3]
101007-06-1 - acrinathrin [C26H21F6NO5]
97886-45-8 - dithiopyr [C15H16F5NO2S2]
96525-23-4 - flurtamone [C18H14F3NO2]
90035-08-8 - flocoumafen [C33H25F3O4]
88485-37-4 - fluxofenim [C12H11ClF3NO3]
85758-71-0 - 1-Decanol, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heneicosafluoro-
[ C10-H-F21-O ]
83164-33-4 - diflufenican [C19H11F5N2O2]
82657-04-3 - bifenthrin [C23H22ClF3O2]
81613-59-4 - flupropadine [C20H23F6N]
80164-94-9 - Methanone, phenyl((trifluoromethyl)phenyl)-,
dichloro deriv. [ C14-H7-Cl2-F3-O
]
80020-41-3 - furyloxyfen [C17H13ClF3NO5]
79622-59-6 - fluazinam [C13H4Cl2F6N4O4]
79538-32-2 - tefluthrin [C17H14ClF7O2]
77501-63-4 - lactofen [C19H15ClF3NO7]
77501-60-1 - fluoroglycofen [C16H9ClF3NO7]
76674-21-0 - flutriafol [C16H13F2N3O]
72850-64-7 - flurazole [C12H7ClF3NO2S]
72178-02-0 - fomesafen [C15H10ClF3N2O6S]
71422-67-8 - chlorfluazuron [C20H9Cl3F5N3O3]
69806-34-4 - Haloxyfop [C15H11ClF3NO4]
69335-91-7 - fluazifop [C15H12F3NO4]
68694-11-1 - Triflumizole [ C15-H15-Cl-F3-N3-O
]
68085-85-8 - cyhalothrin [C23H19ClF3NO3]
67485-29-4 - hydramethylnon [C25H24F6N4]
66332-96-5 - flutolanil [C17H16F3NO2]
64628-44-0 - triflumuron [C15H10ClF3N2O3]
63333-35-7 - bromethalin [C14H7Br3F3N3O4]
62924-70-3 - flumetralin [C16H12ClF4N3O4]
61213-25-0 - flurochloridone [C12H10Cl2F3NO]
59756-60-4 - fluridone [C19H14F3NO]
57041-67-5 - Desflurane [ C3-H2-F6-O
]
56425-91-3 - flurprimidol [C15H15F3N2O2]
55283-68-6 - ethalfluralin [C13H14F3N3O4]
53780-34-0 - mefluidide [C11H13F3N2O3S]
50594-66-6 - acifluorfen [C14H7ClF3NO5]
42874-03-3 - oxyfluorfen [C15H11ClF3NO4]
40856-07-3 - Difluoromethanesulphonic
acid [ C-H2-F2-O3-S ]
37924-13-3 - perfluidone [C14H12F3NO4S2]
35367-38-5 - diflubenzuron [C14H9ClF2N2O2]
33245-39-5 - fluchloralin [C12H13ClF3N3O4]
31251-03-3 - fluotrimazole [C22H16F3N3]
29091-21-2 - prodiamine [C13H17F3N4O4]
29091-05-2 - dinitramine [C11H13F3N4O4]
28606-06-6 - na
28523-86-6 - Sevoflurane [ C4-H3-F7-O
]
27314-13-2 - norflurazon [C12H9ClF3N3O]
26675-46-7 - Isoflurane [ C3-H2-Cl-F5-O
]
26399-36-0 - profluralin [C14H16F3N3O4]
25366-23-8 - thiazafluron [C6H7F3N4OS]
24751-69-7 - Nucleocidin [ C10-H13-F-N6-O6-S
]
14477-72-6 - Acetic acid, trifluoro-, ion(1-) [ C2-F3-O2
]
9002-84-0 - Polytetrafluoroethylene (Teflon) ( (C2-F4)mult-
or (C2-F4)x-)
2837-89-0 - 1,1,1,2-Tetrafluoro-2-chloroethane (Freon 124) [
C2-H-Cl-F4 ]
2164-17-2 - fluometuron [C10H11F3N2O]
1861-40-1 - benfluralin [C13H16F3N3O4]
1827-97-0 - 2,2,2-Trifluoroethanesulfonic
acid [ C2-H3-F3-O3-S ]
1763-23-1 - Perfluorooctane sulfonic acid [ C8-H-F17-O3-S
]
1717-00-6 - 1,1-Dichloro-1-fluoroethane [ C2-H3-Cl2-F
]
1582-09-8 - trifluralin [C13H16F3N3O4]
1493-13-6 - Trifluoromethanesulfonic acid
[ C-H-F3-O3-S ]
811-97-2 - 1,1,1,2-Tetrafluoroethane (Norflurane) [ C2-H2-F4
]
754-91-6 - Perfluorooctanesulfonamide [ C8-H2-F17-N-O2-S
]
640-19-7 - fluoroacetamide [C2H4FNO]
513-62-2 - Fluoroacetate [ C2-H2-F-O2
]
453-13-4 - 1,3-Difluoro-2-propanol [ C3-H6-F2-O
]
420-46-2 - 1,1,1-Trifluoroethane [ C2-H3-F3
]
406-90-6 - Fluroxene (Ethene, (2,2,2-trifluoroethoxy)-) [ C4-H5-F3-O
]
370-50-3 - flucofuron [C15H8Cl2F6N2O]
335-76-2 - Perfluorodecanoic acid [ C10-H-F19-O2
]
335-67-1 - Perfluorooctanoic acid (PFOA) [ C8-H-F15-O2
]
311-89-7 - Perfluorotributylamine [ C12-F27-N
]
306-83-2 - 2,2-Dichloro-1,1,1-trifluoroethane [Freon 123) [
C2-H-Cl2-F3 ]
151-67-7 - 2-Bromo-2-chloro-1,1,1-trifluoroethane (HALOTHANE)
[ C2-H-Br-Cl-F3 ]
144-49-0 - Fluoroacetic acid [ C2-H3-F-O2
]
116-14-3 - Tetrafluoroethylene [ C2-F4
]
98-56-6 - 1-Chloro-4-(trifluoromethyl)benzene [ C7-H4-Cl-F3
]
88-30-2 - TFM (3-Trifluoromethyl-4-nitrophenol)[ C7-H4-F3-N-O3
]
79-38-9 - Chlorotrifluoroethylene [ C2-Cl-F3
]
76-38-0 - Methoxyflurane [ C3-H4-Cl2-F2-O
]
76-15-3 - Chloropentafluoroethane (Freon 115 )[C2-Cl-F5
]
76-14-2 - Dichlorotetrafluoroethane (Freon 114 )[ C2-Cl2-F4
]
76-13-1 - 1,1,2-Trichloro-1,2,2-trifluoroethane (Freon 113 )
[C2-Cl3-F3 ]
76-05-1 - Trifluoroacetic acid [ C2-H-F3-O2]
75-71-8 - Dichlorodifluoromethane (Freon 12) [ C-Cl2-F2]
75-69-4 - Trichloromonofluoromethane (
Freon 11, 11A, 11B) [C-Cl3-F]
75-68-3 - 1-Chloro-1,1-difluoroethane (Freon 142, Freon 142b)
[ C2-H3-Cl-F2]
75-45-6 - Chlorodifluoromethane (Freon 21) [ C-H-Cl-F2]
75-43-4 - Dichlorofluoromethane (Freon
21) [C-H-Cl2-F]
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