Return to Primisulfuron-methyl
Systematic Name for
Benzoic acid, 2-(((((4,6-bis(difluoromethoxy)-2-
pyrimidinyl)amino)carbonyl)amino)sulfonyl)-, methyl ester
to plants and algae
data is primarily for Primisulfuron-methyl
Information (only comprehensive for the US)
Note: PAN presents its data as one for
EPA PC Code:
EPA Permit Date
(includes only a limited list of countries)
Finland, Hungary, New Zealand, US
Maximum Residue Levels permitted
in food commodities
in or on 24 food commodities
Cattle, Corn, Egg, Goat, Hog, Horse, Milk,
Safety Data Sheets & Labels
- Primisulfuron-methyl: Report of the
Food Quality Protection Act (FQPA) Tolerance Reassessment Progress
and Risk Management Decision (TRED). Also
a shortened TRED
Fact Sheet is available.
29, 2001 - Proposed
Regulatory Decision Document PRDD2001-02. Canada
Pest Management Regulatory Agency.
17, 2001 - Regulatory
Decision Document: Primisulfuryon-methyl. RDD2001-03. Canada
Pest Management Regulatory Agency.
30, 2001 - Primisulfuron-methyl.
Canada Food and Drug
Regulations - Amendments. Schedule 1215. Maximum
Residue Limits in Corn and Milk at 0.02 ppm; and 0.1 ppm in
Eggs and Meat and Meat by-products of cattle, goats, hogs, horses,
poultry, and sheep.
24, 1994. Primisulfuron-methyl.
York State approval of label addition of the use of Beacon
Herbicide for aerial use. Letter
from Normal Nosenchuck, director, NYS Div. of Hazardous Substances
Regulation to Ciba Plant Protection.
"... The active ingredient methyl primisulfuron is
registered for weed control on field corn and popcorn in
New York State. The submitted Special Local Need (SLN) label
expands usage to allow aerial application ... Both the New
York State-Department of Health and this Department's Division
of Fish and Wildlife have agreed that the 150 foot buffer
zone incorporated in the SLN label will minimize any adverse
impact caused by aerial spraying of this pesticide product.
This conclusion was reached after evaluation cf drift studies
submitted by Ciba Plant Protection demonstrated that, under
the conditions of these submitted studies, spray drift may
occur. Also, the Division of Fish and Wildlife has determined
from experience with mosquito control programs that aerial
applications can be made with accuracy within this established
1992 - New York State: Conditional
Registration of Beacon herbicide.
1990 - Primisulfuron-methyl.
Herbicide Fact Sheet
- US EPA
Map of Pesticide Use: 1992-1995
2001 - Primisulfuron-methyl. Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration.
for US EPA to add Primisulfuron methyl
to the Toxic Release Inventory
a 90-day dog feeding study, reduced thyroid weights accompanied
by colloid depletion and parafollicular hyperplasia and
anemia were observed at the LOEL of 25 mg/kg/day. The NOEL
was 0.625 mg/kg/day. In a 1-year dog study, dietary administration
of 250/125 mg/kg/day (LOEL: the dose was changed after week
10 in the study) produced thyroid hyperplasia, anemia, increased
platelet levels, vacuolar changes, and increased absolute
and relative liver weights. The NOEL was 25 mg/kg/day. In
an 18-month study in mice, dietary administration of 1.7
mg/kg/day produced increased absolute and relative liver
weights in females. No NOEL was established. Based on this
study, an oral RfD of 0.006 mg/kg/day was derived. In a
2-year mouse study, increases in absolute and relative liver
weights were observed at 408 mg/kg/day in males and 1.7
mg/kg/day in females. The systemic LOEL and NOEL in males
was 408 mg/kg/day and 40.2 mg/kg/day, respectively. The
systemic LOEL in females was 1.7 mg/kg/day and a NOEL could
not be established. EPA believes that there is sufficient
evidence for listing primisulfuron on EPCRA section 313
pursuant to EPCRA section 313(d)(2)(B) based on the available
thyroid and liver toxicity data for this chemical.
toxicity values include a duckweed 14-day EC 50 of 0.27
ppb and an algae 7-day EC 50 of 24 ppb. EPA believes
that there is sufficient evidence for listing primisulfuron
on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(C)
based on the available environmental toxicity data for this
USEPA/OPP. Support Document for the Addition of Chemicals
from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA)
Active Ingredients to EPCRA Section 313. U. S. Environmental
Protection Agency, Washington, DC (1993).
As cited by US EPA in:
Register: January 12, 1994. Part
IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic
Chemical Release Reporting; Community Right-to-Know; Proposed
of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know. Final
was included in the deferral of 40 chemicals: EPA
is deferring final action on 40 chemicals and one chemical
category until a later date. These chemicals and the comments
received on them raised particularly difficult technical
or policy issues which will require additional time to address.
The Agency does not believe that it would be in the spirit
of community right-to-know to delay final action on the
remaining 286 chemicals and chemical categories, pending
completion of work on the more limited group. In a future
rulemaking, EPA will make a final determination as to whether
these chemicals should be added to EPCRA section 313. The
public comment that has been received specific to these
deferred chemicals will be addressed as part of the future
rulemaking discussed above.
US EPA Tolerances are for the residues of primisulfuron-methyl
and its metabolites
EPA's Pesticide Reregistration Performance Measures and Goals.
was one of 21 TREDS
completed by US EPA in Fiscal Year 2002.
-- EPA issues Reports on FFDCA Tolerance Reassessment Progress
and Interim Risk Management Decisions, known as TREDs, for pesticides
that require tolerance reassessment decisions under FFDCA, but
do not require a reregistration eligibility decision at present
¥ The pesticide was first registered after November 1984 and
is considered a ``new'' active ingredient, not subject to reregistration
(e.g., fenarimol and primisulfuron-methyl in FY 2002)...
Report of the FQPA Tolerance Reassessment Progress and Risk
Management Decision (TRED); Notice of Availability. EPA
has reassessed the 24 tolerances, or legal limits, established
for residues of primisulfuron-methyl in/on raw agricultural
commodities in the TRED
report (a shortened TRED
Fact Sheet is also available). These tolerances are now
considered safe under the Federal Food, Drug, and Cosmetic
Act (FFDCA), as amended by the FQPA of 1996. Therefore, 23
existing tolerances for primisulfuron-methyl have been reassessed
and remain unchanged, and 1 tolerance on sweet corn will be
revoked because current labels prohibit use on sweet corn.
Although EPA is considering a petition for a new use on Kentucky
bluegrass grown for seed, the Agency has not yet made a decision
to register this new use or establish any associated tolerances.
EPA is issuing the primisulfuron-methyl TRED as a final decision
without a formal public comment period.
status of reregistration and tolerance reassessment.
of Expired Time Limited Tolerances. FINAL RULE.
Primisulfuron-methyl: the time-limited tolerance for bluegrass
hay is being removed from 40 CFR 180.452 because it expired
on April 30, 2000.
of Tolerance for Emergency Exemptions. - FINAL RULE.
This rule extends a time-limited tolerance for residues
of the herbicide primisulfuron-methyl and its metabolites in
or on bluegrass hay at 0.1 ppm for an additional 18-month period,
to April 30, 2000.
Tolerances for Emergency Exemptions. - FINAL RULE.
This regulation establishes a time-limited tolerance for residues
of primisulfuron-methyl in or on bluegrass grown for seed AT
Subject to Tolerance Reassessment.
Exemptions. EPA has granted specific exemptions for the
use of primisulfuron-methyl on blue grass, grown for seed to
control quackgrass, windgrass, and other weeds, to: Idaho Department
of Agriculture; March 15, 1996, to November 30, 1996; and to
the Washington Department of Agriculture; April 15, 1996, to
November 30, 1996.
of Certain Chemicals; Toxic Chemical Release Reporting; Community
deferring final action on 40 chemicals and one chemical category
until a later date. These chemicals and the comments received
on them raised particularly difficult technical or policy
issues which will require additional time to address. The
Agency does not believe that it would be in the spirit of
community right-to-know to delay final action on the remaining
286 chemicals and chemical categories,
pending completion of work on the more limited group. In a
future rulemaking, EPA will make a final determination as
to whether these chemicals should be added to EPCRA section
313. The public comment that has been received specific to
these deferred chemicals will be addressed as part of the
future rulemaking discussed above. These chemicals follow:
proposal to add 41
fluorine and organofluorine chemicals to the Toxics Release
Inventory (TRI). See excerpt in box
above. Also available at http://www.epa.gov/tri/frnotices/59fr1788.htm