from The National Technical Information Service (NTIS)
- Pesticide Fact Sheet: Hexaflumuron. Environmental
Protection Agency, Washington, DC. Office of Prevention,
Pesticides and Toxic Substances.
INITIAL SUBMISSION TO USEPA SUBMITTING RESULTS ON A STUDY
CONDUCTED IN ENGLAND ON
SUBMISSION SUMMARY REPORT:
2,6-DIFLUOROBENZAMIDE - (HEXAFLUMURON) WITH COVER LETTER DATED
|U S EPA
Ecotoxicol Environ Saf. 2005 Aug
17; [Epub ahead of print]
Effects of insect growth regulators on
the nontarget soil arthropod Folsomia candida (Collembola).
Campiche S, Becker-van Slooten K, Ridreau
C, Tarradellas J.
Ecole Polytechnique Federale de Lausanne, ENAC-ISTE, Laboratory
of Environmental Chemistry and Ecotoxicology, Station 2, CH-1015
The aim of this study was to assess the effect of several insect
growth regulators (IGRs) on the nontarget soil arthropod Folsomia
candida (Collembola). The survival and reproduction rates of F.
candida were evaluated after 28 days of exposure to six IGRs (methoprene,
fenoxycarb, precocene II, tebufenozide,
hexaflumuron and teflubenzuron) and to one herbicide (diuron)
in artificial soil. The differences in the sensitivity of F. candida
to these different substances are high. The
chitin synthesis inhibitors teflubenzuron and hexaflumuron were
the most toxic compounds with an EC50 of 0.05mg/kg (dry
weight) for teflubenzuron and an EC50 of
0.6mg/kg for hexaflumuron. Teflubenzuron is toxic for F.
candida at concentrations that are probably close to environmental
levels of this insecticide. Inhibition of reproduction is strongly
related to adult survival for the juvenile hormone agonist methoprene
and for the antijuvenile hormone precocene II, with an EC50 of
173mg/kg and a LC50 of 178mg/kg for methoprene and an EC50 of
15mg/kg and a LC50 of 26mg/kg for precocene II. Fenoxycarb, another
juvenile hormone analog, showed a dose-response curve for mortality
different from that of methoprene; at concentrations such as 3052mg/kg
no effect on adult survival was observed. However, the EC50 value
of 113mg/kg is of the same order of magnitude as that obtained
for methoprene. A test with compressed soil contaminated with
fenoxycarb was conducted to observe parameters such as numbers
of eggs laid and juveniles hatched. No differences were observed
between these two endpoints for fenoxycarb. An EC50 of 109mg/kg
was obtained for the ecdysone agonist tebufenozide. The herbicide
diuron showed a relatively high toxicity for F. candida with an
EC50 of 20mg/kg. Our results show that some
of the tested IGRs can have effects on Collembola at environmentally
relevant concentrations (toxicity/exposure ratios <5 for teflubenzuron,
hexaflumuron, and diuron).
PMID: 16112194 [PubMed - as supplied by publisher]
J AOAC Int. 2001 May-Jun;84(3):901-9.
Determination of five pesticide residues
in oranges by matrix solid-phase dispersion and liquid chromatography
to estimate daily intake of consumers.
Valenzuela AI, Pico Y, Font G.
Universitat de Valencia, Laboratori, de Toxicologia, Facultat
de Farmacia, Burjassot, Spain.
Residues of benzoylphenylurea insecticides (diflubenzuron,
hexaflumuron, and flufenuxuron), carboxamide acaricides
(hexythiazox), and carbamate insecticides (benfuracarb) were determined
in 150 orange fruit samples from September 1998 to June 1999,
to estimate exposure of the Valencian population to oranges contaminated
with these newly developed pesticides. The method for monitoring
these residues is based on matrix solid-phase dispersion and liquid
chromatography with UV or atmospheric pressure chemical ionization/mass
spectrometry (APCI/MS) detection. Orange samples representing
11 varieties were collected from an agricultural cooperative and
examined for the 5 pesticides. In 74.6% of all analyzed samples,
the pesticide residues were below detection limits, which ranged
from 0.002 to 0.05 mg/kg. Residues were
detected in 25.4% of the samples, with higher incidences of diflubenzuron,
flufenuxuron, hexythiazox, and benfuracarb; hexaflumuron residues
were detected only occasionally. Two different pesticides
exceeded maximum residue limits (MRLs) in 4 (2.7%) of the orange
samples. Diflubenzuron surpassed 1 mg/kg MRL in 3 samples and
flufenuxuron exceeded the 0.3 mg/kg MRL in 3 samples. The estimated
daily intake of the 5 pesticide residues during the period was
0.077 microg/kg body weight per day. This value is much lower
than the total admissible daily intake proposed by the Food and
Agricultural Organization and the World Health Organization.
PMID: 11417653 [PubMed - indexed for MEDLINE]
From Science Direct
Journal of Cultural Heritage; Volume 1, Issue 3 , 2 November
2000, Pages 207-216
Use of Hexaflumuron baits against subterranean
termites for protection of historical and artistic structures:
experiment carried out in selected test areas at the church
of Santa Maria della Sanità in Naples
A. Gambetta (a), V. Zaffagnini (b) and
E. De Capua (a)
a Istituto per la Ricerca sul Legno – CNR, Via Barazzuoli
23, Florence, Italy
b Dow AgroSciences B.V., via d'Azeglio
25, Bologne, Italy
Subterranean termites are a serious problem for historical and
artistic structures in Italy. Remedial control is difficult because
of their large populations and foraging territories. A revolutionary
solution comes from using ‘baiting technology’ that
incorporates a slow-acting toxicant. The termite bait system tested
here is based on Hexaflumuron, a chitin synthesis inhibitor developed
by Dow AgroSciences, and ensures an effective, safe, not
invasive and environmentally responsible treatment. The research
was conducted in Naples, at the church of S. Maria della Sanità,
where a Reticulitermes lucifugus infestation has been studied
in depth since September 1997. During the pre-baiting survey a
monitoring network was established to connect termite populations.
Then a baiting program was applied in two zones selected as ‘sample
areas’ where live infestations were found; site ‘Transept’
and site ‘Arciconfraternita’. At both sites termite
control was achieved in September 1998 by the use of 430 mg
of Hexaflumuron within 4 months of baiting. After the baiting
procedure, in November 1998, a follow-up monitoring was initiated
to confirm control of the infestation at both sites. This phase,
which is still continuing, was extended to the whole structure
in order to provide continuous protection from new potential infestations.
Thanks to the monitoring device-network established also in unbaited
zones a new termite invasion was readily detected and a specific
baiting program, which is now in progress, was initiated. This
work showed that Hexaflumuron baits offer a modern solution against
the infestation of subterranean termites in urban locations and
confirmed the importance of a ‘monitoring-baiting-monitoring’
approach to termite control.
From Toxline at Toxnet
J APPL TOXICOL; 13 (1). 1993. 67-68.
Comparative study on the effects of five
benzoylphenylurea insecticides on haematological parameters in
TASHEVA M, HRISTEVA V
National Cent. Hygiene Med. Ecology, Boul. D. Nestorov 15, 1431,
BIOSIS COPYRIGHT: BIOL ABS. Five benzoylphenylurea insecticides
were administered to male Wistar rats for 28 days at oral doses
of 100 mg kg-1 each. Elevation of methaemoglobin was found only
in the diflubenzuron- and triflumuron treated groups. The number
of reticulocytes was increased in all of the treated groups.
CAS Registry Numbers:
evaluation of the insecticide Sonet and the characteristics of
the mechanism of its toxic action in an experiment]
IM, Larionov VG.
evaluation of a new insecticide Sonet was realized. It was established
that by its toxicity Sonet belongs to hazardous substances of
class III. The main manifestations of its
toxic effect on the body warm-blooded animals is its influence
on the erythropoiesis and functional state of the liver.
1364620 [PubMed - indexed for MEDLINE]
of hygienic standards for the insecticide sonet in potatoes]
A study of
the toxic properties of sonet in chronic experiment on white rats
established the threshold and non-acting dose of the insecticide.
The accumulation of the insecticide in the potato tubers during
the entire vegetation period as well as its effect on the potato
quality were investigated. The author recommends 0.05 mg/g of
sonet per 1 g of potato as a maximum permissible level.
[PubMed - indexed for MEDLINE]
Gig Sanit. 1992 Feb;(2):33-4.
[Effect of the insecticide "Sonet"
on the microflora and biological activity of soil]
[Article in Russian]
Iatsula GS, Sviatyi IM, Debrivnaia IE.
No abstract available
PMID: 1427157 [PubMed - indexed for MEDLINE]
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