Abstracts
Hexaflumuron
CAS No. 86479-06-3
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Adverse Effects

ACTIVITY: Insecticide, Termiticide (Benzoylurea)

CAS Name: N-[[[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide

Structure:

Available from The National Technical Information Service (NTIS)
- see http://www.ntis.gov/
Order No. Title Keywords CAS No.
NTIS/PB94-219029 (7 pages)

1994 - Pesticide Fact Sheet: Hexaflumuron. Environmental Protection Agency, Washington, DC. Office of Prevention, Pesticides and Toxic Substances.

Pesticides
Insecticides
Registration
Hexaflumuron
86479-06-3

NTIS/OTS0529912

EPA/OTS; Doc #88-910000030

1990 - INITIAL SUBMISSION TO USEPA SUBMITTING RESULTS ON A STUDY CONDUCTED IN ENGLAND ON
N-(((3,5-DICHLORO-4-(1,1,2,2-
TETRAFLUOROETHOXY)PHENYL)AMINO)CARBONYL)-
2,6-TRIFLUOROBENZAMIDE
DOW CHEM CO
HEXAFLUMURON
ENVIRONMENTAL EFFECTS
CHRONIC TOXICITY
INVERTEBRATES
86479-06-3

NTIS/OTS0529912

EPA/OTS; Doc #8EHQ-0391-1114

1990 - USEPA SUBMISSION SUMMARY REPORT:
N-(((3,5-DICHLORO-4-(1,1,2,2-
TETRAFLUOROETHOXY)PHENYL)AMINO)CARBONYL)-
2,6-DIFLUOROBENZAMIDE - (HEXAFLUMURON) WITH COVER LETTER DATED 12-17-90
U S EPA
HEXAFLUMURON
ENVIRONMENTAL EFFECTS
CHRONIC TOXICITY
INVERTEBRATES
86479-06-3

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16112194&query_hl=1

Ecotoxicol Environ Saf. 2005 Aug 17; [Epub ahead of print]

Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola).

Campiche S, Becker-van Slooten K, Ridreau C, Tarradellas J.

Ecole Polytechnique Federale de Lausanne, ENAC-ISTE, Laboratory of Environmental Chemistry and Ecotoxicology, Station 2, CH-1015 Lausanne, Switzerland.

The aim of this study was to assess the effect of several insect growth regulators (IGRs) on the nontarget soil arthropod Folsomia candida (Collembola). The survival and reproduction rates of F. candida were evaluated after 28 days of exposure to six IGRs (methoprene, fenoxycarb, precocene II, tebufenozide, hexaflumuron and teflubenzuron) and to one herbicide (diuron) in artificial soil. The differences in the sensitivity of F. candida to these different substances are high. The chitin synthesis inhibitors teflubenzuron and hexaflumuron were the most toxic compounds with an EC50 of 0.05mg/kg (dry weight) for teflubenzuron and an EC50 of 0.6mg/kg for hexaflumuron. Teflubenzuron is toxic for F. candida at concentrations that are probably close to environmental levels of this insecticide. Inhibition of reproduction is strongly related to adult survival for the juvenile hormone agonist methoprene and for the antijuvenile hormone precocene II, with an EC50 of 173mg/kg and a LC50 of 178mg/kg for methoprene and an EC50 of 15mg/kg and a LC50 of 26mg/kg for precocene II. Fenoxycarb, another juvenile hormone analog, showed a dose-response curve for mortality different from that of methoprene; at concentrations such as 3052mg/kg no effect on adult survival was observed. However, the EC50 value of 113mg/kg is of the same order of magnitude as that obtained for methoprene. A test with compressed soil contaminated with fenoxycarb was conducted to observe parameters such as numbers of eggs laid and juveniles hatched. No differences were observed between these two endpoints for fenoxycarb. An EC50 of 109mg/kg was obtained for the ecdysone agonist tebufenozide. The herbicide diuron showed a relatively high toxicity for F. candida with an EC50 of 20mg/kg. Our results show that some of the tested IGRs can have effects on Collembola at environmentally relevant concentrations (toxicity/exposure ratios <5 for teflubenzuron, hexaflumuron, and diuron).

PMID: 16112194 [PubMed - as supplied by publisher]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11417653

J AOAC Int. 2001 May-Jun;84(3):901-9.

Determination of five pesticide residues in oranges by matrix solid-phase dispersion and liquid chromatography to estimate daily intake of consumers.

Valenzuela AI, Pico Y, Font G.

Universitat de Valencia, Laboratori, de Toxicologia, Facultat de Farmacia, Burjassot, Spain.

Residues of benzoylphenylurea insecticides (diflubenzuron, hexaflumuron, and flufenuxuron), carboxamide acaricides (hexythiazox), and carbamate insecticides (benfuracarb) were determined in 150 orange fruit samples from September 1998 to June 1999, to estimate exposure of the Valencian population to oranges contaminated with these newly developed pesticides. The method for monitoring these residues is based on matrix solid-phase dispersion and liquid chromatography with UV or atmospheric pressure chemical ionization/mass spectrometry (APCI/MS) detection. Orange samples representing 11 varieties were collected from an agricultural cooperative and examined for the 5 pesticides. In 74.6% of all analyzed samples, the pesticide residues were below detection limits, which ranged from 0.002 to 0.05 mg/kg. Residues were detected in 25.4% of the samples, with higher incidences of diflubenzuron, flufenuxuron, hexythiazox, and benfuracarb; hexaflumuron residues were detected only occasionally. Two different pesticides exceeded maximum residue limits (MRLs) in 4 (2.7%) of the orange samples. Diflubenzuron surpassed 1 mg/kg MRL in 3 samples and flufenuxuron exceeded the 0.3 mg/kg MRL in 3 samples. The estimated daily intake of the 5 pesticide residues during the period was 0.077 microg/kg body weight per day. This value is much lower than the total admissible daily intake proposed by the Food and Agricultural Organization and the World Health Organization.

PMID: 11417653 [PubMed - indexed for MEDLINE]


From Science Direct

Journal of Cultural Heritage; Volume 1, Issue 3 , 2 November 2000, Pages 207-216

Use of Hexaflumuron baits against subterranean termites for protection of historical and artistic structures: experiment carried out in selected test areas at the church of Santa Maria della Sanità in Naples

A. Gambetta (a), V. Zaffagnini (b) and E. De Capua (a)

a Istituto per la Ricerca sul Legno – CNR, Via Barazzuoli 23, Florence, Italy
b Dow AgroSciences B.V., via d'Azeglio 25, Bologne, Italy

Subterranean termites are a serious problem for historical and artistic structures in Italy. Remedial control is difficult because of their large populations and foraging territories. A revolutionary solution comes from using ‘baiting technology’ that incorporates a slow-acting toxicant. The termite bait system tested here is based on Hexaflumuron, a chitin synthesis inhibitor developed by Dow AgroSciences, and ensures an effective, safe, not invasive and environmentally responsible treatment. The research was conducted in Naples, at the church of S. Maria della Sanità, where a Reticulitermes lucifugus infestation has been studied in depth since September 1997. During the pre-baiting survey a monitoring network was established to connect termite populations. Then a baiting program was applied in two zones selected as ‘sample areas’ where live infestations were found; site ‘Transept’ and site ‘Arciconfraternita’. At both sites termite control was achieved in September 1998 by the use of 430 mg of Hexaflumuron within 4 months of baiting. After the baiting procedure, in November 1998, a follow-up monitoring was initiated to confirm control of the infestation at both sites. This phase, which is still continuing, was extended to the whole structure in order to provide continuous protection from new potential infestations. Thanks to the monitoring device-network established also in unbaited zones a new termite invasion was readily detected and a specific baiting program, which is now in progress, was initiated. This work showed that Hexaflumuron baits offer a modern solution against the infestation of subterranean termites in urban locations and confirmed the importance of a ‘monitoring-baiting-monitoring’ approach to termite control.


From Toxline at Toxnet

J APPL TOXICOL; 13 (1). 1993. 67-68.

Comparative study on the effects of five benzoylphenylurea insecticides on haematological parameters in rats.

TASHEVA M, HRISTEVA V

National Cent. Hygiene Med. Ecology, Boul. D. Nestorov 15, 1431, Sofia, Bulgaria.

BIOSIS COPYRIGHT: BIOL ABS. Five benzoylphenylurea insecticides were administered to male Wistar rats for 28 days at oral doses of 100 mg kg-1 each. Elevation of methaemoglobin was found only in the diflubenzuron- and triflumuron treated groups. The number of reticulocytes was increased in all of the treated groups.

CAS Registry Numbers:
101463-69-8
99039-56-2
86479-06-3
64628-44-0
35367-38-5


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1364620&dopt=Abstract

Lik Sprava. 1992 Jan;(1):84-7.

[A hygienic evaluation of the insecticide Sonet and the characteristics of the mechanism of its toxic action in an experiment]

[Article in Russian]

Sviatnyi IM, Larionov VG.

A toxicological evaluation of a new insecticide Sonet was realized. It was established that by its toxicity Sonet belongs to hazardous substances of class III. The main manifestations of its toxic effect on the body warm-blooded animals is its influence on the erythropoiesis and functional state of the liver.

PMID: 1364620 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1455844&dopt=Abstract

Lik Sprava. 1992 Jun;(6):98-100.

[The setting of hygienic standards for the insecticide sonet in potatoes]

[Article in Russian]

Sviatnyi IM.

A study of the toxic properties of sonet in chronic experiment on white rats established the threshold and non-acting dose of the insecticide. The accumulation of the insecticide in the potato tubers during the entire vegetation period as well as its effect on the potato quality were investigated. The author recommends 0.05 mg/g of sonet per 1 g of potato as a maximum permissible level.

PMID: 1455844 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1427157

Gig Sanit. 1992 Feb;(2):33-4.

[Effect of the insecticide "Sonet" on the microflora and biological activity of soil]

[Article in Russian]

Iatsula GS, Sviatyi IM, Debrivnaia IE.

No abstract available

PMID: 1427157 [PubMed - indexed for MEDLINE]


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