Hexaflumuron
CAS No. 86479-06-3

 
 

Return to
Adverse Effects
Abstracts

ACTIVITY: Insecticide, Termiticide (Benzoylurea)

CAS Name: N-[[[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide

Structure:

Adverse Effects:

Blood
Eye
Kidney
Liver

Environmental Effects:

Persistent in soil

Very Toxic to Aquatic Animals

Potential for bioconcentration in aquatic organisms is very high

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 118202 
California Chemical Code 3899 
US EPA Permit Date
and Registrant:
1994, Dow Elanco 
Registered use in
(includes only a limited list of countries)

Australia, Hungary, Japan, Madagascar, Philippines, Portugal, Taiwan, US

Japan's Pesticide Standard Limits

Apple, Cotton seeds, Japanese pear, Pear, Potato, Tea, Watermelon 

-- Note the very high levels - 15 ppm - for Tea (Green, Black, Oolong, Wulung)

Other Information
Molecular Formula: C16H8Cl2 F6 N2O3 
Entry Year: 1987 
Manufacturers: Dow Agro 
Other Names:
Consult (DowElanco)
DE-473
DOWCO 473
Hexafluron
NAF-46
Recruit
Sonet
XRD 473

N-[[[3,5-dichloro-4-(1,1,2,2- tetrafluoroethoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide

1-[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea

Benzamide, N-(((3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)carbonyl)-2,6-
difluoro-
Manufacture site: US:
Dow Agro, Greenfield, Indiana 46140-0708
 
Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
October 2005 - NASHVILLE, Tenn. – When pest management professionals arrive in Music City for PestWorld 2005, they will visit the 15th most termite-infested major city in the United States.
Since its inception 10 years ago, the Sentricon® [Hexaflumuron] Termite Colony Elimination System has been installed on more than 76,000 sites throughout the state, a number slightly less than the entire population of Tennessee when it became a state in 1796... At PestWorld 2005, Dow AgroSciences is sponsoring the Saturday Opening General Session, where attendees will have the opportunity to hear keynote speaker Tom Ridge, former Homeland Security Advisor. 
The Dow AgroSciences booth, themed “Don’t Gamble on Termite Control,” will feature Texas Hold‘em poker and other related activities and giveaways.  Visitors to the booth will have the opportunity to learn about Dow AgroSciences entire portfolio of products, including Vikane® gas fumigant and Halo™ Electronic Termite Detection.

Ref: Dow to introduce new products, enhancements at PestWorld 2005.
PCT (Pest Conrol Technology) website.

http://www.pctonline.com/news/news.asp?ID=3779
US EPA identifies Hexaflumuron in the category of a "Reduced-Risk Pesticide"
Recruit (hexaflumuron) Health Effects: eye irritant, liver and kidney damage. U.S. National Park Service Conserve O Gram. September 2001. Number 2/17. "Physical Properties And Health Effects of Pesticides Used On National Park Service Collections."
Technical Fact Sheet for Hexaflumuron. National Pesticide Telecommunications Network.
http://ace.orst.edu/info/npic/factsheets/hextech.pdf
1989-2001: Dow's "History of the Sentricon System" using hexaflumuron as termite bait. - see: http://www.sentricon.com/us/story/history.htm  
International Chemical Safety Card - NIOSH 
Hexaflumuron gets Green Chemistry Award. -
Chemical & Engineering News, July 10, 2000
 
October 1998 - Structural Pest Management pesticides. FAN's compilation of information cited on fluorine and organofluorine pesticides published in General Pest Management, Category 7A. A Guide for Commercial Applicators. Prepared by: Carolyn Randall, MSU Pesticide Education Program. Published by MSU Pesticide Education (Michigan State University). MSU manual number: E-2048.  
1990: USEPA SUBMISSION SUMMARY REPORT: N-(((3,5-DICHLORO-4-(1,1,2,2-TETRAFLUOROETHOXY)PHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE - (HEXAFLUMURON) WITH COVER LETTER DATED 12-17-90. Order Number: NTIS/OTS0529912. Source: EPA/OTS; Doc #8EHQ-0391-1114
Abstracts 
Insecticide Products - partial list
Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

Hexaflumuron is the first active ingredient registered with the US EPA as a reduced-risk persticide. A reduced risk pesticide is one that EPA believes poses less risk to human health and the environment than existing alternatives.
Ref: Technical Fact Sheet for Hexaflumuron. National Pesticide Telecommunications Network.
http://ace.orst.edu/info/npic/factsheets/hextech.pdf


Subterranean Termites. Part 2, by Caroline Cox
Journal of Pesticide Reform / Summer 1997. Vol. 17, No. 2

Hexaflumuron is the active ingredient used in the Sentricon bait system. It inhibits the synthesis of chitin (6) the material making up the skeleton of termites and other insects. It was first registered in 1994 as a “reduced-risk” pesticide (7). EPA’s reduced risk program waives tests for new pesticides that are thought to pose fewer hazards than existing pesticides. This means that many standard tests are lacking for hexaflumuron: medium- term (subchronic) toxicity testing, delayed neurotoxicity testing, and tests for developmental or reproductive effects (6)...

In long-term (chronic) feeding tests, hexaflumuron increased the incidence and severity of a liver cell abnormality (6). Hexaflumuron is very toxic to aquatic animals; concentrations of 0.1 parts per billion kill water fleas (6). It is persistent in soil, with a half-life (the time required for breakdown of half the amount applied) between 100 and 160 days (8).

6. - U.S. EPA. Office of Pesticide Programs. 1994. Pesticide fact sheet: Hexaflumuron. Washington, D.C. (Mar. 10)
7. - U.S. EPA. 1995. Office of Pesticide Programs annual report for 1994. Washington, D.C. (Jan.).
8. - Yon, D. et al. 1992. The environmental distribution of hexaflumuron. Brighton Crop Protection Conference-Pests and diseases-1992: 902-912.


US Federal Register

Date Published Docket Identification Number Details
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 24(c) Registrations canceled for non-payment of the 2005
maintenance fee are shown in the following Table 1:

Table 1.--Section 24(c) Registrations Canceled for Non-Payment of Maintenance Fee

SLN no. Product Name
062719 LA-97-0003 Recruit AG
062719 OH-97-0005 Recruit AG
062719 SC-97-0004 Recruit AG
 
Fluoride Action Network | Pesticide Project | 315-379-9200 | pesticides@fluoridealert.org