Halfenprox
CAS No. 111872-58-3

 
 

ACTIVITY: Acaricide; Insecticide (pyrethroid)

CAS Name: 1-[[2-[4-(bromodifluoromethoxy)phenyl]-2-methylpropoxy]methyl]-3-phenoxybenzene

Structure:

Note: This pesticide contains both bromine and fluorine; a combination that has the potential to produce severe adverse effects - particularly to the brain.

Adverse Effects:

Note from FAN:

• No toxicological data available. See above.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No 
European Commission:

Not allowed to be used as an active ingredient after July 25, 2003.

Registered use in
(includes only a limited list of countries)

China, Japan, Taiwan, Vietnam

China:
Papayas: 0.5 ppm
Pears, 0.5 ppm
Tea, 5.0 ppm
Wax Apples, 1.0 ppm

Taiwan:
Pears, 0.5 ppm
Tea, 5.0 ppm
Wax apples, 1.0 ppm

Japan's Maximum Residue Levels (MRLs) Apple, Grapefruit, Lemon, Lime, Natsudaidai (whole), Orange, Other Citrus fruits, Tea, Unshu orange  
Other Information
Molecular Formula: C24H23Br F2 O3 
Entry Year: 1994 
Manufacturers: Mitsui Toatsu Chem., Inc. 
Other Names: Brofenprox
MTI-732
Sirbon 5 EC
 
Of special interest:
PAN Data 
November 26, 2002 - European Commission: Halfenprox (ala Brofenprox) is one of 320 pesticides to be withdrawn in July 2003. Some 320 substances used in plant protection products (PPPs) - including insecticides, fungicides and herbicides - are to be withdrawn from the market by 25 July 2003 as part of the European Commission's new approach to the evaluation of active substances in plant protection products. This aims to improve safeguards to ensure that all such products in use are safe for the environment and human health. Users, wholesalers and retailers of plant protection products will need to be aware of whether the products they use or sell are likely to be withdrawn, so as to prevent them being left with stocks of unusable material. Those concerned should contact their national authority to check the authorisation status for any particular product. The Regulation (ní 2076/2002 of 20 November 2002), with the list of the 320 substances, has now been published in the Offical Journal. Ref: MIDDAY EXPRESS. News from the Press and Communication Service's midday briefing. 
Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. 

JOURNAL OF PESTICIDE SCIENCE; 21 (3). 1996. 311-316.

Comparison of acaricidal, insecticidal, and nerve activities of halfenprox (MTI-732) and related compounds.

Authors: NISHIMURA K, OKIMOTO H, UENO T, SHIRAISHI S, KODAKA K, TOMODA K

BIOSIS COPYRIGHT: BIOL ABS. The 2-(4-perhalomethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ethers related to etofenprox were prepared. Their insecticidal potencies against common cutworms and American cockroaches were close to the respective potency of etofenprox. The acaricidal potency of the CF2BrO derivative (halfenprox) against two-spotted spider mites was about 200 times higher than etofenprox (C2H5O derivative). Halfenprox and related compounds induced repetitive discharges with a single electrical stimulus in the excised central nerve cord of the American cockroach as a class of conventional pyrethroids. These compounds also induced the slow-lasting sodium tail-current upon step repolarization of the crayfish axonal membrane. These nerve effects may be the major mode of action for the in vivo activities of this class of compounds. Hydrophobicity is likely to play some role in the variations of acaricidal potency.

AGROCHEMICALS JAPAN; 0 (67). 1995. 16-17

ANNIVERSE HALFENPROX MTI-732 SIRBON A NEW ACARICIDE

Authors: TOMODA K-I.

Abstract: BIOSIS COPYRIGHT: BIOL ABS. RRM JOURNAL ARTICLE PANONYCHUS-CITRI TETRANYCHUS-URTICAE PHYSICAL PROPERTIES, CHEMICAL PROPERTIES, TOXICOLOGICAL PROPERTIES, BIOLOGICAL PROPERTIES


June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm )

This document presents a "priority list of substances for further evaluation of their role in endocrine disruption. During 2000, a candidate list of 553 man-made substances and 9 synthetic/natural hormones has been identified."

Category included on the Endocrine Disruptor Liist
Synthetic pyrethroids While only the broad category "Synthetic pyrethroids" was included in the Commission's list, it might be of some interest to note that the following organofluorine pesticides are "Synthetic pyrethroids:" Acrinathrin, Bifenthrin, beta-Cyfluthrin, Cyhalothrin, gamma-Cyhalothrin, lambda-Cyhalothrin, Fenfluthrin, Flucythrinate, Flufenprox, Flumethrin, Fluvalinate, tau-Fluvalinate, Halfenprox, Protrifenbute, Silafluofen, Tefluthrin, Transfluthrin
 
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