Diflufenozopyr
CAS No. 109293-97-2
US Federal Register
 
 
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Adverse Effects
Abstracts

ACTIVITY: Herbicide (urea)

CAS Name for Diflufenzopyr: 2-[1-[[[(3,5-difluorophenyl)amino]carbonyl]hydrazono]ethyl]-3-pyridinecarboxylic acid

Structure for Diflufenzopyr:

US Federal Register entries for

Diflufenzopyr - CAS No. 109293-97-2

Date Published Docket Identification Number Details
October 5, 2007 No docket number

Notice of Availability of the Record of Decision for the Final Programmatic Environmental Impact Statement for Vegetation Treatments Using Herbicides on Bureau of Land Management Lands in 17 Western States. The fluorinated herbicides included for use are diflufenzopyr and fluridone. (Of the six herbicides rejected for use is the fluorinated mefluidide.) As part of the Proposed Action and this decision, the BLM also adopts the protocol for identifying, evaluating and approving herbicides. Copies of the Record of Decision are available in hard copy or CD upon request from Brian Amme, Nevada State Office, P.O. Box 12000, 1340 Financial Blvd., Reno, NV 89520, or via the Internet at the BLM National Web site http://www.blm.gov/. The Record of Decision is available for review in either hard copy or on compact disks (CDs) at all BLM State, District, and Field Office public rooms.

This national, FPEIS provides a comprehensive analysis of BLM's use of chemical herbicides in its various vegetation treatment programs related to hazardous fuels reduction; noxious weed, invasive terrestrial and aquatic plant species management; resource rehabilitation following catastrophic fires, and other disturbances. The FPEIS addresses human health and ecological risk for use of chemical herbicides on public lands and provides a cumulative impact analysis of the use of chemical herbicides in conjunction with other treatment methods. The decision area includes public lands administered by 11 BLM state offices: Alaska, Arizona, California, Colorado, Idaho, Montana (North Dakota/South Dakota), New Mexico (Oklahoma/Texas/Nebraska), Nevada, Oregon (Washington), Utah and Wyoming.

Draft PEIS, Part 1 AND Draft PEIS, Part 2. The PEIS provides a comprehensive programmatic NEPA document that addresses the primary controversial issue identified through scoping: the BLM’s continuing use and proposed increased use of herbicides in vegetation treatment programs that would implement the National Fire Plan and other related initiatives.

Draft PER describes the environmental effects of using non-herbicide treatment methods, including prescribed fire and mechanical, manual and biological controls, on vegetation, watersheds, and fish and wildlife habitat on surface lands administered by the BLM in the western United States, including Alaska.

Human Health Risk Assessment
Ecological Risk Assessment Protocol and Assessments
Draft Biological Assessment

August 29, 2002 OPP-2002-0220  IR-4; BASF. Pesticide Tolerances. FINAL RULE. This regulation establishes tolerances for combined residues of diflufenzopyr in or on corn, sweet, forage; corn, sweet, kernel plus cob with husks removed; and corn, sweet, stover at 0.05 ppm; corn, pop, grain and corn, pop, stover at 0.05 ppm; grass, forage at 22 ppm; and grass, hay at 7.0 ppm. This regulation also establishes time-limited tolerances for combined residues of diflufenzopyr in or on cattle, goat, hog, horse, and sheep meat at 0.60 ppm; cattle, goat, hog, horse, and sheep kidney at 4.0 ppm; cattle, goat, hog, horse, and sheep meat byproducts, except kidney at 0.50 ppm; cattle, goat, hog, horse, and sheep fat at 0.30 ppm; and milk at 3.0 ppm. The nature of the toxic effects caused by diflufenzopyr is discussed in the Final Rule on Diflufenzopyr published in the FR of January 28, 1999 - some excerpts:
-- In a subchronic feeding study in rats, male and female Wistar rats were fed test diets containing technical diflufenzopyr, purity 96%, at dose levels of 0, 1,000, 5,000, 10,000 and 20,000 ppm (equal to 0, 60.8, 352, 725 and 1,513 milligram/kilogram body weight/day (mg/kg bw/day) for males, and 0, 72.8, 431, 890 and 1,750 mg/kg bw/day for females) for a period of 13 weeks. decreased food intake (20,000 ppm, males only); slight increases in cholesterol (20,000 ppm, both sexes, and 10,000 ppm, males only) and ALAT (10,000 and 20,000 ppm, both sexes); and slightly lower chloride (20,000 ppm, both sexes). Histopathological findings were an increased incidence of foamy macrophages in the lungs in the 10,000 and 20,000 ppm groups, both sexes, and testicular atrophy in the 20,000 ppm group. Following the 4- week recovery period, the only treatment-related effects which showed partial or no evidence of recovery were foamy macrophages in the lungs and testicular atrophy.
-- In a subchronic toxicity study in dogs, diflufenzopyr (98% a.i.) was administered to beagle dogs (4/sex/dose) by feeding at dose levels of 0, 1,500, 10,000, or 30,000 ppm (0, 58, 403, or 1,131 mg/kg/ day for males; 0, 59, 424, or 1,172 mg/kg/day for females) for 13 weeks. The lowest adverse effect level (LOAEL) for this study is 10,000 ppm (403 mg/kg/day in males and 424 mg/kg/day in females), based on the occurrence of erythroid hyperplasia in the bone marrow, extramedullary hemopoiesis in the liver, and hemosiderin deposits in Kupffer cells.
-- In a chronic toxicity study in dogs, diflufenzopyr (98.1% a.i.) was administered to beagle dogs (4/sex/dose) by feeding at dose levels of 0, 750, 7,500, or 15,000 ppm (0, 26, 299, or 529 mg/kg/day for males; 0, 28, 301, or 538 mg/kg/day for females) for 52 weeks. The LOAEL for this study is 7,500 ppm (299 mg/kg/day for males and 301 mg/ kg/day for females), based on erythroid hyperplasia in the bone marrow in bone sections, reticulocytosis, and increased hemosiderin deposits in the liver, kidneys, and spleen.
-- In a developmental toxicity study, technical diflufenzopyr (98.1% a.i.) in 0.5% aqueous methyl cellulose was administered by gavage to 25 female Crl: CD BR VAF/Plus (Sprague Dawley) rats/dose at dose levels of 0, 100, 300, or 1,000 mg/kg/day from days 6 through 15 of gestation. The maternal NOAEL is 300 mg/kg/day and the maternal LOAEL is 1,000 mg/kg/day based on decreases in food consumption and weight gain. Developmental effects, characterized as significantly lower fetal body weights in males ( 5%) and skeletal variations, exhibited as incompletely ossified and unossified sternal centra and reduced fetal ossification sites for caudal vertebrae, were observed at 1,000 mg/kg/day.
-- In a developmental toxicity study, technical diflufenzopyr (98.1% a.i.) in 0.5% aqueous methyl cellulose was administered by gavage to 20 female New Zealand White Hra: (NZW)SPF rabbits/dose at dose levels of 0, 30, 100, or 300 mg/kg/day from days 6 through 19 of gestation. The maternal LOAEL is 100 mg/kg/day, based on minimal reductions in body weight gain with no reduction in food consumption and clinical signs of toxicity (abnormal feces). The maternal NOAEL is 30 mg/kg/day. Developmental effects, characterized as significant increases (p<ls-thn-eq>0.01) in the incidence of supernumerary thoracic rib pair ossification sites (12.74 vs. 12.54 for controls) occurred at the 300 mg/kg/day dose.
-- In a 2-generation reproduction study, technical diflufenzopyr (98.1% a.i.) was administered continuously in the diet to 26 Wistar rats/sex/dose at dose levels of 0, 500, 2,000 or 8,000 ppm in the diet (0, 27.3-42.2, 113.1-175.9, or 466.2-742.0 mg/kg/day). The systemic LOAEL is 2,000 ppm (113.1-175.9 mg/kg/day) based on reduced body weight gain, increased food consumption, and increased seminal vesicle weights. The systemic NOAEL is 500 ppm (27.3-42.2 mg/kg/day). The reproductive LOAEL is 8,000 ppm (466.2-742.0 mg/kg/day) based on lower live birth and viability indices, total pre-perinatal loss, reduced body weights and body weight gain during lactation, a higher proportion of runts, and a higher percentage of offspring with no milk in the stomach.
-- In an acute neurotoxicity study, diflufenzopyr (96.4% a.i.) was administered by gavage to Crl:CD BR rats (10/sex/group) at dose levels of 0, 125, 500 or 2,000 mg/kg. The rats were evaluated for reactions in functional observations and motor activity measurements at 3 hours, 7 days, and 14 days postdosing. Histopathological evaluation on the brain and peripheral nerves was assessed after day 14.
Diflufenzopyr had no definite impact on neurotoxic responses, although a few abnormalities were observed in the functional battery on the day of dosing. A decrease in immediate righting responses that was observed in several males in all treatment groups was not concentration- dependent. Nasal staining was observed in more rats in the 2,000 mg/kg treatment groups (6 males; 3 females), but was not considered a definite or significant response to treatment. Lower mean brain weights in all female treatment groups lacked associated macroscopic and microscopic histopathological changes, and were only 4-5% lower than the control brain weight. Mean locomotor activities for the 2,000 mg/kg female treatment groups were decreased on Days 7 (<difference> 27%, p < 0.05) and 14 (<difference>15%, not significant) after dosing, but the pattern of activity for the individual animals was similar to the individual controls over time...
-- Diflufenzopyr was tested up to cytotoxic dose levels and mutation frequencies were determined for dose levels selected on the basis of relative
growth. Although initially declared positive by the then study director, application of more recent criteria for mutagenic responses has rendered the test article negative for forward gene mutation at the TK locus in mouse L5178Y cells in the presence and absence of S9 activation.
 
June 12, 2002 2002-0095

Petition for time-limited tolerances for Diflufenzopyr and its metabolites in or on the raw agricultural commodities of cattle, goat, hog, horse, and sheep meat at 0.60 ppm; cattle, goat, hog, horse, and sheep kidney at 4.0 ppm; cattle, goat, hog, horse, and sheep meat by-products (except kidney) at 0.50 ppm; cattle, goat, hog, horse, and sheep fat at 0.30 ppm; and milk at 3.0 ppm. The nature of the toxic effects caused by diflufenzopyr is discussed in Unit II.B. of the Federal Register of December 12, 2001.

Dec 12, 2001 PF-1058

IR-4 * and BASF - Pesticide Tolerance Petition; for residues in or on Forage at 3.0 ppm; hay at 1.5 ppm; and corn, sweet, fresh at 0.05 ppm; corn, sweet, forage at 0.05 ppm; corn, sweet, stover at 0.05 ppm, and corn, pop, stover at 0.05 ppm.

March 3, 1999 na

BASF - Approval of Herbicide Product Registrations: Diflufenzopyr Technical Herbicide, Sodium Diflufenzopyr Technical Herbicide, and Distinct Herbicide.

Jan 28, 1999 OPP-300778

BASF - Pesticide Tolerance Petition for residues in or on field corn stover, forage and grain of 0.05 ppm. - FINAL RULE.

Sept 25, 1998 OPP-30460
  • BASF - Application to register 3 pesticides:
  • 1. File Symbol: 7969-RLT. Diflufenzopyr Technical Herbicide. Active ingredient: Diflufenzopyr at 99.1%. For formulation of herbicides for use on corn.
  • 2. File Symbol: 7969-RLR. Sodium Diflufenzopyr Technical Herbicide. Active ingredient: Sodium salt of diflufenzopyr: 2-[1-[[[(3,5-difluorophenyl)amino] carbonyl]hydrazono]ethyl]-3-pyridinecarboxylic acid, sodium salt at 93%. For formulation of herbicides for use on corn.
  • 3. File Symbol: 7969-RLN. Diflufenzopyr Technical Herbicide. Herbicide. Active ingredients: Sodium salt of diflufenzopyr: 2-[1- [[[(3,5-difluorophenyl)amino] carbonyl]hydrazono]ethyl]-3- pyridinecarboxylic acid at 21.4% and Sodium salt of 3,6-dichloro-o- anisic acid at 55%. For control of annual broadleaf weeds and grasses on corn.
Dec 31, 1997 na

BASF - Extension of Experimental Use Permit 7969-EUP-37. This experimental use permit allows the use of 609 pounds of the herbicide sodium salt of diflufenzopyr on 1,740 acres of corn to evaluate the control of various broadleaf weeds and grasses. The program is authorized only in the States of Colorado, Georgia, Iowa, Illinois, Indiana, Kansas, Kentucky, Maryland, Michigan, Minnesota, Missouri, Nebraska, North Carolina, Ohio, Pennsylvania, South Dakota, Tennessee, Texas, and Wisconsin. The experimental use permit is effective from March 1, 1998 to October 1, 1998. This permit is issued with the limitation that all treated crops are destroyed or used for research purposes only.

Nov 21, 1997 PF-778

BASF - Pesticide Tolerance Petition for residues in or on the raw agricultural commodities CORN: grain, forage and fodder at 0.05 ppm.

* Interregional Research Project No. 4 (IR-4)

 

 
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