persistent in soil
contamination is likely
(only comprehensive for the US)
- Emergency exemption pending (2005)
EPA PC Code:
(includes only a limited list of countries)
Brazil, France, Germany, Hungary, Italy, New Zealand, Russia,
South Africa, Tanzania, UK
Changzhou Nanjing Chemical Factory, No. 1 Xun Xi South Road,
Safety Data Sheets & Labels
6, 2005: Comments
on Flutriafol submitted to US EPA. Docket No. OPP-2005-0243.
Submitted by Fluoride Action Network Pesticide Project.
Svalbard archipelago in arctic Norway receives considerable
semivolatile organic contaminant (SOC) inputs from the atmosphere...
surface sample also had highest concentrations of pendimethalin
(herbicide, 18.6 ng L-1) and flutriafol,
the lone observed fungicide (9.6 ng L-1).
Current-Use and Legacy Pesticide History in the Austfonna Ice
Cap, Svalbard, Norway. By Mark H. Hermanson et al. Environ.
Sci. Technol., 39 (21), 8163 -8169, 2005. See
(Denmark) - information submitted
as background for Emergency Exemption use request by Minnesota
and South Dakota on Sept 21, 2005 (see Federal Register below)
Evaluation on: Flutriafol. Issue No. 158,
UK Department for Environment, Food and
Rural Affairs, Pesticides Safety Directorate, Mallard House,
Kings Pool, 3 Peasholme Green, York YO1 7PX.
introduced flutriafol in 1981. Since its introduction
the compound has attained an important position in the global
fungicide market, where flutriafol products have proved effective
in controlling a vast number of diseases affecting a wide range
In April 2001, Cheminova acquired
the global flutriafol business from Syngenta,
including all of the rights, know-how, registrations, and trademarks
for the product. Today, Cheminova sells the product throughout
the world as a foliar application product for cereals and other
arable crops, as a microgranule product for use in coffee
and maize and as a seed treatment product for the control
of major seedborne and soil-borne diseases in cereals. The foliar
products are mainly marketed under the well-known trade name
Impact® whereas the seed treatment
products are sold under the trade name Vincit®."
Ref: Cheminova. http://www.cheminova.com/en/fungicides/vincit/background_01.htm
Beer in the UK: 23 organofluorine
pesticides approved for use on malting barley. Published
by the British Beer and Pubs Association and Brewing Research
- includes reports from the NTIS
29, 2000 - UK Department for Environment, Food & Rural Affairs
in the online report, "Design of
a Tax or Charge Scheme for Pesticides." Annex C3:
Overview of Pesticide Industry
21, 2001 - Syngenta
announces global sale to Cheminova -
- by Kate Griffiths and Dr. Phil Salisbury.
Article from Australia.
2001 - Glossary
of Pesticide Chemcials - A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration.
10, 2001 - Australia:
RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS."
number 20 for "Most Widely used pesticides in the UK
(by Area Treated)" and "Chlorothalonil/flutriafol"
ranked no. 48 in the same category.
applied (kg ai)
April 29, 2000. UK Department for Environment, Food &
Rural Affairs in the online report, "Design of a Tax
or Charge Scheme for Pesticides. " Annex C3: Overview
of Pesticide Industry
14, 2001 - Implementation
of the Community Strategy for Endocrine Disruptors - a
range of substances suspected of interfering with the hormone
systems of humans and wildlife. Communication from the Commission
to the Council and the European Parliament. Commission of
the European Communities, Brussels COM (2001) 262 final. (More
information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm
document presents a "priority list of substances for
further evaluation of their role in endocrine disruption.
During 2000, a candidate list of 553 man-made substances and
9 synthetic/natural hormones has been identified." Organofluorine
pesticides in this list include:
included on the Endocrine Disruptor Liist
included on the Endocrine Disruptor Liist
tributylfluoro [Tributyltin fluoride]
for Emergency Exemption. EPA has received a quarantine
exemption request from the
Minnesota and South Dakota Departments of Agriculture to use
the pesticide product flutriafol (Impact
125SC), (CAS No. 76674-21-0), on soybeans to control
Asian soybean rust. The Applicant proposes
the use of a new chemical which has not been registered by
EPA. EPA is soliciting public comment before making
the decision whether or not to grant the exemption.
March 2005 request from the states of Minnesota and South
Dakota (Docket No. OPP-2005-0242-0002):
has a low toxicity to mammals, birds, and insects (see Appendix
5, this addendum). Flutriafol
may be toxic to fish and aquatic invertebrates. In
Minnesota the endangered Higgins Eye and Winged Mapleleaf
mussels are found in the St. Croix River between Minnesota
and Wisconsin. The counties adjacent to the St. Croix River
in Minnesota account for less than one percent of the total
soybean acres and are not in the primary soybean production
areas of Minnesota. It is not likely that flutriafol would
reach the mussel habitat and would not be expected to be
continuously or recurrently present in water as a result
of use under this exemption. The endangered Topeka shiner
fish live in small to mid-sued prairie streams and is found
only in sub-watersheds of the Missouri River basin. In Minnesota,
this includes the counties of Lincoln, Murray, Nobles, Pipestone,
and Rock. To mitigate risk to Topeka shiners from use of
flutriafol under this sec. 18, the Minnesota sec. 18 flutriafol
use directions would include a statement
'To prevent risk to the endangered species Topeka shiner,
flutriafol should not be applied in
Lincoln, Murray, Nobles, Pipestone, or Rock counties
if heavy rainfall is imminent." Based
on the above discussion, the use of flutriafol under this
exemption would not be a risk to threatened and endangered
mammals, birds, insects, fish or aquatic organisms in Minnesota
metconazole, flusilazole, prothioconazole,
and flutriafol are triazole fungicides.
EPA is evaluating the toxicological significance of triazole
metabolites 1,2,4-triazole, triazolylalanine (TA) and triazolylacetic
acid (TAA). Of the three metabolites,
only 1,2,4-triazole can be considered toxicologically significant
and EPA has identified developmental toxicity as the endpoint
of concern. An industry Triazole
Task Force has submitted worst-case studies (Appendix
J, original submission) to EPA demonstrating a reasonable
certainty of no harm for 1,2,4-triazole stemming from triazole
detivative fungicides for food only, as well as for food
and water (p 29).
manufacturers of flusilazole (Punch) and flusilazole + famoxadone
(Charisma) -DuPont Crop Protection,
Inc.; and, flutriafol (Impact) -Cheminova,
are aware of and supportive of this request. Letters of
support and draft labels for soybeans have been received
(Appendix 3, this addendum) (p 30).
request is the first request for the use of each of the
requested products; Alto, Quadris Xtra, Caramba,
Headline-Caramba, Operetta, Punch, Charisma, JAU 6476, and
Impact on soybean by all states (p 30).
- DuPont is actively pursuing registration of flusilazole
on soybeans. See Appendlx 1. this addendum for studies on
product chemistry, toxicology and ecotoxicology, environmental
fate and residues (p 30).
- Cheminova will submit its first application for registration
of flutriafol to EPA this summer. Field residue and processing
studies on soybeans in the U.S. are underway (p 31).
October 5, 2005 - Comments
submitted to EPA by the Agricultural Retailers Association.
Docket No. OPP-2005-0243-0004. From James D. Thrift, V.P.,
Regulatory Policy and Corporate Relations.
October 6, 2005:
Comments on Flutriafol
submitted to US EPA. Docket No.
OPP-2005-0243. Submitted by Fluoride Action Network Pesticide