CAS No. 98967-40-9

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Adverse Effects

ACTIVITY: Herbicide (triazolopyrimidine)

CAS NAME: N-(2,6-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide


Adverse Effects:


Environmental Effects:

Highly toxic to Fish and Zooplankton

Potential Ground Water Pollutant

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes 
US EPA PC Code: 129016 
California Chemical Code 3927 
US Tolerances: CFR 180.468 
US EPA Permit Date
and Registrant:
1993, Dow Elanco 
Registered use in
(includes only a limited list of countries)
Australia, Canada, New Zealand, South Africa, Tanzania, US 
US Maximum Residue Levels permitted in food commodities

Corn, field: (grain, forage,stover),

Other Information
Molecular Formula: C12H9 F2 N5O2S  
Entry Year: 1990 
Inventing Company: Dow Elanco 
Manufacturers: Dow Agro  
Other Names:

DE 498
Python Wdg
XRD 498

Manufacture site: US:
Dow Agro, Chemdesign Corporation, Fitchburn 012420
Of special interest:
PAN Data 
Material Safety Data Sheets & Labels
US Map of Pesticide Use: 1992-1995
August 2001 - IR-4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes:  Flumetsulam 
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

Table 3. Flumetsulam End-Use Products (EPs) with Food/Feed Uses. (pages 4-5)

Ref: Aug 31, 2004. Flumetsulam. Summary of Analytical Chemistry and Residue Data for the Tolerance Reassessment Eligibility Decision (TRED) Document.

EPA Reg.
Formulation (1) Label
Registrant Product Name Commodity
352-593 19.1% WDG 9/11/03 E. I. du Pont De Nemours and Co., Inc.
Accent Gold ® Herbicide Field corn
352-612 15.9% WDG 3/5/03 E. I. du Pont De Nemours and Co., Inc. Dupont Accent Gold ®
WDG Herbicide
Field corn
62719-222 2.67% EC 2/16/99 Dow AgroSciences, LLC Broadstrike ® + Treflan ® Soybean, dry bean
62719-224 74.9% WDG 10/20/93 Dow AgroSciences, LLC Broadstrike ® Field corn, soybean
62719-239 2.1% EC 2/23/98 Dow AgroSciences, LLC Broadstrike ® + Dual ® Field corn, soybean, dry
62719-240 2.6% EC 3/19/98 Dow AgroSciences, LLC Broadstrike ® SF + Dual ® Field corn, soybean
62719-253 23.1% WP 6/14/01 Dow AgroSciences, LLC Hornet ® Field corn
62719-264 9.3% WP 10/26/00 Dow AgroSciences, LLC Scorpion III ® Field corn
62719-277 80% WDG 9/24/03 Dow AgroSciences, LLC Python ® WDG Soybean, dry bean
62719-278 13.9% WP 3/26/96 Dow AgroSciences, LLC NAF-280 ® Field corn
62719-279 12.1% WP 3/26/96 Dow AgroSciences, LLC NAF-281 ® Field corn
62719-299 40% WDG 7/2/02 Dow AgroSciences, LLC Frontrow ® Soybean
62719-315 18.5% WDG 2/20/03 Dow AgroSciences, LLC Hornet ® WDG Field corn
(1). WDG = water-dispersible granules; EC = emulsifiable concentrate; WP = wettable powder.

US Federal Register
Date Published Docket Identification Number Details
October 4, 2006 EPA-HQ-OPP-2006-0670 Dow AgroSciences. Pesticide tolerance. FINAL RULE.
-- Beans (dry) at 0.05 ppm
August 25, 2006 EPA-HQ-OPP-2006-0670 Dow AgroSciences. Pesticide petition: PP 7F 4851.
in or on food commodity dry beans at 0.05 ppm.
Sept 24, 2004 OPP-2004-0317

Tolerance Reassessment Decision (TRED) for Low Risk Pesticide; Notice of Availability.
The following is from the HED Risk Assessment for the Tolerance Reassessment Eligibility Document (TRED).
-- Flumetsulam is in the triazolopyrimidine chemical class and has a mode of action similar to the sulfonylurea herbicides that are acetolactate synthase inhibitors (regulate plant growth).
-- The kidney appears to be the primary target organ of rats and dogs following subchronic to chronic exposures.
-- A neurotoxicity study was not conducted, however, flumetsulam showed no indication of being a neurotoxicant in the reviewed studies.
-- A 90-day inhalation study and a subchronic dog study were not conducted, but it is doubtful these would provide any additional useful information.
-- A developmental neurotoxicity study is not required since there was no evidence of neurotoxicity or neuropathy from the available studies.
-- Due to the lack of repeated dose inhalation toxicity study, oral studies were selected for the appropriate duration of exposure. Absorption via inhalation is assumed to be equivalent to oral absorption.

TRED documents available for review and comment:
Sept 9, 2004

Report of the Food Quality Protection Act (FQPA) Tolerance Reassessment Progress and Risk Management Decision (TRED) for Flumetsulam

5 pages

Signed by:
Debra Edwards,
Director, Special Review and Reregistration Div.

Mika J. Hunter - contact for questions regarding this decision.

EPA OPPT (7508C)
Aug 31, 2004

Flumetsulam: HED Risk Assessment for the Tolerance Reassessment Eligibility Document (TRED).

23 pages

Memorandum From:

Elissa Reaves, Toxicologist Reregistration Branch II, Health Effects Div. (7509C)

EPA OPPT (7509C)
Aug 30, 2004

Flumetsulam. Chronic Dietary Exposure Assessment for the TRED document.

8 pages

Memorandum From:

Samuel Ary, Chemist, Reregistration Branch II, Health Effects Div. (7509C)

EPA OPPT (7509C)

DP Barcode: D306279

PC Code: 129016

Aug 31, 2004

Flumetsulam. Summary of Analytical Chemistry and Residue Data for the Tolerance Reassessment Eligibility Decision (TRED) Document.

32 pages

Memorandum From:

Samuel Ary, Chemist
Reregistration Branch II, Health Effects Div. (7509C)

This summary of analytical chemistry and residue data document was originally prepared under contract by Versar, Inc. (Springfield, VA 22151; submitted June 11, 2004).

EPA OPPT (7509C)

DP Barcode: D306242

PC Code: 129016

May 19, 2004

Drinking Water Assessment for Flumetsulam for Uses on Field Corn and Soybeans

15 pages

Memorandum From:

James Lin, Environmental Engineer,
Stephanie Syslo, RAPL
Environmental Risk Branch III Environmental Fate and Effects Div. (7507C)

EPA OPP (7507C)

PC Code: 129016

DPBarcode: 301361

Sept 17, 1997 PF-753

DOW ELANCO - Pesticide Tolerance Petition; for residues in or on dry beans at 0.05 ppm.

Aug 4, 1997 OPP-300523 Pesticides Subject to Tolerance Reassessment.
Oct 28, 1993 na

DOW ELANCO - Pesticide Tolerance. Final Rule. This rule establishes a tolerance for residues of the new herbicide flumetsulam in or on the raw agricultural commodities corn, field, grain; corn, field, fodder; corn, field, forage; and soybeans at 0.05 ppm. This regulation was requested by DowElanco. This regulation becomes effective on October 28, 1993. Note: The Fed. Reg. does not have online access to its 1993 publication; the PMEP at Cornell U. is the source of this notice.

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