FLUCYTHRINATE
CASRN: 70124-77-5 For other data, click on the Table of Contents
Human Health Effects:
Human Toxicity Excerpts:
Experimental application of flucythrinate to the ear lobe of human volunteers
at 130 ug/cm sq caused a marked paraesthesia which began 30 min after application
and persisted for 24 hr. Flucythrinate produced the
most severe paresthesia of the four pyrethroids tested. A second
study using forearm skin and application at 13.8 mg/cm sq produced paresthesia
after a delay of 4-5 hr lasting for 3 days, indicating that the thinner facial
skin is more sensitive than other areas. [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.597 (1991)]**PEER REVIEWED**
May be fatal if ingested or absorbed through the skin. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Synthetic pyrethroids are neither cutaneous sensitizers nor irritants. Although
these compounds do not cause signs of inflammation (edema, erythema, vesiculation),
they do produce paresthesias after contact. Typically, symptoms begin several
hours after cutaneous exposure, peak in the evening, and resolve by the following
day. /Synthetic pyrethroids/ **PEER REVIEWED**
Contact allergy from pyrethroids ... has not been observed. /Pyrethroids/
[Zenz, C. Occupational Medicine-Principles and Practical Applications.
2nd ed. St. Louis, MO: Mosby-Yearbook, Inc, 1988. 146]**PEER REVIEWED**
The allergenic properties of pyrethroids /with early pyrethrum preparations/
are marked in comparison with other pesticides. Many cases of contact dermatitis
and respiratory allergy have been reported. Persons sensitive to ragweed pollen
are particularly prone to such reactions. Preparations containing synthetic
pyrethroids are less likely to cause allergic reactions than are the preparations
made from pyrethrum powder. /Pyrethroids/ [Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman
and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY.
Pergamon Press, 1990. 1629]**PEER REVIEWED**
There have been very few systemic poisonings of humans by pyrethroids. /Pyrethroids/
[Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.35 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Pyrethroids are not cholinesterase inhibitors. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.35 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Extraordinary absorbed doses may rarely cause incoordination, tremor, salivation,
vomiting, diarrhea, and irritability to sound and touch. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.35 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Some pyrethroid (eg, deltamethrin, fenvalerate, cyhalothrin, lambda-cyhalothrin,
flucythrinate, and cypermethrin) may cause a transient itching and/or burning
sensation in exposed human skin. /Synthetic pyrethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.13 (1990)]**PEER
REVIEWED**
Skin, Eye and Respiratory Irritations:
Immediately irritating to the eye. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
The chief effect from exposure ... is skin rash particularly on moist areas
of the skin. ... May irritate the eyes. /Pyrethroids/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 1]**PEER REVIEWED**
Medical Surveillance:
Initial medical screening: Employees should be screened for history of certain
medical conditions ... which might place the employee at increased risk from
/pyrethroid/ exposure. Chronic respiratory disease: In persons with chronic
respiratory disease, especially asthma, the inhalation of /pyrethroids/ might
cause exacerbation of symptoms due to its sensitizing properities. Skin disease:
/Pyrethroids/ can cause dermatitis which may be allergic in nature. Persons
with pre-existing skin disorders may be more susceptible to the effects of this
agent. Any employee developing the above-listed conditions should be referred
for further medical examination. /Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 1]**PEER REVIEWED**
Probable Routes of Human Exposure:
Occupational exposure to flucythrinate occurs through dermal contact and inhalation
of dust and sprays, especially to workers applying the compound as an insecticide(1).
[(1) Parmeggiani L; Encyl Occup Health & Safety 3rd ed. Geneva,
Switzerland: International Labour Office pp. 1616-46 (1983)]**PEER REVIEWED**
Emergency Medical Treatment:
Emergency Medical Treatment:
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The following Overview, *** PYRETHRINS ***, is relevant for this HSDB
record chemical.
Life Support:
o This overview assumes that basic life support measures
have been instituted.
Clinical Effects:
SUMMARY OF EXPOSURE
0.2.1.1 ACUTE EXPOSURE
o The mammalian toxicity of natural pyrethrins is
generally low. Very young children are perhaps more
susceptible to poisoning because they may not hydrolyze
the pyrethrum esters efficiently. In humans, allergic
reactions are the main toxic manifestations of
pyrethrin exposure.
1. Pyrethrum and the pyrethrins produce typical type I
motor symptoms in mammals. Severe type I poisoning
may include the following signs in humans:
Severe fine tremor
Marked reflex hyperexcitability
Sympathetic activation
Paresthesia (dermal exposure)
o DERMAL - These compounds are not primary irritants.
The chief effect, however, from exposure is dermatitis.
The usual lesion is a mild erythematous dermatitis with
vesicles, papules in moist areas, and intense pruritus;
a bulbous dermatitis may also occur. Pyrethrins can
cause allergic dermatitis and systemic allergic
reactions.
o INHALATION is the major route of exposure, with airway
irritation as the primary toxic effect. Following
inhalation, a stuffy, runny nose and scratchy throat
are common. Hypersensitivity reactions including
wheezing, sneezing, shortness of breath and
bronchospasm may be noted.
o OCULAR - Eye exposures may result in mild to severe
corneal damage that generally resolves with
conservative care.
o Piperonyl butoxide and other compounds are often added
to pyrethrin insecticides as synergists and may
contribute to toxicity.
o Synthetic pyrethroids, which are related to pyrethrins,
are covered in a separate management.
HEENT
0.2.4.1 ACUTE EXPOSURE
o A stuffy, runny nose and scratchy throat following
inhalational exposure may be noted.
o Eye exposures may result in mild to severe corneal
damage, decreased visual acuity and periorbital edema.
CARDIOVASCULAR
0.2.5.1 ACUTE EXPOSURE
o Hypotension and tachycardia, associated with
anaphylaxis, may occur.
RESPIRATORY
0.2.6.1 ACUTE EXPOSURE
o Hypersensitivity reactions characterized by
pneumonitis, cough, dyspnea, wheezing, chest pain, and
bronchospasm may occur. Rare cases of respiratory
failure and cardiopulmonary arrest have been reported.
NEUROLOGIC
0.2.7.1 ACUTE EXPOSURE
o Paresthesias, headaches, and dizziness are common.
Massive exposure may result in hyperexcitability and
seizures, but this is rare.
GASTROINTESTINAL
0.2.8.1 ACUTE EXPOSURE
o Nausea, vomiting and abdominal pain commonly occur and
develop within 10 to 60 minutes following ingestion.
DERMATOLOGIC
0.2.14.1 ACUTE EXPOSURE
o Irritant and contact dermatitis may develop. Erythema
which mimics sunburn has also been noted after
prolonged repeated exposure.
ENDOCRINE
0.2.16.1 ACUTE EXPOSURE
o Type I motor symptoms following severe poisoning may
result in sympathetic activation.
IMMUNOLOGIC
0.2.19.1 ACUTE EXPOSURE
o Sudden bronchospasm, swelling of oral and laryngeal
mucous membranes, and anaphylactoid reactions have been
reported after pyrethrum inhalation. Hypersensitivity
pneumonitis characterized by cough, shortness of
breath, chest pain, and bronchospasm may be noted.
GENOTOXICITY
o Pyrethrum is not mutagenic in bacterial reversion tests
(Ray, 1991).
Laboratory:
o Pyrethrin plasma levels are not clinically useful or
readily available.
o Monitor for allergic responses such as asthma or contact
dermatitis.
Treatment Overview:
ORAL EXPOSURE
o There is no specific antidote for pyrethrin poisoning.
Treatment is symptomatic and supportive and includes
monitoring for the development of hypersensitivity
reactions with respiratory distress. Provide adequate
airway management when needed. Gastric decontamination
is usually not required unless the pyrethrin product is
combined with a hydrocarbon.
o ALLERGIC REACTION: MILD: antihistamines with or
without epinephrine. SEVERE: oxygen, aggressive
airway management, antihistamines, epinephrine (ADULT:
0.3 to 0.5 mL of a 1:1000 solution subcutaneously;
CHILD: 0.01 mL/kg; may repeat in 20 to 30 min),
corticosteroids, ECG monitoring, and IV fluids.
INHALATION EXPOSURE
o INHALATION: Move patient to fresh air. Monitor for
respiratory distress. If cough or difficulty breathing
develops, evaluate for respiratory tract irritation,
bronchitis, or pneumonitis. Administer oxygen and
assist ventilation as required. Treat bronchospasm with
beta2 agonist and corticosteroid aerosols.
EYE EXPOSURE
o DECONTAMINATION: Irrigate exposed eyes with copious
amounts of tepid water for at least 15 minutes. If
irritation, pain, swelling, lacrimation, or photophobia
persist, the patient should be seen in a health care
facility.
DERMAL EXPOSURE
o DECONTAMINATION: Remove contaminated clothing and wash
exposed area thoroughly with soap and water. A
physician may need to examine the area if irritation or
pain persists.
o Vitamin E topical application is highly effective in
relieving paresthesias.
Range of Toxicity:
o The minimal lethal dose of pyrethrum is not established,
but is probably in the range of 10 to 100 grams.
o Hypersensitivity reactions may be noted, especially
following a chronic dermal or inhalation exposure.
Patients with underlying asthma may be predisposed to
severe bronchospastic reactions after exposure.
Treatment is supportive, and most casual exposures require only decontamination.
Topical vitamin E may ameliorate the paresthesias that accompany contact with
synthetic pyrethroids containing an alpha-cyano group (e.g., fenvalerate, cypermethrin,
flucythrinate). /Synthetic pyrethroids/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 1081]**PEER REVIEWED**
FOR LIFE-THREATENING ALLERGIC REACTION TO PYRETHRUM (SEVERE ASTHMA OR ANAPHYLAXIS),
GIVE 0.1 TO 0.5 ML OF 1:1000 ADRENALIN INTRAMUSCULARLY, OR SLOWLY INTRAVENOUSLY.
REPEAT IF NECESSARY TO RELIEVE RESPIRATORY DISTRESS & MAINTAIN BLOOD PRESSURE.
IV AMINOPHYLLINE (10 ML, SLOWLY) MAY BE INDICATED. GIVE HYDROCORTISONE (50-100
MG), OR EQUIVALENT STEROID, INTRAVENOUSLY. LESS SEVERE ALLERGIC REACTIONS (RHINITIS)
CAN BE MANAGED WITH ANTIHISTAMINES & DECONGESTANTS, GIVEN ORALLY. HYPERSENSITIVITY
PNEUMONITIS MAY REQUIRE OXYGEN, STEROIDS, ANTIBIOTICS & SEVERAL DAYS BEDREST,
DEPENDING ON SEVERITY. /PYRETHRUM, PYRETHRINS, PYRETHROIDS, AND PIPERONYL BUTOXIDE/
[Morgan, D.P. Recognition and Management of Pesticide Poisonings.
EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982.
44]**PEER REVIEWED**
DO NOT ADMIN OR INSTILL MILK, CREAM, OR OTHER SUBSTANCES CONTAINING VEGETABLE
OR ANIMAL FATS, WHICH ENHANCE ABSORPTION OF LIPOPHILIC SUBSTANCES, SUCH AS ...
PYRETHROIDS. DIAZEPAM (VALIUM (R)), 5-10 MG IN ADULT, 0.1 MG/KG IN CHILDREN,
GIVEN ORALLY OR SLOWLY IV, SHOULD CONTROL NERVOUSNESS & TREMORS IN RARE
CASES ... AFTER EXTRAORDINARY EXPOSURE TO ... PYRETHROIDS. /PYRETHRUM, PYRETHRINS,
PYRETHROIDS, AND PIPERONYL BUTOXIDE/ [Morgan, D.P. Recognition and Management of Pesticide Poisonings.
EPA 540/9-80-005. Washington, DC: U.S. Government Printing Office, Jan. 1982.
44]**PEER REVIEWED**
To minimize absorption of pyrethrins and piperonyl butoxide following ingestion,
gastric lavage should be performed immediately and saline cathartics administered.
Treatment of overdosage mainly involves symptomatic and supportive care. /Pyrethrins/
[McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2126]**PEER REVIEWED**
Skin contamination should be removed by washing with soap and water. If irritant
or paresthetic effects occur, treatment by a physician should be obtained. Because
/vapor exposure/ of pyrethroid apparently accounts for paresthesia affecting
the face, strenuous measures should be taken (ventilation, protective face mask
and hood) to avoid vapor contact with the face and eyes. Vitamin E Oil preparations
(dl-alpha tocopheryl acetate) are uniquely effective in preventing and stopping
the paresthetic reaction. They are safe for application to the skin under field
conditions. Corn oil is somewhat effective, but possible side effects with continuing
use make it less suitable. Vaseline is less effective than corn oil and zinc
oxide actually worsens the reaction. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.36 EPA540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Eye contamination should be treated immediately by prolonged flushing of the
eye with copious amounts of clean water or saline. If irritation persists, professional
ophthalmologic care should be obtained. ... Extraordinary measures should be
taken to avoid eye and skin contamination with this product. Should accidental
eye contamination occur, expert ophthalmologic care should be obtained after
flushing the eye free of the chemical with copious amounts of clean water. /Pyrethroids/
[Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.36 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Ingestion of pyrethroid insecticide presents relatively little risk. However,
if large amounts have been ingested, empty the stomach by intubation, aspiration,
and lavage. Based on observations in laboratory animals, large ingestions of
either allethrin, cismethrin, fenvalerate or deltamethrin would be the most
likely to generate neurotoxic manifestations. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.36 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
If only small amounts of pyrethroid have been ingested, or if treatment has
been delayed, oral administration of activated charcoal and cathartic probably
represents optimal management. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.36 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Animal Toxicity Studies:
Non-Human Toxicity Excerpts:
Non-phytotoxic when used as directed. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Rats fed 300 ppm for 28 days showed severe motor symptoms, and rats fed 150
ppm showed moderate motor symptoms. In both cases these disappeared within 48
hr of reverting to normal diet. Flucythrinate has no teratogenic or mutagenic
activity. [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.597 (1991)]**PEER REVIEWED**
In 2 yr feeding trials, rats receiving 60 mg/kg diet showed no ill-effects.
Non-mutagenic in the Ames test. No teratogenic effects were observed in investigations
on rats and rabbits. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Non-irritating to skin and eyes (rabbits), but undiluted formulations may
be irritating. No skin sensitization. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Synthetic pyrethroids are neuropoisons acting on the axons in the peripheral
and central nervous systems by interacting with sodium channels in mammals and/or
insects. A single dose produces toxic signs in mammals, such as tremors, hyperexcitability,
salivation, choreoathetosis, and paralysis. ... At near-lethal dose levels,
synthetic pyrethroids cause transient changes in the nervous system, such as
axonal swelling and/or breaks and myelin degeneration in sciatic nerves. They
are not considered to cause delayed neurotoxicity of the kind induced by some
organophosphorus compounds. /Synthetic prethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.13 (1990)]**PEER
REVIEWED**
Extreme doses /of pyrethroids/ have caused convulsions in laboratory animals.
/Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.35 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Synthetic pyrethroids have been shown to be toxic for fish, aquatic arthropods,
and honeybees in laboratory tests. But, in practical usage, no serious adverse
effects have been noticed because of the low rates of application and lack of
persistence in the environment. The toxicity of synthetic pyrethroids in birds
and domestic animals is low. /Synthetic pyrethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.13 (1990)]**PEER
REVIEWED**
The Type II /poisoning/ syndrome, also known as the "CS syndrome," is produced
by those esters containing the alpha-cyano substituent and elicits intense hyperactivity,
incoordination, and convulsions in cockroaches, whereas rats display burrowing
behavior, coarse tremors, clonic seizures, sinuous writhing (choreoathetosis),
and profuse salivation without lacrimation; hence the term CS (choreoathetosis/salivation)
syndrome. /Pyrethroid esters containing the alpha-cyano substituent/ [Amdur, M.O., J. Doull, C.D. Klaasen (eds). Casarett and Doull's
Toxicology. 4th ed. New York, NY: Pergamon Press, 1991. 593]**PEER REVIEWED**
The in vitro effects of pyrethroids on the mitogenic responsiveness of murine
splenic lymphocytes to concanavalin A and lipopolysaccharide were determined.
Allethrin was the most potent inhibitor, with effective concn in the range of
1X10-6 to 1.5X10-5 M. The results support the possibility of immune suppression
by pyrethroid exposure. /Pyrethroids/ [Stelzer KJ, Gordon MA; Res Commun Chem Pathol Pharmacol 46 (1):
137-50 (1984)]**PEER REVIEWED**
Following absorption through the chitinous exoskeleton of arthropods, pyrethrins
stimulate the nervous system, apparently by competitively interfering with cationic
conductances in the lipid layer of nerve cells, thereby blocking nerve impulse
transmissions. Paralysis and death follow. /Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
Non-systemic insecticide with contact action. Causes paralysis initially,
with death occurring later. Has some acaricidal activity. /Pyrethrins/ [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A357/Aug 87]**PEER REVIEWED**
Non-systemic insecticide with contact and stomach action. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Non-Human Toxicity Values:
LD50 Rat male oral 81 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LD50 Mice female oral 76 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LD50 Rat female oral 67 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LD50 Rabbit percutaneous >1000 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Rat inhalation 4.85 mg/l air/4 hr [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Ecotoxicity Values:
LD50 Mallard duck oral >2510 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LD50 Bobwhite quail oral 2708 mg/kg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Mallard duck dietary 4885 mg/kg diet/8 day [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Bob white quail dietary 3443 mg/kg diet/8 day [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Bluegill sunfish 0.71 ug/l/96 hr /Conditions of bioassay not specified/
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Channel catfish 0.51 ug/l/96 hr /Conditions of bioassay not specified/
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Rainbow trout 0.32 ug/l/96 hr /Conditions of bioassay not specified/
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LC50 Sheepshead minnow 1.6 ug/l/96 hr /Conditions of bioassay not specified/
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
LD50 Honey bee 0.078 ug/bee (topical application as a dust) [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Metabolism/Pharmacokinetics:
Metabolism/Metabolites:
Flucythrinate is rapidly metabolized by ester cleavage and oxidation. [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.597 (1991)]**PEER REVIEWED**
The metabolic pathways for the breakdown of the pyrethroids vary little between
mammalian species but vary somewhat with structure. ... Essentially, pyrethrum
and allethrin are broken down mainly by oxidation of the isobutenyl side chain
of the acid moiety and of the unsaturated side chain of the alcohol moiety with
ester hydrolysis playing and important part, whereas for the other pyrethroids
ester hydrolysis predominates. /Pyrethrum and pyrethroids/ [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.588 (1991)]**PEER REVIEWED**
The relative resistance of mammals to the pyrethroids is almost wholly attributable
to their ability to hydrolyze the pyrethroids rapidly to their inactive acid
and alcohol components, since direct injection into the mammalian CNS leads
to a susceptibility similar to that seen in insects. Some additional resistance
of homeothermic organisms can also be attributed to the negative temperature
coefficient of action of the pyrethroids, which are thus less toxic at mammalian
body temperatures, but the major effect is metabolic. Metabolic disposal of
the pyrethroids is very rapid, which means that toxicity is high by the intravenous
route, moderate by slower oral absorption, and often unmeasureably low by dermal
absorption. /Pyrethroids/ [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.588 (1991)]**PEER REVIEWED**
FASTEST BREAKDOWN IS SEEN WITH PRIMARY ALCOHOL ESTERS OF TRANS-SUBSTITUTED
ACIDS SINCE THEY UNDERGO RAPID HYDROLYTIC & OXIDATIVE ATTACK. FOR ALL SECONDARY
ALCOHOL ESTERS & FOR PRIMARY ALCOHOL CIS-SUBSTITUTED CYCLOPROPANECARBOXYLATES,
OXIDATIVE ATTACK IS PREDOMINANT. /PYRETHROIDS/ [The Chemical Society. Foreign Compound Metabolism in Mammals.
Volume 5: A Review of the Literature Published during 1976 and 1977. London:
The Chemical Society, 1979. 469]**PEER REVIEWED**
Pyrethrins are reportedly inactivated in the GI tract following ingestion.
In animals, pyrethrins are rapidly metabolized to water soluble, inactive compounds.
/Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
Synthetic pyrethroids are generally metabolized in mammals through ester hydrolysis,
oxidation, and conjugation, and there is no tendency to accumulate in tissues.
In the environment, synthetic pyrethroids are fairly rapidly degraded in soil
and in plants. Ester hydrolysis and oxidation at various sites on the molecule
are the major degradation processes. /Synthetic pyrethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.13 (1990)]**PEER
REVIEWED**
Absorption, Distribution & Excretion:
In rats, following oral administration, 60-70% is eliminated within 24 hours,
and >95% within 8 days, in the feces and urine. In the feces, the parent
compound makes up most of the material excreted, but in the urine and in tissue,
several metabolites are present. The major route of degradation is through hydrolysis,
with subsequent hydroxylation of the hydrolysis products. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
/PYRETHROIDS/ READILY PENETRATE INSECT CUTICLE AS SHOWN BY TOPICAL LD50 TO
PERIPLANETA (COCKROACH) ... /PYRETHROIDS/ [White-Stevens, R. (ed.). Pesticides in the Environment: Volume
1, Part 1, Part 2. New York: Marcel Dekker, Inc., 1971. 75]**PEER REVIEWED**
WHEN RADIOACTIVE PYRETHROID IS ADMIN ORALLY TO MAMMALS, IT IS ABSORBED FROM
INTESTINAL TRACT OF THE ANIMALS & DISTRIBUTED IN EVERY TISSUE EXAMINED.
EXCRETION OF RADIOACTIVITY IN RATS ADMIN TRANS-ISOMER: DOSAGE: 500 MG/KG; INTERVAL
20 DAYS; URINE 36%; FECES 64%; TOTAL 100%. /PYRETHROIDS/ [MIYAMOTO J; ENVIRON HEALTH PERSPECT 14: 15-28 (1976)]**PEER
REVIEWED**
Pyrethrins are absorbed through intact skin when applied topically. When animals
were exposed to aerosols of pyrethrins with piperonyl butoxide being released
into the air, little or none of the combination was systemically absorbed. /Pyrethrins/
[McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
Although limited absorption may account for the low toxicity of some pyrethroids,
rapid biodegradation by mammalian liver enzymes (ester hydrolysis and oxidation)
is probably the major factor responsible. Most pyrethroid metabolites are promptly
excreted, at least in part, by the kidney. /Pyrethroids/ [Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.35 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Mechanism of Action:
The synthetic pyrethroids delay closure of the sodium channel, resulting in
a sodium tail current that is characterized by a slow influx of sodium during
the end of depolarization. Apparently the pyrethroid molecule holds the activation
gate in the open position. Pyrethroids with an alpha-cyano group (e.g., fenvalerate)
produce more prolonged sodium tail currents than do other pyrethroids (e.g.,
permethrin, bioresmethrin). The former group of pyrethroids causes more cutaneous
sensations than the latter. /Synthetic pyrethroids/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 1081]**PEER REVIEWED**
Interaction with sodium channels is not the only mechanism of action proposed
for the pyrethroids. Their effects on the central nervous system have led various
workers to suggest actions via antagonism of gamma-aminobutyric acid (GABA)-mediated
inhibition, modulation of nicotinic cholinergic transmission, enhancement of
noradrenaline release, or actions on calcium ions. Since neurotransmitter specific
pharmacological agents offer only poor or partical protection against poisoning,
it is unlikely that one of these effects represents the primary mechanism of
action of the pyrethroids, and most neurotransmitter release is secondary to
increased sodium entry. /Pyrethroids/ [Hayes WJ, Laws ER, eds; Handbook of Pesticide Toxicology V2
p.588 (1991)]**PEER REVIEWED**
The symptoms of pyrethrin poisoning follow the typical pattern of nerve poisoning:
(1) excitation, (2) convulsions, (3) paralysis, and (4) death. The effects of
pyrethrins on the insect nervous system closely resemble those of DDT, but are
apparently much less persistent. Regular, rhythmic, and spontaneous nerve discharges
have been observed in insect and crustacean nerve-muscle preparations poisoned
with pyrethrins. The primary target of pyrethrins seems to be the ganglia of
the insect central nervous system although some pyrethrin-poisoning effect can
be observed in isolated legs. /Pyrethrins/ [Matsumura, F. Toxicology of Insecticides. 2nd ed. New York,
NY: Plenum Press, 1985. 147]**PEER REVIEWED**
Electrophysiologically, pyrethrins cause repetitive discharges and conduction
block. /Pyrethrins/ [Matsumura, F. Toxicology of Insecticides. 2nd ed. New York,
NY: Plenum Press, 1985. 147]**PEER REVIEWED**
The interaction of a series of pyrethroid insecticides with the sodium channels
in myelinated nerve fibers of the clawed frog, Xenopus laevis, was investigated
using the voltage clamp technique. Of 11 pyrethroids, 9 insecticidally active
cmpd induced a slowly decaying sodium tail current on termination of a step
depolarization, whereas the sodium current during depolarization was hardly
affected. /Pyrethroids/ [Vijverberg HP M et al; Biochem Biophys Acta 728 (1): 73-82 (1983)]**PEER
REVIEWED**
The biochemical process by which various pyrethroid insecticides alter membrane-bound
ATPase activities of the squid nervous system was examined. Of the 5 ATP-hydrolyzing
systems tested, only Ca(2+)-stimulated ATPase activities were clearly affected
by the pyrethroids. The natural type /I/ pyrethroid, allethrin, primarily inhibits
Ca-ATPase activity. /Pyrethroids/ [Clark JM, Matsumura F; Pestic Biochem Physiol 18 (2): 180-90
(1982)]**PEER REVIEWED**
Mode of action of pyrethrum & related cmpd has been studied more in insects
& in other invertebrates than in mammals. This action involves ion transport
through the membrane of nerve axons &, at least in invertebrates & lower
vertebrates, it exhibits a negative temperature coefficient. In both of these
important ways & in many details, the mode of action of pyrethrin &
pyrethroids resembles that of DDT. Esterases & mixed-function oxidase system
differ in their relative importance for metabolizing different synthetic pyrethroids.
The same may be true of the constituents of pyrethrum, depending on strain,
species, & other factors. /Pyrethrins and pyrethroids/ [Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London:
Williams and Wilkins, 1982. 75]**PEER REVIEWED**
The interactions of natural pyrethrins and 9 pyrethroids with the nicotinic
acetylcholine (ACh) receptor/channel complex of Torpedo electronic organ membranes
were studied. None reduced (3)H-ACh binding to the receptor sites, but all inhibited
(3)H-labeled perhydrohistrionicotoxin binding to the channel sites in presence
of carbamylcholine. Allethrin inhibited binding noncompetitively, but (3)H-labeled
imipramine binding competitively, suggesting that allethrin binds to the receptor's
channel sites that bind imipramine. The pyrethroids were divided into 2 types
according to their action: type A, which included allethrin, was more potent
in inhibiting (3)H-H12-HTX binding and acted more rapidly. Type B, which included
permethrin, was less potent and their potency increased slowly with time. The
high affinities that several pyrethroids have for this nicotinic ACh receptor
suggest that pyrethroids may have a synaptic site of action in addition to their
well known effects on the axonal channels. /Pyrethrins and Pyrethroids/ [Abbassy MA et al; Pestic Biochem Physiol 19 (3): 299-308 (1983)]**PEER
REVIEWED**
... Pyrethroid esters /containing the alpha-cyano substituent/ produce an
even longer delay /than those lacking the substituent/ in sodium channel inactivation,
leading to a persistent depolarization of the nerve membrane without repetitive
discharge, a reduction in the amplitude of the action potential, and an eventual
failure of axonal conduction and a blockade of impulses. /Pyrethroid esters
containing the alpha-cyano substituent/ [Amdur, M.O., J. Doull, C.D. Klaasen (eds). Casarett and Doull's
Toxicology. 4th ed. New York, NY: Pergamon Press, 1991. 595]**PEER REVIEWED**
The primary target site of pyrethroid insecticides in the vertebrate nervous
system is the sodium channel in the nerve membrane. Pyrethroids without an alpha-cyano
group (allethrin, d-phenothrin, permethrin, and cismethrin) cause a moderate
prolongation of the transient increase in sodium permeability of the nerve membrane
during excitation. This results in relatively short trains of repetitive nerve
impulses in sense organs, sensory (afferent) nerve fibers, and, in effect, nerve
terminals. On the other hand the alpha-cyano pyrethroids cause a long lasting
prolongation of the transient increase in sodium permeability of the nerve membrane
during excitation. This results in long-lasting trains of repetitive impulses
in sense organs and a frequency-dependent depression of the nerve impulse in
nerve fibers. The difference in effects between permethrin and cypermethrin,
which have identical molecular structures except for the presence of an alpha-cyano
group on the phenoxybenzyl alcohol, indicates that it is this alpha-cyano group
that is responsible for the long-lasting prolongation of the sodium permeability.
Since the mechanisms responsible for nerve impulse generation and conduction
are basically the same throughout the entire nervous system, pyrethroids may
also induce repetitive activity in various parts of the brain.
The difference in symptoms of poisoning by alpha-cyano pyrethroids, compared
with the classical pyrethroids, is not necessarily due to an exclusive central
site of action. It may be related to the long-lasting repetitive activity in
sense organs and possibly in other parts of the nervous system, which, in a
more advance state of poisoning, may be accompanied by a frequency-dependent
depression of the nervous impulse. /Synthetic pyrethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.89 (1990)]**PEER
REVIEWED**
Pyrethroids also cause pronounced repetitive activity and a prolongation of
the transient increase in sodium permeability of the nerve membrane in insects
and other invertebrates. Available information indicates that the sodium channel
in the nerve membrane is also the most important target site of pyrethroids
in the invertebrate nervous system. /Synthetic pyrethroids/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.90 (1990)]**PEER
REVIEWED**
In the electrophysiological experiments using giant axons of cray-fish, the
Type II pyrethroids retain sodium channels in a modified continuous open state
persistently, depolarize the membrane, and block the action potential without
causing repetitive firing. /Pyrethroids type II/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.87 (1990)]**PEER
REVIEWED**
Diazepam, which facilitates GABA reaction, delayed the onset of action of
deltamethrin and fenvalertae, but not permethrin and allethrin, in both the
mouse and cockroach. Possible mechanisms of the Type II pyrethroid syndrome
include action at the GABA receptor complex or a closely linked class of neuroreceptor.
/Pyrethroids type II/ [WHO; Environmental Health Criteria 99: Cyhalothrin p.87 (1990)]**PEER
REVIEWED**
Interactions:
/Pyrethroid/ detoxification ... important in flies, may be delayed by the
addition of synergists ... organophosphates or carbamates ... to guarantee a
lethal effect. ... /Pyrethroid/ [Buchel KH (ed); Chemistry of Pesticides p.19 (1983)]**PEER REVIEWED**
Piperonyl butoxide potentiates /insecticidal activity/ of pyrethrins by inhibiting
the hydrolytic enzymes responsible for pyrethrins' metabolism in arthropods.
When piperonyl butoxide is combined with pyrethrins, the insecticidal activity
of the latter drug is increased 2-12 times /Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
At dietary level of 1000 ppm pyrethrins & 10000 ppm piperonyl butoxide
... /enlargement, margination, & cytoplasmic inclusions in liver cells of
rats/ were well developed in only 8 days, but ... were not maximal. Changes
were proportional to dosage & similar to those produced by DDT. Effects
of the 2 ... were additive. /Pyrethrins/ [Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London:
Williams and Wilkins, 1982. 78]**PEER REVIEWED**
Pharmacology:
Therapeutic Uses:
MEDICATION (VET): ectoparasiticide [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**QC REVIEWED**
Pyrethrins with piperonyl butoxide are used for topical treatment of pediculosis
(lice infestations). Combinations of pyrethrins with piperonyl butoxide are
not effective for treatment of scabies (mite infestations). Although there are
no well-controlled comparative studies, many clinicians consider 1% lindane
to be pediculicide of choice. However, some clinicians recommend use of pyrethrins
with piperonyl butoxide, esp in infants, young children, & pregnant or lactating
women ... . If used correctly, 1-3 treatments ... are usually 100% effective
... Oil based (eg, petroleum distillate) combinations ... produce the quickest
results. ... For treatment of pediculosis, enough gel, shampoo, or solution
... should be applied to cover affected hair & adjacent areas ... After
10 min, hair is ... washed thoroughly ... treatment should be repeated after
7-10 days to kill any newly hatched lice. /Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
Interactions:
/Pyrethroid/ detoxification ... important in flies, may be delayed by the
addition of synergists ... organophosphates or carbamates ... to guarantee a
lethal effect. ... /Pyrethroid/ [Buchel KH (ed); Chemistry of Pesticides p.19 (1983)]**PEER REVIEWED**
Piperonyl butoxide potentiates /insecticidal activity/ of pyrethrins by inhibiting
the hydrolytic enzymes responsible for pyrethrins' metabolism in arthropods.
When piperonyl butoxide is combined with pyrethrins, the insecticidal activity
of the latter drug is increased 2-12 times /Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
At dietary level of 1000 ppm pyrethrins & 10000 ppm piperonyl butoxide
... /enlargement, margination, & cytoplasmic inclusions in liver cells of
rats/ were well developed in only 8 days, but ... were not maximal. Changes
were proportional to dosage & similar to those produced by DDT. Effects
of the 2 ... were additive. /Pyrethrins/ [Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London:
Williams and Wilkins, 1982. 78]**PEER REVIEWED**
Environmental Fate & Exposure:
Environmental Fate/Exposure Summary:
Flucythrinate's use as an insecticide releases the compound directly to the
environment through applications in sprays and other application routes. If
released to the atmosphere, flucythrinate will degrade rapidly in the vapor
phase by reaction with photochemically produced hydroxyl radicals (estimated
half-life of 6 hr). Particulate phase flucythrinate will be removed physically
from air by wet and dry deposition. If released to soil or water, flucythrinate
can degrade through biodegradation, hydrolysis and photodegradation. Various
persistence studies have suggested that flucythrinate will have environmental
half-lives of roughly one week to several weeks in soil or natural water. Estimated
log Koc values of 4.31-4.75 suggest that partitioning from water to sediment
and suspended matter will occur; also these log Koc values suggest that leaching
should not occur in most soils. Persistence in sediment is expected to be longer
than in the water-phase. Occupational exposure to flucythrinate occurs through
dermal contact and inhalation of dust and sprays, especially to workers applying
the compound as an insecticide. (SRC) **PEER REVIEWED**
Probable Routes of Human Exposure:
Occupational exposure to flucythrinate occurs through dermal contact and inhalation
of dust and sprays, especially to workers applying the compound as an insecticide(1).
[(1) Parmeggiani L; Encyl Occup Health & Safety 3rd ed. Geneva,
Switzerland: International Labour Office pp. 1616-46 (1983)]**PEER REVIEWED**
Artificial Pollution Sources:
Flucythrinate's use as an insecticide(1) releases the compound directly to
the environment through applications in sprays and other application routes(1,SRC).
[(1) Worthing CR, Walker SB; The Pesticide Manual 8th ed. Lavenham,
Suffolk, England: Lavenham Press Ltd p. 409 (1987)]**PEER REVIEWED**
Environmental Fate:
TERRESTRIAL FATE: In soil, there is low mobility and no leaching with a half-
life of ca 2 months. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
AQUATIC FATE: Rapidly hydrolysed in water under alkaline conditions, but more
slowly under neutral or acidic conditions. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
TERRESTRIAL FATE: Flucythrinate can degrade in soil through aqueous hydrolysis
and biodegradation. Photodegradation can occur on surfaces exposed to sunlight.
Flucythrinate hydrolyzes in water with half-lives of 52 days at pH 5 and 6.3
days at pH 9 and 27 deg C(1); hydrolysis will be more important in alkaline
soil than in neutral or acidic soil. One sediment persistence study found flucythrinate
to have a half-life of about 16 days, with sterile-control tests suggesting
that most degradation was occurring through biotic means(2). A field study measured
flucythrinate half-lives of 9.4-11.9 days in an agricultural soil(3). A laboratory
study using a silt loam soil observed degradations of 28.6-45.6% in 6 weeks
under dry conditions(4). Laboratory tests have shown that flucythrinate photodegrades
on glass and plant surfaces(5). Estimated Koc values of log 4.31-4.75(6,SRC)
suggest that flucythrinate will not leach(SRC). [(1) Worthing CR, Walker SB; The Pesticide Manual 8th ed. Lavenham,
Suffolk, England: Lavenham Press Ltd p. 409 (1987) (2) Schimmel SC et al; J
Agric Food Chem 31: 104-13 (1983) (3) Agnihotri NP, Jain HK; Pesticides 31:
163-73 (1987) (4) Smith S, Willis GH; Soil Sci 144: 67-71 (1987) (5) Chattopadhyaya
S, Dureja P; Pestic Sci 31: 163-73 (1991) (6) Lyman WJ et al; Handbook of Chemical
Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 5-4, 5-10 (1990)]**PEER
REVIEWED**
AQUATIC FATE: Flucythrinate is expected to degrade in water through hydrolysis,
biodegradation and photodegradation. It hydrolyzes in water with half-lives
of 52 days at pH 5 and 6.3 days at pH 9 and 27 deg C(1); hydrolysis will be
more important in alkaline water than in neutral or acidic water. A seawater-sediment
persistence study found flucythrinate to have a half-life of about 16 days with
sterile-control tests suggesting that most degradation was occurring through
biotic means(2). An agricultural water-sediment persistence study found that
flucythrinate disappeared entirely within 15 days in the water(3); however,
it persisted beyond 20 days in the sediment(3). In a seawater solution study,
flucythrinate had a 6.1 day half-life when exposed to sunlight, but only a 38
day half-life under no-sunlight conditions(2) thus suggesting that photodegradation
may be important in some environmental waters(SRC). Estimated Koc values of
log 4.31-4.75(4,SRC) suggest that partitioning from the water column to sediment
and suspended matter will occur(SRC). [(1) Worthing CR, Walker SB; The Pesticide Manual 8th ed. Lavenham,
Suffolk, England: Lavenham Press Ltd p. 409 (1987) (2) Schimmel SC et al; J
Agric Food Chem 31: 104-13 (1983) (3) Agnihotri NP, Jain HK; Pesticides 31:
163-73 (1987) (4) Lyman WJ et al; Handbook of Chemical Property Estimation Methods
Washington, DC: Amer Chem Soc pp. 5-4, 5-10 (1990)]**PEER REVIEWED**
ATMOSPHERIC FATE: Based upon a reported vapor pressure of 8.7X10-8 mm Hg at
25 deg C(1), flucythrinate can exist in both the vapor and particulate phases
in the ambient atmosphere(2,SRC). It will degrade rapidly in the vapor phase
by reaction with photochemically produced hydroxyl radicals with an estimated
half-life of about 6 hr(3,SRC). Particulate phase flucythrinate and aerosols
released to air during spray applications of flucythrinate insecticide will
be removed from air physically by dry and wet deposition(SRC). [(1) Wauchope RD et al; Rev Environ Contam Toxicol 123: 1-36
(1991) (2) Bidleman TF; Environ Sci Technol 22: 361-7 (1988) (3) Atkinson R;
Environ Toxicol Chem 7: 435-42 (1988)]**PEER REVIEWED**
Environmental Biodegradation:
In a laboratory study using sediment and seawater collected from a salt marsh
near Escambia County, Florida flucythrinate was observed to have a half-life
of about 16 days(1); however, when the media were sterilized, flucythrinate
showed no appreciable degradation after 28 days of incubation(1), thus suggesting
that degradation was occurring through biotic means(SRC). [(1) Schimmel SC et al; J Agric Food Chem 31: 104-13 (1983)]**PEER
REVIEWED**
Environmental Abiotic Degradation:
The rate constant for the vapor phase reaction of flucythrinate with photochemically
produced hydroxyl radicals has been estimated to be 6.36X10-11 cu cm/molecule-sec
at 25 deg C which corresponds to an atmospheric half-life of about 6 hours at
an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The aqueous
hydrolysis rate of flucythrinate at 27 deg C has been reported as follows(2);
50% loss in 40 days at pH 3, 52 days at pH 5 and 6.3 days at pH 9. Flucythrinate
absorbs light strongly in the environmental spectra (>290 nm)(3); when exposed
to sunlight, thin films of flucythrinate on glass surfaces were observed to
have a half-life of about 8 days(3); on bean leaves, the photodegradation half-life
was about 3 days(3); only minor degradation occurred on dark control glass and
leaf surfaces(3); the faster rate on leaf surfaces was thought to result from
photo-sensitization by chlorophyll and plant waxes(3). In a seawater solution
study, flucythrinate had a 6.1 day half-life when exposed to sunlight, but only
a 38 day half-life under no-sunlight conditions(4). [(1) Atkinson R; Environ Toxicol Chem 7: 435-42 (1988) (2) Worthing
CR, Walker SB; The Pesticide Manual 8th ed. Lavenham, Suffolk, England: Lavenham
Press Ltd p. 409 (1987) (3) Chattopadhyaya S, Dureja P; Pestic Sci 31: 163-73
(1991) (4) Schimmel SC et al; J Agric Food Chem 31: 104-13 (1983)]**PEER REVIEWED**
Environmental Bioconcentration:
Based upon a measured log Kow of 6.20(1) and a water solubility of 0.06 mg/L
(taken from the USDA's evaluated database of pesticide properties)(2), the BCF
for flucythrinate can be estimated to be 30,000 and 3,000, respectively, from
recommended regression-derived equations(3,SRC). In a 28-day laboratory study,
a steady-state BCF of 2300 was measured in eastern oysters (Crassostrea virginica)(1).
[(1) Schimmel SC et al; J Agric Food Chem 31: 104-13 (1983) (2)
Wauchope RD et al; Rev Environ Contam Toxicol 123: 1-36 (1991) (3) Lyman WJ
et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer
Chem Soc pp. 5-4, 5-10 (1990)]**PEER REVIEWED**
Soil Adsorption/Mobility:
Based upon a measured log Kow of 6.20(1) and a water solubility of 0.06 mg/L
(taken from the USDA's evaluated database of pesticide properties)(2), the log
Koc for flucythrinate can be estimated to be 4.75 and 4.31, respectively, from
regression-derived equations(3,SRC). According to a suggested classification
scheme(4), these estimated Koc values suggest that it is immobile in soil(SRC).
In a field study conducted in New Delhi, India (farm soil, pH 8.1 organic content
0.3%) flucythrinate did not leach below a 7.5 cm depth after a 40-day observation
period(5). [(1) Schimmel SC et al; J Agric Food Chem 31: 104-13 (1983) (2)
Wauchope RD et al; Rev Environ Contam Toxicol 123: 1-36 (1991) (3) Lyman WJ
et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer
Chem Soc pp. 5-4, 5-10 (1990) (4) Swann RL et al; Res Rev 85: 23 (1983) (5)
Agnihotri NP, Jain HK; Pesticides 31: 163-73 (1987)]**PEER REVIEWED**
Volatilization from Water/Soil:
Based upon a water solubility of 0.06 mg/L(1) and a vapor pressure of 8.7X10-9
mm Hg at 25 deg C(1), the Henry's Law constant for flucythrinate can be estimated
to be 8.61X10-8 atm-cu m/mole(SRC). This value of Henry's Law constant indicates
flucythrinate is essentially non-volatile from water(2); therefore, volatilization
from water will not be an important fate process(SRC). [(1) Wauchope RD et al; Rev Environ Contam Toxicol 123: 1-36
(1991) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods.
Washington, DC: Amer Chem Soc pp. 15-15 to 15-29 (1990)]**PEER REVIEWED**
Environmental Standards & Regulations:
FIFRA Requirements:
Tolerances are established for residues of the insecticide flucythrinate in
or on the following raw agricultural commodities: Apples; cabbage; cattle, fat;
cattle (meat byproducts and meat); corn (fodder and forage); corn grain; cottonseed;
goats, fat; goats (meat byproducts and meat); hogs, fat; hogs (meat byproducts
and meat); horses, fat; horses (meat byproducts and meat; lettuce, head; milk;
milk, fat; pears; sheep, fat; and sheep (meat byproducts and meat). [40 CFR 180.400 (7/1/91)]**PEER REVIEWED**
A tolerance is established for residues of the insecticide flucythrinate in
or on the food commodity cottonseed oil, resulting from application of the insecticide
to the growing crop. [40 CFR 185.3300 (7/1/91)]**PEER REVIEWED**
A tolerance is established for residues of the insecticide flucythrinate in
or on the processed feed apple pomace (dry) when present therein as a result
of application of the insecticide to the growing crop. [40 CFR 186.3300 (7/1/91)]**PEER REVIEWED**
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive
review of older pesticides to consider their health and environmental effects
and make decisions about their future use. Under this pesticide reregistration
program, EPA examines health and safety data for pesticide active ingredients
initially registered before November 1, 1984, and determines whether they are
eligible for reregistration. In addition, all pesticides must meet the new safety
standard of the Food Quality Protection Act of 1996. Pesticides for which EPA
had not issued Registration Standards prior to the effective date of FIFRA,
as amended in 1988, were divided into three lists based upon their potential
for human exposure and other factors, with List B containing pesticides of greater
concern and List D pesticides of less concern. Flucythrinate is found on List
B. Case No: 2290; Pesticide type: Insecticide; Case Status: No products containing
the pesticide are actively registered ... The case /is characterized/ as "cancelled."
Under FIFRA, pesticide producers may voluntarily cancel their registered products.
EPA also may cancel pesticide registrations if registrants fail to pay required
fees or make/meet certain reregistration commitments, or if EPA reaches findings
of unreasonable adverse effects.; Active ingredient (AI): (+-)-flucythrinate;
AI Status: The active ingredient is no longer contained in any registered pesticide
products ... "cancelled." [USEPA/OPP; Status of Pesticides in Registration, Reregistration
and Special Review p.183 (Spring, 1998) EPA 738-R-98-002]**QC REVIEWED**
Acceptable Daily Intakes:
FAO/WHO ADI: 0.02 mg/kg [FAO/WHO; Pesticide Residues in Food - 1990. Evaluations Part
1 - Residues p.422 Plant Prod Protect Paper 103/1 (1990)]**QC REVIEWED**
Allowable Tolerances:
Tolerances are established for residues of the insecticide flucythrinate in
or on the following raw agricultural commodities: Apples: 1.0 ppm; Cabbage:
2.0 ppm; Cattle, fat: 1.0 ppm; Cattle (meat byproducts and meat): 0.1 ppm; Corn
(fodder and forage): 3.00 ppm; Corn grain: 0.05 ppm; Cottonseed: 0.1 ppm; Goats,
fat: 1.0 ppm; Goats (meat byproducts and meat): 0.1 ppm; Hogs, fat: 1.0 ppm;
Hogs (meat byproducts and meat): 0.1 ppm; Horses, fat: 1.0 ppm; Horses (meat
byproducts and meat): 0.1 ppm; Lettuce, head: 2.0 ppm; Milk: 0.1 ppm; Milk,
fat: 2.0 ppm; Pears: 0.05 ppm; Sheep, fat: 1.0 ppm; and Sheep (meat byproducts
and meat): 0.1 ppm. [40 CFR 180.400 (7/1/91)]**PEER REVIEWED**
A tolerance of 0.2 ppm is established for residues of the insecticide flucythrinate
in or on the food commodity cottonseed oil, resulting from application of the
insecticide to the growing crop. [40 CFR 185.3300 (7/1/91)]**PEER REVIEWED**
A tolerance of 10.0 ppm is established for residues of the insecticide flucythrinate
in or on the processed feed apple pomace (dry) when present therein as a result
of application of the insecticide to the growing crop. [40 CFR 186.3300 (7/1/91)]**PEER REVIEWED**
Chemical/Physical Properties:
Molecular Formula:
C26-H23-F2-N-O4 [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**PEER REVIEWED**
Molecular Weight:
451.48 [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**PEER REVIEWED**
Color/Form:
Viscous liquid [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**PEER REVIEWED**
Boiling Point:
108 deg C at 0.35 mm Hg [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Density/Specific Gravity:
1.189 at 22 deg C [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Solubilities:
Sol in acetone, xylene, 2-propanol [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**PEER REVIEWED**
In water at 21 deg C, 0.5 mg/l. In ... corn oil 560, cottonseed oil 300, soya
bean oil 300, hexane 90 (all in g/l at 21 deg C). [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Spectral Properties:
Index of refraction: 1.541 at 25 deg C/D [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Vapor Pressure:
0.0012 mPa at 25 deg C [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Other Chemical/Physical Properties:
Dark amber viscous liquid, with a faint ester-like odor. /Technical flucythrinate/
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Chemical Safety & Handling:
Skin, Eye and Respiratory Irritations:
Immediately irritating to the eye. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
The chief effect from exposure ... is skin rash particularly on moist areas
of the skin. ... May irritate the eyes. /Pyrethroids/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 1]**PEER REVIEWED**
Fire Potential:
/Pyrethrins/ ... burn with difficulty. /Pyrethrins/ [Bureau of Explosives; Emergency Handling of Haz Matl in Surface
Trans p.434 (1981)]**PEER REVIEWED**
Fire Fighting Procedures:
Use carbon dioxide, foam, or dry chemical /on fires involving pyrethroids/.
/Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Fire-fighting: Self-contained breathing apparatus with a full facepiece operated
in pressure-demand or other positive-pressure mode. /Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 5]**PEER REVIEWED**
Extinguish fire using agent suitable for type of surrounding fire. /Pyrethrins/
[Bureau of Explosives; Emergency Handling of Haz Matl in Surface
Trans p.434 (1981)]**PEER REVIEWED**
Hazardous Reactivities & Incompatibilities:
Incompatibility: Strong oxidizers. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
... Incompatible with lime & ordinary soaps because acids & alkalies
speed up processes of hydrolysis. /Pyrethrins/ [Farm Chemicals Handbook 1986. Willoughby, Ohio: Meister Publishing
Co., 1986.,p. C-198]**PEER REVIEWED**
Protective Equipment & Clothing:
Employees should be provided with and required to use dust- and splash-proof
safety goggles where /pyrethroids/ ... may contact the eyes. /Pyrethroids/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 3]**PEER REVIEWED**
Employees should be provided with and be required to use impervious clothing,
gloves, and face shields (eight-inch minimum). /Pyrethroids/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Wear appropriate equipment to prevent: Repeated or prolonged skin contact.
/Pyrethrum and pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Wear eye protection to prevent: Reasonable probability of eye contact. /Pyrethrins/
[NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Max concn for use: 50 mg/cu m: Respirator
Classes: Any chemical cartridge respirator with organic vapor cartridge(s) in
combination with a dust, mist, and fume filter. May require eye protection.
Any supplied-air respirator. May require eye protection. Any self-contained
breathing apparatus. May require eye protection. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Max concn for use: 125 mg/cu m:
Respirator Classes: Any supplied-air respirator operated in a continuous flow
mode. May require eye protection. Any powered, air-purifying respirator with
organic vapor cartridge(s) in combination with a dust, mist, and fume filter.
May require eye protection. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Max concn for use: 250 mg/cu m:
Respirator Classes: Any chemical cartridge respirator with a full facepiece
and organic vapor cartridge(s) in combination with a high-efficiency particulate
filter. Any self-contained breathing apparatus with a full facepiece. Any supplied-air
respirator with a full facepiece. Any powered, air-purifying respirator with
a tight-fitting facepiece and organic vapor cartridge(s) in combination with
a high-efficiency particulate filter. May require eye protection. /Pyrethrins/
[NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Max concn for use: 5,000 mg/cu m:
Respirator Class: Any supplied-air respirator with a full facepiece and operated
in a pressure-demand or other positive pressure mode. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Condition: Emergency or planned
entry into unknown concn or IDLH conditions: Respirator Classes: Any self-contained
breathing apparatus that has a full facepiece and is operated in a pressure-demand
or other positive pressure mode. Any supplied-air respirator with a full face
piece and operated in pressure-demand or other positive pressure mode in combination
with an auxiliary self-contained breathing apparatus operated in pressure-demand
or other positive pressure mode. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Recommendations for respirator selection. Condition: Escape from suddenly
occurring respiratory hazards: Respirator Classes: Any air-purifying, full-facepiece
respirator (gas mask) with a chin-style, front- or back-mounted organic vapor
canister having a high-efficiency particulate filter. Any appropriate escape-type,
self-contained breathing apparatus. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Preventive Measures:
Use with adequate ventilation, and wear goggles or a face shield when handling.
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Skin that becomes contaminated with /pyrethrum/ should be promptly washed
or showered with soap or mild detergent and water. /Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 3]**PEER REVIEWED**
Clothing contaminated with /pyrethrum/ should be placed in closed containers
for storage until provision is made for the removal of /pyrethrum/ from the
clothing. /Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Respirators may be used when engineering and work practice controls are not
technically feasible, when such controls are in the process of being installed,
or when they fail or need to be supplemented. Respirators may also be used for
operations which require entry into tanks or closed vessels, and in emergency
situations. /Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Employees who handle /pyrethrum/ ... should wash their hands thoroughly with
soap or mild detergent and water before eating, smoking, or using toilet facilities.
/Pyrethrum/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 3]**PEER REVIEWED**
Avoid contact with skin. Keep out of any body of water. Do not contaminate
water by cleaning of equipment or disposal of waste. Do not reuse empty container.
Destroy it by perforating or crushing. /Pyrethrum/ [Farm Chemicals Handbook 1986. Willoughby, Ohio: Meister Publishing
Co., 1986.,p. C-198]**PEER REVIEWED**
Contact lenses should not be worn when working with this chemical. /Pyrethrins/
[NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Workers should wash: Promptly when skin becomes contaminated. /Pyrethrins/
[NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Work clothing should be changed daily: If it is reasonably probable that the
clothing may be contaminated. /Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
Remove clothing: Promptly if it is non-impervious clothing that becomes contaminated.
/Pyrethrins/ [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS(NIOSH) Publication
No. 90-117. Washington, DC: U.S. Government Printing Office, June 1990 190]**PEER
REVIEWED**
If /pyrethrins/ are not involved in a fire: keep /pyrethrins/ out of water
sources and sewers. Build dikes to contain flow as necessary. /Pyrethrins/ [Bureau of Explosives; Emergency Handling of Haz Matl in Surface
Trans p.434 (1981)]**PEER REVIEWED**
SRP: The scientific literature for the use of contact lenses in industry is
conflicting. The benefit or detrimental effects of wearing contact lenses depend
not only upon the substance, but also on factors including the form of the substance,
characteristics and duration of the exposure, the uses of other eye protection
equipment, and the hygiene of the lenses. However, there may be individual substances
whose irritating or corrosive properties are such that the wearing of contact
lenses would be harmful to the eye. In those specific cases, contact lenses
should not be worn. In any event, the usual eye protection equipment should
be worn even when contact lenses are in place. **QC REVIEWED**
Stability/Shelf Life:
Stable to light. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Stable for > 1 year at 37 deg C, > 2 years at 25 deg C. /Technical flucythrinate/
[Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual
- A World Compendium. 8th ed. Thornton Heath, UK: The British Crop Protection
Council, 1987. 409]**PEER REVIEWED**
Hydrolysis rates (half-lives in days): ca 40 at pH3, 52 at pH6, 6.3 at pH
9, 40 in distilled water (all at 27 deg C; ca 40 at pH 3, 31 at pH 6, 2.6 at
pH 9, 29 in distilled water (all at 35 deg C). [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Pyrethrins ... /are/ stable for long periods in water-based aerosols where
... emulsifiers give neutral water systems. /Pyrethrins/ [Farm Chemicals Handbook 1986. Willoughby, Ohio: Meister Publishing
Co., 1986.,p. C-198]**PEER REVIEWED**
Storage Conditions:
Pyrethrins with piperonyl butoxide topical preparations should be stored in
well-closed containers at a temperature less than 40 deg C, preferably between
15-30 deg C. /Pyrethrins/ [McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug
Information 92. Bethesda, MD: American Society of Hospital Pharmacists, Inc.,
1992 (Plus Supplements 1992). 2125]**PEER REVIEWED**
Cleanup Methods:
Spillages of pesticides at any stage of their storage or handling should be
treated with great care. Liquid formulations may be reduced to solid phase by
evaporation. Dry sweeping of solids is always hazardous: these should be removed
by vacuum cleaning, or by dissolving them in water, or other solvent in the
factory environment. /Pesticides/ [International Labour Office. Encyclopedia of Occupational Health
and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office,
1983. 1619]**PEER REVIEWED**
Environmental consideration - Land spill: Dig a pit, pond, lagoon, or holding
area to contain liquid or solid material. /SRP: If time permits, pits, ponds,
lagoons, soak holes, or holding areas should be sealed with an impermeable flexible
membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane,
or foamed concrete. Absorb bulk liquid with fly ash, or cement powder. /Pyrethrins/
[Bureau of Explosives; Emergency Handling of Haz Matl in Surface
Trans p.434 (1981)]**PEER REVIEWED**
Environmental consideration - Water spill: If /pyrethrins/ are dissolved,
apply activated carbon at ten times the spilled amount in the region of 10 ppm
or greater concn. Use mechanical dredges or lifts to remove immobilized masses
of pollutants and precipitates. /Pyrethrins/ [Bureau of Explosives; Emergency Handling of Haz Matl in Surface
Trans p.434 (1981)]**PEER REVIEWED**
Disposal Methods:
Incineration would be an effective disposal procedure where permitted. If
an efficient incinerator is not available, the product should be mixed with
large amounts of combustible material and contact with the smoke should be avoided.
/Pyrethrin products/ [Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens,
1985. 2nd ed. Park Ridge, NJ: Noyes Data Corporation, 1985. 762]**PEER REVIEWED**
The following wastewater treatment technology has been investigated for chlorinated
pesticides: Concentration process: Resin adsorption. /Chlorinated pesticides/
[USEPA; Management of Hazardous Waste Leachate, EPA Contract
No.68-03-2766 p.E-195 (1982)]**PEER REVIEWED**
Group I Containers: Combustible containers from organic or metallo-organic
pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should
be disposed of in pesticide incinerators or in specified landfill sites. /Organic
or metallo-organic pesticides/ [40 CFR 165.9(a) (7/1/90)]**PEER REVIEWED**
Group II Containers: Non-combustible containers from organic or metallo-organic
pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must
first be triple-rinsed. Containers that are in good condition may be returned
to the manufacturer or formulator of the pesticide product, or to a drum reconditioner
for reuse with the same type of pesticide product, if such reuse is legal under
Department of Transportation regulations (eg 49 CFR 173.28). Containers that
are not to be reused should be punctured ... and transported to a scrap metal
facility for recycling, disposal or burial in a designated landfill. /Organic
or metallo-organic pesticides/ [40 CFR 165.9(b) (7/1/90)]**PEER REVIEWED**
Occupational Exposure Standards:
Manufacturing/Use Information:
Major Uses:
The active ingredient is no longer contained in any registered pesticide products
... "cancelled." [USEPA/OPP; Status of Pesticides in Registration, Reregistration
and Special Review p.183 (Spring, 1998) EPA 738-R-98-002]**QC REVIEWED**
Control of a wide range of insect pests, particularly on cotton (bollworms,
leafworms, sucking insects, whiteflies, beetles, etc) and fruit trees (Lepidoptera,
Homoptera, Coleoptera, etc). Also used on vines, strawberries, citrus fruit,
bananas, pineapples, olives, coffee, cocoa, hops, vegetables, soya beans, cereals,
maize, lucerne, sugar beet, sunflowers, tobacco, and ornamentals. Efficacy at
higher temperatures is greater than for several other pyrethroid insecticides.
[Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Insecticide /Pyrethrins/ [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 1267]**PEER REVIEWED**
MEDICATION (VET) **QC REVIEWED**
MEDICATION **QC REVIEWED**
General Manufacturing Information:
Synthetic pyrethroid insecticide with contact and stomach poison activity.
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 645]**PEER REVIEWED**
/Pyrethroids/ are modern synthetic insecticides similar chemically to natural
pyrethrins, but modified to increase stability in the natural environment. /Pyrethroids/
[Morgan DP; Recognition and Management of Pesticide Poisonings.
4th ed. p.34 EPA 540/9-88-001. Washington, DC: U.S. Government Printing Office,
March 1989]**PEER REVIEWED**
Formulations/Preparations:
Emulsifiable concentrate; ULV liquid; water-dispersible granules. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Laboratory Methods:
Analytic Laboratory Methods:
Product analysis is by high performance liquid chromatography and gas liquid
chromatography. Residues may be determined by gas liquid chromatography. [Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual
- A World Compendium. 8th ed. Thornton Heath, UK: The British Crop Protection
Council, 1987. 410]**PEER REVIEWED**
Pyrethrins ... in pesticide formulations are analyzed using gas chromatography
equipped with flame ionization detection. Average recovery is 98% with a precision
of 0.0044-0.011. /Pyrethrins/ [Association of Official Analytical Chemists. Official Methods
of Analysis. 15th ed. and Supplements. Washington, DC: Association of Analytical
Chemists, 1990,p. V1 172]**PEER REVIEWED**
... Liquid chromatography method has been developed to quantitate pyrethrins
in pesticide formulations. ... Detection was monitored at 240 nm. ... Percent
coefficients of variation ranged from 1.39 to 9.68 with the majority less than
5.00. ... /Pyrethrins/ [Bushway RJ; J Assoc Off Anal Chem 68 (6): 1134-6 (1985)]**PEER
REVIEWED**
Pyrethrins were detected in soils by gas chromatography after extraction with
hexane. /Pyrethrins/ [Siltanen H et al; Ryrethrum Post 14 (3): 65-7 (1978)]**PEER
REVIEWED**
Low level pyrethrin formulations are extracted with tetrahydrofuran and determined
via capillary gas chromatography with electron capture detection. ... Analysis
of 5 formulations gave an average standard deviation of 3.3%. /Pyrethrins/ [Stringham RW, Schutz RP; J Assoc Off Anal Chem 68 (6): 1137-9
(1985)]**PEER REVIEWED**
Special References:
Special Reports:
Clark JR et al; Toxicity of pyrethroids to Marine Invertebrates and Fish:
A Literature Review and Test Results with Sediment-Sorbed Chemicals. Environ
Toxicol Chem 8 (5): 393-401 (1989). Data on acute and chronic toxicity of permethrin,
fenvalerate, cypermethrin, and flucythrinate to marine invertebrates and fishes
are reviewed.
Miyamoto J; Environ Health Perspect 14: 15-28 (1976). Degradation, metabolism,
and toxicity of synthetic pyrethroids.
Miyamoto J, et al; Pure Appl Chem 53: 1967-2022 (1981). The chemistry, metabolism,
and residue analysis of synthetic pyrethroids.
Hutson DH; Progress in Drug Metabolism 3: 215-252 (1979). The metabolic fate
of synthetic pyrethroid insecticides in mammals.
Gammon DW; Fundam Appl Toxicol (5) 1: 9-23 (1985). Correlations between in
vitro and in vivo mechanisms of pyrethroid insecticide action.
Casida JE et al; Ann Rev Pharmacol Toxicol 23: 413-38 (1983). The mechanisms
of selective action of pyrethroid insecticide are discussed.
Papadopoulou-Mourkidou E; Residue Rev 89: 179-208 (1983). A review with many
references on analysis of allethrin & other pyrethroid insecticides.
Emulsifiable concentrate; ULV liquid; water-dispersible granules. [Hartley, D. and H. Kidd (eds.). The Agrochemicals Handbook.
2nd ed. Lechworth, Herts, England: The Royal Society of Chemistry, 1987.,p.
A550/Aug 87]**PEER REVIEWED**
Administrative Information:
Hazardous Substances Databank Number: 6647
Last Revision Date: 20010808
Last Review Date: Reviewed by SRP on 3/11/1993
Update History:
Field Update on 08/08/2001, 1 field added/edited/deleted.
Field Update on 05/16/2001, 1 field added/edited/deleted.
Complete Update on 09/12/2000, 1 field added/edited/deleted.
Complete Update on 06/12/2000, 1 field added/edited/deleted.
Complete Update on 03/13/2000, 2 fields added/edited/deleted.
Complete Update on 02/08/2000, 1 field added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 08/27/1999, 1 field added/edited/deleted.
Complete Update on 06/08/1999, 6 fields added/edited/deleted.
Field Update on 06/03/1998, 1 field added/edited/deleted.
Field Update on 11/01/1997, 1 field added/edited/deleted.
Field Update on 05/09/1997, 1 field added/edited/deleted.
Complete Update on 03/17/1997, 2 fields added/edited/deleted.
Complete Update on 02/28/1997, 1 field added/edited/deleted.
Complete Update on 10/20/1996, 1 field added/edited/deleted.
Complete Update on 05/14/1996, 1 field added/edited/deleted.
Complete Update on 02/01/1996, 1 field added/edited/deleted.
Complete Update on 08/21/1995, 1 field added/edited/deleted.
Complete Update on 11/28/1994, 1 field added/edited/deleted.
Complete Update on 03/01/1994, 59 fields added/edited/deleted.