Flucythrinate
CAS No. 70124-77-5
 
 

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Adverse Effects
Abstracts

ACTIVITY: Acaricide; Insecticide (pyrethroid)

CAS Name: cyano(3-phenoxyphenyl)methyl (S)-4-(difluoromethoxy)-?-(1-methylethyl)benzeneacetate

Structure:

Adverse Effects:

Ataxia
Body Weight Decrease
Bone
Brain
Cancer: Potential for tumor promotion
Endocrine: Breast

Endocrine: Pituitary
Endocrine: Testicular
Endocrine: Uterus
G-Protein effect: inhibits intercellular communication
Heart
Kidney

Liver
Lung
Sciatic Nerve

Spleen

Environmental Effects:

Very highly toxic to Fish, Insects, and Zooplankton

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No 
US EPA PC Code: 118301 
California Chemical Code 2168 
US Tolerances: Revoked  
FDA LMS Code: 229
US EPA Permit Date
and Registrant:
1982, American Cyanamid 
Note: Banned in Norway
European Commission: Not allowed to be used as an active ingredient after July 25, 2003. 
Registered use in
(includes only a limited list of countries)

India, Japan, Portugal

Japan's Maximum Residue Levels (MRLs)

Partial list: Apple, Artichoke, Barley, Beans (dry), Broad Beans, Broccoli, Brussels Sprouts, Cabbage, Cauliflower, Cherry, Coffee beans, Corn, Cotton seeds, Cucumber,Ginger, Grape, Grapefruit, Hop, Horseradish, Kale, Lemon, Lime, Loquat, Natsudaidai, Onion, Orange, Peach, Pear, Peas, Potato, Quince, Radish, Rape seeds, Soybeans, Spinach, Taro, Tea, Tomato, Turnip, Watercress, Wheat

-- Note the very high levels - 20 ppm - for Tea (Green, Black, Oolong, Wulung)  

Other Information
Molecular Formula: C26H23 F2 NO4 
Manufacturers: DuPont, BASF 
Other Names: AC 222, 705,
Aastar,
CL 222705,
Cybolt,
Cythrin,
Gurardian Pay-Off 
Of special interest:
PAN BAD ACTOR (Acute Toxicity) 
TOXNET profile from Hazardous Substances Data Bank
Flucythrinate: Material Safety Data Sheets & Labels
Abstracts
Highly hazardous. WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2000-2002. Table 2. Highly hazardous (Class Ib) technical grade active ingredients of pesticides, p 18
November 26, 2002 - European Commission: Flucythrinate is one of 320 pesticides to be withdrawn in July 2003. "Some 320 substances used in plant protection products (PPPs) – including insecticides, fungicides and herbicides – are to be withdrawn from the market by 25 July 2003 as part of the European Commission’s new approach to the evaluation of active substances in plant protection products. This aims to improve safeguards to ensure that all such products in use are safe for the environment and human health. Users, wholesalers and retailers of plant protection products will need to be aware of whether the products they use or sell are likely to be withdrawn, so as to prevent them being left with stocks of unusable material. Those concerned should contact their national authority to check the authorisation status for any particular product. The Regulation (n° 2076/2002 of 20 November 2002), with the list of the 320 substances, has now been published in the Offical Journal. Ref: MIDDAY EXPRESS. News from the Press and Communication Service's midday briefing. 
September 2001 - Draft Toxicological Profile for Pyrethrins and Pyrethroids. Organofluorine pyrethroids discussed in the Profile include Flucythrinate (Type 2), US Department of Health and Human Services. Public Health Service Agency for Toxic Substances and Disease Registry.  
June 14, 2001 - Implementation of the Community Strategy for Endocrine Disruptors - a range of substances suspected of interfering with the hormone systems of humans and wildlife. Communication from the Commission to the Council and the European Parliament. Commission of the European Communities, Brussels COM (2001) 262 final. (More information available at: http://europa.eu.int/comm/environment/docum/01262_en.htm  
1987 - Summary of Toxicological Data for Flucythrinate. California EPA, Department of Pesticide Regulation, Medical Toxicology Branch. July 18, 1986 Revised August 12, 1987.
June 1993 - Pesticide Information Profile - Pesticide Management Education Program at Cornell U 
1985 - World Health Organization Review. 
April 2000 - Food and Drug Administration Pesticide Residue Monitoring. - Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring.
March 12, 2001 - EC: Maximum Residue Level (MRL) in Tea is 0.1 ppm. Page 400.
1993 - Evaluation (152) by FAO (Food and Agriculture Organization of the U.N.
October 2001 - Glossary of Pesticide Chemicals. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration.  

US Federal Register
Date Published Docket Identification Number Details
Sept 27, 1995 OPP-300328A Revocation of Tolerances. FINAL RULE. The proposal to revoke the tolerances was published in the Federal Register of April 14, 1994 (59 FR 17754). EPA initiated this action because all registered uses of these pesticide chemicals in or on raw agricultural commodities and processed foods and feeds have been canceled. The registrations for these pesticide chemicals were canceled because the registrant failed to pay the required maintenance fee, or the registrant voluntarily canceled all registered uses of the pesticide. The sections of CFR are:
Sec. 180.400
Sec. 185.3300
Sec. 186.3300
 
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