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Fluazifop-P-butyl Adverse Effects
ACTIVITY: Herbicide
(Arylphenoxy
ether ester)
See also Fluazifop-butyl
- Fluazifop
Systematic Name for
Fluazifop-p-butyl: Propanoic acid, 2-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)-,
butyl ester, (R)-
Structure for Fluazifop-p-butyl:
Systematic Name for
Fluazifop-P: Propanoic acid, 2-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)-,
(R)-
Structure for Fluazifop-P:
| Adverse
Effects for
Fluazifop-P-butyl
Blood
Body
Weight Decrease
Bone
Endocrine:
Ovary
Endocrine: Pituitary
Endocrine: Prostate
Endocrine:
Testicular
Endocrine: Uterine
Eye
Fetotoxic
Kidney
Liver
Lung
Reproductive
Spleen
Stomach
Teratogenic
|
| Environmental
Effects:
Very
high to high toxicity
to fish.
Metabolites are Highly persisent in water and in soil. |
Regulatory
Information
(only comprehensive for the US) -
mainly for Fluazifop-p-butyl |
| US
EPA Registered: |
Yes |
| US
EPA PC Code: |
122809 |
| California
Chemical Code |
5815 |
| US
Tolerances: |
CFR
180.411
On
May 24, 2000
CFR 185.3250
CFR 186.3250
were consolidated into 180.411(a)(1) |
US
EPA Permit Date
and Registrant: |
1985,
Zeneca |
Registered
use in
|
Australia,
Canada, Denmark, Finland, Germany, Hungary, Netherlands, New
Zealand, Philippines, Portugal, UK, US
Africa:
Burkina
Faso, Cape Verde, Chad, Gambia, Guinea-Bissau, Mali, Mauritania,
Niger, Senegal, South Africa |
|
Note: |
Banned
in Norway |
| Japan's
Maximum Residue Levels (MRLs) |
Partial
list: All berries, Apricot, Asparagus,
Avocado, Banana, Beans (dry), Broccoli, Brussel Sprouts, Cabbage,
Carrot, Cauliflower, Celery, Cherry, Coffee beans, Cucumber,
Endive, Garlic, Grape, Hop, Kale, Kiwifruit, Lemon, Lettuce,
Mango, Nectarine, Onion, Orange, Papaya, Peach, Peanuts (dry),
Pear, Pecan, Pineapple, Plum, Potato, Soybeans (dry), Strawberry,
Sugar beet, Taro, Watercress, Yam |
US
Maximum Residue Levels permitted
in food commodities
|
permitted
in or on 74 food commodities, including:
Asparagus, Carrots, Coffee beans, Cotton
seed / oil, Eggs, Endive, Stone fruits, Cattle, Goats, Hogs,
Horse, Milk, Macadamia nuts, Onions (dry bulb), Pecans, Peppers
(tabasco), Poultry, Rhubarb, Sheep, Soybeans, Spinach, Sweet
potatoes |
| Other
Information |
| Molecular
Formula for
Fluazifop-p-butyl: |
C19-H20-F3-N-O4 |
| Molecular
Formula for Fluazifop-P: |
C15-H12-F3-N-O4
|
| Entry
Year: |
1981 |
| Inventing
Company: |
Zeneca |
| Manufacturers: |
Syngenta
(Zeneca) |
Other
Names for
Fluazifop-p-butyl |
Fusilade
5
Fusion
ICI-A0005
SL-118
Fusilade 2000
Fusilade Super
Oramec
PP 005 2E Herbicide
Tornado
Typhoon |
Other
Names for
Fluazifop-P:
(R)-2-(4-((5-(Trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoic
acid
(R)-2-(4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy)propionic acid
|
| Manufacture
site: |
UK:
Zeneca, Hudderfield |
| Of
special interest: |
| PAN
Data |
| •
new - Fluazifop-p-butyl:
Material Safety Data Sheets and Labels |
2005
- Schedule for Reregistration & Tolerance Reassessment (RED)
is expected to be July 2005. Contact at EPA: Lance Wormell (703)
603-0523; wormell.lance@epa.gov . According to EPA:
Through the pesticide reregistration and tolerance reassessment
programs, EPA is assessing risks and making risk management
decisions for older pesticides. These decisions are summarized
in documents known as REDs, IREDs, and TREDs. By making decisions
according to the schedule below, EPA will meet its statutory
deadlines for completing reregistration and tolerance reassessment.
Some of the decision dates presented in the schedule may change
due to the dynamic nature of the review process. Any pesticide
decisions that are not completed during the current fiscal year
will be rescheduled for the following year. EPA is committed
to meeting its reregistration and tolerance reassessment deadlines.
http://www.epa.gov/pesticides/reregistration/decision_schedule.htm
|
The
estimate for total domestic use (annual average) is approximately
250,000 lbs. active ingredient. More
than 90% of fluazifop-P-butyl’s total usage is on soybeans
(75%) and
cotton (21%) (page
2).
Ref: October 29, 2003.
Tier 1 Drinking Water Assessment for Fluazifop-P-butyl.
EPA Federal Register Docket No. OPP-2004-0347-0011.
http://www.fluorideaction.org/pesticides/f-p-b.opp-2004-0347-0011.pdf
|
|
| US
Pesticide Use Map - 1992-1995 |
| July
26, 2004. Australia:
Urgent Recall for Fusilade Post-Emergence Selective Herbicide.
Australian Pesticides & Veterinary Medicines Authority. |
| May
20, 2002 - SUMMARY
OF TOXICOLOGY DATA FLUAZIFOP-P-BUTYL. California
EPA. Department of Pesticide Regulation. Medical Tooxicology
Branch. |
| January
21, 2002 -
Fluazifop- P - butyl: Material
Data Safety Sheet for Fusilade DX. Syngenta. |
| Fluazifop-P.
One of 8 fluorinated pesticides used to cultivate grapes in
Australia. |
1995
-
Fluazifop-p-butyl: McFarland,
Kern County, California. The community
asked ATSDR, EPA, state, and local agencies to provide assistance
in evaluating current health conditions in the area. Health
concerns include a perceived increase in the number of childhood
cancer cases, incidence of adult cancers, low birth weight,
miscarriages, and developmental anomalies. The community is
surrounded by agricultural fields where ground and aerial
application of pesticides and fertilizers are reported to
occur frequently. According to residents, during periods of
heavy rain, surface water run-off appears to flow through
the neighborhood into sump areas. Potential contaminated soil
from surface water run-off is also of concern. The drinking
water issue is of primary concern, specifically the status
of municipal wells used for drinking water in the neighborhood...
Fusilade (fluazifop-p-butyl) was one
of 6 substances found in an analysis of the community's drinking
water at low concentrations in three samples at levels of:
0.16 µg/L, 0.06 µg/L, and 0.17 µg/L. Fusilade is not
a common contaminant of groundwater because it is rapidly
broken down in water and has low mobility in soils. It is
listed as an EPA class IV contaminant
and is considered relatively nontoxic.
Ref: PETITIONED PUBLIC HEALTH ASSESSMENT MCFARLAND STUDY AREA
MCFARLAND, KERN COUNTY, CALIFORNIA. Agency for Toxic Substances
and Disease Registry. http://www.atsdr.cdc.gov/HAC/PHA/mcfarland/msa_p1.html#sum |
| October
2001 -
Fluazifop-butyl and Fluazifop-p-butyl.
Glossary of Pesticide Chemicals. A
listing of pesticides subject to analysis of residues in foods
and feeds by the US Food and Drug Administration. |
| Fluazifop-p-butyl:
Pesticide Information Profile - Cornell
Management Education Program |
| Herbicide
Products - partial list |
| PubMed
Abstracts |
PAN
Data for Fluazifop-butyl
PAN
Data for Fluazifop |
The
submitted metabolism data on fluazifop-butyl
and fluazifop-P-butyl (the subject of reregistration)
support the finding that they are
similar, if not identical in toxicity. Rat metabolism
data showed that [RS] fluazifop-butyl is converted to [R]
fluazifop acid within a short time period. Fluazifop-butyl
is rapidly hydrolyzed to fluazifop acid by blood esterases
and the [S] enantiomer is rapidly converted to the [R] enantiomer;
apparently the [R] enantiomer is the preferred configuration.
Whether rats are administered [RS] fluazifop-butyl (50:50
mixture) or [R] fluazifop-P-butyl (purified, 90%:10%= [R]:[S]),
a ratio of [R]:[S]= 97%:3% for fluazifop acid was identified
within a hour in the blood of rats (Page 9) ... Based on
their structures, the Metabolism Assessment Review Committee
(MARC) was unable to conclude that the major
metabolites of fluazifop-P-butyl will be significantly
less toxic than the parent and therefore, recommended that
for risk assessment purposes, the
residues of concern are parent, fluazifop acid (free and
conjugated), 5-trifluoromethyl-2-pyridone, and 2-(4hydroxyphenoxy)
propionic acid (free and conjugated).
Ref:
December 10, 2004. US
EPA> Fluazifop-P-butyl: Revised HED Chapter of the Tolerance
Reassessment Eligibility Decision (TRED) Document. EPA Docket
number: OPP-2004-0347-0003
http://www.fluorideaction.org/pesticides/f-p-b.opp-2004-0347-0003.pdf
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••
Note: Due to length, the following is a partial list. Click
here to see full list of FR entries. |
| Published
Date |
Docket
Identification Number |
Details |
| February 28, 2007 |
EPA-HQ-OPP-2007-0005 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations. Comments due by August 27, 2007.
| Registration
No. |
Product Name |
Registrant |
| 034704-00766 |
Kleenup Grass & Weed Killer Formula
II |
Loveland Products, Inc., P.O.
Box 1286, Greeley, CO 80632 |
| 040849-00070 |
AT Weed & Grass Killer Concentrate |
Enforcer Products, A Division
of Acuity Specialty Products
Group, Inc,
1420 Seaboard Industrial Blvd., Atlanta, GA 30318 |
|
| October
21, 2005 |
OPP-2004-0347 |
Tolerance
Reassessment Decision (TRED); Notice of Availability for Public
Comment. EPA
has issued its Report on Food Quality Protection Act (FQPA)
Tolerance Reassessment Progress and Risk Management Decision
for fluazifop-P-butyl, known as a TRED, as well as related
technical support documents. EPA
must review tolerances and tolerance exemptions that were
in effect when FQPA was enacted in August 1996, to ensure
that these existing pesticide residue limits for food and
feed commodities meet the safety standard established by the
new law.
|
••
Note: Due to length, the above is a partial list. Click
here to see full list of FR entries.
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