Adverse Effects
Triflumuron
CAS No. 64628-44-0

 
 

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Activity: Insecticide (Benzoylurea)
Structure:



Adverse Effects:
Blood
Environmental

• As of October 2003 - No toxicological information available.

• 10 of the 11 benzoylurea insecticides cited in this article are organofluorines (highligted in red).
"Benzoylureas are an entirely different class of insecticides that act as insect growth regulators (IGRs). Rather than being the typical poisons that attack the insect nervous system, they interfere with chitin synthesis and are taken up more by ingestion than by contact. Their greatest value is in the control of caterpillars and beetle larvae. Benzoylureas were first used in Central America in 1985, to control a severe, resistant leafworm complex (Spodoptera spp., Trichoplusia spp.) outbreak in cotton. The withdrawal of the ovicide chlordimeform made their control quite difficult due to their high reistance to almost all insecticide classes, including the pyrethroids. The first benzoylureas were introduced in 1978 by Bayer of Germany, triflumuron (Alsystin(r)) being the first. Others appearing since then are chlorfluazuron (Atabron(r), Helix(r)), followed by teflubenzuron (Nomolt(r), Dart(r)), hexaflumuron (Trueno(r), Consult(r)), flufenoxuron (Cascade(r)), and flucycloxuron (Andalin(r)). Others are flurazuron, novaluron, and diafenthiuron. Lufenuron (Axor(r)) is the newest addition to this group, appearing in 1990. Surprisingly, none of these are registered in the U.S. The only benzoylurea registered in the U.S. is diflubenzuron (Figure 21) (Dimilin(r), Adept(r), Micromite(r))...
Ref: An Introduction to Herbicides (3rd edition) by George W. Ware


Average pesticide residues in Australian fleece wool
Ref: Sheep. Low-cost residue test will keep wool clean.
Page 63. FARMING AHEAD No. 109 - January 2001

- Organo-
phosphates
Synthetic
pyrethroids
Cyromazine Dicyclanil Diflubenzuron Triflumuron
1992-93
10.2
5.8
-
-
-
-
1993-94
9.0
6.6
-
-
-
-
1994-95
4.3
5.7
5.2
-
-
-
1995-96
4.4
5.5
6.3
-
-
-
1996-97
4.5
3.8
8.7
-
1.2
3.5
1997-98
5.8
3.3
5.8
-
3.6
6.1
1998-99
2.4
1.6
7.4
-
3.5
7.6
1999-00
2.2
2.0
5.1
0.1
2.9
9.0
Source: Woolmark Company


Blood (click on for all fluorinated pesticides)

Abstract: The effects of five benzoylphenylurea insecticides, diflubenzuron (35367385), flufenoxuron (101463698), hexaflumuron (86479063), teflubenzuron (83121180), and triflumuron (64628440) were comparatively evaluated on hematological parameters in rats. Sixty adult Wistar-rats were divided into five dose groups and a control group. Daily doses of 100mg/kg of each tested insecticide were administered by gavage for 28 days, after which rats were sacrificed and blood was taken for examination. Parameters measured were red blood cell count, hemoglobin (Hb), hematocrit, mean corpuscular volume, mean corpuscular Hb concentration, methemoglobin (metHb), and reticulocyte counts. Results showed that treatment with insecticides at the dose given did not produce any overt signs of toxicity. However, with regard to hematological parameters, both diflubenzuron and triflumuron induced elevated metHb levels. The no observed effect level for metHb was 45mg/kg. The reticulocyte level was increased in all treated groups, even at dose levels of 50mg/kg. The authors conclude that the metHb level increase and reticulocyte increase are the most sensitive parameters, but that one might be independent of the other.
Ref: 1993. J Appl Toxicol; Jan-Feb;13(1):67-8. Comparative study on the effects of five benzoylphenylurea insecticides on haematological parameters in rats, by Tasheva M, Hristeva V.

Environmental (click on for all fluorinated pesticides)

Triflumuron is very toxic to aquatic organisms. Triflumuron is toxic to bees.
Triflumuron: Fish toxicity:
LC50 (96 hr) bluegill sunfish (Lepomis macrochirus) > 20.8 µg/L
LC50 (96 h) rainbow trout (onchorhynchus mykiss) > 24.2 µg/L
Triflumuron: Daphnia toxicity:
EC50 (48 h) water flea (Daphnia magna) 1.6 µg/L
Triflumuron: Algal toxicity:
Growth rate: IC50 (72 h) green algae (Desmodesmus subspicatus) > 0.025 mg/L

Ref: August 9, 2004. Material Safety Data Sheet for Alsystin 250 Larvicide. Bayer CropScience.

Triflumuron is a toxic hazard to juvenile aquatic and terrestrial arthropods
Fish toxicity:
LC50: > 10 mg/L (96 h) rainbow trout
LC50: >100 mg/L (96 hours) golden orfe
Daphnia toxicity:
EC50: 0.23 mg/L (48 hours) daphnia magna.
Environmental fate, persistence and degradation:
Degradation of active constituent - half life:

t l/2: 960 days at pH4 (22 0 C)
t l/2: 580 days at pH7 (22 0 C)
tl/2: 11 days at pH9 (22 0 C)
Ref: Material Safety Data Sheet for Intrigue Termite Dust. Supplier: Bayer Environmental Science A Business Group of Bayer CropScience Pty Ltd ABN 87 000 226 022 Address: 391 - 393 Tooronga Road, East Hawthorn Victoria 3123, Australia
http://www.fluorideaction.org/pesticides/triflumuron.msds.bayer.02.pdf

Acute Aquatic Ecotoxicity Summaries for Triflumuron on Fish. PAN Pesticides Database - Chemical Toxicity Studies on Aquatic Organisms.
http://www.pesticideinfo.org/List_AquireAcuteSum.jsp?Rec_Id=PC34658&Taxa_Group=Fish
Common Name Scientific Name Avg Species LC50 (ug/L) LC50 Std Dev Number of Studies Avg Species Rating
Fish
Western mosquitofish Gambusia affinis 10.0 - 1 Very Highly Toxic
 
 
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