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to Prodiamine Index Page
Activity:
Herbicide
(2,6-Dinitroaniline)
Structure:
Adverse Effects:
Body
Weight Decrease
Cancer:
Possible Human Carcinogen: THYROID,
PANCREAS, FIBROSARCOMAS
Endocrine: Suspected Disruptor
Endocrine:
Thyroid
Fibrosarcomas
Liver
Pancreas
Environmental
Body
Weight Decrease (click
on for all fluorinated pesticides)
--
Chronic/Subchronic Toxicity Studies. Prodiamine: Liver (alteration
and enlargement) and thyroid effects (hormone imbalances) at high
dose levels (rats); decreased body weight
gains.
-- Carcinogenic Potential. Prodiamine: Benign thyroid tumors (rat).
None observed (mouse).
-- Target Organs. Prodiamine: Liver and Thyroid.
Ref: Material Safety Data Sheet for Barricade
65WG Herbicide. Novartis. February 28, 2000.
http://www.fluoridealert.org/pesticides/Prodiamine.MSDS.2000.pdf
Cancer:
Possible Human Carcinogen:
THYROID
(click on for all fluorinated
pesticides)
Group C--Possible Human Carcinogen.
Reviewed 7/ 15/ 91.
Ref: List of Chemicals Evaluated for Carcinogenic
Potential. Science Information Management Branch, Health Effects
Division, Office of Pesticide Programs, U. S. Environmental Protection
Agency. March 15, 2002.
http://www.biomuncie.org/chemicals_evaluated_for_carcinog.htm
Title of this publshed
paper: Mode of carcinogenic action of pesticides
inducing thyroid follicular cell tumors in rodents.
Some mutagenic data are available on all 24
pesticides producing thyroid tumors. "... acetochlor,
clofentezine, fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene,
prodiamine, pyrimethanil, and thiazopyr
seem to enhance the hepatic metabolism and
excretion of thyroid hormone." The
organofluorine pesticides cited in this abstract are: Fipronil,
Prodiamine, Thiazopyr,
and Trifluralin.
Ref: 1998. Mode
of carcinogenic action of pesticides inducing thyroid follicular
cell tumors in rodents; by Hurley
PM. Environ Health Perspect Aug;106(8):437-45.
--
Carcinogenic Potential. Prodiamine: Benign thyroid tumors (rat).
None observed (mouse).
-- Target Organs. Prodiamine: Liver
and Thyroid.
Ref: Material Safety Data Sheet for Barricade
65WG Herbicide. Novartis. February 28, 2000.
http://www.fluoridealert.org/pesticides/Prodiamine.MSDS.2000.pdf
Endocrine:
Suspected Disruptor (click
on for all fluorinated pesticides)
Suspected Endocrine Disruptor
Ref: PAN
Pesticides Database
Suspected Endocrine Disruptor
Ref: June 14, 2001 - Implementation of the
Community Strategy for Endocrine Disruptors - a range of substances
suspected of interfering with the hormone systems of humans and
wildlife. Communication from the Commission to the Council and
the European Parliament. Commission of the European Communities,
Brussels COM (2001) 262 final.
http://www.fluoridealert.org/pesticides/Endocrine.Disruptors.EC2001.pdf
- More information available at:
http://europa.eu.int/eur-lex/en/com/cnc/2001/com2001_0262en01.pdf
Endocrine:
Thyroid (click
on for all fluorinated pesticides)
Abstract: Of 240 pesticides screened for carcinogenicity by the
U.S. Environmental Protection Agency Office of Pesticide Programs,
at least 24 (10%) produce thyroid follicular
cell tumors in rodents. Thirteen of the thyroid carcinogens
also induce liver tumors, mainly in mice, and 9 chemicals produce
tumors at other sites. Some mutagenic data are available on all
24 pesticides producing thyroid tumors. Mutagenicity does not
seem to be a major determinant in thyroid carcinogenicity, except
for possibly acetochlor; evidence is less convincing for ethylene
thiourea and etridiazole. Studies on thyroid-pituitary functioning,
including indications of thyroid cell growth and/or changes in
thyroxine, triiodothyronine, or thyroid-stimulating hormone levels,
are available on 19 pesticides. No such antithyroid information
is available for etridiazole, N-octyl bicycloheptene dicarboximide,
terbutryn, triadimefon, and trifluralin. Of the studied chemicals,
only bromacil lacks antithyroid activity under study conditions.
Intrathyroidal and extrathyroidal sites
of action are found: amitrole, ethylene thiourea, and mancozeb
are thyroid peroxidase inhibitors; and acetochlor, clofentezine,
fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene,
prodiamine, pyrimethanil, and thiazopyr
seem to enhance the hepatic metabolism and
excretion of thyroid hormone. Thus, with 12 pesticides
that mode of action judgments can be made, 11 disrupt thyroid-pituitary
homeostasis only; no chemical is mutagenic only; and acetochlor
may have both antithyroid and some mutagenic activity. More information
is needed to identify other potential antithyroid modes of thyroid
carcinogenic action.
Ref: Hurley PM (1998). Mode of carcinogenic
action of pesticides inducing thyroid follicular cell tumors in
rodents. Environ Health Perspect; Aug;106(8):437-45.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9681970&dopt=Abstract
•
Note from FAN:
Of the pesticides cited in the above abstract
the following are organofluorines:
Fipronil, Prodiamine, Thiazopy, and Trifluralin
--
Chronic/Subchronic Toxicity Studies. Prodiamine: Liver (alteration
and enlargement) and thyroid effects (hormone
imbalances) at high dose levels (rats); decreased body
weight gains.
-- Carcinogenic Potential. Prodiamine: Benign
thyroid tumors (rat). None observed (mouse).
-- Target Organs. Prodiamine: Liver
and Thyroid.
Ref: Material Safety Data Sheet for Barricade
65WG Herbicide. Novartis. February 28, 2000.
http://www.fluoridealert.org/pesticides/Prodiamine.MSDS.2000.pdf
Fibrosarcomas
(click
on for all fluorinated pesticides)
Group
C -- Possible Human Carcinogen. Thyroid
follicular
cell neoplasia (M & F); Pancreatic adenomas
(F) in Sprague-Dawley rats. Fibrosarcomas;
CD-1 mice (M).
Ref: April
26, 2006 . Chemicals Evaluated for Carcinogenic Potential by the
Office of Pesticide Programs. From: Jess Rowland, Chief Science
Information Management Branch Health Effect Division (7509C) Office
of Pesticide Programs, USEPA.
http://www.fluorideaction.org/pesticides/pesticides.cancer.potential.2006.pdf
Liver
(click on for all fluorinated pesticides)
--
Chronic/Subchronic Toxicity Studies. Prodiamine: Liver
(alteration and enlargement) and thyroid effects (hormone
imbalances) at high dose levels (rats); decreased body weight
gains.
-- Carcinogenic Potential. Prodiamine: Benign thyroid tumors (rat).
None observed (mouse).
-- Target Organs. Prodiamine: Liver
and Thyroid.
Ref: Material Safety Data Sheet for Barricade
65WG Herbicide. Novartis. February 28, 2000.
http://www.fluoridealert.org/pesticides/Prodiamine.MSDS.2000.pdf
Pancreas
(click
on for all fluorinated pesticides)
Group
C -- Possible Human Carcinogen. Thyroid
follicular
cell neoplasia (M & F); Pancreatic adenomas
(F) in Sprague-Dawley rats. Fibrosarcomas;
CD-1 mice (M).
Ref: April
26, 2006 . Chemicals Evaluated for Carcinogenic Potential by the
Office of Pesticide Programs. From: Jess Rowland, Chief Science
Information Management Branch Health Effect Division (7509C) Office
of Pesticide Programs, USEPA.
http://www.fluorideaction.org/pesticides/pesticides.cancer.potential.2006.pdf
Environmental
(click
on for all fluorinated pesticides)
Prodiamine:
Highly toxic to fish and invertebrates.
Prodiamine: Eco-Acute Toxicity
-- Rainbow Trout 96-hour LC50 0.83
ppm
-- Bluegill Sunfish 96-hour LC 50
0.55 ppm
-- Daphnia magna 48-hour LC50 0.66
ppm
Ref: 2002 - Material Safety
Data Sheet. Barricade 4FL Herbicide. Syngenta.
http://www.fluoridealert.org/pesticides/Prodiamine.MSDS.Syngenta.02.pdf
Ref:
Acute Aquatic Ecotoxicity Summaries
for Prodiamine on Fish, Pesticide Action Network.
http://www.pesticideinfo.org/PCW/List_AquireAcuteSum.jsp?CAS_No=29091-21-2&Rec_Id=PC34255&Taxa_Group=Fish |
Common
Name |
Scientific
Name |
Avg
Species LC50 (ug/L) |
LC50
Std Dev |
Number
of Studies |
Avg
Species Rating |
Fish |
Sheepshead
minnow |
Cyprinodon variegatus |
450.0 |
- |
1 |
Highly
Toxic |
Channel
catfish |
Ictalurus
punctatus |
76,000 |
24,000 |
2 |
Slightly
Toxic |
Bluegill |
Lepomis
macrochirus |
7,777 |
8,428 |
3 |
Moderately
Toxic |
Rainbow
trout,donaldson trout |
Oncorhynchus
mykiss |
829.0 |
- |
1 |
Highly
Toxic |
|
Pro |