Return to Index

Activity: Insecticide, Wood Preservative (Inorganic)

Structure:

Adverse Effects:
Blood
Bone
CNS
Heart

Blood • Bone • CNS • Heart (click on for all pesticides)

LD50 ranges of sodium, potassium, or ammonium fluorosilicates administered intragastrically in rats and mice were 89-128 and 45-64 mg fluoride ion/kg, respectively. Severe cornea damage was observed 3 hr after the administration of 50 mg of any of the salts into rabbits' eyes. Min toxic dose (intragastric) of fluorosilicic acid in rats was 8 mg/kg. Min toxic concn in 4 hr inhalation of the salt aerosols were 7.4-9.6 mg/cu m; nontoxic concn was 0.8 mg/cu m. Main toxic effects were decreased activities of cholinesterase and lactate dehydrogenase in blood serum. The intragastric effects of the fluorosilicates were similar to and additive with those of sodium fluoride. [Rumyantser GI et al; Oig Sanit (11): 80-2 (1988)]
Ref: TOXNET profile from Hazardous Substances Data Bank for AMMONIUM SILICOFLUORIDE.
http://www.fluoridealert.org/pesticides/Ammonium.Silicofluor.TOXNET.htm

Abstract: International Chemical Safety Card. Exposure routes: inhalation and ingestion. Short term exposure effects: irritation of the skin, eyes and respiratory tract; effects on the calcium metabolism, resulting in cardiac disorders and impaired function. Long-term exposure effects: effects on the bone, resulting in fluorosis. Threshold limit value: 2.5mg/m3 (TWA) as fluorine (ACGIH 1997-1998).
Ref: Ref: [Potassium hexafluorosilicate]. Source: English/French versions: Internet documents, 1999. Spanish version: Instituto Nacional de Seguridad e Higiene en el Trabajo, Ediciones y Publicaciones, c/Torrelaguna 73, 28027 Madrid, Spain, 1991. 2p. Illus. As cited at Toxline at Toxnet.