Adverse Effects
Nuarimol
CAS No.
63284-71-9

 
 

Return to Nuarimol Index Page

Activity: Fungicide (pyrimidine)
Structure:


Adverse Effects:
Ataxia
Body Weight Decrease
Liver

UK Pesticide Safty Directorate:
PSD were advised in June 2003 that the active substance nuarimol was not being supported in the EU review programme. This active substance has a limited use in the UK on barley for control of mildew and Rhynchosporium, but has not been commercially available for some while. PSD has concluded that an essential use derogation for this active substance is therefore not justified.

Ref: http://www.pesticides.gov.uk/farmers/minor_uses/essential_use_update1.htm

The EPA has refused to set a permissible amount of residue (known as food residue tolerances) for both haloxyfop and nuarimol, a DowElanco product sold under the trade names "Gauntlet" and "Tridal." The EPA refused to permit any nuarimol residues on food because it creates cancer and birth defects in laboratory animals. Nevertheless, Greenpeace reports that nuarimol is used in Africa, Colombia and Honduras and Europe. Though the EPA technically bans haloxyfop or nuarimol residues on food sold in the United States, they are likely to appear anyway, since "food is rarely tested for residues at the border," according to the Greenpeace report.
Ref: CORPORATE PROFILE DOW: THE MENACE FROM MIDLAND
http://multinationalmonitor.org/hyper/issues/1991/07/mm0791_10.html

See also: 1992 Greenpeace report:
"Never-Registered Pesticide"


US EPA Index of Cleared Science Reviews Nuarimol (Pc Code 224100)
http://www.epa.gov/opppmsd1/foia/reviews/224100.htm

May 3, 1985. Review. 33 Page(s).
Anonymous. Dynamac Corporation.
Nuarimol Final Report 
Task 1: Review and Evaluation of Individual Studies 
Task 2: Environmental Fate and Exposure Assessment 

Acc. No. 073331.


See box at bottom for studies submitted to US EPA by Eli Lilly in 1992

Ataxia (click on for all fluorinated pesticides)

Exposure to nuarimol causes both acute and chronic effects. It is moderately acutely toxic, with a WHO classification of Class III, or "slightly hazardous" and a rat oral LD50 of 1250 mg/kg. (24) DowElanco data indicates a single oral as well as inhalation exposure of the product caused laboratory rats to exhibit reduced activity, clonic convulsion (muscle contraction), ataxia (loss of balance and coordination), labored breathing, reduced weight gain, and coma. Laboratory animals exhibited increases in liver weight and enzyme activity and microscopic liver cell changes when repeatedly exposed to the product. (8) The product is also an eye irritant. (8,16,21) As mentioned above, EPA has concerns over the product's ability to cause cancer and birth defects in lab animals. (10)
Ref: NEVER-REGISTERED PESTICIDES: Rejected Toxics Join the "Circle of Poison." Greenpeace USA Pesticide Campaign report. By Sandra Marquardt, Laura Glassman and Elizabeth Sheldon. February 1992.

http://www.fluoridealert.org/pesticides/Nuarimol.Greenpeace.1992.htm

Body Weight Decrease (click on for all fluorinated pesticides)

Exposure to nuarimol causes both acute and chronic effects. It is moderately acutely toxic, with a WHO classification of Class III, or "slightly hazardous" and a rat oral LD50 of 1250 mg/kg. (24) DowElanco data indicates a single oral as well as inhalation exposure of the product caused laboratory rats to exhibit reduced activity, clonic convulsion (muscle contraction), ataxia (loss of balance and coordination), labored breathing, reduced weight gain, and coma. Laboratory animals exhibited increases in liver weight and enzyme activity and microscopic liver cell changes when repeatedly exposed to the product. (8) The product is also an eye irritant. (8,16,21) As mentioned above, EPA has concerns over the product's ability to cause cancer and birth defects in lab animals. (10)
Ref: NEVER-REGISTERED PESTICIDES: Rejected Toxics Join the "Circle of Poison." Greenpeace USA Pesticide Campaign report. By Sandra Marquardt, Laura Glassman and Elizabeth Sheldon. February 1992.

http://www.fluoridealert.org/pesticides/Nuarimol.Greenpeace.1992.htm

Liver (click on for all fluorinated pesticides)

Abstract: Early hepatic changes induced by nuarimol (63284719) were studied in rats. Male Wistar-rats were administered 0, 31.5, 62.5, or 125mg/kg nuarimol orally daily for up to 5 days. Selected rats were killed after 1, 3, or 5 days of exposure or 10 days after the last dose and weighed. The livers were removed and weighed and liver tissues were assayed for p-nitroanisole-O-demethylase (PNAD). The DNA was isolated and the effects of nuarimol on DNA synthesis were evaluated by measuring uptake of tritiated thymidine. Fragments of liver tissue were examined for histopathological changes. The number of hepatocytes undergoing mitosis was determined. Nuarimol did not affect body weight. Administration of three doses of 62.5 and 125mg/kg nuarimol significantly increased relative liver weight. The 31.5mg/kg dose did not affect liver weight. PNAD activity was significantly increased after the first doses of 62.5 and 125mg/kg nuarimol. Three doses of 31.5mg/kg nuarimol were required to induce a significant increase in PNAD activity. Single doses of nuarimol caused a dose dependent increase in DNA synthesis and the mitotic index. After three and five doses, the level of DNA synthesis decreased, returning to the control level after five doses. After five doses of 31.5, 62.5, and 125mg/kg nuarimol mitotic activity returned to the control value. Nuarimol caused time dependent increases in the number of binucleated hepatocytes. One and three administrations caused a dose related increase in cytoplasmic vacuolization and focal destruction of centrilobular hepatocytes. These changes partially disappeared after five doses. The authors conclude that the early hepatic effects of nuarimol include increases in PNAD activity and cellular hyperplasia, as manifested by increases in the level of DNA synthesis and mitotic activity. The increase in the number of binucleated hepatocytes and signs of necrosis suggest that the hepatomitogenic effect of nuarimol may reflect a regeneration response.
Ref: Kostka G et al (1994). Early Hepatic Changes Induced by Nuarimol in Rats. Journal of Applied Toxicology, Vol. 14, No. 5, pages 337-342. As cited at Toxnet.

Exposure to nuarimol causes both acute and chronic effects. It is moderately acutely toxic, with a WHO classification of Class III, or "slightly hazardous" and a rat oral LD50 of 1250 mg/kg. (24) DowElanco data indicates a single oral as well as inhalation exposure of the product caused laboratory rats to exhibit reduced activity, clonic convulsion (muscle contraction), ataxia (loss of balance and coordination), labored breathing, reduced weight gain, and coma. Laboratory animals exhibited increases in liver weight and enzyme activity and microscopic liver cell changes when repeatedly exposed to the product. (8) The product is also an eye irritant. (8,16,21) As mentioned above, EPA has concerns over the product's ability to cause cancer and birth defects in lab animals. (10)
Ref: NEVER-REGISTERED PESTICIDES: Rejected Toxics Join the "Circle of Poison." Greenpeace USA Pesticide Campaign report. By Sandra Marquardt, Laura Glassman and Elizabeth Sheldon. February 1992.

http://www.fluoridealert.org/pesticides/Nuarimol.Greenpeace.1992.htm

Studies submitted to USEPA by Eli Lilly in 1992.
There probably are more studies that have not been made publicly available -
check with Toxline at Toxnet. The following were available on Toxline on Dec 8, 2004.

• Note: FAN would like to obtain these studies. If you have copies and are willing to share, FAN will reimburse postage and reasonable copying fees. Or send your copy to us and we will copy and return. Thanks. EC

Order No. Title Keywords Source
NTIS/OTS0543004 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & CO TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE INHALATION STUDY WITH NUARIMOL AND CAPTAN IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920004689
NTIS/OTS0543029 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004714
NTIS/OTS0543030 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004715
NTIS/OTS0543031 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004716
NTIS/OTS0543032 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL N RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004717
NTIS/OTS0543033 1992 -   INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004718
NTIS/OTS0543034 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL AND TRIDEMORPH IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004719
NTIS/OTS0543035 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004720
NTIS/OTS0543036 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004721
NTIS/OTS0543037 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004722
NTIS/OTS0543038 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS ATTACHMENTS   ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004723
NTIS/OTS0543039 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004724
NTIS/OTS0543040 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004725
NTIS/OTS0543041 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004726
NTIS/OTS0543042 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004727
NTIS/OTS0543043 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE INHALATION STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920004728
NTIS/OTS0543044 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE INHALATION STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920004729
NTIS/OTS0543045 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE INHALATION STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920004730
NTIS/OTS0543046

1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL TOXICITY STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS

ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004731
NTIS/OTS0543048 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004733
NTIS/OTS0543060 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING ENCLOSED RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL IN RATS WITH ATTACHMENT ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004745
NTIS/OTS0543110
1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND LINDANE IN RATS WITH ATTACHMENT
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004795
NTIS/OTS0543112 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND LINDANE IN RATS WITH ATTACHMENT ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920004797
NTIS/OTS0543113 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND CAPTAN IN RATS WITH ATTACHMENT ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004798
NTIS/OTS0543114
1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL IN RATS WITH ATTACHMENT
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004799
NTIS/OTS0543117 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND SOLFOSAN IN RATS WITH ATTACHMENT ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE

EPA/OTS; Doc #88-920004802
NTIS/OTS0543118 1992 - RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND SOLFOSAN IN RATS WITH ATTACHMENTS
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004803
NTIS/OTS0543119 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL AND LINDANE IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004804
NTIS/OTS0543120 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & COMPANY TO USEPA SUBMITTING RESULTS ON AN ACUTE ORAL STUDY WITH NUARIMOL IN RATS WITH ATTACHMENTS ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920004805
NTIS/OTS0543769 1992 - INITIAL SUBMISSION: ALPHA-(2-CHLOROPHENYL)-1-ALPHA-(4-FLUOROPHENYL)-5-PYRIMIDINEMETHANOL: TWO-YEAR DIETARY EVALUATION IN THE ICR MOUSE WITH COVER SHEET & LETTER DATED 08-21-92 ELI LILLY & CO
ALPHA-(2-CHLOROPHENYL)-1-
ALPHA-(4-FLUOROPHENYL)-5-
PYRIMIDIN*
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
MICE
ORAL
DIET
EPA/OTS; Doc #88-920006697
NTIS/OTS0544617 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND IMAZALIL WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL AND IMAZALIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005960
NTIS/OTS0544618 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL, MANEBE, AND MANCOZEBE WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL, MANEBE, AND MANCOZEBE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005961
NTIS/OTS0544619 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND CHLOROTHALONIL WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL AND CHLOROTHALONIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005962
NTIS/OTS0544620 1992 -   INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL, THIRAM, AND LINDANE WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL, THIRAM, AND LINDANE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005963
NTIS/OTS0544623 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND CHLOROTHALONIL WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL AND CHLOROTHALONIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005966
NTIS/OTS0544624 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL, THIRAM, AND LINDANE WITH COVER LETTER DATED 08-03-92 ELI LILLY & CO
NUARIMOL, THIRAM, AND LINDANE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005967
NTIS/OTS0544625 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL, THIRAM, AND LINDANE WITH COVER LETTER DATED 08-03-92 AND ATTACHMENT ELI LILLY & CO
NUARIMOL, THIRAM, AND LINDANE
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005968
NTIS/OTS0544626 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND IMAZALIL WITH COVER LETTER DATED 08-03-92 AND ATTACHMENT ELI LILLY & CO
NUARIMOL AND IMAZALIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005969
NTIS/OTS0544627 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND CHLOROTHALONIL WITH COVER LETTER DATED 08-03-92 AND ATTACHMENT ELI LILLY & CO
NUARIMOL AND CHLOROTHALONIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005970
NTIS/OTS0544628 1992 - INITIAL SUBMISSION: ACUTE RAT ORAL STUDY WITH NUARIMOL AND CHLOROTHALONIL WITH COVER LETTER DATED 08-03-92 AND ATTACHMENT ELI LILLY & CO
NUARIMOL AND CHLOROTHALONIL
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920005971
NTIS/OTS0545091 1992 - INITIAL SUBMISSION: THREE-MONTH SUBACUTE ORAL TOXICITY STUDIES WITH NUARIMOL IN MICE WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
MICE
ORAL
DIET
EPA/OTS; Doc #88-920006492
NTIS/OTS0545117 1992 - INITIAL SUBMISSION: LETTER FROM ELI LILLY & CO SUBMITTING TWO CHRONIC RAT ORAL TOXICITY STUDIES WITH A-(2-
CHLOROPHENYL)-A-(4-
FLUOROPHENYL)-5-PYRIMIDINEMETHANOL
ELI LILLY & CO
A-(2-CHLOROPHENYL)-A-(4-
FLUOROPHENYL)-5-
PYRIMIDINEMETHANOL
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006518
NTIS/OTS0545119
1992 - INITIAL SUBMISSION: ONE-YEAR ORAL TOXICITY STUDY WITH NUARIMOL IN BEAGLE DOGS WITH COVER LETTER DATED 08-21-92
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
DOGS
ORAL
GAVAGE
EPA/OTS; Doc #88-920006520
NTIS/OTS0545123 1992 - INITIAL SUBMISSION: SUBCHRONIC INHALATION TOXICITY STUDY WITH NUARIMOL IN FISCHER 344 RATS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
EPA/OTS; Doc #88-920006524
NTIS/OTS0545125 1992 - INITIAL SUBMISSION: A MULTI-GENERATION REPRODUCTION STUDY WITH NUARIMOL IN FISCHER 344 RATS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
COMBINED TERATOGENICITY/REPRODUCTIVE EFFECTS
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006526
NTIS/OTS0545127 1992 - INITIAL SUBMISSION: A PILOT REPRODUCTION STUDY WITH NUARIMOL IN RABBITS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
ORAL
GAVAGE
EPA/OTS; Doc #88-920006528
NTIS/OTS0545128 1992 - INITIAL SUBMISSION: A TERATOLOGY STUDY WITH NUARIMOL IN RABBITS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
ORAL
GAVAGE
EPA/OTS; Doc #88-920006529
NTIS/OTS0545130 1992 - INITIAL SUBMISSION: A ONE-YEAR DIETARY TOXICITY STUDY WITH NUARIMOL IN MICE WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
CHRONIC TOXICITY
MAMMALS
MICE
ORAL
DIET
EPA/OTS; Doc #88-920006531
NTIS/OTS0545145
1992 - INITIAL SUBMISSION: A ONE-YEAR DIETARY TOXICITY STUDY WITH NUARIMOL IN RATS WITH COVER LETTER DATED 08-21-92
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
CHRONIC TOXICITY
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006546
NTIS/OTS0545146 1992 - INITIAL SUBMISSION: FERTILITY OF MALE WISTAR RATS EXPOSED TO NUARIMOL PRENATALLY AND THROUGHOUT POSTNATAL LIFE WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006547
NTIS/OTS0545184 1992 - INITIAL SUBMISSION: A CROSS-OVER REPRODUCTION STUDY WITH NUARIMOL IN RATS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
EPA/OTS; Doc #88-920006585
NTIS/OTS0545237 1992 - INITIAL SUBMISSION: AN ENZYME INDUCTION STUDY WITH NUARIMOL IN FISCHER 344 RATS WITH COVER LETTER DATED 08-21-92 ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006699
NTIS/OTS0545244
1992 - INITIAL SUBMISSION: A TWO-YEAR DIETARY EVALUATION WITH NUARIMOL IN RATS WITH COVER LETTER DATED 08-21-92
ELI LILLY & CO
NUARIMOL
HEALTH EFFECTS
CHRONIC TOXICITY
MAMMALS
RATS
ORAL
DIET
EPA/OTS; Doc #88-920006706
NTIS/OTS0570704 1992 - INITIAL SUBMISSION: ACUTE DERMAL TOXICITY OF 5-PYRIMIDINEMETHANOL, A-(2-
CHLOROPHENYL)-A-(4-FLUROPHENYL)- IN RABBITS WITH COVER LETTER DATED
08-18-92
ELI LILLY & CO
5-PYRIMIDINEMETHANOL, A-
(2-CHLOROPHENYL)-A-(4-
FLUOROPHENYL)H
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RABBITS
DERMAL
EPA/OTS; Doc #88-920008422

 

 
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