little toxicological information available.
Not allowed to be used as an active ingredient after July
WHO: believed obsolete or discontinued
Major Uses : 1-CHLORO-4-(TRIFLUOROMETHYL)BENZENE - Intermediate
for herbicides with a diphenyl ether structure -
fluorodifen and acifluorfen
- and the insecticide fluvalinate.
Hazardous Substances Data Bank for
1-CHLORO-4-(TRIFLUOROMETHYL)BENZENE CASRN: 98-56-6.
4-CHLORO-3-NITROBENZOTRIFLUORIDE CASRN: 121-17-5
Major Uses : CHEM INT FOR HERBICIDES,
Ref: Hazardous Substances
Data Bank for 4-CHLORO-3-NITROBENZOTRIFLUORIDE CASRN: 121-17-5.
Available at Toxnet.
(click on for all fluorinated pesticides)
Twenty-two herbicides were studied in 67 tests for induction of
DNA damage, gene mutation and chromosomal changes in vitro and
in vivo. Triazine and urea-type herbicides were found to be inactive
in all but one test. Of 4 thiocarbamates, molinate and vernolate
caused chromosomal changes, namely increased incidence of sister
chromatid exchanges and chromosomal aberrations in vitro and increased
frequency of micronucleated polychromatic erythrocytes in mouse
bone marrow. These compounds, however, did not cause gene mutation
and only molinate gave equivocal positive result in bacterial
repair test. Out of 11 miscellaneous herbicides, ethofumesate,
alachlor, dichlorprop and fluorodifen proved
to be positive only in one or two tests. In the light of
clastogenicity of some thiocarbamates, serious consideration should
be given to start animal carcinogenicity studies with these chemicals.
Ref: Pinter A et al. (1989). Genotoxicity
of selected herbicides. Ann
Ist Super Sanita; 25(4):577-82.