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Return
to Flumetsulam Index Page
Activity: Herbicide
(triazolopyrimidine)
Structure:
Adverse
Effects:
Kidney
Environmental
•
Very little toxicological data available up to September
24, 2004, when EPA released the following documents. EPA
lists Flumetsulam as a "low-risk" pesticide, however,
several studies have not been done, eg:
-- A
neurotoxicity study was not conducted,
-- A 90-day inhalation study and a
subchronic dog study were not conducted
-- A developmental neurotoxicity study
is not required since there was no evidence of neurotoxicity
or neuropathy from the available studies.
-- Due to the lack of repeated dose
inhalation toxicity study, oral studies were selected
for the appropriate duration of exposure. Absorption via
inhalation is assumed to be equivalent to oral absorption.
| TRED
(Tolerance Reassessment Decision) (TRED) documents: |
| Sept
9, 2004 |
Report
of the Food Quality Protection Act (FQPA) Tolerance
Reassessment Progress and Risk Management Decision
(TRED) for Flumetsulam
5
pages |
Signed
by:
Debra
Edwards,
Director, Special Review and Reregistration Div.
Mika
J. Hunter
- contact for questions regarding this decision. |
EPA
OPPT (7508C) |
| Aug
31, 2004 |
Flumetsulam:
HED Risk Assessment for the Tolerance Reassessment
Eligibility Document (TRED).
23
pages |
Memorandum
From:
Elissa
Reaves,
Toxicologist Reregistration Branch II, Health Effects
Div. (7509C) |
EPA
OPPT (7509C) |
| Aug
30, 2004 |
Flumetsulam.
Chronic Dietary Exposure Assessment for the TRED document.
8
pages |
Memorandum
From:
Samuel
Ary,
Chemist, Reregistration Branch II, Health Effects
Div. (7509C) |
EPA
OPPT (7509C)
DP
Barcode: D306279
PC
Code: 129016 |
| Aug
31, 2004 |
Flumetsulam.
Summary of Analytical Chemistry and Residue Data for
the Tolerance Reassessment Eligibility Decision (TRED)
Document.
32
pages |
Memorandum
From:
Samuel
Ary,
Chemist
Reregistration Branch II, Health Effects Div. (7509C)
This
summary of analytical chemistry and residue data document
was originally prepared under contract by Versar,
Inc. (Springfield, VA 22151; submitted June
11, 2004). |
EPA
OPPT (7509C)
DP
Barcode: D306242
PC Code: 129016 |
| May
19, 2004 |
Drinking
Water Assessment for Flumetsulam for Uses on Field
Corn and Soybeans
15
pages
|
Memorandum
From:
James
Lin,
Environmental Engineer,
Stephanie Syslo, RAPL
Environmental Risk Branch III Environmental Fate and
Effects Div. (7507C) |
EPA
OPP (7507C)
PC Code: 129016
DPBarcode: 301361 |
•
As of February 16, 2005, this herbicide is permitted in
or on the food commodities
corn and soybean in the United States - see list at the
bottom of page.
|
Kidney
(click on for all fluorinated
pesticides)
-- 90-Day oral toxicity, Rat - NOAEL (M/F) 250 mg/kg/day. LOAEL
(M/F) 1000 mg/kg/day based on severe bilateral
tubular-interstitial nephritis.
-- -- The
kidney appears to be the primary target organ of rats and dogs
following subchronic to chronic exposures.
Ref: August 31, 2004: Flumetsulam:
HED Risk Assessment for the Tolerance Reassessment Eligibility
Document (TRED).
Chronic toxicity. In
a 1-year dietary study in dogs, the NOEL was 100 mg/kg/day and
the LOEL was 500 mg/kg/day. The animals were administered feed
containing 0, 20, 100, and 500 mg/kg/day. Reduced body weights
and inflammatory and atrophic changes in
the kidneys occurred in the
500 mg/kg/day dose groups. In a combined feeding carcinogenicity/chronic
study in mice there were no treatment-related effects and there
was no evidence of a carcinogenic response. Systemic NOEL was
greater than or equal to 1,000 mg/kg/day (limit dose); a LOEL
was not established. In a combined feeding carcinogenicity/chronic
study in rats, renal pathological alterations
were seen in males. No treatment-related effects were seen
in females at the highest dose (1,000 mg/kg/day) which is the
limit dose. There was no carcinogenic response. The NOELs were
500 mg/kg/day in males and 1,000mg/kg/day in females. The LOEL
was 1,000 mg/kg/day in males; a LOEL was not established in females.
Based on the chronic toxicity data, EPA has established the RfD
for flumetsulam at 1.0 milligram (mg)/kilogram (kg)/day. The RfD
for flumetsulam is based on the 1-year chronic study in dogs with
a NOEL of 100 mg/kg/day and an uncertainty (or safety) factor
of 100. Thus, it would not be necessary to require the application
of an additional uncertainty factor above the 100-fold factor
already applied to the NOEL.
Ref: Federal Register: September 17, 1997
[Notices] [Page 48842-48848]. Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Flumetsulam.FR.Sept.17.1997.htm
| Environmental
(click on for all fluorinated
pesticides)
Abstract:
... To obtain information on the occurrence of SU, SA, and
IMI herbicides in the Midwestern United States, 212 water
samples were collected from 75 surface-water and 25 ground-water
sites in 1998. These samples were analyzed for 16 SU, SA and
IMI herbicides by USGS Methods Research and Development Program
staff using high-performance liquid chromatography/mass spectrometry.
Samples were also analyzed for 47 pesticides or pesticide
degradation products. At least one of the 16 SUs, SAs or IMIs
was detected above the method reporting limit (MRL) of 0.01
microg/l in 83% of 130 stream samples. Imazethapyr was detected
most frequently (71% of samples) followed
by flumetsulam (63% of samples)
and nicosulfuron (52% of samples)...
Ref: Battaglin WA et al (2000).
Occurrence of sulfonylurea, sulfonamide, imidazolinone, and
other herbicides in rivers, reservoirs and ground water in
the Midwestern United States, 1998. Sci Total Environ. Apr
5;248(2-3):123-33.
http://www.fluorideaction.org/pesticides/flumetsulam.abstracts.htm
Flumetsulam.
Data from Pesticide Action Network
http://www.pesticideinfo.org/PCW/List_AquireAcuteSum.jsp?CAS_No=98967-40-9&Rec_Id=PC35035
|
| Common
Name |
Scientific
Name |
Avg
Species LC50 (ug/L) |
Number
of Studies |
Avg
Species Rating |
| FISH |
| Bluegill |
Lepomis
macrochirus |
300.0 |
1 |
Highly
Toxic |
| Atlantic
silverside |
Menidia menidia |
380.0 |
1 |
Highly
Toxic |
| Rainbow
trout,donaldson trout |
Oncorhynchus
mykiss |
300.0 |
1 |
Highly
Toxic |
| Fathead
minnow |
Pimephales promelas |
293.0 |
1 |
Highly
Toxic |
| ZOOPLANKTON |
| Marsh
grass shrimp |
Palaemonetes vulgaris |
349.0 |
1 |
Highly
Toxic |
|
| A
February
16, 2005,
check at the Code
of Federal Regulations for Flumetsulam: this herbicide is
permitted in or on 4 food
commodities in the United States.
The
following list identifies these crops for which EPA has set
pesticide tolerances. |
| [Code
of Federal Regulations]
[Title 40, Volume 22]
[Revised as of July 1, 2004]
From the U.S. Government Printing Office via GPO Access
[CITE: 40CFR180.468]
[Page 465]
TITLE 40--PROTECTION OF ENVIRONMENT
CHAPTER I--ENVIRONMENTAL PROTECTION AGENCY (CONTINUED)
PART 180_TOLERANCES AND EXEMPTIONS FROM TOLERANCES FOR PESTICIDE
CHEMICALS
IN FOOD--Table of Contents
Subpart C_Specific Tolerances
Sec. 180.468 Flumetsulam; tolerances for residues.
Tolerances are established for residues of the herbicide
flumetsulam, N-(2,6-difluorophenyl)-5-methyl-(1,2,4)-triazolo-[1,5a]-
pyrimidine-2-sulfonamide, in or on the following raw agricultural
commodities: |
| Commodity |
Parts
per million |
| Corn,
field, grain |
0.05 |
| Corn,
field, forage |
0.05 |
| Corn,
field, stover |
0.05 |
| Soybean |
0.05 |
[58
FR 57967, Oct. 28, 1993]
[[Page
466]] |
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