Potential Adverse Effects
CAS No. 86811-58-7

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Activity: Acaricide (benzoylphenyl urea)

• Note: As there is little data available on Fluazuron, we include the following.

The northern fowl mite, Ornithonyssus sylviarum, is the major ectoparasite of poultry flocks in Ontario and North America causing millions of dollars in damage to the industry (est. $2M for Ontario). Traditionally, northern fowl mites have been controlled using a variety of dermally applied acaricides. The efficacy of the experimental systemic acaricide, Fluazuron® (CGA 157419) to control northern fowl mites on chickens was determined. Fluazuron® effectively eliminated mite populations on infested birds when administered at 10 mg active ingredient per kilogram of body weight. Although mite populations declined on birds treated repeatedly with 1 or 3 mg of Fluazuron® per kg of body weight, birds treated at these dosages remained infested. Based on analysis of mite population age structure and percent hatch of deposited eggs, the mode of action of Fluazuron® on mites was unclear. Fluazuron® residues could be measured in adipose up to 123 days following treatment with 10 mg/kg and trace amounts of the drug were consistently observed in breast meat up to 30 days after treatment. Thus unless the legal tolerance for Fluazuron® residues in selected tissues are modified, this product has little chance of registration for control of northern fowl mites, despite its observed efficacy against these ectoparasites.
Ref: Ontario Agriculture, Food, and Rural Affairs (Canada)Research Projects Summary. FOOD SYSTEMS 2002 - PEST MANAGEMENT RESEARCH PROGRAM. *FS7143 - Evaluation of the Benzoylphenyl Urea, Lufenuron7 for Control of the Northern Fowl Mite, Ornithonyssus Sylviarum

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Cattle Oral application of 2.0 mg/kg b.w. of fluazuron gives rise to more rapid absorption and maintains higher level of fluazuron in the bloodstream of cattle than a dermal treatment at the same dose level (Bull and Strong, 1994). The compound distributed to the tissues such as muscle, kidney, liver, lung and brain but deposited preferentially in the fat. When the radiolabelled fluazuron was administered subcutaneously to cattles at 1.5 mg/kg b.w., the mean maximum plasma level of total radioactivity was reached in 48 hours post dose. The radioactivity was absorbed slowly from the site of injection. Half life of the radioactivity in the blood was around 78 days (Cameron, B.D., Somers, K. and Speirs, G.C. (1992). The Distribution and Excretion of [U-14C]Cl-Phenyl CGA 157419 after Subcutaneous Injection to Cattle. Unpublished report No. 141232. Inveresk Research International Limited, Tranent, Scotland. Submitted to JECFA by Ciba-Geigy Limited, Basle, Switzerland.)
Ref: Fluazuron. UN Food and Agriculture Organization. First draft prepared by Dr. P. S. Tantiyaswasdikul, Department of Pharmacology, Faculty of Pharmaceutical Sciences Chulalongkorn University, Bangkok, Thailand.


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