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Activity: Herbicide
(pyrazolylphenyl)
Structure:
Adverse
Effects:
Contamination
incident
Environmental
•
No Toxicological studies available
| Herbicides
(TRADE) |
Registrant
|
Chemistry |
Pest
Control Spectrum/Traits |
Status
|
Fluazolate
(JV 485) |
Bayer
Crop Science and Monsanto |
Pyrazole
Benzoate |
Pre-emergence
control of broadleaf weeds and grasses |
Registered
on corn. Potential use on wheat.
[FAN note: not registered in the US as
of Oct 1, 2003] |
Ref:
IR-4 NEW PRODUCTS/TRANSITIONAL SOLUTION LIST - July 2002 Compiled
by J. Baron, IR-4 Project
http://pmep.cce.cornell.edu/ir4/chemical_list_702.html
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Contamination
/ Environmental
(click on for all fluorinated
pesticides)
--
5.1 - Members
considered the first evaluation of a full safety and efficacy
dossier supporting an application for approval of fluazolate,
a new herbicide intended for pre-emergence use on winter wheat
for control of annual grasses and broad-leaved weeds.
-- 5.2
- The Committee confirmed that they considered two
of the metabolites (M01 and M06) to be "relevant metabolites"
in terms of the Uniform Principles and that there would therefore
be a legal requirement to prevent these
metabolites from entering groundwater at predicted concentrations
above 0.1 m g/l. The Committee agreed that there may be scope
to achieve this using a regulatory approach that prevented the
product being used on certain soil series. However, this approach
would only be viable if it were shown to be enforceable and could
be audited. The Committee noted that this kind of approach might
become more practical as a consequence of ongoing developments
such as the DEFRA Geographical Information System (GIS) field
mapping project.
5.3 - In addition to the problem of ground
water contamination by metabolites, the Committee identified
several other issues that would need to be resolved before approval
could be recommended. Reference values could not be set due to
evidence from observations in humans following
a contamination incident, which suggested
that fluazolate was absorbed and that a
biological effect occurred at lower doses than those which produced
effects in animal studies. There were also concerns
over certain aspects of the reproductive toxicity studies in animals.
The Committee agreed that toxicological data would be required
on the metabolite M06 if significant
human exposures were predicted to result
from contamination of groundwater or residues in
following crops. There were also concerns regarding the buffer
zone distance that would be needed to manage the risk to algae
in UK, and about possible risks to non-target plants and
adjacent crops.
5.4 - The Committee concluded that until these various
issues have been resolved, approval could not be recommended.
Ref: UK Advisory Committee on Pesticides.
January 17, 2002.
http://www.fluorideaction.org/pesticides/fluazolate.uk.jan17.2002.htm
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