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Activity: Acaricide, Insecticide (bridged diphenyl)
Structure:

Adverse Effects:
• Brain
• Environmental
• Potent mitochondrial uncoupler

• No toxicological studies accessible

Brain (click on for all fluorinated pesticides)

PubMed abstract title: Observations on 2'-chloro-2,4-dinitro-5',6-di(trifluoromethyl)-diphenylamine-induced edema in the white matter of the central nervous system of the rat.
Ref: Lock EA, Scales MD, Little RA. Toxicol Appl Pharmacol 1981 Aug;60(1):121-30.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7281170&dopt=Abstract

Potent mitochondrial uncoupler

Abstract. Studies on an acaricide with mitochondrial uncoupling activity [fentrifanil; 2'-chloro-2,4-dinitro-5',6-di(trifluoromethyl)-diphenylamine] are presented. Isolated mitochondria (from mice livers) were incubated with fentrifanil, and oxygen uptake was measured polarographically using a Clark oxygen electrode. The ADP ratio, respiratory control index (RCI), and stimulation of state 4 respiration were also measured. Fentrifanil was found to stimulate oxygen consumption, reduce the RCI, lower the ADP/O ratio, and release the oligomycin block of ADP-stimulated respiration. In terms of the concentration required to decrease the RCI value by 50%, fentrifanil was about 4500-fold more potent than 2,4-dinitrophenol and slightly more potent than carbonylcyanide m-chlorophenylhydrazone (MCCP).
Ref: Biochem Biophys Res Commun 1980 Sep 30;96(2):704-10
Fentrifanil: a diarylamine acaricide with potent mitochondrial uncoupling activity.
Nizamani SM, Hollingworth RM.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7426009&dopt=Abstract