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Return
to Benzotrifluoride
Index Page
ACTIVITY: Insecticide
Also
known as Trifluoromethylbenzene
Structure:
Adverse Effects:
Body Weight Decrease
CNS
Eye
Kidney
Liver
Lung
Environmental
Major
Uses:
IN
MANUFACTURE OF SUBSTITUTED BENZOTRIFLUORIDES [Budavari,
S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs
and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989.
173]
CHEM
INT FOR LAMPREYCIDE, 3-HYDROXY-6-NITROBENZOFLUORIDE;
AGENT IN DIELECTRIC FLUIDS; CHEM INT FOR DYES, PHARMACEUTICALS,
COMPD USED IN HIGH POLYMER CHEMISTRY & INT IN OTHER MISC
APPLICATIONS [SRI]
SOLVENT;
VULCANIZING AGENT; INSECTICIDES [Lewis,
R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993
133]
Manufacturers:
OCCIDENTAL
PETROLEUM CORP, HOOKER CHEM CORP, SUBSID, HOOKER CHEMS AND
PLASTICS CORP, SUBSID, ELECTROCHEMICAL AND SPECIALTY CHEMS
DIV, NIAGARA FALLS, NY 14303 [SRI]
Ref:
Hazardous Substance Data Bank.
http://www.fluorideaction.org/pesticides/benzotrifluoride.toxnet.hsd.htm
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Body
Weight Decrease
(click
on for all fluorinated pesticides)
-- Trifluoromethylbenzene
was studied for oral toxicity in Crj:CD (SD) rats in an OECD combined
repeat dose and reproductive/developmental toxicity screening
test at doses of 0, 20, 100 and 500 mg/kg/day... Depression
of body weight gain in offspring of all treatment groups
was observed without any necropsy findings. The NOELs are considered
to be 500 mg/kg/day for reproductive performance of the parents
and less than 20 mg/kg/day for offspring development.
Ref:
1988. GINC: Global Information Network on Chemicals. The Databases
of Chemicals.
http://www.fluorideaction.org/pesticides/benzotrifluoride.toxicity.htm
CNS
(click
on for all fluorinated pesticides)
-- TARGET ORGANS: Central
Nervous System, Eyes, Skin, Respiratory Tract.
-- SHORT-TERM EXPOSURE (ACUTE) INHALATION: May produce symptoms
of central nervous system depression including
headache, dizziness, nausea, loss of balance and drowsiness.
Ref: BENZOTRIFLUORIDE Material Safety Data
Sheet. OxyChem. Issue Date: 07-08-98
http://www.oxychem.com/products/msds/m7644.pdf
-- Human Health Effects:
Human Toxicity Excerpts: TOXIC BY INHALATION. [Hawley, G.G. The
Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand
Reinhold Co., 1977. 100]
-- Animal Toxicity Studies Non-Human Toxicity Excerpts: Moderate
toxic by animal-experiment; effective to
central nervous system. [ITII. Toxic
and Hazardous Industrial Chemicals Safety Manual. Tokyo, Japan:
The International Technical Information Institute, 1988. 68]
Ref: TOXNET profile from Hazardous Substances
Data Base.
http://www.fluoridealert.org/pesticides/Benzotrifluoride.TOXNET.HSD.htm
Eye
(click
on for all fluorinated pesticides)
TARGET
ORGANS: Central
Nervous System, Eyes, Skin,
Respiratory Tract.
Ref: BENZOTRIFLUORIDE Material Safety Data
Sheet. OxyChem. Issue Date: 07-08-98
http://www.oxychem.com/products/msds/m7644.pdf
SYMPTOMS: This comound
is extremely destructive to the mucous membranes, upper respiratory
tract, skin and eyes. Inhalation
may be fatal as a result of spasm, inflammation and edema of the
larynx and bronchi; chemical pneumonitis and pulmonary edema.
Other symptoms include a burning sensation, coughing, wheezing,
laryngitis, shortness of breath; headache, nausea and vomiting.
Ref: 1987 Fact Sheet by National Toxicology
Program.
http://www.fluoridealert.org/pesticides/Benzotrifluoride.1987.NTP.htm
Kidney
(click
on for all fluorinated pesticides)
-- Trifluoromethylbenzene
was studied for oral toxicity in Crj:CD (SD) rats in an OECD combined
repeat dose and reproductive/developmental toxicity screening
test at doses of 0, 20, 100 and 500 mg/kg/day. With regard to
repeated dose toxicity, effects on liver and kidney
were observed in both sexes given more than 100 mg/kg, indicating
a NOEL is of 20 mg/kg/day for both sexes. In the reproductive/developmental
toxicity study, there were no effects of the test article on the
reproductive performance of the parents. Depression
of body weight gain in offspring of all treatment groups was
observed without any necropsy findings. The NOELs are considered
to be 500 mg/kg/day for reproductive performance of the parents
and less than 20 mg/kg/day for offspring development.
-- Test Results: ... As necropsy findings,
renal hypertrophy and discoloration were observed in males of
the 500 mg/kg group. Increase kidney weights
in males given more than 100 mg/kg and in females of the
500 mg/kg group, and increased liver weights in males given more
than 100 mg/kg were observed. On histopathological examination,
centrilobular hepatocyte hypertrophy in both sexes, and hyaline
droplets, necrosis, basophilic change and dilatation of renal
proximal tubules in males were noted in the 100 and 500
mg/kg groups. Therefore, the NOEL is considered to be 20 mg/kg/day
for both sexes.
Ref: 1988. GINC: Global Information Network
on Chemicals. The Databases of Chemicals.
http://www.fluorideaction.org/pesticides/benzotrifluoride.toxicity.htm
Liver
(click
on for all fluorinated pesticides)
-- Trifluoromethylbenzene
was studied for oral toxicity in Crj:CD (SD) rats in an OECD combined
repeat dose and reproductive/developmental toxicity screening
test at doses of 0, 20, 100 and 500 mg/kg/day. With regard to
repeated dose toxicity, effects on liver
and kidney were observed in both
sexes given more than 100 mg/kg, indicating a NOEL is of 20 mg/kg/day
for both sexes...
-- Test Results: ... As necropsy findings,
renal hypertrophy and discoloration were observed in males of
the 500 mg/kg group. Increase kidney weights
in males given more than 100
mg/kg and in females of the 500 mg/kg group, and increased liver
weights in males given more than 100 mg/kg were observed.
On histopathological examination, centrilobular
hepatocyte hypertrophy in both sexes, and hyaline droplets,
necrosis, basophilic change and dilatation of renal
proximal tubules in males were noted in the 100 and 500
mg/kg groups. Therefore, the NOEL is considered to be 20 mg/kg/day
for both sexes.
Ref: 1988. GINC: Global Information Network
on Chemicals. The Databases of Chemicals.
http://www.fluorideaction.org/pesticides/benzotrifluoride.toxicity.htm
Lung
(click
on for all fluorinated pesticides)
TARGET ORGANS:
Central Nervous System, Eyes, Skin, Respiratory
Tract.
Ref: BENZOTRIFLUORIDE Material Safety Data
Sheet. OxyChem. Issue Date: 07-08-98
http://www.oxychem.com/products/msds/m7644.pdf
SYMPTOMS: This comound
is extremely destructive to the mucous membranes, upper
respiratory tract, skin and eyes. Inhalation may be fatal
as a result of spasm, inflammation and edema of the larynx and
bronchi; chemical pneumonitis and pulmonary
edema. Other symptoms include a burning sensation, coughing,
wheezing, laryngitis, shortness of breath; headache, nausea and
vomiting.
Ref: 1987 Fact Sheet by National Toxicology
Program for Benzotrifluoride.
http://www.fluoridealert.org/pesticides/Benzotrifluoride.1987.NTP.htm
| Environmental
(click on for all fluorinated
pesticides)
--
Experimental BCF values of 26-54 and 31-58 suggest
that benzotrifluoride will bioconcentrate in aquatic organisms.
-- Environmental Bioconcentration: An estimated BCF value
of 110 was calculated for benzotrifluoride(SRC), using an
experimental log Kow of 3.01(1) and a recommended regression-derived
equation(2). Bioconcentration factors determined from a
six week study in carp using 100 and 10 ug/L benzotrifluoride
were 26-54 and 31-58, respectively(3). According to a classification
scheme(4), these BCF values suggest
that bioconcentration in aquatic organisms will be an important
fate process(SRC).
[(1) Hansch C, Leo A; The Log P Database. Claremont, CA:
Pomona College (1987) (2) Lyman WJ et al; Handbook of Chemical
Property Estimation Methods. Washington DC: Amer Chem Soc
pp. 5-4, 5-10 (1990) (3) Chemicals Inspection and Testing
Institute; Biodegradation and Bioaccumulation Data of Existing
Chemicals Based on the CSCL Japan. Japan Chemical Industry
Ecology - Toxicology and Information Center. ISBN 4-89074-101-1
(1992) (4) Franke C et al; Chemosphere 29: 1501-14 (1994)]
Ref: TOXNET profile from
Hazardous Substances Data Base.
http://www.fluoridealert.org/pesticides/Benzotrifluoride.TOXNET.HSD.htm
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