Note: This is not an exhaustive list.
When time allows more information will be added.

Ammonium bifluoride - Wood Preservative - CAS No. 1341-49-7

Ingestion: May cause salivation, nausea, vomiting, diarrhea, and abdominal pain, followed by symptoms of weakness, tremors, shallow respiration, carpopedal spasm, convulsions, and coma. May cause brain and kidney damage. Affects heart and circulatory system. Death may be caused by respiratory paralysis. Lethal dose estimated at between 1 teaspoonful and 1 oz.
Ref: Analytyka. Material Safety Data Sheet. Online as of September 15, 2003.
http://www.analytyka.com.mx/tabla%20periodica/MSDS/N/AMMONIUM%20BIFLUORIDE.htm

Ammonium fluoride - Wood Preservative - CAS No. 12125-01-8

-- Ingestion produces nausea, salivation, vomiting, abdominal pain, diarrhea, hemorrhagic gastroenteritis, muscular weakness, tremors, convulsions, vascular collapse. Incr respiration is followed by depression, death. Chronic toxicity: mottling of enamel, generalized osteosclerosis, calcification in tendons and ligaments, synostoses. [The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983. 78]
-- SYMPTOMATOLOGY: A. Ingestion of soluble fluoride salts. 1. Salty or soapy taste, salivation, nausea. Repeated small doses (as in drinking water) may produce no other symptoms, but polyuria and polydipsia have also been reported. 2. Large doses lead promptly to burning or crampy abdominal pain, intense vomiting and diarrhea, often with hematemesis and melena. Dehydration and thirst. 3. Muscle weakness, tremors, and rarely transient epileptiform convulsions, preceded or followed by progressive central nervous depression (lethargy, coma and respiratory arrest, even in the absence of circulatory failure)...
-- Mechanism of Action: INHIBITION OF ONE OR MORE ENZYMES CONTROLLING CELLULAR RESPIRATION AND GLYCOLYSIS MAY RESULT IN CRITICAL BIOCHEMICAL DEFECTS. ... FLUORIDE POISONING CAN LEAD TO SEVERE HYPOCALCEMIA IN WHICH REDUCTIONS OCCURR IN THE PLASMA LEVELS OF BOTH TOTAL CALCIUM AND IONIC CALCIUM. ... ITS MOST SPECTACULAR CONSEQUENCE IS TETANY, IE, PAINFUL, INVOLUNTARY MUSCLE CONTRACTIONS, INITIALLY IF THE DISTAL EXTREMITIES ... . FLUORIDE IN CONCENTRATIONS AS LOW AS 0.5 MMOL FACILITATES NEUROMUSCULAR TRANSMISSIONS AT VERTEBRATE MOTOR END PLATES, APPARENTLY BY INCREASING THE SENSITIVITY OF CHOLINERGIC RECEPTORS TO ACETYLCHOLINE. ... TETANY IS NEVER THE FIRST SIGN IN ACUTE FLUORIDE POISONING; IT MAY NOT APPEAR FOR SEVERAL HOURS AND SOMETIMES NOT AT ALL, IN SPITE OF SEVERE HYPOCALCEMIA. [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. III 187]
Ref: TOXNET profile from Hazardous Substances Data Bank for AMMONIUM FLUORIDE
http://www.fluoridealert.org/pesticides/Ammonium.fluoride.TOXNET.htm

Ammonium silicofluoride - Insecticide, Miticide, Wood Preservative, EPA List 3 Inert - CAS No. 16919-19-0

Human Toxicity Excerpts: SYMPTOMATOLOGY: A. Ingestion of soluble fluoride salts. 1. Salty or soapy taste, salivation, nausea. Repeated small doses (as in drinking water) may produce no other symptoms, but polyuria and polydipsia [def: excessive thirst] have also been reported. 2. Large doses lead promptly to burning or crampy abdominal pain, intense vomiting and diarrhea, often with hematemesis [ def: Vomiting of blood] and melena. Dehydration and thirst. 3. Muscle weakness, tremors, and rarely transient epileptiform convulsions, preceded or followed by progressive central nervous depression (lethargy, coma and respiratory arrest, even in the absence of circulatory failure).
Ref: TOXNET profile from Hazardous Substances Data Bank for AMMONIUM SILICOFLUORIDE
http://www.fluoridealert.org/pesticides/Ammonium.Silicofluor.TOXNET.htm

Bifenthrin - Acaricide, Insecticide - CAS Numbers: 82657-04-3 (Cis); 83322-02-5 (Trans)

For the inhalation endpoint, no appropriate studies were available. EPA determined that the risk assessment should be inclusive of oral and inhalation exposure components assuming 100 percent absorption via the inhalation route. An aggregate oral and inhalation risk assessment is appropriate due to the similarity in the toxicity endpoint (neurotoxicity) seen in rats via these routes. The inhalation study used for comparison purposes was an acute toxicity study in rats on the 25.1 percent formulation where tremors, convulsions, and loss of hindlimb motor control was observed among other clinical signs of toxicity.
Ref: Federal Register: November 26, 1997. Bifenthrin; Pesticide Tolerances. Final Rule.
http://www.fluoridealert.org/pesticides/Bifenthrin.FR.Nov.1997.htm

-- Acute dietary general population including infants and children: Developmental toxicity, Rats - tremors in dams during & post dosing
-- Chronic dietary all populations: Chronic oral, dogs - tremors in both sexes
-- Short-term dermal (1 to 7 days) (Occupational/Residential): Developmental toxicity, Rats - tremors in dams during & post dosing
-- Intermediate-term dermal (1 week to several months) (Occupational/Residential): Developmental toxicity, Rats - tremors in dams during & post dosing
-- Chronic dermal (several months to lifetime) (Occupational/Residential): Chronic oral, dogs - tremors in both sexes
-- All time periods: Inhalation (Occupational/Residential): Development toxicity, Rats - tremors in dams during & post dosing (No appropriate inhalation studies available)
Ref: Federal Register: September 27, 2001. Bifenthrin; Pesticide Tolerances for Emergency Exemptions. Final Rule.
http://www.fluoridealert.org/pesticides/Bifenthrin.FR.Sept.27.2001.htm

1996: A chronic dietary exposure/risk assessment has been performed for bifenthrin using a Reference Dose (RfD) of 0.015 mg/kg of bwt/day. The RfD was based on a No Observed Effect Level (NOEL) of 1.5 mg/kg/day from the 1-year study in dogs and a safety factor of 100. The endpoint effect of concern was intermittent tremors in test animals at the lowest effect level.
Ref: Federal Register: June 12, 1996. Bifenthrin; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Bifenthrin.Fr.June.12.1996.htm

Nov. 26, 1997:
A 13-week feeding study in dogs (by capsule) of doses at nominal dose levels of 0, 2.5, 5, 10, or 20 milligram/kilogram/day (mg/kg/day) (equivalent to 2.21, 4.42, 8.84, and 17.7 mg/kg/day, based on percent active ingredient (a.i.)) for 13 weeks... Tremors were noted in 3 dogs/sex at 4.42 mg/kg/day and in 4 dogs/sex at 8.84 and 17.7 mg/kg/day.
A 90-day feeding study in rats fed at doses of 0, 12, 50, 100, and 200 ppm (0, 0.6, 2.5, 5, or 10 mg/kg/day) with a NOEL of 2.5 mg/kg/ day and LOEL of 5 mg/kg/day based on the increased incidence of tremors in both sexes.
A 1-year chronic/carcinogenicity study in dogs was administered in the diet at dose levels of 0, 0.75, 1.5, 3, or 5 mg/kg/day... Tremors were noted in all males and females at 5 mg/kg/day during weeks 15-29 and in \1/4\ males and \2/4\ females at 3 mg/kg/day during weeks 16-23... The LOEL for this 52- week study is 3 mg/kg/day based on the increased incidence of tremors in both sexes. The NOEL is 1.5 mg/kg/day.
A chronic/carcinogenicity study in mice fed at doses of 0, 50, 200, 500, or 600 ppm (0, 2.5, 10, 25, or 30 mg/kg/day) in the diet for 87 weeks (males) or 92 weeks (females). Chronic LOEL is 10 mg/kg/day based on the incidence of tremors in both sexes.
Chronic/carcinogenicity study in rats was administered for in the diet at doses of 0, 12, 50, 100, or 200 ppm (0, 0.6, 2.5, 5, or 10 mg/kg/day). Chronic LOEL is 5 mg/kg/day based on the increased incidence of tremors in both sexes and possible increases in organ-to- body weight ratios in males. Chronic NOEL is 2.5 mg/kg/day.
In a pilot developmental study in rats bifenthrin was administered in the diet at dose levels of 0, 0.5, 1.0, 2.0, or 2.5 mg/ kg/day during days 6-15 of gestation. Three of 10 rats at 2.5 mg/kg/day died on days 14-15. Tremors were noted in all 10 rats at 2.5 mg/kg/day and in \9/10\ at 2.0 mg/kg/day... The maternal LOEL is 2.0 mg/kg/day based on sporadic tremors (gestation days 7-18) and 30 percent mortality at 2.5 mg/kg/day. The maternal NOEL is 1.0 mg/kg/day. The developmental LOEL and NOEL were not determined; fetuses were not examined.
A developmental study in rats given gavage doses of 0, 0.5, 1.0, or 2.0 mg/kg/day was administered... Maternal toxicity NOEL was 1.0 mg/kg/day based on tremors at LOEL of 2.0 mg/kg/day.
A developmental study in rabbits given gavage doses of 0, 2.67, 4.0, or 8.0 mg/kg/day or with 3.0 gram/kilogram/day (g/kg/day) resulted in no developmental toxicity observed under the conditions of the study. The maternal NOEL is 2.67 mg/kg/day, based on head and forelimb twitching at LOEL of 4.0 mg/kg/day. The developmental NOEL is 8.0 mg/kg/day, the highest dose tested.
A 2-generation reproduction study in rats fed diets containing doses of 0, 30, 60, or 100 ppm (0, 1.5, 3 or 5 mg/kg/day). Systemic LOEL is 5 mg/kg/day based on the incidence of tremors and marginally lower bwts in P and F1 generation females during gestation and lactation. Systemic NOEL is 3 mg/kg/day.
For the inhalation endpoint, no appropriate studies were available. EPA determined that the risk assessment should be inclusive of oral and inhalation exposure components assuming 100 percent absorption via the inhalation route. An aggregate oral and inhalation risk assessment is appropriate due to the similarity in the toxicity endpoint (neurotoxicity) seen in rats via these routes. The inhalation study used for comparison purposes was an acute toxicity study in rats on the 25.1 percent formulation where tremors, convulsions, and loss of hindlimb motor control was observed among other clinical signs of toxicity.
Ref: Federal Register: November 26, 1997. Bifenthrin; Pesticide Tolerances. Final Rule.
http://www.fluoridealert.org/pesticides/Bifenthrin.FR.Nov.1997.htm

Bromethalin - Rodenticide - CAS No. 63333-35-7

PubMed Abstract: Dogs given a single oral dose of bromethalin at 6.25 mg/kg developed a toxic syndrome characterized by hyperexcitability, tremors, seizures, depression, and death within 15-63 hours after bromethalin administration. Gross lesions included mild cerebral edema (2/5) and mild pulmonary congestion (2/5). Histologic lesions included diffuse white matter spongiosis (5/5), mild microgliosis (3/5), optic nerve vacuolization (3/5), mild thickening of Bowman's capsule (2/5), and occasional splenic megakaryocytes (2/5). Ultramicroscopic examination of midbrain stem revealed occasional swollen axons, intramyelinic vacuolization, and myelin splitting at the intraperiod line. Bromethalin was detected in kidney, liver, fat, and brain tissues, using gas chromatography with electron capture detection. Photodegradation of extracted bromethalin may limit accurate quantification of tissue residues.
Ref: Diagnosis of bromethalin toxicosis in the dog, by Dorman DC, Simon J, Harlin KA, Buck WB. J Vet Diagn Invest 1990 Apr;2(2):123-8
http://www.fluoridealert.org/pesticides/Bromethalin-MEDLINE.htm

Abstract: Bromethalin is a new rodenticide for the control of commensal rodents. Doses in excess of the LD50 (2 mg/kg in rats) will cause death within 8-12 hr and it is preceded by one to three episodes of clonic convulsions with death usually due to respiratory arrest. Multiple low doses or sublethal intoxication yields hind leg weakness and loss of tactile sensation in rodents. Histopathology of the brain and spinal cord of these animals revealed a spongy degeneration of the white matter which was shown upon ultramicroscopic examination to be intramyelenic edema.
Ref: Fundam Appl Toxicol 1988 Nov;11(4):664-72 The toxicity and mechanism of action of bromethalin: a new single-feeding rodenticide. by van Lier RB and Cherry LD.
http://www.fluoridealert.org/pesticides/Bromethalin-MEDLINE.htm

Carbon Tetrafluoride - Former US EPA List 3 Inert - CAS No. 75-73-0

EARLY ANIMAL WORK...INDICATED THAT HIGH VAPOR CONCN (EG, 20%) MAY CAUSE CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA, BUT...EFFECTS...GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976.,p. II-109]
Ref: TOXNET profile from Hazardous Substances Data Base for TETRAFLUOROMETHANE (Carbon Tetrafluoride)
http://www.fluoridealert.org/pesticides/Carbon.Tetrafluoride.TOXNET.htm

1-chloro-1,1-difluoroethane - Solvent - CAS No. 75-68-3

EARLY ... HUMAN EXPERIENCE INDICATED THAT HIGH VAPOR CONCN (EG, 20%) MAY CAUSE CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA, BUT THAT THESE EFFECTS WERE GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. ... CAUSE OF DEATH /FROM ABUSE OF FLUOROCARBONS/ IS IN CONSIDERABLE DOUBT. FREEZING OF AIRWAY SOFT TISSUES CAN PROBABLY BE ELIMINATED AS A CAUSE OF DEATH EXCEPT IN CASES WHERE THE PRODUCT WAS SPRAYED DIRECTLY INTO THE MOUTH FROM ITS CONTAINER OR FROM A BALLOON CONTAINING SOME LIQUID. LARYNGEAL SPASM OR EDEMA, OXYGEN DISPLACEMENT, OR SENSITIZATION OF MYOCARDIUM TO ENDOGENOUS CATECHOLAMINES WITH SUBSEQUENT VENTRICULAR FIBRILLATION APPEAR TO BE REASONABLE POSSIBILITIES. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]
Ref: TOXNET profile from Hazardous Substances Data Bank for 1-CHLORO-1,1-DIFLUOROETHANE
http://www.fluoridealert.org/pesticides/1-Chloro-1,1,-Difluo.TOXNET.htm

Chlorodifluoromethane - Insecticide, Fungicide, Propellant - CAS No. 75-45-6

... GUINEA PIGS SHOWED DEFINITE NERVOUS SYSTEM RESPONSE TO CONCN OF 16% BY VOL IN AIR, OVER PERIOD OF 55 MIN. THEY SHOWED TREMORS & CONVULSIVE MOVEMENTS BUT RECOVERED ON REMOVAL. AT 40%, THEY SHOWED TREMORS & WERE HELPLESS OVER A PERIOD OF 2.5 HR BUT RECOVERED ... AT CONCN OF 58%, DEATH OCCURRED IN 8 MIN. [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 1324]
Ref: TOXNET profile from Hazardous Substances Data Base for CHLORODIFLUOROMETHANE
http://www.fluoridealert.org/pesticides/Chlorodifluoromethan.TOXNET.htm

Clodinafop-propargyl - Herbicide - CAS No. 105512-06-9

Chronic toxicity. In a 12-month feeding study in dogs, 500 ppm resulted in transient dermatitis and reduced body weight gain. Two females were more severely affected and showed inappetence, body weight loss, tremors and severe dermatitis, and necessitated an interruption of the treatment in order to avoid mortality. Histopathology revealed slight hepatocellular hypertrophy in one male and one female. The NOEL of 100 ppm was equivalent to a mean daily intake of 3.38 mg/kg in males and 3.37 mg/kg in female.
Ref: Federal Register: June 5, 1998 [Page 30750-30756]. Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/Clodinafop-prop.FR.Ju5.1998.htm

Cyfluthrin - Insecticide - CAS No. 68359-37-5

In a 14-day rat study, oral administration of 60 mg/kg/day produced tremors, uncoordinated gait, salivation, slight brain hemorrhages, necrosis of the skeletal muscle fibers, and death. The NOEL was not defined.
Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993). As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

-- Cyfluthrin (95.4% a.i.). Reproduction and fertility effects study-- rat (dietary). Parental NOAEL = Parental: 3/4 (M/F) Offspring NOAEL = 7 (M/F) Parental LOAEL = 9/10 (M/F) based on reductions in body weights and food consumption. Offspring LOAEL = 19 based on coarse tremors in pups during lactation and decreases in mean litter weight .
-- Cyfluthrin (95.7-96.2% a.i.). Pilot 1-generation reproduction study--rat. Parental systemic NOAEL = 22.9 Offspring systemic NOAEL = 7.8 Parental systemic LOAEL = 59.6 based on hind leg splay, ataxia, reduction in body weight gain. Pup systemic LOAEL = 22.9 based on tremors during lactation and pup weight decreases.
Ref: Federal Register. September 27, 2002. Cyfluthrin; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Cyfluthrin.FR.Sept.27.2002.htm

Cyhalothrin - Acaricide, Insecticide - CAS No. 68085-85-8

Cyhalothrin administered orally (in capsules) to dogs at 10 mg/kg/day for 26 weeks produced occasional disturbances of the nervous system (unsteadiness and/or muscular trembling). The NOEL for these effects was not defined. In a 1-year dog study, ataxia, muscle tremors, and convulsions were observed following oral administration at 3.5 mg/kg/day. Abnormal gait and convulsions were observed at 0.5 mg/kg/day. The LOEL of the study was 0.5 mg/kg/day and the NOEL was 0.1 mg/kg/day. EPA believes that there is sufficient evidence for listing cyhalothrin on EPCRA section 313 pursuant to EPCRA section 313(d)(2)(B) based on the available neurological toxicity data.
Ref: USEPA/OPP. Support Document for the Addition of Chemicals from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA) Active Ingredients to EPCRA Section 313. U. S. Environmental Protection Agency, Washington, DC (1993). As cited by US EPA in: Federal Register: January 12, 1994. Part IV. 40 CFR Part 372. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right-to-Know; Proposed Rule.

Cyhalothrin, lambda - Insecticide - CAS No. 91465-08-6

A 12-month feeding study in dogs fed dose (by capsule) levels of 0, 0.1, 0.5, 3.5 milligrams(mg)/kilogram (kg)/day with a no-observedeffect level (NOEL) of 0.1 mg/kg/day. The lowest-observed-effect-level (LOEL) for this study is established at 0.5 mg/kg/day based upon clinical signs of neurotoxicity ataxia, muscle tremors, convulsions.
Ref: Federal Register: March 27, 1995. Lambda-Cyhalothrin; Pesticide Tolerances. Final Rule.
http://www.fluoridealert.org/pesticides/Lambda-Cyhal.FR.Mar.27.1995.htm

Dichlorodifluoromethane - (Freon 12) - Insecticide, Fungicide, Propellant, US EPA List 2 Inert - CAS No. 75-71-8

-- Inhalation of Freon compounds at moderate concentrations initially produces CNS anesthetic effects of intoxication and loss of psychomotor coordination. In humans, this effect occurred at levels of 2500 ppm for Freon 113 and 10,000 ppm for Freon 12. Higher concentrations produce marked in coordination, slurring of speech, apprehension, and finally descreasing levels of consciousness. Attendent hypoxia at high concentrations may also produce tremors, convulsions, and cerebral edema. Cardiac sensitization occurs at higher concentrations than initial CNS intoxication. [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1281]
-- .. Dogs, monkeys, rats, rabbits & guinea pigs /had continuous exposure/ to 810 ppm of FC 12, 24 hr daily for 90 days. No deaths were attributed to exposure and pathologic changes ... occurred only in guinea pigs, who showed microscopic liver injury. ... At 200,000 ppm, guinea pigs, dogs and monkeys exposed some 40 hr weekly for 10-12 weeks showed generalized tremors and other signs of mild /CNS depression/, as well as slight blood changes, but no pathologic effects. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH:American Conference of Governmental Industrial Hygienists, 1986.]
-- DOGS, MONKEYS, & GUINEA PIGS EXPOSED TO 20% OF GAS IN AIR FOR SEVERAL HR A DAY FOR SEVERAL DAYS SHOWED TEMPORARY INTOXICATION WITH TREMORS, ATAXIA, AND TENDENCY TO STARE, SALIVATE, & LACRIMATE, BUT NO CUMULATIVE TOXIC EFFECT & NO SPECIFIC OCULAR DISTURBANCE. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 322]
Ref: TOXNET profile from Hazardous Substances Data Bank for DICHLORODIFLUOROMETHANE
http://www.fluoridealert.org/pesticides/Dichlorodifluorometh.TOXNET.htm

Dichlorofluoromethane (CFC-21) - Propellant, EPA List 2 Inert - CAS No. 75-43-4

-- Exposure to 100,000 ppm killed rats and guinea pigs within an hour. Clinical signs included loss of coordination, tremors ... /CNS depression/ and prostration; limited pathologic examination, partly obscured by post-mortem change, revealed lung and liver changes. [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 434]
-- WHEN GUINEA PIGS WERE EXPOSED UP TO 2 HR ... @ CONCN RANGING FROM 1.2-10.2% BY VOL (12,000-102,000 PPM), CONCN OF 5.2% & HIGHER PRODUCED SIGNS OF IRRITATION, TREMORS, INCOORDINATION, & IRREGULAR BREATHING. [American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values for Substances in Workroom Air. Third Edition, 1971. Cincinnati, Ohio: AmericanConference of Governmental Industrial Hygienists, 1971. (Plus supplements to 1979) 81].
Ref: TOXNET profile from Hazardous Substances Data Base for DICHLOROFLUOROMETHANE
http://www.fluoridealert.org/pesticides/Dichlorofluoromethan.TOXNET.htm

Flonicamid - Insecticide - CAS No. 158062-67-0

In a subchronic toxicity study in dogs with capsule administration, the NOAEL was 20 mg/kg/day based on findings of severe toxicity at a dose exceeding the maximum tolerated dose; symptoms included collapse, prostration and convulsions leading to early sacrifice at the LOAEL of 50 mg/kg/day.
Ref: Federal Register. Jully 7, 2004. Flonicamid; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food. [OPP-2004-0132; FRL-7362-5].
http://www.fluoridealert.org/pesticides/flonicamid.fr.july7.2004.htm

Indoxacarb - Insecticide - CAS No. 144171-61-9

In a subchronic neurotoxicity study in rats, there was no evidence of neurotoxicity at 11.9 and 6.09 mg/kg/day, the highest dose tested for males and females, respectively. The standard subchronic rat study showed equivocal evidence of neurotoxicity (i.e., ataxia and tremors) but only in moribund animals.
Ref: Federal Register: April 16, 1998 [Page 18912-18919]. Notice of Filing of Pesticide Petitions.
http://www.fluoridealert.org/pesticides/DPX-MP062.FR.Apr16.1998.htm

DPX-MP062 150SC in high single oral doses caused gait abnormalities, incoordination, hypoactivity, convulsions, tremors, hypothermia, hair loss, labored respiration, ocular discharge, and vocalization in rats.
Ref: Dupont's Material Safety Data Sheet for STEWARD insecticide. January 2001.
http://www.fluoridealert.org/pesticides/DPX-MP062.MSDS.STEWARD.htm

Methanesulfonyl fluoride - Fumigant, Insecticide - CAS No. 558-25-8

Range of Toxicity:
-- Minimum lethal human exposure is unknown. In rats exposed by inhalation to a concentration of 2.2 ppm for 1 hour, only minimal salivation was seen; at 5 ppm for the same duration, copious salivation, eye and nose exudates, diarrhea, depression, ataxia, and tremors were observed.
-- ACUTE EXPOSURE. Methanesulfonyl fluoride is an irreversible inhibitor of acetylcholinesterase in vitro. It also inhibits butyrylcholinesterase and trypsinogen in vitro.
-- NEUROLOGIC. ACUTE EXPOSURE. Symptoms noted in experimental animals included CNS depression, tremors, ataxia, and convulsions. ANTICHOLINESTERASE COMPOUNDS can affect the CENTRAL NERVOUS SYSTEM, producing restlessness, anxiety, headaches, convulsions, and coma.
Ref: TOXNET profile from Hazardous Substances Data Base.
http://www.fluoridealert.org/pesticides/Methanesulfonyl.fluo.TOXNET.htm

Sulfuryl fluoride - Fumigant insecticide - CAS No. 2699-79-8

-- In 2-week inhalation studies in rats, dogs and rabbits, different target organs were affected. In rats, the primary target organ was the kidneys, in which severe histopathological lesions were observed. These lesions included papillary necrosis, hyperplasia of the epithelial cells of the papillae, and degeneration/regeneration of collecting tubules and proximal tubules. In dogs, the primary target organ was the upper respiratory tract, in which minimal inflammation was observed. Intermittant tremors and tetany were also noted in dogs. In rabbits, the primary target organ was the brain, in which malacia (necrosis) and vacuolation were observed in the cerebrum. Inflammation of the upper respiratory tract was also noted in rabbits.
-- In subchronic (90-day) inhalation studies in rats, dogs, rabbits and mice, the brain was the major target organ. Malacia and/or vacuolation were observed in the white matter of the brain in all four species. The portions of the brain most often affected were the caudate-putamen nucleus in the basal ganglia, the white fiber tracts in the internal and external capsules, and the globus pallidus of the cerebrum. In dogs and rabbits, clinical signs of neurotoxicity (including tremors, tetany, incoordination, convulsions and/or hind limb paralysis) were also observed.
Ref: Federal Register: September 5, 2001 [Page 46415-46425]. Sulfuryl Fluoride; Proposed Pesticide Temporary Tolerances.
http://www.fluoridealert.org/pesticides/Sulfuryl.Flu.FR.Sept.5.2001.htm

tau-Fluvalinate - Acaricide, Insecticide - CAS No. 102851-06-9

-- A 2-generation reproduction toxicity study in rats with tau fluvalinate showed parental and developmental effects in the mid and high dose group. 2 of 4 males of the F1-generation from the median dose group failing to mate had strophic seminiferous tubles in both testes and spermatozoa were partly absent from the epididymides. Litter and mean pup weights of the F2 generation of the median dose group were lower between days 8 and 21. Incidence of fur loss and scabbing was a marginally increased among adults. F1 and F2 pups of the highest groups had tremors, mainly around lactation day 14, indicating toxic effects of tau fluvalinate excreted in rat milk....
-- Neurotoxic effects of tau fluvalinate were seen in rats after administration by gavage of 60 mg/kg bw/day in corn oil for 7 days. Body weight decrease, symptoms such as fear, ruffled fur, ataxia, startle response hyperreactivity, spasms, and signs of neurotoxicity (reduced grip strength, irritability, reduced motion, spasms and abnormal gait) were observed, accompanied by nerve fibre degeneration correlating to incidence and severity of the symptoms. Severity and number of the lesions were reduced in animals allowed to recover for 7 days. 10 mg/kg bw/day resulted in a marginal increase in vocalisation when handled and hyperalgesia.
Ref: Revised Summary Report. EMEA/MRL/021-REV1/95. Committee for Veterinary Medicinal Products. The European Agency for the Evaluation of Medicinal Products.
http://www.fluorideaction.org/pesticides/tau.fluvalinate.1995.review.pdf

Tefluthrin - Insecticide - CAS No. 79538-32-2

-- In a developmental toxicity study, rabbits were dosed at 0, 3, 6, or 12 mg/kg/day from days 7 through 19 of gestation. The maternal LOEL is 3 mg/kg/day, based on treatment-related clinical signs of toxicity (tremors). The maternal NOEL is <3 mg/kg/day. There was no developmental toxicity demonstrated at any dose level. There were no treatment-related effects on in utero survival and growth or on litter size and sex ratio of the fetuses. The skeletal variant data showed significant (p<0.01 or 0.05) increases in incidence of extra thoracic ribs and 27 pre-sacral vertebrae among fetuses in the dosed groups; however, when the litter was used as the unit for comparison, the incidences of these respective variants were comparable between all groups. The incidences of these variants were not biologically significant. The NOEL for developmental toxicity is 12 mg/kg/day. The developmental LOEL was not observed.
-- Toxicological Endpoints 1. Acute toxicity. For acute dietary risk assessment, EPA recommends use of a NOEL of 0.5 mg/kg/day based on increased incidence of tremors and ataxia in both sexes of dogs at 2.0 mg/kg/day (LOEL) on day 1 of the study from the 1 year oral chronic toxicity study in dogs.
-- Toxicological Endpoints 2. Short - and intermediate - term toxicity. For short- and intermediate term MOE's, EPA recommends use of a NOEL of 0.5 mg/kg/day based on increased incidence of tremors and ataxia in both sexes of dogs at 2.0 mg/kg/day (LOEL) from the one year oral toxicity study in dogs and use of a dermal absorption rate of 25%. A dermal absorption rate of 25% was recommended based on the weight-of-the-evidence available for structurally related pyrethroids.
-- Chronic toxicity. EPA has established the RfD for tefluthrin at 0.005 milligrams/kilogram/day (mg/kg/day). This RfD is based on increased incidence of tremors and ataxia in both sexes of dogs in a chronic toxicity study and an uncertainty factor of 100 to account for both interspecies extrapolation and intraspecies variability.
Ref: Federal Register: November 26, 1997. Tefluthrin; Pesticide Tolerance. Final Rule.
http://www.fluoridealert.org/pesticides/Tefluthrin.FR.Nov.1997.htm

1,1,1,2-Tetrafluoroethane (HFC-134a) - Propellant, US EPA List 4B Inert - CAS No. 811-97-2

-- In a developmental toxicity study, Lu and Staples (1981) exposed pregnant CD rats to HFC-134a at 30,000, 100,000, or 300,000 ppm for 6 h/d from days 6 to 15 of gestation. Following exposure of dams at 300,000 ppm, there was a significant reduction in fetal weight and significant increases in several skeletal variations. At 300,000 ppm, signs of maternal toxicity included reduced food consumption, reduced body weight gain, lack of response to noise stimuli, severe tremors, and uncoordinated movements. Dams exposed at 100,000 ppm showed reduced response to noise stimuli and uncoordinated movements. No terata or evidence for developmental toxicity were observed following exposure of dams at 30,000 or 100,000 ppm.
-- Lu M, Staples R. 1981. 1,1,1,2-tetrafkyirietgabe (FC-134a): embryo-fetal toxicity and teratogenicity study by inhalation in the rat. Report No. 317-81. Haskell Laboratory, Wilmington, DE.
Ref: National Research Council. 2002. Acute Exposure Guideline Levels for Selected Airborne Chemicals. Volume 2. Subcommittee on Acute Exposure Guideline Levels, Committee on Toxicology, Board of Environmental Studies and Toxicology, Division of Earth and Life Studies. Available from: National Academy Press, 2101 Constitution Ave, NW, Box 285, Washington DC 20055. ISBN 0-309-08511-X. Online at:
http://books.nap.edu/books/030908511X/html/index.html

Transfluthrin - Insecticide - CAS No. 118712-89-3

-- Reproductive Toxicity. Developmental studies in both the rat and rabbit provided no evidence of teratogenicity when transfluthrin was administered at 125 and 150 mg kg d respectively. One death occurred at 125 mg kg d in the rat study and 2 deaths (1 each at 50 and 150 mg kg d) occurred in the rabbit study. NOELs of 15 and 15 mg kg d were established for maternal toxicity in the rat and rabbit respectively. These were based tremors at 55 mg kg d in the rat and mortality (following severe tremors) at 50 mg kg d in the rabbit...
-- 3.3.3.4 Summary ... Following oral administratin the major target organ in the rat and dog was the liver, with evidence of kidney toxicity also seen in the rat. Fluoride determinations were undertaken in the rat only and showed evidence of accumulation in teeth and bone from 50 ppm (4 mg kg d). In the rat, mortalities and body tremors were seen at 250 mg kg d following gavage dosing...
-- 3.2.3.2 In Vivo Studies. In a micronucleus study, Bor: NMRI (SPF Han) mice (5/sex) received a single gavage dose of 375 mg kg transfluthrin (95% pure) in Lutrol E 400. This dose was chosen following a range finding study in which mice received doses of between 250 and 2500 mg kg. In the range finding study, mortalities (1/5) and significant signs of toxicity (roughened fur, lateral position, twitching, spasm, salivation and shivering) were observed at 475 mg kg and above. In the main study similar signs of toxicity were observed for up to 24 h post dosing. It was reported that 7/40 animals died during this study and that a replacement group were treated in parallel to replace the animals which died. Sampling was undertaken at 24, 48 and 72 h post dosing. 1000 PCE's were scroed per animal and NCE's per 1000 PCE. Individual results were not reported. The PCE/NCE ratio as 1.06, 0.74 and 1.36 at 24, 48 and 72 h. Thus there is some indication of bone marrow toxicity at 48 h.
-- 3.2.5.1.2 Rabbit. In an adequately conducted teratology study, pregnant Himalayan rabbits (15/group) were administered transfluthrin (94% purity) in 0.5% (v/v) aqueous Cremophor EM emulsion by gavage at doses of 0, 15, 50 and 150 mg kg d during days of 6-18 of gestation. Control animals received vehicle alone... Dams were necropsied on day 29 of gestation following delivery of the foetuses by caesarean section. Two deaths occurred, one on day 18 at 50 mg kg d and one on day 19 at 150 mg kg d. Immediately prior to death both animals displayed symptoms consistent with CNS involvement inclusing spasms, severe tremor and prostration (animals found lying on their side). Autopsy of these animals revealed an enlarged lobulated liver and pale lobulated lllungs at 50 mg kg d whereas no pathological fingings were observed at 150 mg kg d.
Ref: Evaluation on: Transfluthrin Use as a Public Hygiene Insecticide. September 1997. Prepared by: the UK Health and Safety Executive, Biocides & Pesticides Assessment Unit, Magdalen House, Stanley Precinct, Bootle, Merseyside L20 3QZ. Available from: Department for Environment, Food and Rural Affairs, Pesticides Safety Directorate, Mallard House, Kings Pool, 3 Peasholme Green, York YO1 7PX. UK. Also at http://www.pesticides.gov.uk/citizen/evaluations/165_confirm-box.htm
• Note: This was transcribed from the copy available on the web. While one can easily read this report on the web, the report is inaccessible, or locked, to any attempt to copy it. Any errors are mine. EC.

Trichlorotrifluoromethane - Solvent, US EPA List 2 Inert - CAS No. 76-13-1

HIGH VAPOR CONCN (EG, 20%) MAY CAUSE CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA ... BUT ... THESE EFFECTS WERE GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]
Ref: TOXNET profile from Hazardous Substances Data Base for TRICHLOROFLUOROMETHANE
http://www.fluoridealert.org/pesticides/Trichlorofluorometha.TOXNET.htm