DICHLORODIFLUOROMETHANE
CASRN: 75-71-8 For other data, click on the Table of Contents
Human Health Effects:
Human Toxicity Excerpts:
... FATAL CASE OF BRONCHOPNEUMONIA /REPORTED/ IN MAN WHO PUNCTURED FREEZING
COIL OF REFRIGERATOR CONTAINING FC-12. IT IS PROBABLE THAT HE ASPIRATED COLD
CONCENTRATED VAPOR OR LIQ, OR WAS EXPOSED TO DEGRADATION PRODUCTS OF REFRIGERANT
CMPD. [American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 181]**PEER
REVIEWED**
... IF INHALED AT 5% BY VOL CONCN INDUCES DIZZINESS IN MAN. IF INHALED AT
15% CONCN, LOSS OF CONSCIOUSNESS RESULTS. [International Labour Office. Encyclopaedia of Occupational Health
and Safety. 4th edition, Volumes 1-4 1998. Geneva, Switzerland: International
Labour Office, 1998.,p. 104.184]**PEER REVIEWED**
STUDIES ON ... VOLUNTEERS SHOWED THAT INHALATION OF 10,000 PPM OF FC12 FOR
2.5 HR CAUSES 7% REDUCTION IN STANDARDIZED PSYCHOMOTOR SCORES. AT CONCN OF 1000
PPM FOR 8 HR/DAY, 5 DAYS/WK FOR TOTAL OF 17 REPETITIVE EXPOSURES, THERE WERE
NO UNTOWARD SUBJECTIVE RESPONSES & NO ABNORMAL PHYSIOLOGICAL RESPONSES OF
LUNGS OR HEART. CONCN AS HIGH AS 27,000 PPM OF FC12 FOR 15 TO 60 SEC CAUSED
INCR IN AIRWAY RESISTANCE & ELECTROCARDIOGRAPHIC CHANGES. [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3091]**PEER REVIEWED**
In brief exptl exposures of humans to F-12 at 198x10+3 mg/cu m vapor concn
in air, tingling sensation, humming in the ears, apprehension, EEG and speech
changes, and deficits in psychological performance were reported. In other test
exposures ... 49x10+3 to 543x10+3 mg/cu m caused cardiac arrhythmia, decreased
consciousness, and amnesia or deficits in performance on psychomotor test scores.
[USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-47-8
(1980) EPA 440/5-80-051]**PEER REVIEWED**
... Women using fluorocarbon-propellant /incl F-12/ aerosol products and receiving
nine or ten times the exposure from normal use /showed/ ... no measureable blood
levels of the fluorocarbons or abnormalities in overall health, respiratory,
or hematologic parameters. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-48
(1980) EPA 440/5-80-051]**PEER REVIEWED**
Refrigeration repair workers may be intermittently exposed to fluorocarbons
and their thermal decomposition products. A case of peripheral neuropathy (distal
axonopathy) in a commercial refrigeration repairman prompted an epidemiological
investigation of the health of refrigeration repair workers. No additional cases
of peripheral neuropathy were identified among the 27 refrigeration repair workers
studied. A reference group of 14 non-refrigeration repair workers was also studied.
No differences were noted between groups for the ulnar (motor and sensory),
median (motor and sensory), peroneal, sural, or tibial nerve conduction velocities.
Refrigeration repair workers reported palpitations and lightheadedness significantly
more often than workers in the reference group. No clinical neurological or
electroneurophysiological abnormalities were detected in eight refrigeration
repair workers followed up for three years during continuous employment. [Campbell DD; Br J Ind Med 43 (2): 107-11 (1986)]**PEER REVIEWED**
/UV-B Radiation is likely to incr by ozone depletion caused by atmospheric
concentrations of chlorofluorocarbons/. Indications are increasing that UV-B
radiation ... plays a role in the induction and growth of cutaneous melanomas,
a ... dangerous type of skin cancer. ... There are indications that ... suppression
of the immune response by UV-B radiation may occur in humans. The antigen presenting
Langerhans cells in the skin are damaged and allergic responses are depressed.
... There are indications that UV-B radiation increases cataract formation,
an important cause of blindness especially in areas with limited medical facilities.
/Chlorofluorocarbons/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.101 (1990)]**PEER REVIEWED**
Many gases emitted as a result of industrial and agricultural activities can
accumulate in the earth's atmosphere and ultimately contribute to alterations
in the vertical distribution and concentrations of stratospheric ozone. Among
the most important are those trace gases that have long residence times in the
atmosphere. This allows accumulation in the troposphere and a gradual upward
migration of the gases into the stratosphere where they contribute to depletion
of stratospheric ozone layer. The atmospheric and chemical processes involved
are extremely complex. Trace gases of particular concern include certain long
lived chlorofluorocarbons, such as CFC-11, CFC-12, and CFC-113. Since the transport
of these gases to the stratosphere is slow, their residence times there are
long, and the removal processes are slow, any effect on stratospheric ozone
already seen is probably the result of anthropogenic emissions of these gases
several decades ago. Those gases already in the atmosphere will continue to
exert stratospheric ozone depletion effects well into the next century. /Chlorofluorocarbons/
[WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.47 (1990)]**PEER REVIEWED**
Increased UV-B radiation would be expected to increase photochemical smog,
and this would aggravate the related health problems in urban and industrialized
areas. /UV-B Radiation/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.21 (1990)]**PEER REVIEWED**
Deaths resulting from cardiovascular collapse after arrhythmias have been
reported after inhalation of Freons 11 and 12. [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 528]**PEER REVIEWED**
This study attempted to determine whether exposure to the fluorocarbons chlorodifluoromethane
or dichlorodifluoromethane during refrigerator repair caused cardiac arrhythmias.
Six repair workers and six plumbers (comparisons) served as study subjects.
They kept diaries about their daily activities including exposure to fluorocarbons,
physical activity, traffic, meals, smoking, and drinking. Ambulatory electrocardiograms
were taken for 24 hours on a day of work exposure and on a comparison day. No
cardiac arrhythmias were found to be clearly connected with exposure to fluorocarbons.
One subject had several ventricle ectopic beats and a connection with exposure
cannot be totally excluded in this worker. Ventricle ectopic beats were somewhat
more common in the refrigerator repair workers than in the plumbers. The number
of ventricle ectopic beats was low, however, when compared with what is known
of ventricle ectopic beats in the normal heart. The average concentrations of
fluorocarbons during work were 170 to 815 cu cm/cu m and the peak concentrations
were 1300 to 10,000 cu cm/ cu m. In two instances the concentrations remained
over 1000 cu cm/cu m for 30 minutes. [Anttipoika M et al; British Journal of Industrial Medicine 47
(2): 138-40 (1990)]**PEER REVIEWED**
A 68 year old man suffered minor burns of both arms and the chest but not
the mouth when he punctured the freezing coil of a refrigerator with an ice
pick, thus releasing dichlorodifluoromethane. His clinical course was characterized
by severe progressive shock, spiking fever, and death in 96 hr. Autopsy revealed
bronchopneumonia and histological changes in the small bronchi thought to represent
the effects of degradation products of the compound and of preexisting degenerative
disease. [Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London:
Williams and Wilkins, 1982. 119]**PEER REVIEWED**
Inhalation of Freon compounds at moderate concentrations initially produces
CNS anesthetic effects of intoxication and loss of psychomotor coordination.
In humans, this effect occurred at levels of 2500 ppm for Freon 113 and 10,000
ppm for Freon 12. Higher concentrations produce marked in coordination, slurring
of speech, apprehension, and finally descreasing levels of consciousness. Attendent
hypoxia at high concentrations may also produce tremors, convulsions, and cerebral
edema. Cardiac sensitization occurs at higher concentrations than initial CNS
intoxication. [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1281]**PEER REVIEWED**
The effects of CFC-11 and CFC-12 on human volunteers under controlled conditions
/were characterized/. A number of biological end-points, including clinical
hematology and chemistry, ECG, EEG, pulmonary function, neurological parameters,
and cognitive tests were monitored. Single exposures to CFC-11 or CFC-12 at
concentrations of 0.025% (CFC-11, 1.4 g/cu m, CFC-1, 1.2 g/cu m), 0.05% (CFC-11,
2.8 g/cu m, CFC-123, 2.5 g/cu m), and 0.1% (CFC-11, 5.6 g/cu m, CFC-12, 5 g/cu
m, for 1 min to 8 hr, induced no observable effects. There was a statistically-significant
decrease in cognitive test performance in subjects exposed to CFC-11 at 5.6
g/cu m, 8 hr/day, 5 days/week, for 2-4 weeks, but not in subjects exposed to
CFC-12 at 5 g/cu m. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.89 (1990)]**PEER REVIEWED**
In another study, 11 subjects (7 being maintenance technicians of large cooling
and refrigerating systems) were exposed for 130 min to CFC-12 (weighted exposure
0.46, 49.9, and 87.7 g/cu m. ... This led to acute reduction of ventilatory
lung capacity only at the two highest CFC-12 concentrations, under which conditions
a significant decrease in the heart frequency was also observed. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.90 (1990)]**PEER REVIEWED**
Ten subjects /were exposed/ to CFC-11, CFC-12, CFC-114, two mixtures of CFC-11
and CFC-12, and a mixture of CFC-12 and CFC-114 (breathing concentrations between
16 and 150 g/cu m) for 15, 45, or 60 seconds, and found significant acute reduction
of ventilatory lung capacity (FEV50, FEF25) on exposure to each chlorofluorocarbon,
as well as bradycardia and increased variability in heart rate in seven subjects,
negative T-waves in two subjects (one was exposed to CFC-11 and CFC-12), and
atrioventricular block in 1 subject (CFC-114). Mixtures exerted stronger respiratory
effects than individual chlorofluorocarbon at the same level of exposure. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.90 (1990)]**PEER REVIEWED**
Allergic contact eczema /was reported/ in patch tests performed on three patients
that had a prior history of skin reactions to deodorant sprays. All three patients
showed strong positive reactions to 11 deodorant sprays and mild to strong reactions
to CFC-11. One patient showed a mild reaction to CFC-12. Fifteen controls (without
prior history of allergy to deodorants) showed no response to either CFC-11
or CFC-12. These results suggest that individuals may become sensitized to certain
chlorofluorocarbons applied repeatedly to the skin surface. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.91 (1990)]**PEER REVIEWED**
Effects of chlorofluorocarbons on bronchiolar tone in asthmatic children /were
studied/. Forced expiratory volume, a measure of bronchial tone, was measured
in 18 children with a history of asthma, before and after inhaling aerosols
of the B2-receptor agonist, fenoterol, or a mixture of CFC-11, CFC-12, and CFC-114,
and in the absence of treatment. The levels of exposure were not reported. Exposure
to the chlorofluorocarbon mixture significantly reduced forced expiratory volume
for 2 hr, relative to "no treatment", and for 8 hr relative to exposure to fenoterol
(containing CFC-11 and CFC-12). The results suggest that chlorofluorcarbons
can decrease bronchial tone in asthmatic patients, but that this effect is transient
and of a sufficiently small magnitude to be superseded by the dilating effects
of fenoterol when both fenoterol and chlorofluorcarbon propellants are inhaled
together. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.91 (1990)]**PEER REVIEWED**
Death rates among 539 workers exposed occupational in constructing and repairing
refrigeration equipment. The chlorofluorocarbons used were CFC-12, HCFC-22,
and CFC-502 (a mixture of CFC-115 and HCFC-22). No increase in total deaths
(18 cases) was seen among those employed more than 6 months, compared to the
expected number (26 cases), nor was there any statistically significant increase
in total tumor deaths or deaths caused by lung cancer or cardiovascular diseases.
When the study was restricted to those exposed for more than 3 or 10 years,
still no significant increases were see. No data on exposure levels were given.
[WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.93 (1990)]**PEER REVIEWED**
Eighty nine workers were examined during their work with refrigerant equipment.
The refrigerants used were mainly CFC-12 (in 56% of the cases) and HCFC-22 (32%),
the rest being CFC-11, CFC-500 (a mixture of CFC-12 and HCFC 152a), CFC-502
( a mixture of CFC-115 and HCFC 22). The mean exposure time was 10 min. Chlorofluorocarbon
concentrations in the breathing zone were measured for each person individually.
The levels exceeded 750 ppm at least once (as one minute mean values) for 60
of the 89 individuals. Cardiac arrhythmias were registered before, during, and
after the exposure by means of a portable ECG instrument connected to a tape
recorder. No statistically significant difference was found between exposed
and nonexposed period, nor was there any dose-related trend for different individuals
when grouped into different exposure groups. In this study, possible effects
on the central nervous system were also studied by means of simple reaction
time measurements before and after the exposure. No impairment was seen. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.93 (1990)]**PEER REVIEWED**
Occasionally liquid or gaseous F12 sprays unexpectedly from a pressurized
container or a refrigeratory into a person's eyes, but no significant injuries
from this source are reported. Because of the speed of reflex closure of the
eyes, it seems extremely unlikely that any serious injury would result from
an accidental spray of F-12 in the eyes of conscious or unanesthetized human
beings. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL:
Charles C. Thomas Publisher, 1986. 322]**PEER REVIEWED**
Five percent is said to induce dizziness. [Zenz, C. Occupational Medicine-Principles and Practical Applications.
2nd ed. St. Louis, MO: Mosby-Yearbook, Inc, 1988. 542]**PEER REVIEWED**
Ordinary occupational and domestic exposure to the gas causes neither ocular
nor respiratory irritation. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL:
Charles C. Thomas Publisher, 1986. 322]**PEER REVIEWED**
Propellant /fluorocarbon/ gases were generated from commercial aerosol units
and applied to the from distance of 50 cm for periods of 15 to 60 sec. At a
measured concn of 95,000 mg/cu m (1700 ppm), there was a biphasic change in
ventilation capacity, the first reduction occurring within a few minutes after
exposure, and second delayed until 13 to 30 min after exposure, and second delayed
until 13 to 30 min after exposure. Most subjects developed bradycardia, and
inversion of the T-wave. /Propellant gases/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1201]**PEER REVIEWED**
EXCESSIVE SKIN CONTACT WITH LIQ FLUOROCARBONS SHOULD BE MINIMIZED TO PREVENT
DEFATTING OF SKIN ... /FLUOROCARBONS/ [International Labour Office. Encyclopedia of Occupational Health
and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office,
1983. 897]**PEER REVIEWED**
... The combination of CFC with a sympathomimetic bronchodilator is potentially
dangerous for the treatment of bronchial asthma. For the same reason, sympathomimetic
drugs are contraindicated in cardiac resuscitation of patients suffering from
CFC poisoning. /Fluorocarbon poisoning/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1183]**PEER REVIEWED**
Fluorocarbon vapors are 4 to 5 times heavier than air. Thus high concn tend
to accumulate in low-lying areas, resulting in hazard of inhalation of concentrated
vapors, which may be fatal. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
Under certain condition, fluorocarbon vapors may decompose on contact with
flames or hot surfaces, creating potential hazard of inhalation of toxic decomposition
products. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
EARLY ... HUMAN EXPERIENCE INDICATED THAT HIGH VAPOR CONCN (EG, 20%) MAY CAUSE
CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA, BUT THAT THESE EFFECTS
WERE GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. ... CAUSE OF DEATH /FROM
ABUSE OF FLUOROCARBONS/ IS IN CONSIDERABLE DOUBT. FREEZING OF AIRWAY SOFT TISSUES
CAN PROBABLY BE ELIMINATED AS A CAUSE OF DEATH EXCEPT IN CASES WHERE THE PRODUCT
WAS SPRAYED DIRECTLY INTO THE MOUTH FROM ITS CONTAINER OR FROM A BALLOON CONTAINING
SOME LIQUID. LARYNGEAL SPASM OR EDEMA, OXYGEN DISPLACEMENT, OR SENSITIZATION
OF MYOCARDIUM TO ENDOGENOUS CATECHOLAMINES WITH SUBSEQUENT VENTRICULAR FIBRILLATION
APPEAR TO BE REASONABLE POSSIBILITIES. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/
[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
Aerosol sprays containing fluorocarbon propellants are another source of solvent
intoxication. Prolonged exposure or daily use may result in damage to several
organ systems. Clinical problems include cardiac arrhythmias, bone marrow depression,
cerebral degeneration, and damage to liver, kidney, & peripheral nerves.
Death occasionally has been attributed to inhalant abuse, probably via the mechanism
of cardiac arrhythmias, especially accompanying exercise or upper airway obstruction.
/Fluorocarbon propellants/ [Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G.
Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics.
9th ed. New York, NY: McGraw-Hill, 1996. 575]**PEER REVIEWED**
A SPECIAL CLASS OF CHEMICALS SUBJECT TO ABUSE BY INHALATION ARE THE FLUOROHYDROCARBONS
... THE "SNIFFING" OF SUCH AEROSOL SPRAYS IS HAZARDOUS PRACTICE. ... 110 "SUDDEN
SNIFFING DEATHS" /HAVE BEEN IDENTIFIED/ ... IN EACH CASE THE VICTIM SPRAYED
THE AEROSOL INTO A PLASTIC BAG, INHALED THE CONTENTS, BECAME EXCITED, RAN 90
M OR SO, COLLAPSED, & DIED. NECROPSY FINDINGS WERE LARGELY NEGATIVE ...
ALTHOUGH AMOUNT OF PROPELLANT ABSORBED INTO BLOOD FROM USE OF HAIRSPRAY, COSMETIC,
HOUSEHOLD, & MEDICATED AEROSOLS MUST VARY WITH CIRCUMSTANCES, PHYSICIAN
IS ADVISED TO COUNSEL ... PATIENT ON POTENTIAL DANGERS, PARTICULARLY FROM THEIR
USE IN POORLY VENTILATED CONFINED AREAS. IT IS POSSIBLE THAT PATIENTS WITH CARDIAC
OR RESPIRATORY DISORDERS MAY PROVE ESPECIALLY SUSCEPTIBLE. /FLUOROHYDROCARBONS/
[Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis
of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975. 910]**PEER
REVIEWED**
Fluorocarbons were initially believed to be compounds low in toxicity. In
the late 1960s there were early reports of deaths caused by intentional inhalation
abuse of various aerosols. Victims frequently discharged the aerosol contents
into a plastic bag and then inhaled the gaseous contents. Suffocation was initially
considered to be the cause of death. In 1970, 110 cases of "sudden sniffing
death" /were reviewed/ without finding evidence of suffocation. The majority
of those deaths (59) involved fluorocarbon propellants. He noted that in several
cases sudden death followed a burst of emotional stress or exercise. No significant
findings were noted at autopsy. /Fluorocarbons/ [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1281]**PEER REVIEWED**
Fluorocarbon propellants are anesthetic and cardiotoxic. ... Aerosol propellants
produce hallucinogenic effects, and, rarely, contact dermatitis. /Fluorocarbon
propellants/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 528]**PEER REVIEWED**
Fluorocarbon propellants, benzene, 1,1,1-trichloroethane, gasoline, toluene,
and hydrocarbons have been implicated in 110 sudden deaths after inhalant abuse
in which no obvious cardiac or pulmonary pathology existed. Heavy exercise or
stress was associated with 18 of those deaths, /it was/ proposed that these
inhalants act to sensitize the myocardium to endogenous catecholamines. Hypoxia,
hypercarbia, and acidosis may exacerbate these effects. /Fluorocarbon propellants/
[Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 841]**PEER REVIEWED**
Chlorinated hydrocarbons may cause systemic toxicity through percutaneous
absorption. Systemic toxicity includes convulsion, delirium, and central nervous
system depression /From table/. /Chlorinated hydrocarbons/ [Zenz, C. Occupational Medicine-Principles and Practical Applications.
2nd ed. St. Louis, MO: Mosby-Yearbook, Inc, 1988. 160]**PEER REVIEWED**
There are isolated reports of poisoning from exposure to refrigerants and
solvents, and some studies showing a higher incidence of coronary heart disease
among hospital personnel are required to establish causal relationship between
fluorine containing organic compounds, and cardiovascular and bronchopulmonary
diseases among exposed workers. The high incidence of cancer among hospital
personnel repeatedly exposed to fluorine-containing general anesthetics raises
a fundamental need to examine other chlorofluorocarbon-exposed workers for similar
effects. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1209]**PEER REVIEWED**
Clinical pathologists exposed to fluorocarbons in the preparation of frozen
tissue sections have been seen to develop coronary heart disease. /Fluorocarbons/
[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1209]**PEER REVIEWED**
There is undisputed evidence that the atmospheric concentrations of chlorofluorocarbons
deplete ozone in the stratosphere. A reduction in ozone concentration will result
in increased transmission of solar ultraviolet radiation through the stratosphere.
Many significant adverse effects of such an increase in exposure to this radiation
have been identified. ... One of the most well-defined human health effects
resulting from stratospheric ozone depletion is an increase in the frequency
of skin cancer expected as a result of even small increases in UV-B radiation
(280-320 nm) reaching the earhs's surface. /Chlorofluorocarbons/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.95 (1990)]**PEER REVIEWED**
Freons are toxic to humans by several mechanisms. Inhaled fluorocarbons sensitized
the myocardium to catecholamines, frequently resulting in lethal ventricular
arrhythmias. Because they are gases heavier than air, fluorocarbons can displace
atmospheric oxygen, thus resulting in asphyxiation. These compounds also have
a central nervous system (CNS) anesthetic effect analogous to a structurally
similar general anesthetic, halothane. Pressurized refrigerant or liquid fluorocarbons
with a low boiling point have a cryogenic effect on exposed tissues, causing
frostbite, laryngeal or pulmonary edema, and gastrointestinal perforation. Certain
fluorocarbons degrade at high temperatures into toxic products of chlorine,
hydrofluoric acid, or phosgene gases. /Freons/ [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1281]**PEER REVIEWED**
... HIGH VAPOR CONCN (EG, 20%) MAY CAUSE CONFUSION, PULMONARY IRRITATION,
TREMORS & RARELY COMA ... BUT ... THESE EFFECTS WERE GENERALLY TRANSIENT
& WITHOUT LATE SEQUELAE. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
Non-occupational exposure and accidental or abusive inhalation of aerosols
/due to Fluorocarbon propellants/ have also been documented, the main symptoms
being CNS depression and cardiovascular reactions. Cardiac arrhythmia, possibly
aggravated by elevated levels of catecholamines due to stress or by moderate
hypercapnia, is suggested as the cause of these adverse response, which may
lead to death. /Aerosols/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.20 (1990)]**PEER REVIEWED**
Manufacturing processes use hydrofluoric acid from fluorospar in the production
of most fluorine containing organic compounds. Some processes use carbon tetrachloride
from carbon disulfide or as a co product of perchloroethylene and chlorination
of propylene, or chloroform from chlorination of methanol. The major hazards
relate primarily to the inadvertent release of hydrofluoric acid or carbon tetrachloride,
rather than to the manufactured final product. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1194]**PEER REVIEWED**
... CAUSE OF DEATH /FROM ABUSE OF FLUOROCARBONS/ IS IN ... DOUBT. FREEZING
OF AIRWAY SOFT TISSUES CAN PROBABLY BE ELIMINATED ... EXCEPT IN CASES WHERE
PRODUCT WAS SPRAYED DIRECTLY INTO MOUTH FROM CONTAINER OR BALLOON CONTAINING
SOME LIQ. /FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
... CAUSE OF DEATH /FROM ABUSE OF FLUOROCARBONS/ ... IN ... DOUBT. ... LARYNGEAL
SPASM OR EDEMA, OXYGEN DISPLACEMENT, OF SENSITIZATION OF MYOCARDIUM TO ENDOGENOUS
CATECHOLAMINES WITH ... VENTRICULAR FIBRILLATION APPEAR TO BE ... POSSIBILITIES.
/FLUOROCARBON REFRIGERANTS & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
The toxicity of Chlorofluorocarbons (CFCs) had been considered to be low;
it is absorbed via the lungs and undergoes little subsequent biotransformation.
In the United States when sudden unexplained deaths of aerosol "sniffers" were
reported they were considered to be possibly due to cardiac arrhythmias induced
by the CFC propellants. /CFCs/ [Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd
ed. Boston, MA: Little, Brown and Company, 1992. 1299]**PEER REVIEWED**
Speizer and coworkers reported that pathology personnel exposed to FC-22 and
FC-12 /dichlorodifluoromethane/ while preparing frozen sections had a greater
prevalence of palpitations than an unexposed control group; ... Continuous electrocardiographic
(EKG) monitoring of several exposed subjects in the course of their work showed
multiple arrhythmias. [Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd
ed. Boston, MA: Little, Brown and Company, 1992. 1300]**PEER REVIEWED**
Studies on two human volunteers who inhaled CFC-12 at 10,000 ppm for 2.5 hours
showed a 7% reduction in a standardized psychomotor test score but no other
adverse effects. [American Conference of Governmental Industrial Hygienists, Inc.
Documentation of the Threshold Limit Values and Biological Exposure Indices.
6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 421]**PEER REVIEWED**
Blood levels of CFC-12 were below detection limits in normal subjects using
household aerosols; in asthmatic subjects using an aerosol inhaler, blood levels
were much lower than in dogs exposed at the threshold for cardiac sensitization.
Radiolabeled tests showed essentially all the dose of CFC-12 (95%-103%) exhaled
within the first hour after a 12 or 17 minute inhalation at 1000 ppm.; total
metabolites were <0.2% of the administered dose. At 30 minutes, retention
of the labeled dose inhaled in a single breath was 10% versus 23%, 20%, &
12% for comparable doses of trichlorofluoromethane (FC-11), 1,1,2-trichloro-1,2,2-trifluoroethane
(FC-113), & 1,2-dichloro-1,1,2,2-tetrafluoroethane (FC-114), respectively.
For an 8 hr inhalation at 1000 ppm, a pharmacokinetic model based on analyses
in dogs & humans gave an estimate of 55% absorption of the inhaled CFC-12.
This dose would result in roughly 1/20th the blood level required to sensitize
dogs also receiving the stress of IV epinephrine. [American Conference of Governmental Industrial Hygienists, Inc.
Documentation of the Threshold Limit Values and Biological Exposure Indices.
6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 421]**PEER REVIEWED**
Following exposure to CFC-12 at a concentration of 1% (50 g/cu m) for 150
min, a 7% decrease in psychomotor test scores was noted, but no effects were
observed at 0.1% (5 g/cu m). [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.19 (1990)]**PEER REVIEWED**
Medical Surveillance:
Employees should be screened for history of certain medical conditions ...
which might place the employee at increased risk from dichlorodifluoromethane
exposure. Cardiovascular disease: In persons with impaired cardiovascular function,
especially those with a history of cardiac arrhythmias, the inhalation of dichlorodifluoromethane
might cause exacerbation of disorders of the conduction mechanism due to its
sensitizing effects on the myocardium. ... Any employee developing the above-listed
conditions should be referred for further medical examination. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 1]**PEER REVIEWED**
Populations at Special Risk:
Employees /with cardiovascular disease are/ at increased risk. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 1]**PEER REVIEWED**
IT IS POSSIBLE THAT PT WITH CARDIAC OR RESP DISORDERS MAY PROVE ESP SUSCEPTIBLE.
/FLUOROCARBONS/ [Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis
of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975. 910]**PEER
REVIEWED**
Probable Routes of Human Exposure:
NIOSH (NOES Survey 1981-1983) has statistically estimated that 435,098 workers
(125,602 of these are female) are potentially exposed to dichlorodifluoromethane
in the US(1). Occupational exposure may be through inhalation and dermal contact
with this compound at workplaces where dichlorodifluoromethane is still used,
such as air conditioning repair shops(SRC). This survey was conducted prior
to the Montreal Protocol which scheduled the production phase-out of this compound
and other chlorofluorocarbons, and is not an accurate measure of the current
occupational exposure(SRC). Due to its long atmospheric residence time, the
general population may be exposed to dichlorodifluoromethane via inhalation
of ambient air(SRC). [(1) NIOSH; National Occupational Exposure Survey (NOES) (1983)]**PEER
REVIEWED**
Body Burden:
In a pilot study of pollutants in the milk of women living in 4 urban-industrial
areas in the US, dichlorodifluoromethane was identified, not quantified, in
2 of 8 samples(1). [(1) Pellizzari ED et al; Bull Environ Contam Toxicol 28: 322-8
(1982)]**PEER REVIEWED**
Emergency Medical Treatment:
Emergency Medical Treatment:
EMT Copyright Disclaimer:
Portions of the POISINDEX(R) database are provided here for
general reference. THE COMPLETE POISINDEX(R) DATABASE, AVAILABLE FROM MICROMEDEX,
SHOULD BE CONSULTED FOR ASSISTANCE IN THE DIAGNOSIS OR TREATMENT OF SPECIFIC
CASES. Copyright 1974-1998 Micromedex, Inc. Denver, Colorado. All Rights
Reserved. Any duplication, replication or redistribution of all or part
of the POISINDEX(R) database is a violation of Micromedex' copyrights and
is strictly prohibited.
The following Overview, *** FLUORINATED HYDROCARBONS ***, is relevant
for this HSDB record chemical.
Life Support:
o This overview assumes that basic life support measures
have been instituted.
Clinical Effects:
SUMMARY OF EXPOSURE
0.2.1.1 ACUTE EXPOSURE
o LOW CONCENTRATION - Inhalations such as those caused by
leaking air conditioners or refrigerators usually
result in transient eye, nose, and throat irritation.
Palpitations, light headedness, and headaches are also
seen.
o HIGH CONCENTRATION - Inhalation associated with
deliberate abuse, or spills or industrial use occurring
in poorly ventilated areas has been associated with
ventricular arrhythmias, pulmonary edema and sudden
death.
HEENT
0.2.4.1 ACUTE EXPOSURE
o EYES - Eye irritation occurs with ambient exposure.
Frostbite of the lids may be severe. Ocular
instillation results in corneal burns in rabbits.
o NOSE - Nasal irritation occurs with ambient exposure.
o THROAT - Irritation occurs. Frostbite of the lips,
tongue, buccal mucosa and hard palate developed in a
man after deliberate inhalation.
CARDIOVASCULAR
0.2.5.1 ACUTE EXPOSURE
o Inhalation of high concentrations is associated with
the development of refractory ventricular arrhythmias
and sudden death, believed to be secondary, primarily,
to myocardial sensitization to endogenous
catecholamines. Some individuals may be susceptible to
arrhythmogenic effects at lower concentrations.
RESPIRATORY
0.2.6.1 ACUTE EXPOSURE
o Pulmonary irritation, bronchial constriction, cough,
dyspnea, and chest tightness may develop after
inhalation. Chronic pulmonary hyperreactivity may
occur. Adult respiratory distress syndrome has been
reported following acute inhalational exposures.
Pulmonary edema is an autopsy finding in fatal cases.
NEUROLOGIC
0.2.7.1 ACUTE EXPOSURE
o Headache, dizziness, and disorientation are common.
Cerebral edema may be found on autopsy. A syndrome of
impaired psychomotor speed, impaired memory and
learning, and emotional lability has been described in
workers with chronic occupational exposure to
fluorinated hydrocarbons.
GASTROINTESTINAL
0.2.8.1 ACUTE EXPOSURE
o Nausea may develop. Ingestion of a small amount of
trichlorofluoromethane resulted in necrosis and
perforation of the stomach in one patient.
HEPATIC
0.2.9.1 ACUTE EXPOSURE
o Jaundice and mild elevations in transaminases may
develop after inhalational exposure or ingestion.
Hepatocellular coagulative necrosis has been observed
on liver biopsy.
DERMATOLOGIC
0.2.14.1 ACUTE EXPOSURE
o Dermal contact may result in defatting, irritation or
contact dermatitis. Severe frostbite has been reported
as an effect of freon exposure. Injection causes
transient pain, erythema and edema.
MUSCULOSKELETAL
0.2.15.1 ACUTE EXPOSURE
o Rhabdomyolysis has been reported in a worker
susceptible to malignant hyperthermia after exposure to
fluorinated hydrocarbons and also following intentional
freon inhalation. Compartment syndrome is a rare
complication of severe exposure.
REPRODUCTIVE HAZARDS
o Dichlorodifluoromethane was not teratogenic in rats and
rabbits.
o The reproductive effects of 1,1,1,2-tetrafluoroethane
were studied in rats. No adverse effects on
reproductive performance was noted or on the
development, maturation or reproductive performance of
up to two successive generations.
GENOTOXICITY
o The hydrochlorofluorocarbons, HCFC-225ca and HCFC-225cb,
were not mutagenic in the Ames reverse mutation assay,
or clastogenic in the chromosomal aberration assay with
Chinese hamster lung cells. Neither induced unscheduled
DNA synthesis in liver cells. Both of these agents were
clastogenic in the chromosomal aberration assay with
human lymphocytes.
Laboratory:
o Fluorinated hydrocarbons plasma levels are not clinically
useful.
o No specific lab work (CBC, electrolyte, urinalysis) is
needed unless otherwise indicated.
o Obtain baseline pulse oximetry or arterial blood gas
analysis.
Treatment Overview:
SUMMARY EXPOSURE
o Monitor EKG and vital signs carefully. Cardiopulmonary
resuscitation may be necessary.
ORAL EXPOSURE
o These substances may cause frostbite to the upper airway
and gastrointestinal tract after ingestion. Administer
oxygen and manage airway as clinically indicated.
Emesis, activated charcoal, and gastric lavage are not
recommended.
INHALATION EXPOSURE
o MONITOR ECG and VITAL SIGNS carefully. Cardiopulmonary
resuscitation may be necessary. AVOID CATECHOLAMINES.
o PROVIDE A QUIET CALM ATMOSPHERE to prevent adrenaline
surge if the patient is seen before the onset of cardiac
arrhythmias. Minimize physical exertion.
o MONITOR pulse oximetry or arterial blood gases.
o Provide symptomatic and supportive care.
o These substances may cause frostbite of the upper airway
with the potential for severe edema. Administer oxygen
and manage airway early in patients with evidence of
upper airway injury.
o PULMONARY EDEMA (NONCARDIOGENIC): Maintain ventilation
and oxygenation and evaluate with frequent arterial
blood gas or pulse oximetry monitoring. Early use of
PEEP and mechanical ventilation may be needed.
EYE EXPOSURE
o DECONTAMINATION: Irrigate exposed eyes with copious
amounts of tepid water for at least 15 minutes. If
irritation, pain, swelling, lacrimation, or photophobia
persist, the patient should be seen in a health care
facility.
o Ophthamologic consultation should be obtained in any
symptomatic patients.
DERMAL EXPOSURE
o DECONTAMINATION: Remove contaminated clothing and wash
exposed area thoroughly with soap and water. A
physician may need to examine the area if irritation or
pain persists.
o If frostbite has occurred, refer to dermal treatment in
the main body of this document for rewarming.
Range of Toxicity:
o Freons are very toxic when inhaled in high concentrations
and/or for extended periods. At lower concentrations or
brief exposure, freons may cause transient eye, nose, and
throat irritation. There is significant interpatient
variation and it is difficult to predict which patient
will exhibit symptoms following exposure.
Treatment is entirely symptomatic. [Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London:
Williams and Wilkins, 1982. 119]**PEER REVIEWED**
... Emergency treatment is supportive and includes decontamination, oxygen,
and any specific therapy required in a particular case such as antiarrhythmics
or anticonvulsants. A few patients may require intermittent positive-pressure
ventilation, dialysis, or treatment for hepatic failure. /Solvent abuse/ [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1259]**PEER REVIEWED**
... In persons who are intoxicated with fluorocarbons, steps can be taken
to lessen the risk of arrhythmias. ... Before evaluation at the hospital, patients
should be advised to avoid strenuous exercise. In the hospital, patients can
be placed in a quiet, nonthreatening environment and sedated if necessary. If
hypoxic, oxygen should be administered and metabolic abnormalities corrected.
Sympathomimetic drugs should be avoided. Ventricular arrhythmias are best treated
with beta-blocking agents. /Fluorocarbons/ [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 81]**PEER REVIEWED**
Patients with fluorohydrocarbon poisoning should not be given epinephrine
(Adrenalin) or similar drugs because of the tendency of fluorohydrocarbon to
induce cardiac arrhythmia, including ventricular fibrillation. /Fluorohydrocarbons/
[Zenz, C. Occupational Medicine-Principles and Practical Applications.
2nd ed. St. Louis, MO: Mosby-Yearbook, Inc, 1988. 543]**PEER REVIEWED**
Victims of Freon inhalation require management for hypoxic, CNS anesthetic,
and cardiac symptoms. Patients must be removed from the exposure environment,
and high-flow supplemental oxygen should be utilized. The respiratory system
should be evaluated for injury, aspiration, or pulmonary edema and treated appropriately.
CNS findings should be treated supportively. A calm environment with no physical
exertion is imperative to avoid increasing endogenous adrenegic levels. Exogenous
adrenergic drugs must not be used to avoid inducing sensitized myocardial dysrhythmias.
Atropine is ineffective in treating bradyarrhythmias. For ventricular dysrhythmias,
diphenylhydantoin and countershock may be effective. Cryogenic dermal injuries
should be treated by water bath rewarming at 40 to 42 deg C until vasodilatory
flush has returned. Elevation of the limb and standard frostbite management
with late surgical debridement should be utilized. Ocular exposure requires
irrigation and slit-lamp evaluation for injury. /Freons/ [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1282]**PEER REVIEWED**
... IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES &
ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE
HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1201]**PEER REVIEWED**
Basic treatment: Establish a patent airway. Suction if necessary. Watch for
signs of respiratory insufficiency and assist ventilations as needed. Administer
oxygen by nonrebreather mask at 10 to 15 L/min. Minimize physical activity and
provide a quiet atmosphere. Monitor for pulmonary edema and treat if necessary
... . Anticipate seizures and treat if necessary ... . For eye contamination,
flush eyes immediately with water. Irrigate each eye continuously with normal
saline during transport ... . Do not use emetics. Rinse mouth and administer
5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a
strong gag reflex, and does not drool. Administer activated charcoal ... . Treat
frostbite with rapid rewarming techniques ... . /Chlorinated fluorocarbons (CFCs)
and related compounds/ [Bronstein, A.C., P.L. Currance; Emergency Care for Hazardous
Materials Exposure. 2nd ed. St. Louis, MO. Mosby Lifeline. 1994. 192]**PEER
REVIEWED**
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway
control in the patient who is unconscious or in respiratory arrest. Positive
pressure ventilation techniques with a bag valve mask device may be beneficial.
Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV
with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if
signs of hypovolemia are present. Watch for signs of fluid overload. Consider
drug therapy for pulmonary edema ... . Treat seizures with diazepam ... . Use
proparacaine hydrochloride to assist eye irrigation ... . /Chlorinated fluorocarbons
(CFCs) and related compounds/ [Bronstein, A.C., P.L. Currance; Emergency Care for Hazardous
Materials Exposure. 2nd ed. St. Louis, MO. Mosby Lifeline. 1994. 192]**PEER
REVIEWED**
Animal Toxicity Studies:
Non-Human Toxicity Excerpts:
... ABOVE 3000 PPM ... ADMIN TO RATS 4 HR/DAY FOR 10 DAYS, CAUSED SLIGHT LIVER
AND BONE MARROW INJURY. [Thienes, C., and T.J. Haley. Clinical Toxicology. 5th ed. Philadelphia:
Lea and Febiger, 1972. 150]**PEER REVIEWED**
... TWITCHING & TREMORS /OBSERVED IN RATS AT/ CONCN OF 30-40%, LOSS OF
REFLEX AT 50% & ABOVE. AT 70 & 80%, CORNEAL REFLEX WAS ABSENT &
ANIMALS WERE IN DEEP ANESTHESIA. A FEW OF THE ANIMALS WERE EXPOSED AS LONG AS
4-6 HR AT 80% AND ... SUFFERED NO PERMANENT EFFECTS. [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II:
Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 1325]**PEER REVIEWED**
... Dogs, monkeys, rats, rabbits & guinea pigs /had continuous exposure/
to 810 ppm of FC 12, 24 hr daily for 90 days. No deaths were attributed to exposure
and pathologic changes ... occurred only in guinea pigs, who showed microscopic
liver injury. ... At 200,000 ppm, guinea pigs, dogs and monkeys exposed some
40 hr weekly for 10-12 weeks showed generalized tremors and other signs of mild
/CNS depression/, as well as slight blood changes, but no pathologic effects.
[American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 181]**PEER
REVIEWED**
DOGS, MONKEYS, & GUINEA PIGS EXPOSED TO 20% OF GAS IN AIR FOR SEVERAL
HR A DAY FOR SEVERAL DAYS SHOWED TEMPORARY INTOXICATION WITH TREMORS, ATAXIA,
AND TENDENCY TO STARE, SALIVATE, & LACRIMATE, BUT NO CUMULATIVE TOXIC EFFECT
& NO SPECIFIC OCULAR DISTURBANCE. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL:
Charles C. Thomas Publisher, 1986. 322]**PEER REVIEWED**
In gaseous or vapor form at room temperature or body temperature, F 12 has
very little toxicity to the eye, inside or outside. A bubble of the gas injected
into the anterior chamber of rabbit eyes has not proved damaging to the cornea.
Exposure of a rabbit eye to pure F 12 gas at room temperature for one and one-half
minutes induced a slight irregularity of the corneal epithelium, but the eye
was completely normal the next day. [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL:
Charles C. Thomas Publisher, 1986. 323]**PEER REVIEWED**
MICE EXPOSED FOR 3 OR 6 WK, 30 MIN/DAY TO 40,000 PPM, SHOWED ... RESP PATHOLOGY.
RATS FED 160 TO 379 MG/KG, 5 DAYS/WK FOR 18 WK, SHOWED ... SLIGHT ELEVATION
OF PLASMA ALKALINE PHOSPHATASE. [American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 181]**PEER
REVIEWED**
... ADMIN BY GAVAGE TO /GROUPS OF 50 MALE & FEMALE ALBINO/ RATS AT 15
OR 150 MG/KG/DAY FOR 2 YR, /CONTROL GROUPS OF 50 RATS OF EACH SEX RECEIVED VEHICLE
BY INTUBATION/; & IN FOOD TO BEAGLE DOGS AT 8 OR 80 MG/KG/DAY FOR 2 YR.
EXCEPT FOR SLIGHT ADVERSE EFFECT ON GROWTH OF RATS THAT RECEIVED HIGH DOSES,
NO CLINICAL, BIOCHEMICAL, URINARY, HEMATOLOGICAL, OR HISTOPATHOLOGICAL CHANGES
... FOUND IN EITHER SPECIES. NO EVIDENCE OF CARCINOGENIC RESPONSE ... OBSERVED.
[National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 103]**PEER REVIEWED**
IN CHRONIC EXPOSURE STUDIES, MALE & FEMALE RATS ... WERE GIVEN ... DOSES
OF 15 OR 150 MG/KG BY INTUBATION. THE RATS WERE THEN BRED & EVALUATED FOR
FERTILITY, CORPORA LUTEA, IMPLANTATION SITES, RESORPTION SITES, & NUMBER
OF LIVE FETUSES/LITTER. NO DOMINANT LETHALITY WAS FOUND AT EITHER DOSE LEVEL.
[National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 103]**PEER REVIEWED**
FREON 12 WAS NOT MUTAGENIC TO CHINESE HAMSTER OVARY CELLS IN THE PRESENCE
OR ABSENCE OF ACTIVATION SYSTEM. [KRAHN DF; BANBURY REP 2 (MAMM CELL MUTAGEN: MATURATION TEST
SYSTEM) 251-61 (1979)]**PEER REVIEWED**
EFFECTS OF FC 12 ON ELECTRICAL ACTIVITY OF CELLS IN ATRIAL & VENTRICULAR
MYOCARDIUM OF ANESTHETIZED RATS WERE RECORDED. MAJOR DECREASE IN DIASTOLIC POTENTIAL,
AMPLITUDE OF ACTION POTENTIAL, & MODIFICATION IN SHAPE OF THE ACTION POTENTIAL
WAS OBSERVED. RHYTHM ABNORMALITIES CONSISTED OF A DECR IN ATRIOVENTRICULAR CONDUCTION
& CHANGES IN THE MYOCARDIAL PASSIVE EXCITABILITY. CARDIOTOXICITY OF FC 12
IS ASSUMED TO AFFECT PASSIVE OR ACTIVE TRANSMEMBRANE IONIC MOVEMENTS. [LESSARD Y ET AL; CR SEANCES SOC BIOL SES FIL 174 (1): 52-7 (1980)]**PEER
REVIEWED**
Pathologic liver changes were reported in guinea pigs chronically exposed
(continued for 90 days; or eight hr daily, 5 days weekly, for six wk) to F 12
at levels of about 4,000 mg/cu m (0.08 % by vol). [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-52-5
(1980) EPA 440/5-80-051]**PEER REVIEWED**
In one chronic (90 day) feeding study of F-12 in rats at 35 and 350 mg/kg/day
... somewhat elevated urinary fluoride and plasma alkaline phosphatase levels.
No changes in dogs at 10 and 100 mg/kg/day were observed. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-56
(1980) EPA 440/5-80-051]**PEER REVIEWED**
In a two-yr study using rats intubated with F 12 in corn oil at 15 and 150
mg/kg/day ... some suppresssion of wt gain at the high dose level, but no effects
with respect to clinical signs, liver function, hematology, or histopathology
/were observed/. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-59
(1980) EPA 440/5-80-051]**PEER REVIEWED**
Significant mutagenic activity of F 12 at 2.47x10+6 mg/cu m (50%) in air in
a Neurospora crassa test system. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-59
(1980) EPA 440/5-80-051]**PEER REVIEWED**
The relative potency of effect of a wide range of halogenated and unsubstituted
hydrocarbons on the CNS and heart of experimental animals were determined. The
chemicals used caused stimulation or depression of the rat CNS after 10 min
inhalation at 0.24-80% (vol/vol), and cardiac sensitization in dogs after 5
minute inhalation at 0.12-80% (vol/vol). The toxicity could not be correlated
with chemical structure, mol wt, the presence or absence of various halogens
or the degree of saturation, but it was inversely related to the saturated vapor
pressure. When the results were expressed on a thermodynamic scale, the chemicals
had similar potencies at relative saturation of 0.004-0.04. The effects of these
chemicals on the CNS and heart are probably structurally non-specific, and the
chemical may be regarded as ... toxicants whose effects are predictable from
their physico-chemical properties. [Clark DG, Tinston DJ; Human Toxicol 1 (3): 239-47 (1982)]**PEER
REVIEWED**
... INSEMINATED WISTAR ALBINO RATS & ALBINO RABBITS ... /WERE/ ADMIN MIXT
OF 90% FREON 12 ... & 10% FREON 11 BY INHALATION FOR 2 HR/DAY. RATS WERE
EXPOSED ON DAYS 4 TO 16 OF GESTATION & RABBITS ON DAYS 5 TO 20. MIXT WAS
ADMIN IN 20% CONCN (200,000 PPM). NO INDICATIONS OF ANY EMBRYOTOXIC, FETOTOXIC
OR TERATOGENIC CHANGES WERE FOUND WHEN DAMS WERE SACRIFICED & FETUSES REMOVED
ON DAY 20 OF GESTATION (RATS) OR DAY 30 OF GESTATION (RABBITS). [National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 103]**PEER REVIEWED**
CFC-11, CFC-12, CFC-113, and CFC-114 at 40% in sesame oil were sprayed onto
shaved rabbit skin for 12 exposures with no effect. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.73 (1990)]**PEER REVIEWED**
CFC-11, CFC-12, CFC-114, and mixtures of CFC-11 and CFC-12 and of CFC-11 and
CFC-22 /were applied/ to the skin, tongue, soft palate and auditory canal of
rats, 1-2 times/day, 5 days/week, for 5-6 weeks. The same compounds were applied
once a day, 5 days/week for 1 month to the eye of rabbits. Slight irritation
was noted only in the skin of the rats and in the eye of the rabbits. The healing
rate of experimental burns on the skin of rabbits, however, was noticeably retarded
by all of the compounds. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.74 (1990)]**PEER REVIEWED**
Experimental evidence suggests that increased UV-B irradiation at the earth's
surface, resulting from ozone depletion /caused by the atmospheric chlorofluorocarbons/,
would have deleterious effects on both terrestrial and aquatic biota. Despite
uncertanities resulting from the complexities of field experiments, the data
currently available suggest that crop yields and forest productivity are vulnerable
to increased levels of solar UV-B radiation. Existing data also suggest that
increased UV-B radiation will notify the distribution and abundance of plants,
and change ecosystem structure. /UV-B Radiation/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.18 (1990)]**PEER REVIEWED**
Various studies of marine ecosystems have demonstrated that UV-B radiation
causes damage to fish larvae and juveniles, shrimp larvae, crab larvae, copepods,
and plants essential to the marine food web. These damaging effects include
decreased fecundity, growth, and survival. Experimental evidence suggests that
even small increases in ambient UV-B exposure could result in significant ecosystem
changes. /UV-B Radiation/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.18 (1990)]**PEER REVIEWED**
Short-term inhalation studies have been reported for CFC-11, CFC-12, CFC-112,
CFC-113, CFC-114, and CFC-115. The results showed low toxicity, and the effects
observed were related mainly to the CNS, respiratory tract, and the liver. Oral
toxicity studies have confirmed the low toxicity. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.18 (1990)]**PEER REVIEWED**
... Dichlorodifluoromethane ... /was/ tested by inhalation on Sprague-Dawley
rats and Swiss mice. The animals were exposed for 4 hr a day, 5 days a week;
rats were exposed for 104 weeks, and mice were exposed for 78 weeks. Animals
were observed until spontaneous death. Exposure of rats to dichlorodifluoromethane
resulted in no noticeable differences in the incidence of total benign and malignant
tumors, and of the most frequently expected or rate of tumors. Exposure of mice
to dichlorodifluoromethane resulted in a higher number of total tumors in males
and females which was dose related in males, pulmonary adenomas in males and
females at 5000 ppm, and leukemias in males at 5000 and 1000 ppm and in females
at 1000 ppm. [Maltoni C et al; Annals of the New York Academy of Sciences
534: 261-82 (1988)]**PEER REVIEWED**
Groups of four male and four female beagle dogs were orally administered CFC-12
(in frozen dog food) at measured doses of 0, 8, or 80 mg/kg per day for 2 years.
None of the dogs died or showed signs of toxicity. No significant differences
between treated and control groups were found in food consumption, body weight,
periodic hematology, clinical chemistry and urine testing, organ weights, or
histopathological findings. An adrenal function test (urinary 17-ketosteroid
excretion) also revealed no effects. There was no evidence of carcinogenicity.
[WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.76 (1990)]**PEER REVIEWED**
In a three-generation, oral gavage study in rats using CFC-12 (in corn oil)
at average doses of 15 and 150 mg/kg per day. No adverse /were found/ effects
on reproductive capability as measured by the fertility index (percentage of
matings resulting in pregnancy), gestation index (percentage of pregnancies
resulting in birth of live litters), viability index (percentage of rats born
that survived four days), and lactation index (percentage of rats alive at 4
days that survived to be weaned at 21 days). [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.77 (1990)]**PEER REVIEWED**
Long term oral studies of CFC-12 /were conducted/ on rats and dogs. As part
of a multi-generation reproductive and chronic toxicity study, groups of 50
male and 50 female Charles River rats of the F1a generation remained in the
test for 2 years, with an interim kill at 1 year. Starting at 6 weeks of age
controls, low dose, and high dose groups were administered CFC-12 in corn oil
or corn oil alone daily by gavage for 6 weeks and 5 times per week thereafter.
Over the course of the study, actual daily doses of CFC-12 for low dose males
and females declined from 27 to 11 and 25 to 11 mg/kg per day respectively and,
for the high dose males and females, declined from 273 to 130 and 242 to 128
mg/kg per day, respectively. Average doses were 15 mg/kg per day for the low
dose groups and 150 mg/kg per day for the high dose groups. Body weight gain
was depressed in the high dose groups, particularly among the females, and a
slight decline in food efficiency was noted in high dose females, relative to
controls. No overt signs of toxicity were seen, and there were no significant
differences between treated and control groups in survival, periodic measurements
of hematological, clinical chemistry, and urinalysis values, or in organ weights
and histopathological findings. No evidence of carcinogenicity was seen. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.76 (1990)]**PEER REVIEWED**
Groups of 25 to 27 pregnant Charles River rats were given CFC-12 in corn oil
by gavage at doses of 16.6 or 179 mg/kg per day on days 6-15 of gestation. Neither
dose induced any evidence of embryotoxicity or teratogenicity. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.78 (1990)]**PEER REVIEWED**
Negative results were also obtained for CFC-11, CFC-12, and CFC-115 in a cell
transformation assay and for CFC-11 and CFC-12 in a mammalian cell mutagenicity
test. CFC-12 was also tested in a plant assay using Tradescantia, and found
to be negative. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.79 (1990)]**PEER REVIEWED**
A dominant lethal assay was performed as part of a reproduction study on rats
using CFC-12 at doses of 15 and 150 mg/kg per day (gavage) for several weeks.
... Negative results were obtained /in this in vivo assay/ ... . [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.79 (1990)]**PEER REVIEWED**
When administered to groups of 90 male and 90 female /Sprague-Dawley/ rats
and 60 male and 60 female /Swiss/ mice at concentrations of 1000 or 5000 ppm
(57 or 285 g CFC-11/cu m; 49 or 247 g CFC-12/cu m), 4 hr/day, 5 days/week, neither
compound was found to have induced statistically significant differences in
the incidence of total benign or malignant tumors when compared with groups
of unexposed rats or mice. The incidence of all tumors and of some particularly
frequently occurring spontaneous tumors in mice showed a tendency to increase
in animals exposed to CFC-11 and CFC-12 and that the increased incidence was
usually observed in one sex and was not always dose related, possibly due to
a longer survival of the treated mice compared with controls. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.82 (1990)]**PEER REVIEWED**
When the lids of a rabbit's eye have been held open and a blast of a mixture
of liquid F-12 and lubricating oil from a refrigeratory has been applied directly
to the open eye continously for a second or two, this has caused momentary freezing
of the anterior segment of the eye followed by slight epithelial edema and partial
loss of epithelium, but complete recovery in three days. Spraying of rabbit
eyes with pure liquified F-12 for five to ten seconds caused damage of the corneal
endothelium, shedding in gray sheets from the posterior surface of the cornea,
and this led to swelling of the stroma. However, there was gradual recovery
so that only a small axial nebula persisted after six weeks. Exposure to the
liquid spray continuously for thirty seconds caused much more severe corneal
damage, the cornea ultimately becoming opaque and the globe /atrophic/ ... .
[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL:
Charles C. Thomas Publisher, 1986. 323]**PEER REVIEWED**
Fluorocarbon inhalation in dogs resulted in dysrhythmias that were enhanced
by anoxia, injected epinephrine, and noise stress. Fatal responses resulted
from inhaled concentrations of 0.35 to 0.61 per cent of Freon 11 and of 5 percent
of Freon 12 and 114. [Haddad, L.M., Clinical Management of Poisoning and Drug Overdose.
2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990. 1281]**PEER REVIEWED**
EARLY ANIMAL ... WORK INDICATED THAT HIGH VAPOR CONCN (EG, 20%) MAY CAUSE
CONFUSION, PULMONARY IRRITATION, TREMORS & RARELY COMA, BUT THAT THESE EFFECTS
WERE GENERALLY TRANSIENT & WITHOUT LATE SEQUELAE. /FLUOROCARBON REFRIGERANTS
& PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
The immume system of experimental animals is suppressed in specific ways by
UV-B radiation. This results in a decreased resistance to implanted UV-B nduced
tumors and an increased growth of such tumors in mice, in the suppression of
sensitization by contact allergens, and the response to allergens in sensitized
animals. /Chlorofluorocarbons/ [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.101 (1990)]**PEER REVIEWED**
Two series of experiments were conducted to determine the effects of bromotrifluoromethane,
bromochlorodifluoromethane, and dichlorodifluoromethane on the isolated, perfused
rabbit heart. Hearts were perfused through the aorta. Left ventricular mechanical
activity was monitored concurrently with action potentials recorded from left
ventricular myocardial fibers. In the first series, mechanical performance curves
were determined for each of 7 hearts using intraventricular balloons to control
end diastolic pressure. The relative effectiveness of these compounds as negative
isotropic agents was bromochlorodifluoromethane > dichlorodifluoromethane
> bromotrifluoromethane. In the 2nd series of experiments, hearts were exposed
to increasing concentrations of each fluorocarbon. Controls were exposed to
equivalent concentrations of nitrogen. Exposure to increasing concentrations
of bromotrifluoromethane decreased peak left ventricular pressure, the integral
of the pressure curve, and the time 20% repolarization of the action potential.
Exposure to increasing concentrations of bromochlorodifluoromethane reduced
peak left ventricular pressure and the maximal rate of rise of the pressure
curve and. Exposure to increasing levels of dichlorodifluoromethane decreased
peak left ventricular pressure and the maximal rate of rise of the pressure
curve. [Toy PA, et al; Toxicol Appl Pharmacol 38 (1): 7-18 (1976)]**PEER
REVIEWED**
... Chlorofluorocarbons (CFCs) could sensitize the canine myocardium to adrenaline,
resulting in serious cardiac arrhythmias. [Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd
ed. Boston, MA: Little, Brown and Company, 1992. 1300]**PEER REVIEWED**
Three propellant chlorofluorocarbons (FC-11, FC-12 /dichlorodifluoromethane/,
FC-22) administered by inhalation at concentrations of 5000 and 1000 ppm for
4 hours daily, 5 days weekly for 78 to 104 weeks to rats and mice had no carcinogenic
effects. [Rom, W.N. (ed.). Environmental and Occupational Medicine. 2nd
ed. Boston, MA: Little, Brown and Company, 1992. 1300]**PEER REVIEWED**
Non-Human Toxicity Values:
LD50 Mouse inhalation 760,000 ppm/30 min [Verschueren, K. Handbook of Environmental Data of Organic Chemicals.
2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983. 485]**PEER REVIEWED**
LD50 Guinea pig inhalation >800,000 ppm/30 min [Verschueren, K. Handbook of Environmental Data of Organic Chemicals.
2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983. 485]**PEER REVIEWED**
LD50 Rabbit inhalation >800,000 ppm/30 min [Verschueren, K. Handbook of Environmental Data of Organic Chemicals.
2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983. 485]**PEER REVIEWED**
LD50 Rat single oral >1 g/kg [Verschueren, K. Handbook of Environmental Data of Organic Chemicals.
2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983. 485]**PEER REVIEWED**
LD50 Rat inhalation >800,000 ppm/30 min [Verschueren, K. Handbook of Environmental Data of Organic Chemicals.
2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983. 485]**PEER REVIEWED**
Metabolism/Pharmacokinetics:
Absorption, Distribution & Excretion:
ELIMINATION IS RAPID. DOGS EXHALED WITHIN 1 HR ESSENTIALLY ALL FC 12 INHALED
DURING 6-20 MIN EXPOSURE TO 8000-12000 PPM. INHALED FC 12 RAPIDLY APPEARED IN
BLOOD, BILE, CEREBROSPINAL FLUID & URINE OF ANESTHETIZED RABBITS & DOGS.
UNANESTHETIZED DOGS EXPOSED TO 1000-100000 PPM FOR 10 MIN SHOWED RAPID RISE
IN BLOOD CONCN ... DURING 1ST 3 TO 5 MIN WHICH WAS PARALLELED BY A RAPID DECLINE
FOR FIRST 5 MIN AFTER EXPOSURE. [American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 181]**PEER
REVIEWED**
BLOOD LEVELS OF FC 12 WERE BELOW DETECTION LIMITS IN NORMAL SUBJECTS USING
HOUSEHOLD AEROSOLS; IN ASTHMATIC SUBJECTS USING AEROSOL INHALER, BLOOD LEVELS
WERE MUCH LOWER THAN IN DOGS EXPOSED AT THRESHOLD FOR CARDIAC SENSITIZATION.
RADIOLABELED TESTS SHOWED ESSENTIALLY ALL DOSE (95-103%) EXHALED WITHIN 1ST
HR AFTER 12 OR 17 MIN INHALATION AT 1000 PPM. ... FOR AN EIGHT HR INHALATION
AT 1000 PPM, A PHARMACOKINETIC MODEL BASED ON ANALYSES IN DOGS AND HUMANS GAVE
AN ESTIMATE OF 55% ABSORPTION OF THE INHALED FC 12. [American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 181]**PEER
REVIEWED**
AT 1000 PPM ... LEVEL IN /HUMAN/ VENOUS BLOOD WAS 1.2 UG/ML. [National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 101]**PEER REVIEWED**
Absorption and elimination are dynamic processes involving equilibria among
air, blood, and various tissues. Upon absorption, a biphasic blood-level pattern
occurs, with an initial rapid then slower rise in blood levels, during which
the material is absorbed from blood into tissue. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-26
(1980) EPA 440/5-80-051]**PEER REVIEWED**
Human & animal studies indicate rapid excretion of inhaled FC-114. In
a study with radiolabeled FC-114, 30 min retention of the dose inhaled in a
single breath was 12% versus 23%, 10%, & 20% for comparable doses of FC-11,
FC-12, and FC-113, respectively. [American Conference of Governmental Industrial Hygienists. Documentation
of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati,
OH:American Conference of Governmental Industrial Hygienists, 1986. 191]**PEER
REVIEWED**
... MAIN FACTOR AFFECTING FATE OF FLUOROCARBONS IS BODY FAT, WHERE THEY ARE
CONCENTRATED & SLOWLY RELEASED INTO BLOOD @ CONCN THAT SHOULD NOT CAUSE
ANY RISK OF CARDIAC SENSITIZATION. /FLUOROCARBONS/ [National Research Council. Drinking Water & Health Volume
1. Washington, DC: National Academy Press, 1977. 781]**PEER REVIEWED**
There is a significant accumulation of fluorocarbons in brain,
liver and lung compared to blood levels, signifying a tissue distribution of
fluorocarbons similar to that of chloroform. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1203]**PEER REVIEWED**
Abosrption of fluorocarbons is much lower after oral ingestion (35-48 times)
than after inhalation. ... The lung generally has the highest fluorocarbon concentrations
on autopsy. /Fluorocarbons/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 884]**PEER REVIEWED**
Although fluorocarbons cause cardiac sensitization in certain animal species,
rapid elimination prevents the development of cardiotoxic concentrations from
aerosol bronchodilator use except at exceedingly high doses (12 to 24 doses
in 2 minutes). /Fluorocarbons/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 884]**PEER REVIEWED**
FLUOROCARBON COMPOUNDS ARE LIPID-SOLUBLE AND THUS ARE GENERALLY WELL ABSORBED
THROUGH LUNG. ABSORPTION AFTER INGESTION IS 35 TO 48 TIMES LOWER THAN AFTER
INHALATION. ... FLUOROCARBONS ARE ELIMINATED BY WAY OF LUNG. /FLUOROCARBON COMPOUNDS/
[National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 101]**PEER REVIEWED**
Regardless of the route of entry, chlorofluorocarbons appear to be eliminated
almost exclusively through the respiratory tract. Little, if any, chlorofluorocarbon
or metabolite has ever been reported in urine or feces. /Chlorofluorocarbons/
[WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.60 (1990)]**PEER REVIEWED**
Biological Half-Life:
The distribution half-life of the common fluorocarbons (Freon 11, Freon 12)
averages 13 to 14 seconds; the elimination half-life is longer (1.5 hours) because
of slower release from fat stores. [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis
and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing
Co., Inc. 1988. 884]**PEER REVIEWED**
Mechanism of Action:
On the basis of an electrophysiological analysis of the action of CFC-12 on
different types of cardiac cells from rats and sheep, the authors conclude that:
1. the cardiac depression observed during inhalation of CFC-12 (and many other
volatile liposoluble compounds) is the consequence of a non-specific impairment
of the membrane properties and notably the inhibition of trans-membrane ionic
currents; 2, CFC-12 action on ionic currents is variable: at high concentrations,
depending on the type of cardiac cell, it can oppose or favor the action of
adrenaline, giving rise to many factors that lead to arrhythmia. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.87 (1990)]**PEER REVIEWED**
CFC-12 and CFC-114 do not markedly affect oxygen consumption or oxidative
phosphorylation in mitochondria isolated from the liver, lung, brain,
heart, or kidney of rats exposed to about 7.5% chlorofluorocarbons prior to
mitochondrial isolation. Further in vitro studies were conducted with liver
and heart mitochondria in which measurements were taken during exposure of the
mitochondria to CFC-12 at 990 g/cu m (20%) (time of exposure not specified).
No effects on either oxidation or phosphorylation were noted. [WHO; Environmental Health Criteria 113: Fully Halogenated Chlorofluorocarbons
p.87 (1990)]**PEER REVIEWED**
Interactions:
AFTER ACUTE EXPOSURE BY INHALATION TO A 13.5% CONCENTRATION FOR 30 SEC, MYOCARDIUM
IN UNANESTHETIZED DOGS WAS SENSITIZED TO SUBSEQUENT INJECTION OF EPINEPHRINE.
IN CONTRAST, A 2.5% CONCENTRATION THAT WAS INHALED 6 HR/DAY FOR 5 DAYS RESULTED
IN NO CARDIAC SENSITIZATION IN DOGS. [National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 102]**PEER REVIEWED**
/IN HUMANS/ A 10 TO 90% MIXTURE OF CFC 11 & CFC 12, RESPECTIVELY, CAUSED
MORE SEVERE RESPIRATORY EFFECTS THAN EITHER FLUOROCARBON INHALED SINGLY. [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1201]**PEER REVIEWED**
IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC
ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT
OF ARRHYTHMIAS. /FLUOROCARBONS/ [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3101]**PEER REVIEWED**
Pharmacology:
Interactions:
AFTER ACUTE EXPOSURE BY INHALATION TO A 13.5% CONCENTRATION FOR 30 SEC, MYOCARDIUM
IN UNANESTHETIZED DOGS WAS SENSITIZED TO SUBSEQUENT INJECTION OF EPINEPHRINE.
IN CONTRAST, A 2.5% CONCENTRATION THAT WAS INHALED 6 HR/DAY FOR 5 DAYS RESULTED
IN NO CARDIAC SENSITIZATION IN DOGS. [National Research Council. Drinking Water and Health. Volume
3. Washington, DC: National Academy Press, 1980. 102]**PEER REVIEWED**
/IN HUMANS/ A 10 TO 90% MIXTURE OF CFC 11 & CFC 12, RESPECTIVELY, CAUSED
MORE SEVERE RESPIRATORY EFFECTS THAN EITHER FLUOROCARBON INHALED SINGLY. [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1201]**PEER REVIEWED**
IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC
ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT
OF ARRHYTHMIAS. /FLUOROCARBONS/ [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3101]**PEER REVIEWED**
Environmental Fate & Exposure:
Environmental Fate/Exposure Summary:
Dichlorodifluoromethane's former production and use as an aerosol propellent,
foaming agent and refrigerant lead to its release to the environment through
various waste streams. Based on a vapor pressure of 4,850 mm Hg at 25 deg C,
dichlorodifluoromethane is expected to exist solely in the gas-phase in the
ambient atmosphere. Gas-phase dichlorodifluoromethane is extremely stable in
the troposphere. This compound does not react with photochemically produced
hydroxyl radicals, ozone molecules or nitrate radicals in the troposphere. This
compound will gradually diffuse into the stratosphere above the ozone layer
where it will slowly degrade due to direct photolysis from UV-C radiation and
contribute to the catalytic removal of stratospheric ozone. Dichlorodifluoromethane
is expected to have moderate mobility in soils based upon an estimated Koc value
of 356. This compound is expected to volatilize rapidly from dry soil surfaces
based on its measured vapor pressure. Volatilization from moist soil surfaces
is expected based upon a Henry's Law constant of 0.343 atm-cu m/mole. Dichlorodifluoromethane
was degraded under anaerobic conditions in laboratory tests, but does not biodegrade
under aerobic conditions. In water, dichlorodifluoromethane is not expected
to adsorb to sediment or particulate matter given its estimated Koc value. This
compound is expected to volatilize rapidly from water surfaces given its Henry's
Law constant. Estimated half-lives for a model river and model lake are 1 hour
and 4 days, respectively. An estimated BCF of 25 suggests the potential for
bioconcentration in aquatic organisms is low. Occupational exposure may be through
inhalation and dermal contact with this compound at workplaces where dichlorodifluoromethane
is still used, such as air condition repair shops. However, since this compound
is no longer produced in the US, very little occupational exposure is expected.
Due to its long atmospheric residence time, the general population is exposed
to dichlorodifluoromethane through inhalation of ambient air. (SRC) **PEER REVIEWED**
Probable Routes of Human Exposure:
NIOSH (NOES Survey 1981-1983) has statistically estimated that 435,098 workers
(125,602 of these are female) are potentially exposed to dichlorodifluoromethane
in the US(1). Occupational exposure may be through inhalation and dermal contact
with this compound at workplaces where dichlorodifluoromethane is still used,
such as air conditioning repair shops(SRC). This survey was conducted prior
to the Montreal Protocol which scheduled the production phase-out of this compound
and other chlorofluorocarbons, and is not an accurate measure of the current
occupational exposure(SRC). Due to its long atmospheric residence time, the
general population may be exposed to dichlorodifluoromethane via inhalation
of ambient air(SRC). [(1) NIOSH; National Occupational Exposure Survey (NOES) (1983)]**PEER
REVIEWED**
Body Burden:
In a pilot study of pollutants in the milk of women living in 4 urban-industrial
areas in the US, dichlorodifluoromethane was identified, not quantified, in
2 of 8 samples(1). [(1) Pellizzari ED et al; Bull Environ Contam Toxicol 28: 322-8
(1982)]**PEER REVIEWED**
Natural Pollution Sources:
There are no known natural sources of dichlorodifluoromethane(1). [(1) Bullister JL, Weiss RF; Science 221: 265-8 (1983)]**PEER
REVIEWED**
Artificial Pollution Sources:
All of the dichlorodifluoromethane that is produced is eventually lost as
emissions. It is estimated that 3.3% of the dichlorodifluoromethane produced
is lost from plant vents and during packaging, a loss which is immediate(1).
Losses from aerosols occur, on the average, 6 months after sale; losses from
domestic refrigerators and freezers have an average life of 12 yr with a 2%
loss during filling; industrial refrigerator charges have an average lifetime
of 4 yr; all of the dichlorodifluoromethane used in closed cell foams are lost
within 2 yr with 75% being lost during the first year(1). The annual world production
and release of dichlorodifluoromethane in 1982 was 443.7 and 422.8 million kg,
respectively(1). Cumulative production and release estimates up until the end
of 1974 were 4698.5 and 4286.2 million kg(1). By the end of 1982 these figures
had increased to 8196.0 and 7520.2 million kg(1). [(1) Gamlen PH et al; Atmos Environ 20: 1077-85 (1986)]**PEER
REVIEWED**
The realization that certain chlorofluorocarbons can accumulate in the upper
atmosphere and deplete the earth's ozone layer has had a major impact on chemicals
like dichlorodifluoromethane which are used in large quantities and have the
stability to reach the stratosphere. Uses such as propellants in aerosols which
had accounted for about 75% of the release of dichlorodifluoromethane and trichlorofluoromethane,
the chemicals of greatest concern (refrigerants and foams accounted for about
14 and 12%, respectively), were banned in the US after Dec 15, 1978(1). Previously
dichlorodifluoromethane was the principal propellant for non-food aerosols(1)
and 60% of dichlorodifluoromethane and trichlorofluoromethane production went
into aerosols(1). [(1) Smart BE; Kirk Othmer's Encycl Chem Tech 3rd NY,NY: Wiley
Interscience 10: 829-70 (1980)]**PEER REVIEWED**
Dichlorodifluoromethane's former production and use as an aerosol propellent,
foaming agent and refrigerant(1) lead to its release to the environment through
various waste streams(SRC). [(1) Sibley HW; Kirk-Othmer Encycl Chem Technol. 4th ed. NY,
NY: Wiley 21: 128-49 (1997)]**PEER REVIEWED**
Environmental Fate:
Due to the high vapor pressure of dichlorodifluoromethane, volatilization
to the atmosphere is quite rapid. ... It does not react readily with hydroxyl
radicals, nor does it photodissociate in the troposphere since it exhibits no
absorption of light greater than 200 nm. ... In the stratosphere, dichlorodifluoromethane
is broken down by the absorption of higher energy, shorter wavelength ultraviolet
light. [Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related
Environmental Fate of 129 Priority Pollutants. Volume I. EPA-440/4 79-029a.
Washington, DC: U.S.Environmental Protection Agency, December 1979.,p. 62-2]**PEER
REVIEWED**
TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated
Koc value of 356(SRC), determined from a log Kow of 2.16(2) and a recommended
regression-derived equation(3), indicates that dichlorodifluoromethane is expected
to have moderate mobility in soil(SRC). Volatilization of dichlorodifluoromethane
is expected from moist soil surfaces(SRC) given a Henry's Law constant of 0.343
atm-cu m/mole(4). Dichlorodifluoromethane is expected to volatilize rapidly
from dry soil surfaces(SRC) based on a vapor pressure of 4,850 mm Hg at 25 deg
C(5). Dichlorodifluoromethane was degraded under anaerobic landfill conditions
in laboratory test digesters(6), suggesting this compound may biodegrade in
soils under anaerobic conditions(SRC). [(1) Swann RL et al; Res Rev 85: 23 (1983) (2) Hansch C, Leo
A; Exploring QSAR Fundamentals and Applications in Chemistry and Biology. Washington,
DC: Amer Chem Soc p. 3 (1995) (3) Lyman WJ et al; Handbook of Chemical Property
Estimation Methods. Washington DC: Amer Chem Soc pp. 4-9 (1990) (4) Warner MJ,
Weiss RF; Deep Sea Res 32A: 1485-97 (1985) (5) Daubert TE, Danner RP; Physical
and Thermodynamic Properties of Pure Chemicals Data Compilation Washington,
DC: Taylor and Francis (1989) (6) Deipser A, Stegmann R; Environ Sci Pollut
Res 4: 209-16 (1997)]**PEER REVIEWED**
AQUATIC FATE: Based on a recommended classification scheme(1), an estimated
Koc value of 356(SRC), determined from a log Kow of 2.16(2) and a recommended
regression-derived equation(3), indicates that dichlorodifluoromethane is not
expected to adsorb to suspended solids and sediment in water(SRC). Dichlorodifluoromethane
is expected to volatilize rapidly from water surfaces(3) based on a Henry's
Law constant of 0.343 atm-cu m/mole(4). Estimated half-lives for a model river
and model lake are 1 hour and 4 days, respectively(SRC). According to a classification
scheme(5), an estimated BCF value of 25(SRC), determined from the log Kow(2),
and a regression-derived equation(3), suggests the potential for bioconcentration
in aquatic organisms is low(SRC). Dichlorodifluoromethane was degraded under
anaerobic conditions over a 100 day incubation period by sediment obtained from
the Potomac River(6). [(1) Swann RL et al; Res Rev 85: 23 (1983) (2) Hansch C, Leo
A; Exploring QSAR Fundamentals and Applications in Chemistry and Biology. Washington,
DC: Amer Chem Soc p. 3 (1995) (3) Lyman WJ et al; Handbook of Chemical Property
Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9, 5-4, 5-10, 15-1 to
15-29 (1990) (4) Warner MJ, Weiss RF; Deep Sea Res 32A: 1485-97 (1985) (5) Franke
C et al; Chemosphere 29: 1501-14 (1994) (6) Lovely DR, Woodward JC; Environ
Sci Technol 26: 925-29 (1992)]**PEER REVIEWED**
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile
organic compounds in the atmosphere(1), dichlorodifluoromethane, which has a
vapor pressure of 4,850 mm Hg at 25 deg C(2), is expected to exist solely as
a gas in the ambient atmosphere. Gas-phase dichlorodifluoromethane is extremely
stable in the troposphere. This compound does not react with photochemically
produced hydroxyl radicals, ozone molecules or nitrate radicals(3,4). This compound
will gradually diffuse into the stratosphere above the ozone layer where it
will slowly degrade due to direct photolysis from UV-C radiation and contribute
to the catalytic removal of stratospheric ozone(SRC). The half-life for this
reaction has been estimated to range from 105 to 169 years(4). [(1) Bidleman TF; Environ Sci Technol 22: 361-367 (1988) (2)
Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals
Data Compilation Washington, DC: Taylor and Francis (1989) (3) Atkinson R; J
Phys and Chem Ref Data Monograph 1: 66 (1989) (4) Fabian P, Gomer D; Fresenius
Z Anal Chem 319: 890-97 (1984)]**PEER REVIEWED**
Environmental Biodegradation:
AEROBIC: No evidence of dichlorodifluoromethane biodegradation was found in
a microcosm designed to simulate Narragansett Bay in a month-long experiment(1).
ANAEROBIC: Pure cultures of Methanosarcina barkerii and Methanobacterium thermoautotrophicum
were shown to biodegrade dichlorodifluoromethane via reductive dehalogenation(2).
Pure bacterial cultures isolated from soils obtained from Rockville, MD were
shown to biodegrade dichlorodifluoromethane(4). Dichlorodifluoromethane was
degraded under anaerobic landfill conditions in laboratory test digesters(3).
The degradation product observed was dichlorofluoromethane(3). Dichlorodifluoromethane
was degraded under anaerobic conditions over a 100 day incubation period by
sediment from the Potomac River(4), but was not biodegraded by an aerobic soil.
[(1) Bopp RF et al; Org Geochem 3: 9-14 (1981) (2) Sylvestre
M et al; Crit Rev Environ Sci Technol 27: 87-111 (1997) (3) Deipser A, Stegmann
R; Environ Sci Pollut Res 4: 209-16 (1997) (4) Lovely DR, Woodward JC; Environ
Sci Technol 26: 925-29 (1992)]**PEER REVIEWED**
Environmental Abiotic Degradation:
... Photolysis of dichlorodifluoromethane in the presence of oxygen at 213.9
nm and 25 deg C, leads to the prodn of difluoromethoxide and chloride ... and
chlorine atoms. [Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related
Environmental Fate of 129 Priority Pollutants. Volume I. EPA-440/4 79-029a.
Washington, DC: U.S.Environmental Protection Agency, December 1979.,p. 62-3]**PEER
REVIEWED**
... PHOTODISSOCIATION OF FLUOROCARBONS IN STRATOSPHERE PRODUCES SIGNIFICANT
AMT OF CHLORINE ATOMS /SRP: FLUORINE ATOMS AND BROMINE ATOMS/ & LEADS TO
DESTRUCTION OF ATMOSPHERIC OZONE. REDUCTION IN OZONE ALLOWS MORE UV LIGHT TO
REACH EARTH'S SURFACE ... /FLUOROCARBONS/ [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3090]**PEER REVIEWED**
Gas-phase dichlorodifluoromethane is extremely stable in the troposphere.
This compound does not react with photochemically produced hydroxyl radicals,
ozone molecules or nitrate radicals(1,2). This compound will gradually diffuse
into the stratosphere above the ozone layer where it will slowly degrade due
to direct photolysis from UV-C radiation and contribute to the catalytic removal
of stratospheric ozone(2). The half-life for this reaction has been estimated
to range from 105 to 169 years(2). Dichlorodifluoromethane is not expected to
undergo hydrolysis or direct photolysis in the troposphere due to the lack of
functional groups that could chemically hydrolyze or absorb light at environmentally
significant wavelengths(3). [(1) Atkinson R; J Phys and Chem Ref Data Monograph 1: 66 (1989)
(2) Fabian P, Gomer D; Fresenius Z Anal Chem 319: 890-97 (1984) (3) Lyman WJ
et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer
Chem Soc pp. 7-4, 7-5 (1990)]**PEER REVIEWED**
Environmental Bioconcentration:
... The log octanol/water partition coefficient (log P) of 2.16 indicates
that dichlorodifluoromethane is lipophilic and that bioaccumulation in organisms
may be possible under conditions of constant exposure. [Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related
Environmental Fate of 129 Priority Pollutants. Volume I. EPA-440/4 79-029a.
Washington, DC: U.S.Environmental Protection Agency, December 1979.,p. 62-4]**PEER
REVIEWED**
An estimated BCF value of 25 was calculated for dichlorodifluoromethane(SRC),
using a log Kow of 2.16(1) and a recommended regression-derived equation(2).
According to a classification scheme(3), this BCF value suggests that the potential
bioconcentration in aquatic organisms is low(SRC). [(1) Hansch C, Leo A; Exploring QSAR Fundamentals and Applications
in Chemistry and Biology. Washington, DC: Amer Chem Soc p. 3 (1995) (2) Lyman
WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer
Chem Soc pp. 5-4, 5-10 (1990) (3) Franke C et al; Chemosphere 29: 1501-14 (1994)]**PEER
REVIEWED**
Soil Adsorption/Mobility:
... The log octanol/water partition coefficient (log P) of 2.16 ... indicates
that absorption onto organic particulates may be possible. [Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related
Environmental Fate of 129 Priority Pollutants. Volume I. EPA-440/4 79-029a.
Washington, DC: U.S.Environmental Protection Agency, December 1979.,p. 62-4]**PEER
REVIEWED**
The Koc of dichlorodifluoromethane is estimated as approximately 356(SRC),
using a log Kow of 2.16(1) and a regression-derived equation(2). According to
a recommended classification scheme(3), this estimated Koc value suggests that
dichlorodifluoromethane is expected to have moderate mobility in soil(SRC).
[(1) Hansch C, Leo A; Exploring QSAR Fundamentals and Applications
in Chemistry and Biology. Washington, DC: Amer Chem Soc p. 3 (1995) (2) Lyman
WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC:
Amer Chem Soc pp. 4-9 (1990) (3) Swann RL et al; Res Rev 85: 23 (1983)]**PEER
REVIEWED**
Volatilization from Water/Soil:
The high vapor pressure and low aqueous solubility of dichlorodifluoromethane
are conductive to rapid volatilization from an aquatic environment. ... Volatilization
is thought to be the major transport process. [Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related
Environmental Fate of 129 Priority Pollutants. Volume I. EPA-440/4 79-029a.
Washington, DC: U.S.Environmental Protection Agency, December 1979.,p. 62-4]**PEER
REVIEWED**
The Henry's Law constant for dichlorodifluoromethane is 0.343 atm-cu m/mole(1).
This value indicates that dichlorodifluoromethane will volatilize rapidly from
water surfaces(2). Based on this Henry's Law constant, the volatilization half-life
from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2)
is estimated as approximately 1 hour(SRC). The volatilization half-life from
a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is
estimated as approximately 4 days(SRC). Dichlorodifluoromethane's Henry's Law
constant(1) indicates that volatilization from moist soil surfaces is expected
occur(SRC). Dichlorodifluoromethane is expected to volatilize rapidly from dry
soil surfaces(SRC) based on the vapor pressure of 4,850 mm Hg at 25 deg C(3).
[(1) Warner MJ, Weiss RF; Deep Sea Res 32A: 1485-97 (1985) (2)
Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington
DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (3) Daubert TE, Danner RP; Physical
and Thermodynamic Properties of Pure Chemicals Data Compilation Washington,
DC: Taylor and Francis (1989)]**PEER REVIEWED**
Environmental Water Concentrations:
GROUNDWATER: Dichlorodifluoromethane was identified, but not quantified in
groundwater under 6 of 13 municipal landfills in Minnesota with suspected leakage
but not in the groundwater under 7 other municipal landfills(1). Dichlorodifluoromethane
was detected in 20 of 2,542 groundwater rural wells at a max concn of about
7 ug/l and in 11 out of 406 urban wells at a max concn of about 70 ug/l in the
US from 1985-1995(2). Dichlorodifluoromethane was detected in shallow wells
in northern Hungary at concns of 0.06-10.36 picomols/l in 1993(3). Dichlorodifluoromethane
was detected at a max concn of 0.6 ug/l in groundwater from Denver, CO(4). [(1) Sabel GV, Clark TP; Waste Manag Res 2: 119-30 (1984) (2)
Squillace PJ et al; Environ Sci Technol 33: 4176-87 (1999) (3) Bohlke JK et
al; Environ Sci Technol 31: 3293-99 (1997) (4) Bruce BW et al; J Hydrol 186:
129-51 (1996)]**PEER REVIEWED**
SURFACE WATER: Of the 696 stations reporting pollutants in ambient waters
in EPA's STORET database, 1.0% contained dichlorodifluoromethane at detectable
levels(1). Dichlorodifluoromethane was identified, but not quantified, in the
open waters of Lake Erie(3). The average concn of dichlorodifluoromethane in
surface water at two stations in the Greenland and Norwegian Sea was 218 and
187 ppb, respectively(2). The concn decreased with depth over many km in the
Greenland Sea and was relatively constant in the upper 0.4 km in the Norwegian
Sea before decreasing(2). The deep water concns of dichlorodifluoromethane in
these seas were 37 and 18 ppb(2). [(1) Staples CA et al; Environ Toxicol Chem 4: 131-42 (1985)
(2) Bullister JL, Weiss RF; Science 221: 265-8 (1983) (3) Great Lakes Water
Quality Board; Report to the Great Lake Water Quality Board Windsor Ontario
Canada pp. 195 (1983)]**PEER REVIEWED**
Effluent Concentrations:
Of the 1,144 stations reporting pollutants in ambient waters in EPA's STORET
database, 1.6% contained dichlorodifluoromethane at detectable levels(1). No
dichlorodifluoromethane was found in the effluent of a large community septic
tank (detection limit 0.7 ppb)(2). In the National Urban Runoff Program in which
samples of runoff were collected from 19 cities (51 catchments) in the U.S.,
no dichlorodifluoromethane was found in any samples(3). Leachate from 2 of 6
municipal landfills tested in Minnesota had detectable quantities of dichlorodifluoromethane(4).
Leachate from 1 out of 5 landfills in Wisconsin contained 180 ppb of the chemical(4).
Dichlorodifluoromethane was emitted from a simulated landfill composed of municipal
refuse and wastewater sludges(5). [(1) Staples CA et al; Environ Toxicol Chem 4: 131-42 (1985)
(2) Dewalle FB et al; Determination of Toxic Chemicals in Effluent from Household
Septic Tanks USEPA-600/S2-85-050. Cincinnati OH: p. 4 (1985) (3) Cole RH et
al; J Water Pollut Control Fed 56: 898-908 (1984) (4) Sabel GV, Clark TP; Waste
Manag Res 2: 119-30 (1984) (5) Vogt WG, Walsh JJ; in Proc - APCA Annu Meet 78th
p. 17 (1985)]**PEER REVIEWED**
Sediment/Soil Concentrations:
None of the 204 stations in EPA's STORET database reported any dichlorodifluoromethane
in sediment(1). [(1) Staples CA et al; Environ Toxicol Chem 4: 131-42 (1985)]**PEER
REVIEWED**
Atmospheric Concentrations:
Mean urban concn for dichlorodifluoromethane ranged from 3.5x10-3 to 2.9x10-2
mg/cu m, and an ocean atmosphere mean of 2.7x10-4 mg/cu m. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-17
(1980) EPA 440/5-80-051]**PEER REVIEWED**
In a beauty shop, where fluorocarbon pressured cosmetic sprays were apt to
be used, concn of 1.8 mg/cu m. [USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-18
(1980) EPA 440/5-80-051]**PEER REVIEWED**
Dichlorodifluoromethane concn in room air as a result of release of aerosol
can products. Level at periods after 60 sec release of hair spray in a 29.3
cu m room (in mg/cu m): during release: 306.8; 30 min after: 12.4; 60 min after:
0.5. Level at periods after 30 second release of insect spray in a 21.4 cu m
room (in mg/cu m): 1 min: 2,304.0; 60 min: 130.4; 150 min: 56.8. /From table/
[USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-19
(1980) EPA 440/5-80-051]**PEER REVIEWED**
Ambient air quality, ground level concn in Los Angeles; July 1970, 0.7 ppb,
Feb 1973, 0.53 ppb; in rural Wash DC; Dec 74-Feb 75: 0.23 ppb. [Verschueren, K. Handbook of Environmental Data on Organic Chemicals.
3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996. 682]**PEER REVIEWED**
S Calif Feb-Aug 1973 at 6700 m, 90 parts per trillion ; New Mexico on 5/23/74
at 6400 m 120 parts per trillion; W Ireland June/July 1974 at sea-level, 101.7
parts per trillion; North Atlantic Oct 1974 at sea-level, 115 parts per trillion;
Pullman, Washington Nov 1974 at 0-3600 m, 230 parts per trillion; West of N
Ireland E of Scotland at 7000-8000 m, 231 parts per trillion; off SW Wales Jan
1976 at 900-7300 m, 236 parts per trillion; off SW Wales Jan 1976 at 900-4900
m, 258 parts per trillion; off NE England Feb 1976 at 400-5200 m, 225 parts
per trillion /From table/ [Verschueren, K. Handbook of Environmental Data on Organic Chemicals.
3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996. 682]**PEER REVIEWED**
RURAL/REMOTE: Sites in the US (431 samples) - 120 parts per trillion, median,
230 parts per trillion, max(1). The average concn of dichlorodifluoromethane
at two stations over the Greenland and Norwegian Sea was 343 parts per trillion(2).
The concn of dichlorofluoromethane in Adrigole, Ireland was 338 parts per trillion(2).
Rural and urban areas of China and rural areas of Oregon contained a median
concn of dichlorofluoromethane was 320 parts per trillion(3). Similarly, median
concns of dichlorodifluoromethane in rural areas of Eastern Washington and the
Caucasus Mountains of the USSR in 1979 was 289 and 313 parts per trillion, respectively(4).
The respective average concns in the morning vs the nighttime in Eastern Washington
was 310 and 318 parts per trillion(4). The background concn of dichlorodifluoromethane
in the northern hemisphere was reported as 530 parts per trillion(5). [(1) Brodzinsky R, Singh HB; Volatile Organic Chemicals in the
Atmosphere: An Assessnebt of Available Data Menlo Park CA: SRI Inter Contract
68-02-3452 (1982) (2) Bullister JL, Weiss RF; Science. 221: 265-8 (1983) (3)
Rasmussen RA et al; Environ Sci Tech 16: 124-6 (1982) (4) Cronn DR et al; Environ
Sci Tech 17: 383-8 (1983) (5) Wang JL et al; Chemosphere 36: 2391-2400 (1998)]**PEER
REVIEWED**
RURAL/REMOTE: The average concns of dichlorodifluoromethane in the Northern
and Southern Hemispheres show slight differences(3). In 1976, their values were
218 and 204 parts per trillion(3), respectively. Concns of dichlorodifluoromethane
at the South Pole has increased from 195 to 284 parts per trillion between 1976
and 1980, while over the same period of time the increase in the Pacific Northwest
was from 228 to 322 parts per trillion(1). The annual rate of increase in these
areas is 7%. As the altitude increases, the concn of dichlorodifluoromethane
in the atmosphere at northern mid-latitudes decreased from 350 parts per trillion
at the earth's surface to 250, 100, and 20 parts per trillion at 10, 20, and
30 km(2). The avg concn of dichlorodifluoromethane in coastal regions of Taiwan
was 515 parts per trillion(4). [(1) Crutzen PJ, Gidel LT; J Geophys Res 88: 6641-61 (1983) (2)
Fabian P, Goemer D; Fresenius' Z Anal Chem 319: 890-7 (1984) (3) Tyson BJ et
al; Geophys Res Lett 5: 535-8 (1978) (4) Wang JL et al; Chemosphere 36: 2391-2400
(1998)]**PEER REVIEWED**
URBAN/SUBURBAN: Dichlorodifluoromethane was detected at various sites in the
US at a median concn of 0.38 ppb and a max concn of 4.9 ppb(1). Various sites
in the US had dichlorodifluoromethane levels ranging from 0.37 to 4.8 ppb while
sites in continental Europe and Japan had levels of 0.410-11.4 ppb(2). In 1975,
the average concn of dichlorodifluoromethane was 0.23 ppb and rising at an annual
rate of 0.0157 ppb(3). The avg concn of dichlorodifluoromethane in Taipei, Taiwan
was 590 parts per trillion(4). Dichlorodifluoromethane was detected in Japan
(1990-1991) at concns of 0.29-1.7 ppb(5). [(1) Brodzinsky R, Singh HB; Volatile Organic Chemicals in the
Atmosphere: An Assessnebt of Available Data Menlo Park CA: SRI Inter Contract
68-02-3452 (1982) (2) Su C, Goldberg ED; pp. 353-74 in Mar Pollut Transfer.
Windom HL et al, eds. Lexington MA: DC Heath Co (1976) (3) Guicherit R, Schulting
FL; Sci Tot Environ 43: 193-219 (1985) (4) Wang JL et al; Chemosphere 36: 2391-2400
(1998) (5) Yamasaki T et al; Wat Sci Technol 25: 33-39 (1992)]**PEER REVIEWED**
Fish/Seafood Concentrations:
None of the 47 stations in EPA's STORET database reported any dichlorodifluoromethane
in biota(1). [(1) Staples CA et al; Environ Toxicol Chem 4: 131-42 (1985)]**PEER
REVIEWED**
Milk Concentrations:
In a pilot study of pollutants in the milk of women living in 4 urban-industrial
areas in the US, dichlorodifluoromethane was found in 2 of 8 samples(1). [(1) Pellizzari ED et al; Bull Environ Contam Toxicol 28: 322-8
(1982)]**PEER REVIEWED**
Environmental Standards & Regulations:
FIFRA Requirements:
Residues of dichlorodifluoromethane are exempted from the requirement of a
tolerance when used as a propellant in accordance with good agricultural practices
as inert (or occasionally active) ingredients in pesticide formulations applied
to growing crops or to raw agricultural commodities after harvest. [40 CFR 180.1001(c) (7/1/2000)]**PEER REVIEWED**
Dichlorodifluoromethane is exempted from the requirement of a tolerance when
used as a propellant in accordance with good agricultural practice as inert
(or occasionally active) ingredients in pesticide formulations applied to animals.
[40 CFR 180.1001(e) (7/1/2000)]**PEER REVIEWED**
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive
review of older pesticides to consider their health and environmental effects
and make decisions about their future use. Under this pesticide reregistration
program, EPA examines health and safety data for pesticide active ingredients
initially registered before November 1, 1984, and determines whether they are
eligible for reregistration. In addition, all pesticides must meet the new safety
standard of the Food Quality Protection Act of 1996. Pesticides for which EPA
had not issued Registration Standards prior to the effective date of FIFRA,
as amended in 1988, were divided into three lists based upon their potential
for human exposure and other factors, with List B containing pesticides of greater
concern and List D pesticides of less concern. Dichloromonofluoromethane is
found on List D. Case No: 4042; Pesticide type: insecticide; Case Status: No
products containing the pesticide are actively registered ... The case /is characterized/
as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their
registered products. EPA also may cancel pesticide registrations if registrants
fail to pay required fees or make/meet certain reregistration commitments, or
if EPA reaches findings of unreasonable adverse effects.; Active ingredient
(AI): Dichloromonofluoromethane; AI Status: The active ingredient is no longer
contained in any registered pesticide products ... "cancelled." [USEPA/OPP; Status of Pesticides in Registration, Reregistration
and Special Review p.312 (Spring, 1998) EPA 738-R-98-002]**PEER REVIEWED**
Acceptable Daily Intakes:
EPA RfD= 0.2 mg/kg [USEPA/OPP; Health Effects Div RfD/ADI Tracking Report p.20 (8/26/91)]**PEER
REVIEWED**
CERCLA Reportable Quantities:
Persons in charge of vessels or facilities are required to notify the National
Response Center (NRC) immediately, when there is a release of this designated
hazardous substance, in an amount equal to or greater than its reportable quantity
of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In
the Washington D.C. metropolitan area (202) 426-2675. The rule for determining
when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
[40 CFR 302.4 (7/1/2000)]**PEER REVIEWED**
RCRA Requirements:
U075; As stipulated in 40 CFR 261.33, when dichlorodifluoromethane, as a commercial
chemical product or manufacturing chemical intermediate or an off-specification
commercial chemical product or a manufacturing chemical intermediate, becomes
a waste, it must be managed according to Federal and/or State hazardous waste
regulations. Also defined as a hazardous waste is any residue, contaminated
soil, water, or other debris resulting from the cleanup of a spill, into water
or on dry land, of this waste. Generators of small quantities of this waste
may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).
[40 CFR 261.33 (7/1/2000)]**PEER REVIEWED**
Atmospheric Standards:
This action promulgates standards of performance for equipment leaks of Volatile
Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry
(SOCMI). The intended effect of these standards is to require all newly constructed,
modified, and reconstructed SOCMI process units to use the best demonstrated
system of continuous emission reduction for equipment leaks of VOC, considering
costs, non air quality health and environmental impact and energy requirements.
Dichlorodifluoromethane is produced, as an intermediate or a final product,
by process units covered under this subpart. [40 CFR 60.489 (7/1/2000)]**PEER REVIEWED**
Federal Drinking Water Guidelines:
EPA 1000 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
State Drinking Water Guidelines:
(AZ) ARIZONA 1400 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(FL) FLORIDA 1,400 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(MA) MASSACHUSETTS 1400 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(ME) MAINE 1050 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(MN) MINNESOTA 1000 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(NC) NORTH CAROLINA 0.19 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
(WA) WASHINGTON 530 ug/l [USEPA/Office of Water; Federal-State Toxicology and Risk Analysis
Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and
Guidelines (11/93)] **QC REVIEWED**
FDA Requirements:
... Essential uses of chlorofluorocarbons: (1) Metered-dose steroid human
drugs for nasal inhalation; (2) Metered-dose steroid human drugs for oral inhalation;
(3) Metered-dose adrenergic bronchodilator human drugs for oral inhalation;
(4) Contraceptive vaginal foams for human use, and (5) Metered-dose ergotamine
tartrate drug products administered by oral inhalation for use in humans; (6)
Intrarectal hydrocortisone acetate for human use; (7) Polymyxin B sulfate-bacitracin
zinc-neomycin sulfate soluble antibiotic powder without excipients, for topical
use on humans; (8) Anesthetic drugs for topical use on accessible mucous membranes
of humans where a cannula is used for application; (9) Metered-dose nitroglycerin
human drugs administered to the oral cavity; (10) Metered-dose cromolyn sodium
human drugs administered by oral inhalation; (11) Metered-dose ipratropium bromide
for oral inhalation; (12) Metered-dose atropine sulfate aerosol human drugs
administered by oral inhalation. /Chlorofluorocarbons/ [21 CFR 2.125 (4/1/91)]**PEER REVIEWED**
Allowable Tolerances:
Residues of dichlorodifluoromethane are exempted from the requirement of a
tolerance when used as a propellant in accordance with good agricultural practices
as inert (or occasionally active) ingredients in pesticide formulations applied
to growing crops or to raw agricultural commodities after harvest. [40 CFR 180.1001(c) (7/1/2000)]**PEER REVIEWED**
Dichlorodifluoromethane is exempted from the requirement of a tolerance when
used as a propellant in accordance with good agricultural practice as inert
(or occasionally active) ingredients in pesticide formulations applied to animals.
[40 CFR 180.1001(e) (7/1/2000)]**PEER REVIEWED**
Chemical/Physical Properties:
Molecular Formula:
C-Cl2-F2 [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 483]**PEER REVIEWED**
LIQUEFIED COMPRESSED GAS [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous
Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office,
1984-5.]**PEER REVIEWED**
Colorless gas ... [Note: Shipped as a liquified compressed gas]. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
96]**PEER REVIEWED**
Odor:
Practically odorless; faint, ether-like odor in high concn [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals,
Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 518]**PEER
REVIEWED**
Boiling Point:
-29.8 deg C @ 760 mm Hg [Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 79th
ed. Boca Raton, FL: CRC Press Inc., 1998-1999.,p. 3-206]**PEER REVIEWED**
Melting Point:
-158 deg C [Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 79th
ed. Boca Raton, FL: CRC Press Inc., 1998-1999.,p. 3-206]**PEER REVIEWED**
Corrosivity:
Noncorrosive [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals,
Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 518]**PEER
REVIEWED**
Critical Temperature & Pressure:
Critical temp: 233.2 deg F= 111.8 deg C= 385.0 deg K; Critical pressure: 598
psia= 40.7 atm= 4.12 mn/sq m [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous
Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office,
1984-5.]**PEER REVIEWED**
Density/Specific Gravity:
1.486 @ -29.8 deg C [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals,
Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 518]**PEER
REVIEWED**
Heat of Combustion:
Nonflammable [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
Heat of Vaporization:
140 Btu/lb= 77.9 cal/g= 3.26X10+5 J/kg (Latent) [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous
Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office,
1984-5.]**PEER REVIEWED**
Octanol/Water Partition Coefficient:
log Kow= 2.16 [Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic,
Electronic, and Steric Constants. Washington, DC: American Chemical Society.,
1995. 3]**PEER REVIEWED**
Solubilities:
0.28 g/l water @ 25 deg C @ 1 atm [Flick, E.W. Industrial Solvents Handbook. 3rd ed. Park Ridge,
NJ: Noyes Publications, 1985. 86]**PEER REVIEWED**
1.9 g/l water @ 25 deg C @ 94.4 psia (the propellant vapor pressure) [Flick, E.W. Industrial Solvents Handbook. 3rd ed. Park Ridge,
NJ: Noyes Publications, 1985. 86]**PEER REVIEWED**
Solubility in water= 0.0076 g water/100 g @ 21 deg C [Flick, E.W. Industrial Solvents Handbook. 3rd ed. Park Ridge,
NJ: Noyes Publications, 1985. 86]**PEER REVIEWED**
Spectral Properties:
SADTLER REF NUMBER: 30865 (IR, PRISM); MAX ABSORPTION (VAPOR): LESS THAN 200
NM [Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed.
Boca Raton, Florida: CRC Press Inc., 1979.,p. C-373]**PEER REVIEWED**
IR: 6837 (Sadtler Research Laboratories IR Grating Collection) [Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic
Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985.,p. V1 840]**PEER
REVIEWED**
MASS: 472 (Atlas of Mass Spectral Data, John Wiley & Sons, New York) [Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic
Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985.,p. V1 840]**PEER
REVIEWED**
Index of refraction: 1.287 @ 25 deg C/D [Lide, D.R. (ed). CRC Handbook of Chemistry and Physics. 72nd
ed. Boca Raton, FL: CRC Press, 1991-1992.,p. 6-171]**PEER REVIEWED**
4,850 mm Hg @ 25 deg C [Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties
of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989.]**PEER
REVIEWED**
Viscosity:
0.262 centipoise at 70 deg F [Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed.
Easton, Pennsylvania: Mack Publishing Co., 1980. 1616]**PEER REVIEWED**
Other Chemical/Physical Properties:
Dipole moment: 0.51 debye [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals,
Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 518]**PEER
REVIEWED**
Ionization potential: 11.97 eV [NIOSH. Pocket Guide to Chemical Hazards. 5th Printing/Revision.
DHHS (NIOSH) Publ. No. 85-114. Washington, D.C.: U.S. Dept. of Health and Human
Services,NIOSH/Supt. of Documents, GPO, Sept. 1985. 98]**PEER REVIEWED**
1 MG/L= 202.3 PPM, 1 PPM= 4.95 MG/CU M AT 25 DEG C, 760 MM HG [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II:
Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 1324]**PEER REVIEWED**
Critical volume: 217 cu m/mmol; critical density: 0.558 g/cu m; specific heat
of liquid @ 25 deg C: 0.232 Cal/g; solubility of water in Freon 12: 0.009% (by
wt) at 25 deg C; specific heat of vapor @ 25 deg C and 1 atm: 0.145 cal/g; heat
of vaporization= 39.47 cal/g [Lide, D.R. (ed). CRC Handbook of Chemistry and Physics. 72nd
ed. Boca Raton, FL: CRC Press, 1991-1992.,p. 6-171]**PEER REVIEWED**
Henry's Law constant= 0.343 atm-cu m/mol @ 20 deg C [Warner MJ, Weiss RF; Deep Sea Res 32A: 1485-97 (1985)]**PEER
REVIEWED**
Dielectric constant; 2.13 @ 29 deg C (liquid); 1.0032 @ 26 deg C and 50.65
kPa. [Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes
1-26. New York, NY: John Wiley and Sons, 1978-1984.,p. V10 (80) 862]**PEER REVIEWED**
Absorbs less than 0.0025% water. [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals,
Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996. 518]**PEER
REVIEWED**
Ozone depletion potential: 1.0. (Ozone depletion potential relative to R11=
1.0. Scientific assessment of ozone: 1989.) /From table/ [Baxter V, Fairchild P; Oak Ridge National Laboratory Review
No. 3 (1990)]**PEER REVIEWED**
Hydroxyl radical rate constant: < 4 X10-16 cu cm/molecule-sec @ 25 deg
C [Atkinson R; J Phys Chem Ref Data Monograph No. 1 p. 66 (1989)]**PEER
REVIEWED**
Chemical Safety & Handling:
DOT Emergency Guidelines:
Fire or explosion: Some may burn, but none ignite readily. Containers may
explode when heated. Ruptured cylinders may rocket. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Health: Vapors may cause dizziness or asphyxiation without warning. Vapors
from liquefied gas are initially heavier than air and spread along ground. Contact
with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire
may produce irritating, corrosive and/or toxic gases. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Public safety: CALL Emergency Response Telephone Number. ... Isolate spill
or leak area immediately for at least 100 meters (330 feet) in all directions.
Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air
and will spread along ground and collect in low or confined areas (sewers, basements,
tanks). Keep out of low areas. Ventilate closed spaces before entering. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Protective clothing: Wear positive pressure self-contained breathing apparatus
(SCBA). Structural firefighters' protective clothing will only provide limited
protection. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Evacuation: Large spill: Consider initial down wind evacuation for at least
500 meters (1/3 mile). Fire: If tank, rail car or tank truck is involved in
a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider
initial evacuation for 800 meters (1/2 mile) in all directions. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Fire: Use extinguishing agent suitable for type of surrounding fire. Small
fires: Dry chemical or CO2. Large fires: Water spray, fog or regular foam. Move
containers from fire area if you can do it without risk. Damaged cylinders should
be handled only by specialists. Fire involving tanks: Fight fire from maximum
distance or use unmanned hose holders or monitor nozzles. Cool containers with
flooding quantities of water until well after fire is out. Do not direct water
at source of leak or safety devices; icing may occur. Withdraw immediately in
case of rising sound from venting safety devices or discoloration of tank. ALWAYS
stay away from the ends of tanks. Some of these materials, if spilled, may evaporate
leaving a flammable residue. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Spill or leak: Do not touch or walk through spilled material. Stop leak if
you can do it without risk. Do not direct water at spill or source of leak.
Use water spray to reduce vapors or divert vapor cloud drift. If possible, turn
leaking containers so that gas escapes rather than liquid. Prevent entry into
waterways, sewers, basements or confined areas. Allow substance to evaporate.
Ventilate the area. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
First aid: Move victim to fresh air. Call emergency medical care. Apply artificial
respiration if victim is not breathing. Administer oxygen if breathing is difficult.
Remove and isolate contaminated clothing and shoes. In case of contact with
liquefied gas, thaw frosted parts with lukewarm water. Keep victim warm and
quiet. Ensure that medical personnel are aware of the material(s) involved,
and take precautions to protect themselves. [U.S. Department of Transportation. 1996 North American Emergency
Response Guidebook. A Guidebook for First Responders During the Initial Phase
of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation
(U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials
Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-126]**PEER
REVIEWED**
Fire Potential:
NONFLAMMABLE GAS [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous
Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office,
1984-5.]**PEER REVIEWED**
Fire Fighting Procedures:
If material involved in fire: Extingiush fire using agent suitable for type
of surrounding fire. (Material itself does not burn or burns with difficulty).
Cool all affected containers with flooding quantities of water. Apply water
from as far a distance as possible. [Association of American Railroads. Emergency Handling of Hazardous
Materials in Surface Transportation. Washington, DC: Association of American
Railroads, Bureau of Explosives, 1994. 352]**PEER REVIEWED**
Toxic Combustion Products:
Toxic gases can be produced in fires involving this material. [Association of American Railroads. Emergency Handling of Hazardous
Materials in Surface Transportation. Washington, DC: Association of American
Railroads, Bureau of Explosives, 1994. 352]**PEER REVIEWED**
Toxic substances may be formed on contact with a flame or hot metal surface.
[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 483]**PEER REVIEWED**
ALL FLUOROCARBONS WILL UNDERGO THERMAL DECOMPOSITION WHEN EXPOSED TO FLAME
OR RED-HOT METAL. DECOMPOSITION PRODUCTS OF THE CHLOROFLUOROCARBONS WILL INCLUDE
HYDROFLUORIC & HYDROCHLORIC ACID ALONG WITH SMALLER AMOUNTS OF PHOSGENE
& CARBONYL FLUORIDE. THE LAST COMPOUND IS VERY UNSTABLE TO HYDROLYSIS &
QUICKLY CHANGES TO HYDROFLUORIC ACID & CARBON DIOXIDE IN THE PRESENCE OF
MOISTURE. /FLUOROCARBONS/ [International Labour Office. Encyclopaedia of Occupational Health
and Safety. 4th edition, Volumes 1-4 1998. Geneva, Switzerland: International
Labour Office, 1998.,p. 104.185]**PEER REVIEWED**
IN CONTACT WITH OPEN FLAME OR VERY HOT SURFACE FLUOROCARBONS MAY DECOMP INTO
HIGHLY IRRITANT & TOXIC GASES: CHLORINE, HYDROGEN FLUORIDE OR CHLORIDE,
& EVEN PHOSGENE. /FLUOROCARBON REFRIGERANT & PROPELLANTS/ [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
Under certain conditions, fluorocarbon vapors may decompose on contact with
flames or hot surfaces, creating the potential hazard of inhalation of toxic
decomposition products. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
Hazardous Reactivities & Incompatibilities:
Chemically-active metals such as sodium, potassium, calcium, powdered aluminum,
zinc & magnesium. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
96]**PEER REVIEWED**
Destruction of the impellers in a centrifugal compressor occurred when abrasion
exposed & heated fresh aluminum surfaces. These surfaces and dichlorodifluoromethane
joined in a self-sustaining reaction with sufficient heat generated to melt
and react much of the aluminum impeller material. [Fire Protection Guide to Hazardous Materials. 12 ed. Quincy,
MA: National Fire Protection Association, 1997.,p. 491-14]**PEER REVIEWED**
In dichlorodifluoromethane vapor, aluminum dust ignited at 580 deg C, and
suspensions of the dust in the vapor gave strong explosions when sparked. [Bretherick, L. Handbook of Reactive Chemical Hazards. 3rd ed.
Boston, MA: Butterworths, 1985. 27]**PEER REVIEWED**
Can react violently with aluminum. [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials.
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1098]**PEER
REVIEWED**
Dangerous ... on contact with acid or acid fumes, they emit highly toxic fumes.
/Fluorides/ [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials.
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1660]**PEER
REVIEWED**
DANGEROUS ... ON CONTACT WITH ACIDS OR ACID FUMES THEY EVOLVE HIGHLY TOXIC
CHLORIDE FUMES. /CHLORIDES/ [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials.
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 715]**PEER REVIEWED**
/Dichlorodifluoromethane/ attacks some forms of plastics, rubber, and coatings
[American Conference of Governmental Industrial Hygienists, Inc.
Documentation of the Threshold Limit Values and Biological Exposure Indices.
6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 420]**PEER REVIEWED**
Hazardous Decomposition:
IF HEATED, THERMAL DECOMP PRODUCTS LIKE HYDROCHLORIC ACID, CHLORINE, HYDROGEN
FLUORIDE, FLUORINE, & PHOSGENE /GAS/ ARE /FORMED/. [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
When heated to decomp it emits highly toxic fumes of phosgene and /hydrogen
chloride and hydrogen fluoride/. [Lewis, R.J. Sax's Dangerous Properties of Industrial Materials.
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1098]**PEER
REVIEWED**
The heated, thermal decomposition products like hydrogen chloride, chlorine,
hydrogen fluoride, fluorine, and phosgene are dangerous. [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology
of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-159]**PEER
REVIEWED**
UNDER CERTAIN CONDITIONS, FLUOROCARBON VAPORS MAY DECOMPOSE ON CONTACT WITH
FLAMES OR HOT SURFACES, CREATING THE POTENTIAL HAZARD OF INHALATION OF TOXIC
DECOMPOSITION PRODUCTS. /FLUOROCARBONS/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
APPEARANCE OF TOXIC DECOMP PRODUCTS SERVES AS WARNING OF OCCURRENCE OF THERMAL
DECOMP & DETECTION OF SHARP ACRID ODOR WARNS OF PRESENCE ... . /FLUOROCARBONS/
[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3101]**PEER REVIEWED**
Immediately Dangerous to Life or Health:
15,000 ppm [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
96]**QC REVIEWED**
Protective Equipment & Clothing:
Employees should be provided with and required to use impervious clothing,
gloves, face-shields (eight-inch minimum), and other appropriate protective
clothing necessary to prevent teh skin from becoming wet with dichloro- difluoromethane
or from becoming frozen from contact with vessels containing dichlorodifluoromethane.
Employees should be provided with and required to use splash-proff safety goggles
where liquid dichlorodifluoromethane may contact the eyes.els containing dichlorodifluoromethane.
[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Wear appropriate personal protective clothing to prevent the skin from becoming
frozen from contact with the liquid or from contact with vessels containing
the liquid. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Wear appropriate eye protection to prevent eye contact with the liquid that
could result in burns or tissue damage from frostbite. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Quick drench facilities and/or eyewash fountains should be provided within
the immediate work area for emergency use where there is any possibility of
exposure to liquids that are extremely cold or rapidly evaporating. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Recommendations for respirator selection. Max concn for use: 10,000 ppm: Respirator
Classes: Any supplied-air respirator. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Recommendations for respirator selection. Max concn for use: 15,000 ppm: Respirator
Class: Any supplied-air respirator operated in a continuous flow mode. Any self-contained
breathing apparatus with a full facepiece. Any supplied-air respirator with
a full facepiece. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Recommendations for respirator selection. Condition: Emergency or planned
entry into unknown concn or IDLH conditions: Respirator Classes: Any self-contained
breathing apparatus that has a full facepiece and is operated in a pressure-demand
or other positive pressure mode. Any supplied-air respirator that has a full
face piece and is operated in pressure-demand or other positive pressure mode
in combination with an auxiliary self-contained breathing apparatus operated
in pressure-demand or other positive pressure mode. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Recommendations for respirator selection. Condition: Escape from suddenly
occurring respiratory hazards: Respirator Classes: Any air-purifying, full-facepiece
respirator (gas mask) with a chin-style, front- or back-mounted organic vapor
canister. Any appropriate escape-type, self-contained breathing apparatus. [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
97]**PEER REVIEWED**
Many of the fluorocarbons are good solvents of skin oil, so protective ointment
should be used. /Fluorocarbons/ [Zenz, C. Occupational Medicine-Principles and Practical Applications.
2nd ed. St. Louis, MO: Mosby-Yearbook, Inc, 1988. 544]**PEER REVIEWED**
Neoprene gloves, protective clothing, and eye protection minimize risk of
topical contact. The degreasing effect on the skin can be treated with lanolin
ointment. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1198]**PEER REVIEWED**
Forced air ventilation and level of vapor concentration together with the
use of individual breathing devices with independent air supply will minimize
risk of inhalation. Lifelines should be worn when entering tanks or other confined
spaces. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
Preventive Measures:
If the use of respirators is necessary, the only respirators permitted are
those that have been approved by the Mine Safety and Health Administration (formerly
Mining Enforcement and Safety Administration) or by the National Institute for
Occupational Safety and Health. In addition to respirator selection, a complete
respiratory protection program should be instituted which includes regular training,
maintenance, inspection, cleaning, and evaluation. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Any clothing which becomes contaminated with liquid dichlorodifluoromethane
should be removed immediately and not reworn until the dichlorodifluoromethane
has evaporated from the clothing. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
Persons not wearing protective equipment and clothing should be restricted
from areas of leaks until cleanup has been completed. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 3]**PEER REVIEWED**
If material not involved in fire: Attempt to stop leak if without undue personnel
hazard. [Association of American Railroads. Emergency Handling of Hazardous
Materials in Surface Transportation. Washington, DC: Association of American
Railroads, Bureau of Explosives, 1994. 352]**PEER REVIEWED**
Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle
broken packages unless wearing appropriate personnel protective equipment. [Association of American Railroads. Emergency Handling of Hazardous
Materials in Surface Transportation. Washington, DC: Association of American
Railroads, Bureau of Explosives, 1994. 352]**PEER REVIEWED**
SRP: Contaminated protective clothing should be segregated in such a manner
so that there is no direct personal contact by personnel who handle, dispose,
or clean the clothing. Quality assurance to ascertain the completeness of the
cleaning procedures should be implemented before the decontaminated protective
clothing is returned for reuse by the workers. Contaminated clothing should
not be taken home at end of shift, but should remain at employee's place of
work for cleaning. **PEER REVIEWED**
SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR
CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/ [International Labour Office. Encyclopedia of Occupational Health
and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office,
1983. 897]**PEER REVIEWED**
Forced air ventilation at the level of vapor concentration together with the
use of individual breathing devices with independent air supply will minimize
the risk of inhalation. Lifelines should be worn when entering tanks or other
confined spaces. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
Enclosure of process materials and isolation of reaction vessels and proper
design and operation of filling heads for packaging and shipping /are administrative
controls that may be instituted to limit occupational exposure to fluorocarbons
during manufacture, packaging, and use/. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
Filling areas should be monitored to ensure that the ambient concn of fluorocarbons
does not exceed 1000 ppm ... Inhalation of fluorocarbon vapors should be avoided
... . If inhalation occurs, epinephrine or other sympathomimetic amines and
adrenergic activators should not be admin since they will further sensitize
heart to development of arrhythmias. /Fluorocarbons/ [Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene
and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York,
NY: John Wiley & Sons Inc., 1993-1994. 1195]**PEER REVIEWED**
APPEARANCE OF TOXIC DECOMP PRODUCTS SERVES AS WARNING OF OCCURRENCE OF THERMAL
DECOMP & DETECTION OF SHARP ACRID ODOR WARNS OF PRESENCE ... . ADEQUATE
VENTILATION ALSO AVOIDS PROBLEM OF TOXIC DECOMPOSITION PRODUCTS. /FLUOROCARBONS/
[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3101]**PEER REVIEWED**
SRP: Local exhaust ventilation should be applied wherever there is an incidence
of point source emissions or dispersion of regulated contaminants in the work
area. Ventilation control of the contaminant as close to its point of generation
is both the most economical and safest method to minimize personnel exposure
to airborne contaminants. **PEER REVIEWED**
Stability/Shelf Life:
STABLE UP TO 550 DEG C. [Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals,
Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989. 483]**PEER REVIEWED**
Shipment Methods and Regulations:
No person may /transport,/ offer or accept a hazardous material for transportation
in commerce unless that person is registered in conformance ... and the hazardous
material is properly classed, described, packaged, marked, labeled, and in condition
for shipment as required or authorized by ... /the hazardous materials regulations
(49 CFR 171-177)./ [49 CFR 171.2 (7/1/2000)]**PEER REVIEWED**
The International Air Transport Association (IATA) Dangerous Goods Regulations
are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions
618 and 619 and constitute a manual of industry carrier regulations to be followed
by all IATA Member airlines when transporting hazardous materials. [IATA. Dangerous Goods Regulations. 41st Ed.Montreal, Canada
and Geneva, Switzerland: International Air Transport Association, Dangerous
Goods Regulations, 2000. 146]**PEER REVIEWED**
The International Maritime Dangerous Goods Code lays down basic principles
for transporting hazardous chemicals. Detailed recommendations for individual
substances and a number of recommendations for good practice are included in
the classes dealing with such substances. A general index of technical names
has also been compiled. This index should always be consulted when attempting
to locate the appropriate procedures to be used when shipping any substance
or article. [IMDG; International Maritime Dangerous Goods Code; International
Maritime Organization p.2129 (1998)]**PEER REVIEWED**
Storage Conditions:
Ambient; venting; Safety relief. [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous
Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office,
1984-5.]**PEER REVIEWED**
Cleanup Methods:
If dichlorodifluoromethane is leaked ... ventilate area of spill or leak to
disperse gas. ... Stop flow of gas. [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 3]**PEER REVIEWED**
Disposal Methods:
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant,
EPA hazardous waste number U075, must conform with USEPA regulations in storage,
transportation, treatment and disposal of waste. [40 CFR 240-280, 300-306, 702-799 (7/1/2000)]**PEER REVIEWED**
A potential candidate for rotary kiln incineration at a temperature range
of 820 to 1,600 deg C and residence times of seconds for liquids and gases,
and hours for solids. A potential candidate for fluidized bed incineration at
a temperature range of 450 to 980 deg C and residence times of seconds for liquids
and gases, and longer for solids. [USEPA; Engineering Handbook for Hazardous Waste Incineration
p.3-12 (1981) EPA 68-03-3025]**PEER REVIEWED**
Dichlorodifluoromethane is a waste chemical stream constituent which may be
subjected to ultimate disposal by controlled incineration. Incineration, preferably
after mixing with another combustible fuel. Care must be exercised to assure
complete combustion to prevent the formation of phosgene. An acid scrubber is
necessary to remove the halo acids produced. [USEPA; Engineering Handbook for Hazardous Waste Incineration
p.2-5 (1981) EPA 68-03-3025]**PEER REVIEWED**
The following wastewater treatment technology has been investigated for dichlorodifluoromethane:
Concentration process: Solvent extraction. [USEPA; Management of Hazardous Waste Leachate, EPA Contract
No.68-03-2766 p.E-114 (1982)]**PEER REVIEWED**
Because of recent discovery of potential ozone decomposition in the stratosphere
by fluorotrichloromethane, this material should be released to the environment
only as a last resort. Waste material should be /recovered and/ returned to
the vendor, or to licensed waste disposal company. [United Nations. Treatment and Disposal Methods for Waste Chemicals
(IRPTC File). Data Profile Series No. 5. Geneva, Switzerland: United Nations
Environmental Programme, Dec. 1985. 207]**PEER REVIEWED**
Occupational Exposure Standards:
OSHA Standards:
Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1000 ppm (4950
mg/cu m). [29 CFR 1910.1000 (7/1/2000)]**PEER REVIEWED**
Threshold Limit Values:
8 hr Time Weighted Avg (TWA) 1,000 ppm [American Conference of Governmental Industrial Hygienists. TLVs
and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents
and Biological Exposure Indices. Cincinnati, OH. 2000. 30]**PEER REVIEWED**
Excursion Limit Recommendation: Excursions in worker exposure levels may exceed
three times the TLV-TWA for no more than a total of 30 min during a work day,
and under no circumstances should they exceed five times the TLV-TWA, provided
that the TLV-TWA is not exceeded. [American Conference of Governmental Industrial Hygienists. TLVs
and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents
and Biological Exposure Indices. Cincinnati, OH. 2000. 6]**PEER REVIEWED**
A4: Not classifiable as a human carcinogen. [American Conference of Governmental Industrial Hygienists. TLVs
and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents
and Biological Exposure Indices. Cincinnati, OH. 2000. 30]**PEER REVIEWED**
NIOSH Recommendations:
Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1,000 ppm (4,950 mg/cu
m). [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
96]**PEER REVIEWED**
Immediately Dangerous to Life or Health:
15,000 ppm [NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH)
Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997.
96]**QC REVIEWED**
Manufacturing/Use Information:
Major Uses:
For Dichlorodifluoromethane (USEPA/OPP Pesticide Code: 000014) there are 0
labels match. /SRP: Not registered for current use in the U.S., but approved
pesticide uses may change periodically and so federal, state and local authorities
must be consulted for currently approved uses./ [U.S. Environmental Protection Agency/Office of Pesticide Program's
Chemical Ingredients Database on Dichlorodifluoromethane (75-71-8). Available
from the Database Query page at http://www.cdpr.ca.gov/docs/epa/epamenu.htm
as of Sept 8, 2000.]**PEER REVIEWED**
Fully halogenated chlorofluorocarbons (CFCs) such as dichlorodifluoromethane
were scheduled for production phase-out in 1987 by the Montreal Protocol. Although
originally scheduled for 50% production phase-out by the year 2000 in developed
countries, the worsening ozone depletion has forced acceleration of the CFC
phase-out. [Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes
1: New York, NY. John Wiley and Sons, 1991-Present.,p. V21 (97) 132]**PEER REVIEWED**
The active ingredient is no longer contained in any registered pesticide products
... "cancelled." [United States Environmental Protection Agency/ Prevention, Pesticides
and Toxic Substances; Status of Pesticides in Registration, Reregistration,
and Special Review. (1998) EPA 738-R-98-002 312]**PEER REVIEWED**
Leak-detecting agent; freezing of foods by direct contact; /SRP: former use/
chilling of cocktail glasses, refrigerant in air conditioners, plastics, blowing
agent, solvent [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
To prepare frozen tissue sections /former use/ [Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial
Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John
Wiley Sons, 1981-1982. 3091]**PEER REVIEWED**
In various "skin freezes" by aerosol application, as propellant for antibiotic
powders, mastitis formulations, etc, and for admixture to other gases such as
ethylene oxide to make them non-flammable. /former use/ [Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer
Publishing Company, 1974. 165]**PEER REVIEWED**
Manufacturers:
Dichlorodifluoromethane has not been manufactured
in the US since 1995. [USEPA; It's Your Choice: Retrofitting Your Car's A/C System.
USEPA/Air and Radiation (6205J). USEPA430-F-97-052. June, 1997. Available from
http://www.epa.gov/ozone/title6/609/choice.html as of July 2, 2000.]**PEER REVIEWED**
Allied Signal Inc. 101 Columbia Road P.O.
Box 1057 Morristown, NJ 07962-1057. (201) 455-2000. Prod
site: Danville, IL 61834 [SRI. 1995 Directory of Chemical Producers-United States of America.
Menlo Park, CA: SRI International, 1995 542]**PEER REVIEWED**
Dupont Chemical Inc. 1007 Market Street
Wilmington, DE 19898 (302) 774-1000. Prod sites: Antioch,
CA 94509; Montague, MI 49437. [SRI. 1995 Directory of Chemical Producers-United States of America.
Menlo Park, CA: SRI International, 1995 542]**PEER REVIEWED**
Elf Atochem North America Inc. Three Parkway
Philadelphia, PA 19102. (215) 587-7000. Prod site:
Calvert City, KT 42029. [SRI. 1995 Directory of Chemical Producers-United States of America.
Menlo Park, CA: SRI International, 1995 542]**PEER REVIEWED**
Methods of Manufacturing:
Reaction of carbon tetrachloride and anhydrous hydrogen fluoride, in the presence
of an antimony halide catalyst [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
PREPD BY SUBSTITUTING 2 CHLORINE ATOMS OF CARBON TETRACHLORIDE WITH FLUORINE
BY ACTION OF ANTIMONYL TRIFLUORIDE IN PRESENCE OF ANTIMONY PENTACHLORIDE. [The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co.,
Inc., 1976. 404]**PEER REVIEWED**
High temperature chlorination of vinylidene fluoride. [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
General Manufacturing Information:
... /The use of chlorofluorocarbons for aerosol sprays/ was prohibited in
1979 except for a few specialized items, because of their depleting effect on
stratospheric ozone. /Chlorofluorocarbons/ [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 256]**PEER REVIEWED**
Their use for aerosol sprays was prohibited ... because of their depleting
effect on stratospheric ozone. /chlorofluorocarbons/ [Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical
Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987. 266]**PEER REVIEWED**
Formulations/Preparations:
USEPA/OPP Pesticide Code 000014; Trade Names: Freon 12; Propellant 12; Frigen
12; Arcton 12; FC 12; Genetron 12; Ledon 12; and Eskimon 12. /Former trade names/
[U.S. Environmental Protection Agency/Office of Pesticide Program's
Chemical Ingredients Database on Dichlorodifluoromethane (75-71-8). Available
from the Database Query page at http://www.cdpr.ca.gov/docs/epa/epamenu.htm
as of Sept 8, 2000.]**PEER REVIEWED**
99.9% min purity [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
Consumption Patterns:
... Refrigerant (46%), foam blowing agent (20%), solvent (16%), fluoropolymers
(7%), other (4%), export (7%). Solvent use is mainly in the aerospace and electronic
industries (1981). [Smart BE; Kirk Othmer's Encycl Chem Tech 3rd NY,NY: Wiley Interscience
10: 829-70 (1980)]**PEER REVIEWED**
Refrigeration/air conditioning, 43%; foam blowing agents, 20%; polymer precursors,
13%; solvent cleaning, 12% aerosol propellants, 2%; medical equipment sterilization,
3%; other, 7%. (1991). /Estimates are for CFC-11,-12,-113,-114,-115 and HCFC-22
only/ [Chemical Profile: Fluorocarbons (1992)]**PEER REVIEWED**
U. S. Production:
(1972) 1.99X10+11 G [SRI]**PEER REVIEWED**
(1975) 1.78X10+11 G [SRI]**PEER REVIEWED**
(1984) 1.54X10+11 g (EST) [CHEMICAL PRODUCTS SYNOPSIS: FLUOROCARBONS, (1984)]**PEER REVIEWED**
(1988) 413,777,000 lb [United States International Trade Commission. Synthetic Organic
Chemicals- United States Production and Sales, 1988. USITC Publication 1989.
Washington,DC: United States International Trade Commission, 1989.,p. 15-7]**PEER
REVIEWED**
(1984) 1.36X10+11 g (EST) /CFC-13, -113, -114, -115, FLUORINATED MONOMERS
AND SPECIALITIES/ [CHEMICAL PRODUCTS SYNOPSIS: FLUOROCARBONS (1984)]**PEER REVIEWED**
(1991) 7x10+8 lb (est) /Estimates are for CFC-11,-12,-113,-114,-115 and HCFC-22
only/ [Chemical Profile: Fluorocarbons (1992)]**PEER REVIEWED**
(1992) 6.1x10+8 lb (est) /Estimates are for CFC-11,-12,-113,-114,-115 and
HCFC-22 only/ [Chemical Profile: Fluorocarbons (1992)]**PEER REVIEWED**
(1996) 3.75x10+8 lb (est) /Estimates are for CFC-11,-12,-113,-114,-115 and
HCFC-22 only/ [Chemical Profile: Fluorocarbons (1992)]**PEER REVIEWED**
U. S. Imports:
(1972) NEGLIGIBLE [SRI]**PEER REVIEWED**
(1975) NEGLIGIBLE [SRI]**PEER REVIEWED**
(1984) 3.95X10+9 g /COMBINATION OF TRICHLOROFLUOROMETHANE & DICHLORODIFLUOROMETHANE/
[BUREAU OF THE CENSUS US IMPORTS FOR CONSUMPTION AND GENERAL
IMPORTS (1984) p.1-363]**PEER REVIEWED**
(1984) GREATER THAN 4.54X10+9 g (EST) /UNCLASSIFIED FLUOROCARBONS/ [CHEMICAL PRODUCTS SYNOPSIS: FLUOROCARBONS (1984)]**PEER REVIEWED**
U. S. Exports:
(1984) RANGE FROM 1.82X10+10 g TO 2.27X10+10 g (EST) /UNCLASSIFIED FLUOROCARBONS/
[CHEMICAL PRODUCTS SYNOPSIS: FLUOROCARBONS (1984)]**PEER REVIEWED**
Laboratory Methods:
Clinical Laboratory Methods:
GAS CHROMATOGRPAHIC METHOD FOR DETERMINING FLUOROCARBONS IS DESCRIBED. CONCN
IN BODY FLUIDS ARE DETERMINED BY MEANS OF HEAD SPACE ANALYSIS. /FLUOROCARBONS/
[RAUWS ET AL; J PHARM PHARMACOL 25 (9): 718-22 (1973)]**PEER
REVIEWED**
HEXANE EXTRACTION PROCEDURE FOR THE DETERMINATION OF COMMON FLUOROCARBON PROPELLANTS
IN BLOOD WAS EVALUATED. AN ANALYSIS OF SAMPLE HEADSPACE WAS ALSO EVALUATED FOR
DETERMINING CHLOROPENTAFLUOROETHANE IN BLOOD. BOTH PROCEDURES INVOLVED ANALYSIS
BY GAS CHROMATOGRAPHY USING ELECTRON CAPTURE DETECTION. THE WIDELY USED HEXANE
EXTRACTION PROCEDURE FOR DETERMINING PPM LEVELS OF VOLATILE HALOCARBONS IN TISSUE
WAS EVALUATED BY A COMBINATION OF RADIOCHEMICAL AND GAS CHROMATOGRAPHIC TECHNIQUES.
THE DATA SUGGEST THAT HEXANE EXTRACTION GIVES SIGNIFICANTLY LOW RESULTS. /FLUOROCARBONS/
[TERRILL JB; AMER IND HYG ASSOC J 33 (11): 736-44 (1972)]**PEER
REVIEWED**
FLUOROCARBON DETERMINATION IN BLOOD: GAS CHROMATOGRAPHY WITH ELECTRON CAPTURE
DETECTION. /FLUOROCARBONS/ [Sunshine, Irving (ed.) Methodology for Analytical Toxicology.
Cleveland: CRC Press, Inc., 1975. 175]**PEER REVIEWED**
Analytic Laboratory Methods:
APHA Method 6210-D Volatile Organics in Water by Gas Chromatographic/ Mass
Spectrometric Purge and Trap Capillary-Column Technique. No detection limit
[USEPA; EMMI. EPA's Environmental Monitoring Methods Index. Version
1.1. PC# 4082. Rockville, MD: Government Institutes (1997)]**PEER REVIEWED**
NIOSH Method 1018. Analyte: Dichlorodifluoromethane. Matrix: Air. Procedure:
Gas chromatography, flame ionization detector. For dichlorodifluoromethane this
method has an estimated detection limit of 0.03 mg/sample. The precision/RSD
is 0.035 at 7.4 to 30 mg and the recovery is not given. Applicability: The working
range is 340 to 2200 ppm (1670 to 11,000 mg/cu m dichlorodifluoromethane for
a 3 liter air sample). Interferences: Methanol and acetone may interfere if
present at high concentrations. [U.S. Department of Health and Human Services, Public Health
Service, Centers for Disease Control, National Institute for Occupational Safety
and Health. NIOSH Manual of Analytical Methods. 4th ed.Methods A-Z & Supplements.
Washington, DC: U.S. Government Printing Office, Aug 1994.]**PEER REVIEWED**
EPA Method 502.1. Purge and Trap Gas Chromatography with halogen-specific
detector for the determination of halogenated volatile compounds including dichlorofluoromethane
in finished drinking water, raw source water, or drinking water in any treatment
stage. Under the prescribed conditions, for dichlorofluoromethane the method
detection limit is not determined. [USEPA; Methods for the Determination of Organic Compounds in
Finished Drinking Water and Raw Source Water (1986)]**PEER REVIEWED**
EPA Method 502.2: Purge-and-Trap Capillary Column Gas Chromatography with
photoionization and electrolytic conductivity detectors in series. The method
is applicable for the determination of volatile organic compounds in finished
drinking water, raw source water, or drinking water in any treatment stage.
For dichlorodifluoromethane no results were given using the photoionization
detector. The method has a detection limit of 0.05 ug/l, a percent recovery
of 89%, and a standard deviation of recovery of 5.9 using the electrolytic conductivity
detector. [USEPA; Methods for the Determination of Organic Compounds in
Finished Drinking Water and Raw Source Water (1986)]**PEER REVIEWED**
EPA Method 524.1. Purge-and-Trap Gas Chromatography/Mass Spectrometry. The
method is applicable for the determination of volatile organic compounds in
water, finished drinking water, raw source water, or drinking water in any treatment
stage. For dichlorodifluoromethane the method has a detection limit of 0.11
ug/l and a standard deviation of 11.9%. [USEPA; Methods for the Determination of Organic Compounds in
Finished Drinking Water and Raw Source Water (1986)]**PEER REVIEWED**
EPA Method 524.2. Purge-and-Trap Gas Chromatography/Mass Spectrometry for
the determination of volatile organic compounds in water including finished
drinking water, raw source water, and drinking water in any treatment stage.
For dichlorodifluoromethane the method has a detection limit of 0.10 ug/l and
a relative standard deviation of 7.7% with a wide bore capillary column, and
a method detection limit of 0.11 ug/l and a relative standard deviation of 8.9%
with a narrow bore capillary column. [USEPA; Methods for the Determinatioon of Organic Compounds in
Finished Drinking Water and Raw Source Water (19860]**PEER REVIEWED**
OSW Method 8240B Determination of Volatile Organic Compounds by Gas Chromatography/Mass
Spectrometry (GC/MS). Detection limit = 5 ug/kg. [USEPA; EMMI. EPA's Environmental Monitoring Methods Index. Version
1.1. PC# 4082. Rockville, MD: Government Institutes (1997)]**PEER REVIEWED**
EPA Method 601. Purge-and-Trap Gas Chromatography with electrolytic conductivity
detection for the analysis of purgeable halocarbons including dichlorodifluoromethane
in municipal and industrial discharges. Under the prescribed conditions, the
method detection limit for dichlorodifluoromethane is 1.61 ug/l. The method
is recommended for use in the concentration range from the method detection
limit to the 1000 times that limit. Precision and method accuracy were found
to be directly related to the concentration of the parameter and essentially
independent of the sample matrix. [40 CFR 136 (7/1/91)]**PEER REVIEWED**
EPA Method 8010. Direct Injection or Purge-and-Trap Gas Chromatography with
halogen-specific detector for the anlaysis of halogenated volatile organics
including dichlorodifluoromethane in solid waste. Under the prescribed conditions
for dichlorodifluoromethane the method detection limit was not given. Precision
and method accuracy were found to be directly related to the concentration of
the parameter and essentially independent of the sample matrix. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 8240. Gas Chromatography/Mass Spectrometry for the determination
of volatile organics. This method can be used to quantify most volatile organic
compounds including dichlorodifluoromethane that have boiling points below 200
deg C and are insoluble or slightly soluble in water. The estimated quantitation
limit is 5 mg/kg in solids and 5 ug/l in water as defined by EPA. Precision
and method accuracy were found to be directly related to the concentration of
the analyte and essentially independent of the sample matrix. [USEPA/SCC; Environmental Monitoring Methods Index p.218 (1992)]**PEER
REVIEWED**
EPA Method 8260. Gas Chromatography/Mass Spectrometry for the determination
of volatile Organic compounds. This method can be used to quantitate most volatile
organic compounds including dichlorodifluoromethane that have boiling points
below 200 deg C and are insoluble or slightly soluble in water. Under the prescribed
conditions for dichlorodifluoromethane the method has a detection limit of 0.10
ug/l, a percent recovery of 7.7%, and a percent relative standard deviation
of 90% using a wide bore capillary column; and a detection limit of 0.11 ug/l,
a percent recovery of 99%, and a percent relative standard deviation of 8.9%
using a narrow bore capillary column. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 5030. Purge and Trap extraction procedure for the analysis of volatile
organics. Such cmpds include low-molecular weight halogenated hydrocarbons,
aromatics, ketones, nitriles, acetates, acrylates, ethers and sulfides. An inert
gas is bubbled through the solution at ambient temperature, and the volatile
components are efficiently transferred from the aqueous phase to the vapor phase.
After purging is complete, the sorbent column is heated and backflushed with
inert gas to desorb the components onto a GC column. Water samples can be analyzed
directly, while preparation is necessary for water-miscible liquids, solids,
wastes and soil/sediments. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 5040. Protocol for Analysis of Sorbent Cartridges from Volatile
Organic Sampling Train. This method covers the determination of volatile principal
organic hazardous constituents collected on Tenax and Tenax/charcoal sorbent
cartridges using a volatile organic sampling train, from wet stack gas effluents
from hazardous waste incinerators. The contents of the sorbent cartidges are
thermally desorbed, bubbled, and trapped on an analytical adsorbent trap. The
desired target detection limit of the analytical method is 0.1 ng/l. Interferences
include phthalate esters, detectable levels of volatile principal hazardous
constituents in blanks, and soap residue on the glassware. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 3580. Waste Dilution. One gram of sample is weighed into a capped
tube and the sample is diluted with an appropriate solvent. This method is designed
for wastes that may contain organic chemicals at a level greater than 20,000
mg/kg. It is recommended that an aliquot of the diluted sample be cleaned up
with an applicable technique. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 8021. Direct Injection or Purge and Trap Gas Chromatography with
an electrolytic conductivity detector and a photoionization detector for the
determination of halogenated and aromatic volatiles organic compounds in solid
waste. Under the prescribed conditions for dichlorodifluoromethane, the method
detection limit is 0.050 ug/l as defined by EPA. [USEPA/SCC; Environmental Monitoring Methods Index p.343 (1992)]**PEER
REVIEWED**
EPA Method 6230 B. Purge and Trap Packed-Column Gas Chromatography with electrolytic
conductivity detector. This method is applicable for the determination of purgeable
halocarbons in municipal and industrial discharges. The detector is a halide-specific
electrolytic conductivity or microcoulometric detector. Under the prescribed
conditions for dichlorodifluoromethane, the method detection limit is 1.8 ug/l
as defined by EPA. [USEPA/SCC; Environmental Monitoring Methods Index p.77 (1992)]**PEER
REVIEWED**
EPA Method IP-1A. High resolution capillary gas chromatography/mass spectrometry
method coupled to one or more detectors (eg flame ionization detector, electron
capture detector, photoionization detector) for the determination of volatile
organic compounds in indoor air using stainless steel canisters. During analysis
, water vapor is reduced in the gas stream by a Nafion(R) dryer and the temperature
of the trap is raised. Under the prescribed conditions, the method detection
limit are not given as defined by EPA. [USEPA/SCC; Environmental Monitoring Methods Index p.94 (1992)]**PEER
REVIEWED**
Sampling Procedures:
Measurements to determine employee exposure are best taken so that the average
eight-hour exposure is based on a single eight-hour sample or two four-hour
samples. Several short time interval samples (up to 30 minutes) may also be
used to determine the average exposure level. Air samples should be taken in
the employee's breathing zone (air that would most nearly represent that inhaled
by the employee). [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.).
NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH)
PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office,
Jan. 1981. 2]**PEER REVIEWED**
NIOSH Method 1018. Analyte: Dichlorodifluoromethane. Matrix: Air. Sampler:
Solid sorbent tubes (two coconut shell charcoal tubes in series, 400 mg/200
mg and 100 mg/50 mg). Flow Rate: 0.01 to 0.05 l/min: Sample Size: 3 liters.
Shipment: Refrigerated. Sample Stability: 100% recovery after 7 days at 25 deg
C. [U.S. Department of Health and Human Services, Public Health
Service, Centers for Disease Control, National Institute for Occupational Safety
and Health. NIOSH Manual of Analytical Methods. 4th ed.Methods A-Z & Supplements.
Washington, DC: U.S. Government Printing Office, Aug 1994.]**PEER REVIEWED**
EPA Method 8010. For the analysis of solid waste, a representative sample
(solid or liquid) is collected in a standard 40 ml glass screw-cap VOA vial
equipped with a Teflon-faced silicone septum. Sample agitation, as well as contamination
of the sample with air, must be avoided. Two vials are filled per sample location,
then placed in separate plastic bags for shipment and storage. [USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
EPA Method 8240. Gas Chromatography/Mass Spectrometry for the determination
of volatile Organics. This method can be used to quantify most volatile organic
compounds including dichlorodifluoromethane that have boiling points below 200
deg C and are insoluble or slightly soluble in water. The detection limit is
not given. Precision and method accuracy were found to be directly related to
the concentration of the analyte and essentially independent of the sample matrix.
[USEPA; Test Methods for Evaluating Solid Waste SW-846 (1986)]**PEER
REVIEWED**
Special References:
Special Reports:
ROSS RH ET AL; REPORT, ORNL/EIS-105 (1978). HEALTH ASPECTS OF ORGANOHALIDE
COMPOUNDS INCLUDING DIFLUORODICHLOROMETHANE ARE PRESENTED.
RUSSELL AD, THOMPSON GM; WATER RESOUR RES 19 (1): 57-60 (1983). MECHANISMS
LEADING TO ENRICHMENT OF ATMOSPHERIC FLUOROCARBONS, DICHLOROFLUOROMETHANE &
FLUOROTRICHLOROMETHANE, IN GROUNDWATER ARE DISCUSSED.
GUNDERSON EC, ANDERSON CC; DHHS (NIOSH) PUBL, US (80-133) (1980). THIS STUDY
SUMMARIZES THE METHODS VALIDATED FOR SAMPLING & ANALYZING 130 SUBSTANCES
IN THE WORKPLACE.
USEPA; Ambient Water Quality Criteria Doc: Halomethanes (1980) EPA 440/5-80-051
Taccola A and Gobba F; Medicina del Lavoro 75: 167-179 (1984); Review of cardiotoxicity
of fluorocarbons.
WHO; Environmental Health Criteria 113 Fully Halogenated chlorofluorocarbons
(1990)
Zakhari S, Aviado DM; Cardiovascular Toxicology of Aerosol Propellants, Refrigerants
and Related Solvents; Target Organ Toxicology Series: Cardiovascular Toxicology,
XII+ 388 pages; Raven Press: New York, NY 281-326 (1982). Review of the toxicology
of aerosol propellants, refrigerants and related solvents on the cardiovascular
system of humans.
EPA Pesticide Chemical Code 000014 **PEER REVIEWED**
ESKIMON 12 **PEER REVIEWED**
FC 12 **PEER REVIEWED**
FLUOROCARBON-12 **PEER REVIEWED**
FREON F-12 **PEER REVIEWED**
FREON 12 **PEER REVIEWED**
FRIGEN 12 **PEER REVIEWED**
GENETRON 12 **PEER REVIEWED**
Halon **PEER REVIEWED**
Halon 122 **PEER REVIEWED**
ISCEON 122 **PEER REVIEWED**
Isotron 2 **PEER REVIEWED**
ISOTRON 12 **PEER REVIEWED**
KAISER CHEMICALS 12 **PEER REVIEWED**
LEDON 12 **PEER REVIEWED**
METHANE, DICHLORODIFLUORO- **PEER REVIEWED**
PROPELLANT 12 **PEER REVIEWED**
R 12 (REFRIGERANT) **PEER REVIEWED**
REFRIGERANT 12 **PEER REVIEWED**
UCON 12 **PEER REVIEWED**
UCON 12/HALOCARBON 12 **PEER REVIEWED**
Formulations/Preparations:
USEPA/OPP Pesticide Code 000014; Trade Names: Freon 12; Propellant 12; Frigen
12; Arcton 12; FC 12; Genetron 12; Ledon 12; and Eskimon 12. /Former trade names/
[U.S. Environmental Protection Agency/Office of Pesticide Program's
Chemical Ingredients Database on Dichlorodifluoromethane (75-71-8). Available
from the Database Query page at http://www.cdpr.ca.gov/docs/epa/epamenu.htm
as of Sept 8, 2000.]**PEER REVIEWED**
99.9% min purity [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary.
13th ed. New York, NY: John Wiley & Sons, Inc. 1997. 364]**PEER REVIEWED**
Shipping Name/ Number DOT/UN/NA/IMO:
UN 1028; Dichlorodifluoromethane
IMO 2.2; Dichlorodifluoromethane
Standard Transportation Number:
49 045 16; Dichlorodifluoromethane
EPA Hazardous Waste Number:
U075; A toxic waste when a discarded commercial chemical product or manufacturing
chemical intermediate or an off-specification commercial chemical product or
manufacturing chemical intermediate.
RTECS Number:
NIOSH/PA8200000
Administrative Information:
Hazardous Substances Databank Number: 139
Last Revision Date: 20010809
Last Review Date: Reviewed by SRP on 1/20/2001
Update History:
Complete Update on 08/09/2001, 1 field added/edited/deleted.
Complete Update on 05/23/2001, 65 fields added/edited/deleted.
Field Update on 05/16/2001, 1 field added/edited/deleted.
Complete Update on 06/12/2000, 1 field added/edited/deleted.
Complete Update on 03/28/2000, 1 field added/edited/deleted.
Complete Update on 03/13/2000, 2 fields added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 08/26/1999, 1 field added/edited/deleted.
Complete Update on 07/20/1999, 6 fields added/edited/deleted.
Complete Update on 03/17/1999, 1 field added/edited/deleted.
Complete Update on 01/20/1999, 3 fields added/edited/deleted.
Field Update on 12/18/1998, 1 field added/edited/deleted.
Complete Update on 11/12/1998, 1 field added/edited/deleted.
Complete Update on 06/02/1998, 1 field added/edited/deleted.
Complete Update on 10/17/1997, 1 field added/edited/deleted.
Complete Update on 07/28/1997, 1 field added/edited/deleted.
Complete Update on 03/27/1997, 2 fields added/edited/deleted.
Complete Update on 02/26/1997, 1 field added/edited/deleted.
Complete Update on 01/09/1997, 1 field added/edited/deleted.
Complete Update on 05/09/1996, 1 field added/edited/deleted.
Complete Update on 04/09/1996, 8 fields added/edited/deleted.
Field Update on 01/18/1996, 1 field added/edited/deleted.
Complete Update on 11/10/1995, 1 field added/edited/deleted.
Complete Update on 09/29/1995, 1 field added/edited/deleted.
Complete Update on 08/14/1995, 1 field added/edited/deleted.
Complete Update on 05/26/1995, 1 field added/edited/deleted.
Complete Update on 01/18/1995, 1 field added/edited/deleted.
Complete Update on 12/19/1994, 1 field added/edited/deleted.
Complete Update on 07/22/1994, 1 field added/edited/deleted.
Complete Update on 03/25/1994, 1 field added/edited/deleted.
Complete Update on 08/07/1993, 1 field added/edited/deleted.
Complete Update on 08/04/1993, 1 field added/edited/deleted.
Complete Update on 06/03/1993, 84 fields added/edited/deleted.
Field Update on 02/05/1993, 1 field added/edited/deleted.
Field update on 12/11/1992, 1 field added/edited/deleted.
Field Update on 11/04/1992, 1 field added/edited/deleted.
Complete Update on 08/17/1992, 72 fields added/edited/deleted.
Field Update on 04/16/1992, 1 field added/edited/deleted.
Field Update on 01/13/1992, 1 field added/edited/deleted.
Complete Update on 10/22/1990, 7 fields added/edited/deleted.
Field Update on 05/14/1990, 1 field added/edited/deleted.
Field Update on 01/15/1990, 1 field added/edited/deleted.
Complete Update on 01/11/1990, 4 fields added/edited/deleted.
Field Update on 05/05/1989, 1 field added/edited/deleted.
Complete Update on 12/09/1988, 2 fields added/edited/deleted.
Complete Update on 09/26/1988, 87 fields added/edited/deleted.
Complete Update on 02/15/1985