Dichlofluanid
CAS No. 1085-98-9
 
 

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Adverse Effects
Abstracts

ACTIVITY: Wood Preservative, Antifoulant, Fungicide, Acaricide

CAS Name: 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-phenylmethanesulfenamide

Structure:

Adverse Effects:

Blood
Bone - Cranial osteosclerosis
Brain
Carginogenic
Endocrine: Ovary; Vitellogenesis

Endocrine: Pituitary
Endocrine: Suspected Disruptor
Endocrine: Testicular

Endocrine: Thyroid
Genotoxic - Potent Cytoxicant
Kidney

Liver

Contamination:

2001 - Denmark:
Wood preservative
sold in Denmark under the retail product name "Rentolin" with no warning against indoor uses. Around 200 people used Rentolin indoors and suffered serious injury. Many houses are now uninhabitable, and several people suffer from chronic diseases.

Environmental Effects:

Although no marine data were submitted, dichlofluanid was shown to be highly toxic to aquatic organisms.

The most commonly used biocides in antifouling paints are: Irgarol 1051, diuron, Sea-nine 211, dichlofluanid, chlorothalonil, zinc pyrithione, TCMS (2,3,3,6-tetrachloro-4-methylsulfonyl) pyridine, TCMTB [2-(thiocyanomethylthio) benzothiazole], and zineb. Since 1993, several studies have demonstrated the presence of these biocides in European coastal environment as a result of their increased use. More recently, the presence of these biocides was also revealed in waters from Japan, United States, Singapore, Australia and Bermuda.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: No
US EPA PC Code: 128844
FDA LMS Code: 588
Registered use in
(includes only a limited list of countries)

Australia, China, Denmark, Germany, Hungry, Japan, New Zealand, Portugal, South Africa, UK
European Commission: Not allowed to be used as an active ingredient after July 25, 2003.
Japan's Maximum Residue Levels (MRLs) Partial List: Apricot • Apple • Banana • Barley • Beans • Blackberry • Blueberry • Brussels sprouts • Cabbage • Carrot • Cauliflower • Cherry• Cranberry • Cucumber (including Gherkin) • Eggplant • Garlic • Ginger • Grape • Grapefruit • Hop • Horseradish • Japanese pear • Japanese persimon • Japanese plum (including Prunes) • KOMATSUNA • Lettuce (Cos lettuce, Leaf lettuce) • Kidney beans (with pods, immature) • Lemon • Lime • Nectarine • Onion • Orange (including Navel) • Other berries • Other cereal grains • Other Citrus fruits • Other Fruits • Other Vegetables • Parsnip • Peach • Pear • Peas • Peas (with pods, immature) • Pimento (Sweet pepper) • Potato • Raspberry • Rye • Salsify • Spinach • Strawberry • Tea • Tomato • Watermelon • Wheat 
Other Information
Molecular Formula: C9H11Cl2 F N2O2S2
Inventing Company: Bayer  
Entry Year: 1965 
Other Names: Bay, BAY 47531,
Dichlofluanide (France),
Elvaron, Eurparen,
Euparene, Flourofolpet,
Kue, 13032c, Preventol,
Rentolin
Manufacture site: GERMANY:
Bayer, Dormagen-Bayerwerk
Of special interest:
PAN Data
June 2005 - CHINA: Asparagus production is expected to remain relatively high in China again this year, with the result the country will remain an intense competitor on world processed asparagus markets. This year;s harvest the potential to reach 400,000 metric tons (), reports the U.S. agricultural attache for the country, with the country exporting around $100 million worth of processed and fresh asparagus ... An independent residue analysis laboratory in China's vegetable export hub of Qingdao reports a range of chemical residues are often found on agricultural products in China that would not normally be associated with controlling pests or disease for the commodity of concern. The lab reports its tests on white and green asparagus did not find levels exceeding allowable levels and that levels were less than one part per million for tests of Atrazine, Biphenyls, Carbendazim, Dichlofluanid, Diphenylamine, Myclobutanil, and p,p'-DDE.
Ref: China Expects 400,000 MT Asparagus Crop. Fresh Plaza.
Denmark: Wood preservative ruined 200 homes. Issue 17, Chemical Awareness (2001)
January 2003 - Evaluation on: Booster biocides in antifouling products. Full review of Dichlofluanid. No. 206. Evaluation of Fully Approved or Provisionally Approved Products. Prepared by : The Health and Safety Executive Biocides & Pesticides Assessment Unit Magdalen House Stanley Precinct Bootle Merseyside L20 3QZ Available from: Department for Environment, Food and Rural Affairs, Pesticides Safety Directorate, Mallard House, Kings Pool, 3 Peasholme Green, York YO1 7PX, UK. Also available at: http://www.pesticides.gov.uk/citizen/Evaluations/206_dichlofluanid.pdf 
ASSESSMENT OF ANTIFOULING AGENTS IN COASTAL ENVIRONMENTS (ACE) MAS3-CT98-0178 Management Report (February 2000 -July 2000) James W Readman (Plymouth Marine Laboratory, UK.) Also available at: http://www.pml.ac.uk/ace/sec/Feb00-Julyfinal.doc.
ABSTRACTS
November 26, 2002 - European Commission: Dichlofluanid is one of 320 pesticides to be withdrawn in July 2003. "Some 320 substances used in plant protection products (PPPs) – including insecticides, fungicides and herbicides – are to be withdrawn from the market by 25 July 2003 as part of the European Commission’s new approach to the evaluation of active substances in plant protection products. This aims to improve safeguards to ensure that all such products in use are safe for the environment and human health. Users, wholesalers and retailers of plant protection products will need to be aware of whether the products they use or sell are likely to be withdrawn, so as to prevent them being left with stocks of unusable material. Those concerned should contact their national authority to check the authorisation status for any particular product. The Regulation (n° 2076/2002 of 20 November 2002), with the list of the 320 substances, has now been published in the Offical Journal...." Ref: MIDDAY EXPRESS. News from the Press and Communication Service's midday briefing.
Citation of hormonal activity for Dichlofluanid in the report: BIOCIDES (II). Refined aquatic environmental risk assessment of 28 priority biocides. RIVM report 601506005. B.J.W.G. Mensink. November 2000. RIVM = Rijksinstituut voor Volksgezondheid en Milieu. National Institute of Public Health and the Environment. http://www.rivm.nl/bibliotheek/rapporten/601506005.pdf
1998 - In this report Dichlofluanide was identified as: "Very high toxicity to aquatic organisms" and "Sensitising." The report, entitled Examples of substances requiring particular attention, was issued by the Swedish National Chemicals Inspectorate in collaboration with the Swedish Environmental Protection Agency and the Swedish National Board of Occupational Safety and Health. NATIONAL CHEMICALS INSPECTORATE. Order No 510 622. Second, revised edition, 1998. See list of the specific Fluorine and organofluorine pesticides cited in the report.
Food and Drug Administration Pesticide Residue Monitoring. April 2000. Table 3. Pesticides detectable by methods used in 1999 regulatory monitoring.
EEC Maximum Residue Levels (MRLs). Pages 261-265. March 12, 2001
 
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