Clodinafop-propargyl
CAS No. 105512-06-9
 
 

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Adverse Effects

ACTIVITY: Herbicide, Plant Growth Regulator (Aryloxyphenoxy propionic acid)

CAS Name for Clodinafop: (R)-2-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenoxy]propanoic acid

Structure for Clodinafop:

Adverse Effects:

Anemia
Bladder (ureter)
Blood
Body Weight Decrease

Bone
Cancer:
Likely to be carcinogenic to humans - PROSTATE, OVARIAN, LIVER, BLOOD
Clastogenicity
Dermal

Endocrine: Ovary
Endocrine: Prostate
Endocrine: Thymus
Kidney
Liver
Tremors

Environmental Effects:

Highly Toxic to Freshwater Fish

The major degradate, CGA-193469, is persistent and has the potential to contaminate drinking water.

Regulatory Information
(only comprehensive for the US)
US EPA Registered: Yes
US EPA PC Code: 125203
US Tolerances: CFR 180.559
FDA LMS Code: B38
Registered use in
(includes only a limited list of countries)

Australia, Canada, Denmark, Hungary, India, Netherlands, New Zealand, South Africa, UK, US
US Maximum Residue Levels permitted in food commodities

US:
Wheat (forage, grain, hay, straw)

Other Information
Molecular Formula: C17H13Cl F NO4
Inventing Company: Ciba Geigy 
Entry Year: 1989 
Manufacturers:   Syngenta (Ciba Geigy),
Novartis
Other Names: Banvel
Celio
CGA-184927
Clarity
Discover,

Harmony
Horizon (Novartis)
Mondak
Platinum
Topik
Manufacture sites: SWITZERLAND:
Novartis, Monthey

UK: Novartis, Grimsby,
NE Lincolnshire
Of special interest:
PAN BAD ACTOR (Carcinogen)
Material Safety Data Sheets & Labels
2006: April 12. Commission Directive 2006/39/EC, ameding Council Directive to include clodinafop as an active substance.
2006: January 27. Final review report fo the active substance clodinafop. European Commission, Health & Consumer Protection Directorat -General. SANCO/10530/2005 - rev. 3.
2005: August 10. Conclusion regarding the peer review of the pesticide risk assessment of the active substance clodinafop. EFSA Scientific Report 34, 1-78.
2005: July 30. Peer Review Report on Clodinafop (based on the variant clodinafop-propargyl). European Food Safety Authority (EFSA).
2005: May. Classification of clodinafop-propargyl with R48/22. The Netherlands.
2005: May 23. U.S. Congressman Lee Terry (R-NE) introduced a bill "to suspend temporarily the duty on Formulations of Clodinafop-propargyl" up to December 31, 2008. The bill was referred to the House Committee on Ways and Means.
2004: November. "Pesticide Info". British Columbia Ministry of Agriculture, Food & Fisheries.
2000: June 6. Conditional Registration; US EPA Fact Sheet


US Federal Register
Date Published Docket Identification Number Details
August 3, 2005 OPP-2005-0201

Cancellation of Pesticides for Non-payment of Year 2005 Registration Maintenance Fees.

Section 24(c) Registrations canceled for non-payment of the 2005
maintenance fee are shown in the following Table 1:

Table 1.--Section 24(c) Registrations Canceled for Non-Payment of Maintenance Fee

SLN no. Product Name
000100 OR-01-0007 Discover Herbicide
June 22, 2000 OPP-301009 Pesticide Tolerance for Wheat (forage, grain, hay) 0.1 ppm; Wheat (straw) at 0.5 ppm. - FINAL RULE.
April 26, 2000 PF-938

NOVARTIS - Pesticide Tolerance Petition in or on Wheat (grain, forage, hay) at 0.1 ppm; Straw at 0.5 ppm.

Sept 25, 1998 OPP-30460

NOVARTIS - Application to register pesticide: Clodinafop 2E Herbicide. Active ingredient: Clodinafop-propargyl at 22.3%. For use in wheat (including Durum) to control wild oats, green and yellow foxtail, and Persian darnel. US EPA File Symbol: 100-ONT.

June 5, 1998 PF-807

NOVARTIS - Pesticide Tolerance Petition; in or on wheat grain at 0.02 ppm and wheat straw at 0.05 ppm.


Dec 10, 2001 Australia: "Current List. RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS."
Oct 2001 Glossary of Pesticide Chemicals, October 2001. A listing of pesticides subject to analysis of residues in foods and feeds by the US Food and Drug Administration. Also available at: http://vm.cfsan.fda.gov/~acrobat/pestglos.pdf
Aug2001 IR - 4: New Products/Transitional Solution List - This list contains brief descriptions of numerous new pest control materials that have been introduced over the last several years. Additionally, it contains information on some "older" crop protection chemicals that are believed to have room for new uses. This List includes: Clodinafop-propargyl  

Novartis. May 9, 2000. Form 20-F/A. US Securities & Exhange Commission.

New pesticide products in development: Butafenacil, Clodinafop, Fludioxonil (Apron), Fluthiacet, Metolachlor, Trifloxystrobin, Trifloxysulfuron. Note: "The Company was created by the merger of Sandoz AG and CIBA-Geigy AG (the "Merger") in December 1996. Prior to the Merger, Sandoz AG and CIBA-Geigy AG were each global participants in the pharmaceutical and agrochemical industries. The predecessor companies of the Company merged to realize sales, cost and cross-sector synergies, and to create a combined entity with the resources and ability to compete in the long term in an increasingly competitive global environment. The Boards of the Company and AstraZeneca announced on December 2, 1999, that they each agreed to spin off and merge Novartis’ Crop Protection and Seeds businesses and Zeneca Agrochemicals to create the world’s first dedicated agribusiness company with pro forma combined sales in 1998 of approximately $7.9 billion. The new company will be named Syngenta AG ("Syngenta"), headquartered in Basel, Switzerland (p 5)... In Crop Protection, the major production sites for the active ingredients are located in India, Switzerland, the UK and the U.S., with the major production sites for formulation and packaging in Brazil, China, France, South Korea, Switzerland and the U.S. (p 36)... Agribusiness. On September 1, 1998, Novartis acquired a production plant and related operating assets from Oriental Chemicals Industries, South Korea for CHF 196 million (p F-13)."

Also available at: http://www.novartis.com/downloads/corporate_publications/form20f_e.pdf

 

Syngenta AG. June 8, 2001. Form 20-F. US Securities and Exchange Commission.

"Divestments. Novartis, AstraZeneca and Syngenta made several divestments in order to satisfy conditions imposed by the FTC and the European Commission in connection with the formation of Syngenta. The divestments completed in 2000 included ... and the divestment to Makhteshim Agan Ltd. of its former Novartis cereal fungicide product range in Denmark, Sweden and Finland (p 9)."... Active Substances. Herbicides:... Clodinafop (Topik, Horizon, Celio, Banvel, Mondak, Clarity)... Nature of operations. Syngenta AG ("Syngenta", the "Company"...) is a world leading crop protection and seeds business that is involved in the discovery, development, manufacture and marketing of a range of agricultural products designed to improve crop yields and food quality. Syngenta is headquartered in Basel, Switzerland and was formed by Novartis AG ("Novartis") and AstraZeneca PLC ("AstraZeneca") through an agreement to spin off and merge the Novartis crop protection and seeds businesses with the Zeneca agrochemicals business to create a dedicated agribusiness company whose shares were then the subject of a global offering (the "Transactions"). The Transactions were completed on November 13, 2000 (the "Transaction Date"). In this annual report, for periods prior to November 13, 2000, we refer to the businesses contributed by Novartis as the "Novartis agribusiness"; and we refer to the businesses contributed to Syngenta by AstraZeneca as the "Zeneca agrochemicals business" (p i)." Also available at: http://www.syngenta.com/en/downloads/Syngenta_2000_Form_20-F1.pdf

 
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