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Benzotrifluoride - CAS No. 98-08-8. 1998: Results from rat oral toxicity tests.
http://wwwdb.mhlw.go.jp/ginc/dbfile1/file/file98-08-8.html
From GINC: Global Information Network on Chemicals. The Databases of Chemicals
-- August 8, 1998
With regard to repeated dose toxicity, effects on liver and kidney were observed in both sexes given more than 100 mg/kg, indicating a NOEL is of 20 mg/kg/day for both sexes. In the reproductive/developmental toxicity study, there were no effects of the test article on the reproductive performance of the parents. Depression of body weight gain in offspring of all treatment groups was observed without any necropsy findings. The NOELs are considered to be 500 mg/kg/day for reproductive performance of the parents and less than 20 mg/kg/day for offspring development.
Trifluoromethylbenzene was not mutagenic to Salmonella typhimurium TA100, TA98, TA1535, TA1537 and Escherichia coli WP2 uvrA, with or without an exogeneous metabolic activation system.
Trifluoromethylbenzene induced neither structural chromosomal aberrations nor polyploidy in CHL/IU cells, in the absence or presence of an exogenous metabolic activation system.
Purity | : | 99.7% |
Test species/strain | : | Rat/Crj:CD (SD) |
Test method | : | OECD Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test |
ÁÁRoute | : | Oral (gavage) |
ÁÁDoses | : | 0 (vehicle), 20, 100, 500 mg/kg/day |
ÁÁNumber of animals/group | : | Males, 12; females, 12 |
ÁÁVehicle | : | Corn oil |
ÁÁAdministration period | : | Males, 49 days Females, from 14 days before mating to day 3 of lactation |
ÁÁTerminal kill | : | Males, day 50 Females, day 4 of lactation |
GLP | : | Yes |
ÁÁ Test Results:
Purity | : | above 98 % |
Test species/strains | : | Salmonella typhimurium TA100, TA1535, TA98, TA1537, Escherichia coli WP2 uvrA |
Test methods | : | Guidelines for Screening Mutagenicity Testing of Chemicals (Japan) and OECD (471 and 472) |
ÁÁProcedures | : | Plate incorporation method |
ÁÁSolvent | : | DMSO |
ÁÁPositive controls | : | -S9 mix, 2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide
(TA100, WP2, TA98), Sodium azide (TA1535) and 9-Aminoacridine (TA1537), +S9 mix, 2-Aminoanthracene (five strains) |
ÁÁDoses | : | -S9 mix, 0, 31.3,
62.5, 125, 250, 500 and 1000 |íg/plate (TA100, TA1535 and TA1537) and
0, 31.3 - 2000 |íg/plate (WP2 and TA98), +S9 mix, 0, 31.3 - 1000|íg/plate (TA1535 and TA1537), 62.5 - 2000 |íg/plate (TA100, WP2 and TA98) |
ÁÁS9 | : | Rat liver, induced with phenobarbital and 5,6-benzoflavone |
ÁÁPlates/test | : | 3 |
ÁÁNumber of replicates | : | 2 |
GLP | : | Yes |
ÁÁ Test results:
Genetic effects:
Salmonella typhimurium TA100, TA1535, TA98, TA1537
+ | ? | - | |
without metabolic activation: | [ ] | [ ] | [*] |
with metabolic activation: | [ ] | [ ] | [*] |
Escherichia coli WP2 uvrA
+ | ? | - | |
without metabolic activation: | [ ] | [ ] | [*] |
with metabolic activation: | [ ] | [ ] | [*] |
Purity | : | more than 98% |
Type of cell used | : | Chinese hamster lung (CHL/IU) cells |
Test method | : | Guidelines for Screening Mutagenicity Testing of Chemicals (Japan) |
ÁÁSolvent | : | Dimethyl sulfoxide |
ÁÁPositive controls | : | -S9 mix, Mitomycin
C +S9 mix, Cyclophosphamide |
ÁÁDoses | : | -S9 mix (continuous
treatment): 0, 0.075, 0.15, 0.30 mg/ml -S9 mix (short-term treatment): 0, 0.38, 0.75, 1.5 mg/ml +S9 mix (short-term treatment): 0, 0.38, 0.75, 1.5 mg/ml |
ÁÁS-9 | : | Rat liver, induced with phenobarbital and 5,6-benzoflavone |
ÁÁPlates/test | : | 2 |
GLP | : | Yes |
ÁÁ Test results:
Genotoxic effects:
clastogenicity | ÁÁpolyploidyÁÁ | ||||||
+ | ? | - | ÁÁ | + | ? | - | |
without metabolic activation: | [ ] | [ ] | [*] | ÁÁ | [ ] | [ ] | [*] |
with metabolic activation: | [ ] | [ ] | [*] | ÁÁ | [ ] | [ ] | [*] |
1) | The tests were performed by Safety Assessment Laboratory, Panapharm Laboratories Co., Ltd. 1285 Kurisaki-machi, Uto-shi, Kumamoto, 869-04, Japan. Tel +81-964-23-5111 Fax +81-964-23-2282 |
2) | The tests were performed by the Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano-shi, Kanagawa, 257, Japan. Tel +81-463-82-4751 Fax +81-463-82-9627 |