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Benfluralin Adverse Effects
ACTIVITY: Herbicide
(2,6-dinitroaniline)
CAS Name: N-butyl-N-ethyl-2,6-dinitro-4-(trifluoromethyl)benzenamine
Structure:
Adverse
Effects:
Ataxia
Blood
Body Weight Decrease
Cancer. Suggestive
Evidence of Carcinogenicity: LIVER.
Endocrine: Thyroid
Kidney
Liver
Spleen |
Environmental
Effects:
Fish:
Slightly
to Very Highly Toxic
Zooplankton:
Moderately to Highly Toxic.
Appendix
2 - Potential Hazardous Polluting Substance.
1978 Agreement between Canada and the
US on Great Lakes Water Quality. |
Regulatory
Information
(only comprehensive for the US) |
US
EPA Registered: |
Yes
|
US
EPA PC Code: |
084301 |
California
Chemical Code |
53 |
FDA
LMS Code: |
191 |
US
Tolerances: |
CFR
180.208 |
Registered
use in
(includes
only a limited list of countries) |
Hungary,
South Africa, Taiwan, US
Taiwan:
Dry beans - 0.5 ppm |
US
Maximum Residue Tolerance Levels:
|
Alfalfa,
Clover, Lettuce, Peanut, Trefoil |
Other
Information |
Molecular
Formula: |
C13H16
F3 N3O4 |
Inventing
Co.: |
Elanco
|
Entry Year: |
1965 |
Manufacturers: |
Dow
Elanco |
Other
Names: |
Benefin,
Balan, EL110,
Carpidor, Balfin, Benafine, Benalan, Benefex,Bonalan,
Bhulan, Quilan, Bethrodine, Benfluraline, Binnell, Emblem, Pel-Tech,
Benefine, Flubalex |
Manufacture
sites: |
CHINA:
Dongyang
Kangfeng Organic Fluorine Chemicals Plant in
Dongyang City,
Zhejiang province. (see box below) |
Of special interest: |
PAN
Data |
2004: July 31.
EPA
Fact Sheet on Benfluralin. EPA-738-F-007. |
Material
Safety Data Sheets & Labels |
|
Availability
of Risk Assessments (Interim Process).
Feb
11, 2003 Overview
of the Benfluralin Risk Assessment (15 pages)
Feb 11, 2003 - Benfluralin
Summary (2 pages)
Oct 30, 2003 - MEMORANDUM
: Benfluralin: Human Health Risk Assessment (Revised)
(64 pages)
April 29, 2003
- Benfluralin:
Health Effects Division (HED) Metabolism Assessment. Review
Committee (MARC) Decision Document.
Dec 2001 - CANCER
ASSESSMENT DOCUMENT. EVALUATION OF THE CARCINOGENIC POTENTIAL
OF BENFLURALIN. Final Report.
•
Many more documents are available in the Federal Register
Docket OPP-2003-0381. |
2002
California use data - the major use for benfluralin:
Commodity |
Total
Lbs Active Ingredient |
Lettuce,
head |
12,454 |
Alfalfa |
2,960 |
Lettuce,
leaf |
2,651 |
Tomato,
processing |
139 |
Tomato |
86 |
Corn
(forage - fodder) |
60 |
Other
uses were non-food |
Ref:
May
27, 2004 letter
From: Rick Melnicoe, Director, Western Region Integrated Pest
Management Center
To: Harold D. Coble, Agronomist, USDA/ARS/OA, Cary, NC
Subject: Benfluralin (Benefin) |
Two
maps of US pesticide use based on 1991-1995 and 1995-1998 data.
These maps were compiled by the Pesticide National Synthesis
Project of the U. S. Geological Survey's National Water Quality
Assessment Program. |
Profile
from Hazardous Substances Data Bank |
April
2000 -
SUMMARY OF TOXICOLOGY DATA BENEFIN. California
EPA, Department of Pesticide Regulation, Medical Toxicology
Branch |
March
1985 -
Herbicide Profile.
Cornell University Pesticide Management
Education Program |
List
of pesticide products |
June
2002-
In Australia when Benefin (Benfluralin) is used "As
an insecticide and acaricide on ornamentals - Seed Lucerne treatment"
no maximum residue levels are required. Ref: June 2002.
Table 5. Uses of substances where maximum residue limits are
not necessary. Australian National Registration Authority for
Agricultural Veterinary Chemicals. The MRL Standard. Maximum
residue limits in food and animal feedstuff.
http://www.nra.gov.au/residues/mrl5.pdf
|
2000
-
"P" is for Poison.
Update on Pesticide Use in California Schools, by
TM Olle. A report by Californians for Pesticide Reform. Also
available at: http://www.calpirg.org/healthyschools/PDFs/healthyschools.pdf
Fluorinated pesticides cited include Benfluralin. |
February
2000 - Hungary's
Pesticide Industry produces the fluorinated pesticides:
Benefin (BENFLURALIN); Flufenzin; Fluometuron;
Trifluralin. Hungary's pesticide industry includes partnerships
with DuPont, Rhone Poulenc, and the American CEDAR group. Hungary's
Ministry of Economic Affairs. |
US
EPA's Index of Cleared Science Reviews |
April
2000 - Food
and Drug Administration Pesticide Residue Monitoring. Table
3. Pesticides detectable by methods used in 1999 regulatory
monitoring. |
December
10, 2001 - Australia:
"Current
List. RECORD OF APPROVED ACTIVE CONSTITUENTS FOR CHEMICAL PRODUCTS." |
October
2001-Glossary
of Pesticide Chemicals. A listing
of pesticides subject to analysis of residues in foods and feeds
by the US Food and Drug Administration. |
2000
Toxic Release Inventory. Brief Summary. |
Rationale
for US EPA to add Benfluralin to the Toxic Release Inventory
Increased
relative liver weights, decreased red blood cell counts
and decreased hematocrit and hemoglobin levels were observed
in dogs orally administered benfluralin at a dose of 125
mg/kg/day for 2 years. The NOAEL was 25 mg/kg/day. Based
on the NOAEL, EPA has established an oral RfD of 0.003 mg/kg/day.
EPA believes that there is sufficient evidence for listing
benfluralin on EPCRA section 313 pursuant to EPCRA section
313(d)(2)(B) based on the available hematological toxicity
data for this chemical.
Ref:
USEPA/OPP. Support Document for the Addition of Chemicals
from Federal Insecticide, Fungicide, Rodenticide Act (FIFRA)
Active Ingredients to EPCRA Section 313. U. S. Environmental
Protection Agency, Washington, DC (1993).
As cited by US EPA in: Federal
Register: January 12, 1994. Part IV. 40 CFR Part 372.
Addition of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right-to-Know; Proposed Rule.
|
Dongyang
Kangfeng Organic Fluorine Chemical Factory
Dongyang Kangfeng Organic Fluorine Chemicals Plant was established
in 1995, it’s a key enterprise for production and
development of organic fluorine series products, which is
one of the hundred tax-payers in Dongyang City. Now, the
plant has a fixed asset of more than USD 500 million, a
working staff of 81 persons including 18 researchers, and
contains more than 20,000 square meters, and has established
a good cooperation with some chemical research institutes
all over the world.
Our plant is located in Xueshi Zai Industrial Zone of Huailu
Dongyang city, which is in the middle
of Zhejiang province P.R. China where is abundant of fluorine
ore. We have a strong technology research group,
advanced production technicals and first class production
equipments, a perfect quality control system and advantageous
location. We have established a set of environmental protection
system. At present, our annual production of benzotrifluoride,
p-chlorobenzotrifluoride and their series products are over
10,000 tons including Herbicides-Trifluralin
and Benefin technical with
4,000 tons 1,000 tons
respectively. They are of good quality and are mainly sold
abroad.
We are sticking to the principle of leading by science and
technology, depending on products' good quality and developing
on good credit and keep our efforts in deep development
of trifluoromethyl series, fluobenzene series medicine and
pesticide, dyeing staff intermediates...
Online as of April 17, 2005, at
http://www.kangfeng.com/pages/about.htm
|
US
Federal Register
••
Note: Due to length, the following is a partial
list. Click here
to see full list of FR entries.
|
Published
Date |
Docket
Identification Number |
Details |
April 13, 2007 |
EPA-HQ-OPP-2007-0005 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
Registration No. |
Product Name |
Registrant |
062719-00096 |
Balan 2.5G |
Dow
Agrosciences LLC
9330 Zionsville Rd 308/2E,
Indianapolis IN 46268-1054 |
062719-00127 |
Balan Dry Flowable |
062719-00146 |
Turf Fertilizer contains Balan 0.92% |
062719-00147 |
Turf Fertilizer contains Balan 1.15% |
062719-00148 |
Turf Fertilizer contains Balan 1.25% |
|
February 28, 2007 |
EPA-HQ-OPP-2007-0005 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
Registration No. |
Product Name |
Registrant |
007401-00046
|
Ferti-Lome
Professional Crabgrass Control |
Brazos
Associates, Inc., Agent
For: Voluntary Purchasing
Group Inc., 1806 Auburn Drive,
Carrollton, TX 75007-1451 |
007401-00298 |
Ferti-Lome
Crabgrass Preventer |
007401-00413 |
Ferti-Lome
Winterizer & Weed Preventer |
007401-00415 |
Ferti-Lome
Weed and Feed Special |
|
November 8, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations.
EPA Registration no. |
Product
Name |
Registrant
|
000228-00158 |
Riverdale Pre- Emergent Crabgrass Control
Concentrate |
Nufarm Americas Inc.
150 Harvester Drive Suite 200,
Burr Ridge IL 6052 |
000228-00172 |
Riverdale 34-0-10 & Benefin Crabgrass
Preventer |
same |
000228-00174 |
Riverdale 2.5g Pre-Emergent Herbicide |
same |
000228-00207 |
Riverdale Team .87 Lawn Weed and Feed |
same |
000228-00256 |
Riverdale Team 1.33% Lawn Weed
and Feed |
same |
009198-00030 |
The Andersons Fertilizer with 0.92% Balan |
The Andersons Lawn Fertilizer
Division, Inc., dba/ Free Flow
Fertilizer,
PO Box 119,
Maumee OH 43537 |
009198-00091 |
The Andersons Tee Time Plus 0.57% Team |
same |
009198-00091 |
The Andersons Tee Time Plus 0.57% Team |
same |
009198-00101 |
The Andersons Fertilizer with 0.87% Team |
same |
009198-00130 |
The Andersons Fertilizer with 1.50% Team |
same |
010404-00036 |
Lesco 2.5 Benefin Granular |
Lesco Inc.,
1301 E. 9th Street,
Suite 1300, Cleveland OH
44114-1849 |
010404-00056 |
Lesco Turf Fertilizer with 1.15% Team
|
same |
|
June 28, 2006 |
EPA-HQ-OPP-2006-0084 |
Notice
of Receipt of Requests to Voluntarily Cancel Certain Pesticide
Registrations.
EPA Registration no. |
Product
Name |
Registrant
|
000829-00211 |
SA-50 Brand Balfin Granules |
Southern Agricultural
Insecticides, Inc.
PO Box 218
Palmet, FL 34220. |
008660-00006 |
Sta-Green Crabgrass Preventer with Fertilizer
25-3-3 |
United Industries Corp. d/b/a
Sylorr Plant Corp.
PO Box 142642
St. Lou, MO 631140642. |
008660-00008 |
Sta-Green Pre-Emergence Crabgrass Preventer
with Balan |
same |
008660-00016 |
Sta-Green ``C-G'' Preventer Plus W/30-2-9
Fertilizer |
same |
008660-00019 |
Sta-Green Crabgrass Preventer Plus Lawn
Fertilizer |
same |
008660-00026 |
Vertagreen Weed and Feed for Professional
Turf |
same |
008660-00027 |
Vertagreen Crabgrass Preventer with Balan |
same |
008660-00030 |
Vertagreen Fertilizer for Professional
Turf w/Balan |
same |
008660-00037 |
Vertagreen Crabgrass Control |
same |
008660-00038 |
Vertagreen Fertilizer for Prof. Use 22-3-9 |
same |
008660-00039 |
Vertagreen for Professional Use with
Balan 16-6-8 |
same |
008660-00040 |
Vertagreen Crabgrass Preventer Plus Turf
Food |
same |
008660-00042 |
Vertagreen Lawn Food and Crabgrass Prevent.
25-3-5 |
same |
008660-00074 |
Pro-Teck with Balan |
same |
008660-00096 |
Vertagreen for Professional Use w/balan
25% Granules |
same |
008660-00099 |
Proteck-Plus-- contains Balan |
same |
008660-00104 |
Vertagreen Proteck 3-Way |
same |
008660-00107 |
Greenup Benefin - 10 Plus |
same |
008660-00112
008660-00113
008660-00139 |
Vertagreen Fertilizer for Professional
Use with Balan |
same |
008660-00130 |
Turf-Pro Balan 2.5% Plus Pre-Emergent
Herbicide Plus 30 |
same |
008660-00143 |
Vertagreen Fertilizer for Professional
Use with Team |
same |
008660-00146 |
Vertagreen Pre-Emergence Weed and Feed |
same |
008660-00149 |
Vertagreen Lawn Food with Crabgrass
Control |
same |
008660-00151 |
Vertagreen for Professional Turf with
Team |
same |
008660-00186 |
Gro-Tone Crabgrass Preventer Plus Lawn
Fertilizer |
same |
008660-00192 |
HWI R Your Link To Value R Lawn Fertilizer |
same |
008660-00225 |
Premium Fairway Food with Crabgrass and
POA |
same |
008660-00235 |
Vigoro Crabgrass Preventer Plus Lawn
Fertilizer |
same |
008660-00236 |
Vigoro Crabgrass Preventer Plus Lawn
Food Northern Form |
same |
008660-00237 |
Vigoro Crabgrass Preventer with Benefin |
same |
008660-00238 |
Vigoro Deep Green Crabgrass Preventer
+ Lawnfood |
same |
008660-00243 |
Vigoro Weed and Crabgrass Preventer contains
Balan |
same |
032802-00007 |
All Season Balan Granular 2.5G. |
Howard Johnson's Enterprises Inc.
700 W. Virginia St
Ste 222,
Milwauk, WI 532041548. |
032802-00008 |
All Season Crabgrass Preventer Plus |
same |
032802-00009 |
Crabgrass Preventer Plus Turf Food |
same |
032802-00010 |
Benefin Plus 25-3-25 Fertilizer |
same |
032802-00011 |
Benefin 1.3% Plus |
same |
032802-00024 |
Excel-N-Plus W/ crabgrass Control +
Lawn Food |
same |
032802-00030 |
Excel-S-Plus |
same |
032802-00033 |
Hi-Tech Crabgrass Control |
same |
032802-00035 |
Lawn Service Crabgrass Control |
same |
032802-00040 |
Proteck 58 |
same |
|
US
Federal Register
••
Note: Due to length, the above is a partial list.
Click here
to see full list of FR entries.
|
|