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3-Trifluoromethyl aniline - (M-(trifluoromethyl)aniline. TOXNET profile from Hazardous Substances Data Bank.
M-(TRIFLUOROMETHYL)ANILINE
CASRN: 98-16-8
For other data, click on the Table of Contents
Human Health Effects:
Drug Warnings:
Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or
Symptom in Infant or Effect on Lactation: Fluorides: None. /from Table 7/
Emergency Medical Treatment:
Emergency Medical Treatment:
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The following Overview, *** M-TRIFLUOROMETHYLANILINE ***, is relevant for this HSDB record chemical. |
| Life Support: |
o This overview assumes that basic life support measures
have been instituted.
|
| Clinical Effects: |
SUMMARY OF EXPOSURE
0.2.1.1 ACUTE EXPOSURE
o Little toxicologic information was found for
m-trifluoromethylaniline. It may burn the skin and
eyes.
HEENT
0.2.4.1 ACUTE EXPOSURE
o Burns may occur in the eyes.
RESPIRATORY
0.2.6.1 ACUTE EXPOSURE
o m-Trifluoroaniline is expected to be a severe
respiratory irritant because of its corrosive
properties. Pulmonary edema is possible.
o Cyanosis has been reported in experimental animals.
NEUROLOGIC
0.2.7.1 ACUTE EXPOSURE
o Behavioral changes and muscle weakness have been
reported in experimental animals.
HEMATOLOGIC
0.2.13.1 ACUTE EXPOSURE
o Methemoglobinemia is a possibility with exposure to
m-trifluoroaniline.
0.2.13.2 CHRONIC EXPOSURE
o Methemoglobin was evident in rats exposed to
m-trifluoromethylaniline for five months.
DERMATOLOGIC
0.2.14.1 ACUTE EXPOSURE
o Burns may occur on the skin.
REPRODUCTIVE HAZARDS
o No reproductive studies were found. Methemoglobin
inducers are considered especially dangerous to the
fetus.
CARCINOGENICITY
0.2.21.2 HUMAN OVERVIEW
o No studies were found on the possible carcinogenicity
of m-trifluoroaniline.
GENOTOXICITY
o m-Trifluoromethylaniline induced dominant lethal
mutations in flies.
OTHER
0.2.23.1 ACUTE EXPOSURE
o m-Trifluoromethylaniline is toxic by the oral,
inhalation, dermal, or IP routes.
|
| Laboratory: |
o Monitor hematologic parameters, methemoglobin, urinalysis,
and liver and kidney function in patients with significant
exposure. If pulmonary irritation is present, monitor
arterial blood gases, pulmonary function, and chest x-ray.
|
| Treatment Overview: |
ORAL EXPOSURE
o Emesis should NOT BE INDUCED.
o DILUTION: Following ingestion and/or prior to gastric
evacuation, immediately dilute with 4 to 8 ounces (120
to 240 mL) of milk or water (not to exceed 15 mL/kg in a
child).
o GASTRIC LAVAGE: Consider after ingestion of a
potentially life-threatening amount of poison if it can
be performed soon after ingestion (generally within 1
hour). Protect airway by placement in Trendelenburg and
left lateral decubitus position or by endotracheal
intubation. Control any seizures first.
1. CONTRAINDICATIONS: Loss of airway protective reflexes
or decreased level of consciousness in unintubated
patients; following ingestion of corrosives;
hydrocarbons (high aspiration potential); patients at
risk of hemorrhage or gastrointestinal perforation; and
trivial or non-toxic ingestion.
o ACTIVATED CHARCOAL/CATHARTIC: Administer charcoal
slurry, aqueous or mixed with saline cathartic or
sorbitol. The FDA suggests 240 mL of diluent/30 g of
charcoal. Usual charcoal dose is 25 to 100 grams in
adults and adolescents, 25 to 50 grams in children (1 to
12 years old), and 1 gram/kilogram in infants less than
1 year old.
1. Routine use of cathartics is NOT recommended. If used,
administer only ONE dose of cathartic. Administer one
dose of a cathartic, mixed with charcoal or given
separately. See "Treatment: Prevention of Absorption"
in the main document.
o METHEMOGLOBINEMIA: Administer 1 to 2 mg/kg of 1%
methylene blue slowly IV in symptomatic patients.
Additional doses may be required.
INHALATION EXPOSURE
o INHALATION: Move patient to fresh air. Monitor for
respiratory distress. If cough or difficulty breathing
develops, evaluate for respiratory tract irritation,
bronchitis, or pneumonitis. Administer oxygen and
assist ventilation as required. Treat bronchospasm with
beta2 agonist and corticosteroid aerosols.
o METHEMOGLOBINEMIA: Administer 1 to 2 mg/kg of 1%
methylene blue slowly IV in symptomatic patients.
Additional doses may be required.
o Respiratory tract irritation, if severe, can progress to
pulmonary edema which may be delayed in onset up to 24
to 72 hours after exposure in some cases.
o PULMONARY EDEMA (NONCARDIOGENIC): Maintain ventilation
and oxygenation and evaluate with frequent arterial
blood gas or pulse oximetry monitoring. Early use of
PEEP and mechanical ventilation may be needed.
EYE EXPOSURE
o DECONTAMINATION: Irrigate exposed eyes with copious
amounts of tepid water for at least 15 minutes. If
irritation, pain, swelling, lacrimation, or photophobia
persist, the patient should be seen in a health care
facility.
DERMAL EXPOSURE
o DECONTAMINATION: Remove contaminated clothing and wash
exposed area thoroughly with soap and water. A
physician may need to examine the area if irritation or
pain persists.
o Clean with a mild disinfectant and water, debride
devitalized skin, apply topical antibiotic. Optimal
dressing may vary with type and location of burn.
Determine tetanus immunization status and administer
tetanus toxoid 0.5 mL IM if required.
o Some chemicals can produce systemic poisoning by
absorption through intact skin. Carefully observe
patients with dermal exposure for the development of any
systemic signs or symptoms and administer symptomatic
treatment as necessary.
o Carefully examine patients with chemical exposure before
administering ipecac to induce emesis. If signs of
oral, pharyngeal, or esophageal irritation, a depressed
gag reflex, or central nervous system excitation or
depression are present, EMESIS SHOULD NOT BE INDUCED.
|
| Range of Toxicity: |
o Minimum lethal human exposure is unknown. |
Animal Toxicity Studies:
Non-Human Toxicity Excerpts:
WHEN ADDED TO FOOD OF LARVAL & IMAGO DROSOPHILA, M-TRIFLUOROMETHYLANILINE
INCR INCIDENCE OF DOMINANT LETHAL MUTATIONS AMONG OFFSPRING & INCR PERCENTAGE
OF UNFERTILIZED EGGS.
Metabolism/Pharmacokinetics:
Pharmacology:
Drug Warnings:
Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or
Symptom in Infant or Effect on Lactation: Fluorides: None. /from Table 7/
Environmental Fate & Exposure:
Environmental Standards & Regulations:
CERCLA Reportable Quantities:
Releases of CERCLA hazardous substances are subject to the release reporting
requirement of CERCLA section 103, codified at 40 CFR part 302, in addition
to the requirements of 40 CFR part 355. Benzenamine, 3-(trifluoromethyl)- is
an extremely hazardous substance (EHS) subject to reporting requirements when
stored in amounts in excess of its threshold planning quantity (TPQ) of 500
lbs.
Chemical/Physical Properties:
Molecular Formula:
C7-H6-F3-N
Molecular Weight:
161.13
Color/Form:
COLORLESS TO YELLOW OILY LIQ
Odor:
Fish-like
Boiling Point:
187.5 DEG C @ 764 MM HG
Solubilities:
SLIGHTLY SOL IN WATER; SOL IN ALC, ETHER
Spectral Properties:
INDEX OF REFRACTION: 1.4787 @ 20 DEG C/D; MAX ABSORPTION (ALCOHOL): 296 NM
(LOG E= 3.45)
IR: 1416 (Coblentz Society Spectral Collection)
UV: 263 (Sadtler Research Laboratories Spectral Collection)
MASS: 620 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)
Other Chemical/Physical Properties:
IR: 2:632H (Aldrich Library of Infrared Spectra, Aldrich Chemical Co, Milwaukee,
WI) /Benzotrifluoride, 2-amino/
NMR: 5:43B (Aldrich Library of Mass Spectra, Aldrich Chemical Co, Milwaukee,
WI) /Benzotrifluoride, 2-amino/
Chemical Safety & Handling:
DOT Emergency Guidelines:
Health: TOXIC; inhalation, ingestion, or skin contact with material may cause
severe injury or death. Contact with molten substance may cause severe burns
to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may
be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff
from fire control or dilution water may be corrosive and/or toxic and cause
pollution.
Fire or explosion: Combustible material: may burn but does not ignite readily.
When heated, vapors may form explosive mixtures with air: indoors, outdoors,
and sewers explosion hazards. Some may polymerize (P) explosively when heated
or involved in a fire. Contact with metals may evolve flammable hydrogen gas.
Containers may explode when heated. Runoff may pollute waterways. Substance
may be transported in a molten form.
Public safety: CALL Emergency Response Telephone Number on Shipping Paper
first. If Shipping Paper not available or no answer, refer to appropriate telephone
number listed on the inside back cover. Isolate spill or leak area immediately
for at least 25 to 50 meters (80 to 160 feet) in all directions. Keep unauthorized
personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.
Protective clothing: Wear positive pressure self-contained breathing apparatus
(SCBA). Wear chemical protective clothing which is specifically recommended
by the manufacturer. Structural firefighters' protective clothing is recommended
for fire situations ONLY; it is not effective in spill situations.
Evacuation: Spill: See the Table of Initial Isolation and Protective Action
Distances for highlighted substances. For non-highlighted substances, increase,
in the downwind direction, as necessary, the isolation distance shown under
"PUBLIC SAFETY". Fire: If tank, rail car or tank truck is involved in a fire,
ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial
evacuation for 800 meters (1/2 mile) in all directions.
Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical,
CO2, alcohol-resistant foam or water spray. Move containers from fire area if
you can do it without risk. Dike fire control water for later disposal; do not
scatter the material. Fire involving tanks or car/trailer loads: Fight fire
from maximum distance or use unmanned hose holders or monitor nozzles. Do not
get water inside containers. Cool containers with flooding quantities of water
until well after fire is out. Withdraw immediately in case of rising sound from
venting safety devices or discoloration of tank. ALWAYS stay away from the ends
of tanks.
Spill or leak: Eliminate all ignition sources (no smoking, flares, sparks
or flames in immediate area). Do not touch damaged containers or spilled material
unless wearing appropriate protective clothing. Stop leak if you can do it without
risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb
or cover with dry earth, sand or other non-combustible material and transfer
to containers. DO NOT GET WATER INSIDE CONTAINER.
First aid: Move victim to fresh air. Call emergency medical care. Apply artificial
respiration if victim is not breathing. Do not use mouth-to-mouth method if
victim ingested or inhaled the substance; induce artificial respiration with
the aid of a pocket mask equipped with a one-way valve or other proper respiratory
medical device. Administer oxygen if breathing is difficult. Remove and isolate
contaminated clothing and shoes. In case of contact with substance, immediately
flush skin or eyes with running water for at least 20 minutes. For minor skin
contact, avoid spreading material on unaffected skin. Keep victim warm and quiet.
Effects of exposure (inhalation, ingestion or skin contact) to substance may
be delayed. Ensure that medical personnel are aware of the material(s) involved,
and take precautions to protect themselves.
Fire Fighting Procedures:
If material on fire or involved in fire: Do not extinguish fire unless flow
can be stopped. Extinguish fire using agent suitable for type of surrounding
fire. (Material itself does not burn or burns with difficulty.) Use water in
flooding quantities as fog. Cool all affected containers with flooding quantities
of water. Apply water from as far a distance as possible. Use foam, dry chemical,
or carbon dioxide. Keep run off water out of sewers and water sources.
Protective Equipment & Clothing:
Wear positive pressure self contained breathing apparatus. ... Wear appropriate
chemical protective clothing.
Preventive Measures:
If material not on fire and not involved in fire: Keep sparks, flames, and
other sources of ignition away. Keep material out of water sources and sewers.
Build dikes to contain flow as necessary. Do not use water.
Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact
with the material. Do not handle broken packages unless wearing appropriate
personnal protective equipment.
Shipment Methods and Regulations:
No person may /transport,/ offer or accept a hazardous material for transportation
in commerce unless that person is registered in conformance ... and the hazardous
material is properly classed, described, packaged, marked, labeled, and in condition
for shipment as required or authorized by ... /the hazardous materials regulations
(49 CFR 171-177)./
The International Air Transport Association (IATA) Dangerous Goods Regulations
are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions
618 and 619 and constitute a manual of industry carrier regulations to be followed
by all IATA Member airlines when transporting hazardous materials.
The International Maritime Dangerous Goods Code lays down basic principles
for transporting hazardous chemicals. Detailed recommendations for individual
substances and a number of recommendations for good practice are included in
the classes dealing with such substances. A general index of technical names
has also been compiled. This index should always be consulted when attempting
to locate the appropriate procedures to be used when shipping any substance
or article.
Occupational Exposure Standards:
Manufacturing/Use Information:
Major Uses:
INT IN MFR OF PHENOTHIAZINE DERIV.
CHEM INT FOR HERBICIDES (EG, FLUOMETRON
& NORFLURAZON), ANTIHYPERTENSIVES
& DIURETICS.
Manufacturers:
Diaz Chemical Corp, Hq, 40 Jackson St,
PO Box 194, Holley, NY 14470, (716) 638-6321; Production
site: Holley, NY 14470
Methods of Manufacturing:
NITRATION OF BENZOTRIFLUORIDE TO 3-NITROBENZOTRIFLUORIDE FOLLOWED BY HYDROGENATION
Formulations/Preparations:
GRADE: TECHNICAL (88% MIN); PURIFIED (98% MIN).
Consumption Patterns:
ESSENTIALLY 100% AS A CHEM INT
U. S. Production:
(1978) PROBABLY GREATER THAN 2.27X10+6 G
(1979) PROBABLY GREATER THAN 2.27X10+6 G
U. S. Imports:
(1977) 1.01X10+7 G (PRINCPL CUSTMS DISTS)
(1979) 2.94X10+8 G (PRINCPL CUSTMS DISTS)
Laboratory Methods:
Analytic Laboratory Methods:
ANALYSIS OF M-AMINOBENZOTRIFLUORIDE BY NONAQUEOUS POTENTIOMETRIC TITRATION,
IR SPECTROSCOPY, & QUANTITATIVE GLC.
Special References:
Synonyms and Identifiers:
Synonyms:
M-AMINOBENZAL FLUORIDE
**PEER REVIEWED**
M-AMINOBENZOTRIFLUORIDE
**PEER REVIEWED**
3-AMINOBENZOTRIFLUORIDE
**PEER REVIEWED**
1-AMINO-3-(TRIFLUOROMETHYL)BENZENE
**PEER REVIEWED**
M-AMINO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
**PEER REVIEWED**
BENZENAMINE, 3-(TRIFLUOROMETHYL)-
**PEER REVIEWED**
TOLUENE, 3-AMINO-ALPHA,ALPHA,ALPHA-TRIFLUORO-
**PEER REVIEWED**
M-TOLUIDINE, ALPHA,ALPHA,ALPHA-TRIFLUORO-
**PEER REVIEWED**
3-Trifluoromethyl aniline
**PEER REVIEWED**
3-(TRIFLUOROMETHYL)BENZENAMINE
**PEER REVIEWED**
ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE
**PEER REVIEWED**
USAF MA-4
**PEER REVIEWED**
Associated Chemicals:
Benzotrifluoride, 2-amino;88-17-5
Formulations/Preparations:
GRADE: TECHNICAL (88% MIN); PURIFIED (98% MIN).
Shipping Name/ Number DOT/UN/NA/IMO:
UN 2948; 3-Trifluoromethyl aniline
IMO 6.1; 3-Trifluoromethyl aniline
Standard Transportation Number:
49 216 59; 3-Trifluoromethyl aniline
RTECS Number:
NIOSH/XU9180000
Administrative Information:
Hazardous Substances Databank Number: 4249
Last Revision Date: 20010809
Last Review Date: Reviewed by SRP on 3/2/1994
Update History:
Complete Update on 08/09/2001, 1 field added/edited/deleted.
Complete Update on 02/08/2000, 1 field added/edited/deleted.
Complete Update on 02/02/2000, 1 field added/edited/deleted.
Complete Update on 09/21/1999, 1 field added/edited/deleted.
Complete Update on 10/20/1998, 1 field added/edited/deleted.
Complete Update on 06/02/1998, 1 field added/edited/deleted.
Complete Update on 05/09/1997, 1 field added/edited/deleted.
Complete Update on 04/23/1997, 2 fields added/edited/deleted.
Complete Update on 01/27/1996, 1 field added/edited/deleted.
Complete Update on 04/20/1995, 1 field added/edited/deleted.
Complete Update on 04/20/1995, 1 field added/edited/deleted.
Complete Update on 12/30/1994, 1 field added/edited/deleted.
Complete Update on 09/16/1994, 1 field added/edited/deleted.
Complete Update on 06/07/1994, 24 fields added/edited/deleted.
Field Update on 03/27/1994, 1 field added/edited/deleted.
Field update on 01/01/1993, 1 field added/edited/deleted.
Complete Update on 01/28/1992, 1 field added/edited/deleted.
Complete Update on 10/05/1990, 7 fields added/edited/deleted.
Field Update on 05/05/1989, 1 field added/edited/deleted.
Complete Update on 10/03/1986