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by phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other
countries); fax at (703)321-8547; and email at orders ntis.fedworld.gov.
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USA. Website at http://www.ntis.gov/
Note: the following studies were located at Toxline at Toxnet
on April 20, 2005. |
NTIS
Order Number
EPA Source Doc. |
Date
/ Title |
Abstract
/ Keywords |
NTIS/AD-A329-199/4 |
1997.
Human Inhalation of Halon 1301, HFC-134a and HFC-227ea for
Collection of Pharmacokinetic Data.
Authors:
Vinegar A
Jepson GW
Cook RS
McCafferty JD
Caracci MC
Author
Address: ManTech Environmental Technology, Inc., Dayton, OH. |
Abstract:
TD3: International agreement and regulatory decisions have driven
activities to replace ozone depleting chemicals (ODCs) in fire
suppression and refrigeration applications. In order to validate
a human physiologically based pharmacokinetic model designed
for use in estimating chemical biodistribution and establishing
egress times, human volunteers were exposed via inhalation to
a series of chemicals relevant to ODC replacement activity.
Seven male volunteers ranging from 21-49 years of age were selected
to inhale bromotrifluoromethane (Halon 1301 0.5%), 1,1,1,2-tetrafluoroethane
(HFC-134a, 0.4%) and 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea,
0.6%). Each inhalation exposure was to a single chemical and
was scheduled to last 30 minutes. Inhaled concentration and
end alveolar expired concentration of chemical were continuously
measured throughout the procedure using a non-rebreathing valve
inhalation apparatus and a mass spectrometer. Blood samples
were drawn through an indwelling cannula at times 0, [abstract
truncated] |
NTIS/OTS0001295
EPA/OTS;
Doc #FYI-OTS-0897-1295 |
1997.
HUMAN INHALATION OF HALON 1301, HFC-134A AND HFC-227EA FOR COLLECTION
OF PHARMACOKINETIC DATA WITH COVER LETTER DATED 08/27/1997 |
DEPT OF
AIR FORCE
HALON 1301, HFC-134A, AND HFC-227EA
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
HUMANS
INHALATION |
NTIS/OTS0557487
EPA/OTS;
Doc #86940001897 |
1994.
HFC 134A, 1,1,1,2-TETRAFLUOROETHANE: STUDY OF THE EFFECTS
ON TESTICULAR ENDOCRINE FUNCTION AFTER INHALATION EXPOSURE
IN RATS WITH COVER LETTER DATED 09/08/94
Corporate
Name: INVERESK RESEARCH INTL |
ALLIED
SIGNAL INC
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY |
NTIS/OTS0537653
EPA/OTS;
Doc #86-930000210 |
1993.
HFC 134A: 2 YEAR INHALATION TOXICITY STUDY IN THE RAT WITH
COVER LETTER DATED 05/11/93
Corporate
Name: ZENECA CENTRAL TOXICOLOGY LAB |
DUPONT
CHEMICALS
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0545647
EPA/OTS;
Doc #88-930000312 |
1993.
INITIAL SUBMISSION: HFC 134A: 2-YEAR INHALATION TOXICITY STUDY
IN THE RAT WITH ATTACHMENTS AND COVER LETTER DATED 04/06/93
Corporate
Name: ZENECA CENTRAL TOX LABS |
ALLIED
SIGNAL INC
ETHANE,1,1,1,2-TETRAFLUORO
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0570885 |
1992.
INITIAL SUBMISSION: EMBRYOTOXICITY INHALATION STUDY IN THE
RABBIT OF HFC 134A WITH COVER LETTER DATED 08/24/92
Corporate
Name: ICI CENTRAL TOXICOL LAB |
DUPONT
CHEM
HFC 134A
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
INHALATION |
NTIS/OTS0555269
EPA/OTS;
Doc #88-920008952 |
1992.
INITIAL SUBMISSION: TERATOGENICITY STUDY OF ARCTON 134A IN
RATS WITH COVER LETTER DATED 08/24/92
Corporate
Name: IMPERIAL CHEM INDUS LTD |
E I DUPONT
DE NEMOURS & CO
ARCTON 134A
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY |
NTIS/OTS0555265
EPA/OTS;
Doc #88-920008948 |
1992.
INITIAL SUBMISSION: LETTER FROM E I DUPONT DE NEMOURS &
CO TO USEPA SUBMITTING RESULTS OF MOUSE MICRONUCLEUS TEST OF
CFC 134A INHALATION TOXICITY WITH COVER LETTER DATED 08/24/92
|
E I DUPONT
DE NEMOURS & CO
CFC 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
MAMMALS
MICE
INHALATION
NEUROTOXICITY |
NTIS/OTS0540599
EPA/OTS;
Doc #88-920004251 |
1992.
INITIAL SUBMISSION: CARDIAC SENSITIZATION STUDY WITH 1,1,1,2-TETRAFLUOROETHANE
IN BEAGLE DOGS WITH COVER LETTER DATED 06/15/92 AND ATTACHMENTS
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
DOGS |
NTIS/OTS0543258
EPA/OTS;
Doc #88-920005407 |
1992.
INITIAL SUBMISSION: LETTER FROM ALLIED-SIGNAL INC TO USEPA SUBMITTING
INFORMATION ON 1,1,1,2-TETRAFLUOROETHANE 2-YEAR INHALATION TOXICITY/CARCINOGENICTY
STUDY IN RATS |
ALLIED-SIGNAL
INC
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0571901
EPA/OTS;
Doc #88-920010755 |
1992.
INITIAL SUBMISSION: TOXICITY TESTING SUMMARY FOR ALTERNATIVE
FLUOROCARBONS WITH COVER LETTER DATED 08/24/92
Corporate
Name: DUPONT CHEM |
PHILLIPS
PETROLEUM CO
FLUOROCARBONS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
CHRONIC TOXICITY
CARCINOGENICITY
DOGS
PRIMARY EYE IRRITATION
RABBITS
DERMAL
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION
CAS Registry
Numbers:
75-10-5
75-37-6
75-43-4
75-45-6
75-68-3
75-88-7
306-83-2
593-70-4
811-97-2
2837-89-0 |
NTIS/OTS0536297
EPA/OTS;
Doc #82-920000957 |
1992.
HYDROFLUOROCARBON 134A: PHARMACOKINETICS & METABOLISM
IN RATS FOLLOWING A SINGLE EXPOSURE BY INHALATION WITH COVER
LETTER DATED 04/29/92
Corporate
Name: ICI CENTRAL TOXICOLOGY LAB |
ICI CHEMICALS
& POLYMERS
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION |
NTIS/OTS0535914
EPA/OTS;
Doc #88-920001530 |
1992.
INITIAL SUBMISSION: 1,1,1,2-TETRAFLUOROETHANE (FC-134A): EMBRYO-FETAL
TOXICITY AND TERATOGENICITY STUDY BY INHALATION IN THE RAT
(FINAL REPORT) W-ATTACHMENTS & LETTER DATED 03/27/92
Corporate
Name: HASKELL LAB |
Abstract:
1,1,1,2-Tetrafluoroethane (FC-134A; 811-97-2) was evaluated
for developmental effects in groups of 7 female Crl:CD(SD)BR
rats (14 control rats were used) administered the test substance
by inhalation at concentrations of 0, 3, 10 and 30% for 6
hours/day on days 6 through 15 of gestation. Animals were
sacrificed on day 21 of gestation. The group exposed to 30%
concentration consumed significantly less feed and gained
significantly less weight than the control group during exposure.
The mean fetal weight at 30% was significantly
less than that of the control group. The average percent
of malformed fetuses per litter was not signi [abstract truncated]
E I DUPONT
DE NEMOURS & CO
|
NTIS/OTS0000695
EPA/OTS;
Doc #FYI-OTS-1091-0695 |
1991.
SUPPLEMENTAL INFORMATION: HFC 134A: TWO-YEAR INHALATION TOXICITY
STUDY IN THE RAT INTERIM REPORT AFTER 52 WEEKS (FINAL REPORT)
WITH COVER LETTER DATED 09/30/91
Corporate
Name: ICI CENTRAL TOXICOLOGY LAB |
ALLIED-SIGNAL INC
HFC 134A
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION |
Order
Number: NTIS/OTS000069513
EPA/OTS;
Doc #FYI-OTS-0991-0695 |
1991.
SUPPLEMENTAL INFORMATION: LETTER SUBMITTING ONE ENCLOSED REVERSE
MUTATION ASSAY AND ONE ENCLOSED CHROMOSOMAL ABERRATION TEST
ON 1,1,1,2-TETRAFLUOROETHANE WITH ATTACHMENTS
Corporate
Name: JAPAN BIOASSAY LAB |
ALLIED-SIGNAL
INC
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHROMOSOMAL EFFECTS
MAMMALS
HAMSTERS |
NTIS/OTS0533521
EPA/OTS;
Doc #86-920000302S |
1991.
LETTER TO USEPA REGARDING THE ENCLOSED HEALTH AND SAFETY STUDIES
ON 2,2-DICHLORO-1,1,1-TRIFLUOROETHANE AND 1,1,1,2-TETRAFLUOROETHANE
WITH ATTACHMENTS (SANITIZED) |
CONFIDENTIAL
2,2-DICHLORO-1,1,1-TRIFLUOROETHANE (306-83-2)
ENVIRONMENTAL FATE
CAS Registry
Numbers:
306-83-2
811-97-2 |
: NTIS/OTS0000695-7
EPA/OTS;
Doc #FYI-OTS-0990-0695 |
1990.
HFC 134A: AN EVALUATION IN THE IN VITRO CYTOGENETIC
ASSAY IN HUMAN LYMPHOCYTES (FINAL REPORT) WITH ATTACHMENTS
AND COVER LETTER DATED 08-22-90
Corporate
Name: ICI CENTRAL TOXICOLOGY LAB |
ALLIED
SIGNAL INC
HFC 134A
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
HUMANS
IN VITRO |
NTIS/OTS0000695-7
EPA/OTS;
Doc #FYI-OTS-0890-0695 |
1990.
HFC 134a: ASSESSMENT FOR THE INDUCTION OF UNSCHEDULED
DNA SYNTHESIS IN RAT HEPATOCYTES IN VIVO (FINAL REPORT) WITH
ATTACHMENTS AND COVER LETTER DATED 07/19/90
Corporate
Name: ICI CENTRAL TOXICOLOGY LAB |
Abstract:
HFC 134a (1,1,2,2-tetrafluoroethane) was evaluated for genotoxicity
in an in vivo unscheduled DNA synthesis assay in rat hepatocytes.
Male rats were exposed to concentrations of 0, 10,000, 50,000,
and 100,000 ppm for a single 6-hour period. Test results were
clearly negative (the percentage of cells in repair were less
than 20; mean net nuclear grain count was zero). HCFC 123 (1,1,1-trifluoro-
2,2-dichloroethane) was tested for subchronic inhalation toxicity
in rats (10/sex/group) exposed to concentrations of 0, 300,
1,000, or 5,000 ppm for 6 hours/day, 5 days/week, for 90 days.
A no- observable-effect-level was not identified. No compound-related
mortality was observed. Increased hepatic peroxisomal beta-
oxidation activity and decreased concentrations of serum triglyceride
and glucose were observed at all doses in both sexes. No gross
or microscopic morphological changes were observed in any tissue. |
NTIS/OTS0530569
EPA/OTS;
Doc #86-910000083S |
1990.
EMBRYO-FETAL TOXICITY AND TERATOGENICITY STUDY OF 1,1,1,2-TETRAFLUOROETHANE
BY INHALATION IN THE RAT WITH ATTACHMENTS AND COVER LETTER
DATED 11/22/90 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0530573
EPA/OTS;
Doc #86-910000087S |
1990.
ACUTE INHALATION TOXICITY STUDY OF TETRAFLUOROETHANE IN RATS
WITH COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0530572
EPA/OTS;
Doc #86-910000086S |
1990.
ACUTE INHALATION TOXICITY STUDY OF FREON 134a IN RATS WITH
COVER LETTER DATED 112290 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0000695-4
EPA/OTS;
Doc #FYI-OTS-0490-0695
Keywords: |
1990.
HCFC 123: 28-DAY INHALATION STUDY TO ASSESS CHANGES IN RAT LIVER
& PLASMA & HFC 134A - AN EVALUATION USING THE SALMONELLA
MUTAGENICITY ASSAY WITH COVER LETTER DATED 03/29/90 |
ALLIED
SIGNAL INC
HCFC 123
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION |
NTIS/OTS0530568
EPA/OTS;
Doc #86-910000082S |
1990.
STUDY OF CARDIAC SENSITIZATION POTENTIAL OF 1,1,1,2-TETRAFLUOROETHANE
IN BEAGLE DOGS WITH COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION |
NTIS/OTS0530570
EPA/OTS;
Doc #86-910000084S |
1990.
MUTAGENIC ACTIVITY OF 1,1,1,2-TETRAFLUORO-ETHANE IN THE SALMONELLA/MICROSOME
ASSAY WITH COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO |
NTIS/OTS0530571
EPA/OTS;
Doc #86-910000085S |
1990.
SUBACUTE INHALATION TOXICITY OF 1,1,1,2-TETRAFLUOROETHANE
IN RATS WITH ATTACHMENTS AND COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0530572
EPA/OTS;
Doc #86-910000086S |
1990.
ACUTE INHALATION TOXICITY STUDY OF FREON 134a IN RATS WITH
COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate
Name: HASKELL LABORATORY |
E I DUPONT
DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION |
NTIS/OTS0530617
EPA/OTS;
Doc #86-910000461 |
1990.
DEFLUORINATION OF 1,1,1,2-TETRAFLUOROETHANE (R-134a) BY RAT
HEPATOCYTES WITH ENCLOSED LETTERS, ATTACHMENTS, AND COVER
LETTER DATED 12/15/90
Corporate
Name: GENERAL MOTORS RES LABS |
GENERAL
MOTORS CORP
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
IN VITRO |
NTIS/OTS0530619
EPA/OTS;
Doc #86-910000463 |
1990.
DEFLUORINATION OF 1,1,1,2-TETRAFLUOROETHANE (R-134a) BY RAT
HEPATOCYTES WITH ENCLOSED LETTER AND COVER LETTER DATED 12/15/90
Corporate Name: GENERAL MOTORS RES LABS |
GENERAL
MOTORS CORP
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
IN VITRO |
NTIS/OTS0000695
EPA/OTS;
Doc #FYI-OTS-0689-0695 |
1989.
ARCTON 134A DOMINANT LETHAL STUDY IN THE MOUSE, EXCRETION,
TISSUE DISTRIBUTION AND METABOLISM IN RAT, TERATOGENICITY,
CYTOGENTIC, AND SUB-ACUTE STUDIES IN RATS WITH LETTER 06/21/89
Corporate
Name: IMPERIAL CHEM INUS LTD |
ICI
PRODUCTS LTD
ARCTON 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
CELL TRANSFORMATION
HAMSTERS
CHROMOSOMAL EFFECTS
INHALATION
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
SUBCHRONIC TOXICITY
MICE
CAS Registry
Numbers:
75-45-6
75-88-7
420-46-2
593-70-4
811-97-2 |