1,1,1,2-Tetrafluoroethane (HFC-134a)
CAS No. 811-97-2
Reports on human and animal studies from the
National Technical Information Service (NTIS)
 
 

ACTIVITY: Aerosol propellant, US EPA List 4B Inert (Halogenated organic)

Structure:

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Note: the following studies were located at Toxline at Toxnet on April 20, 2005.

NTIS Order Number
EPA Source Doc.

Date / Title Abstract / Keywords
NTIS/AD-A329-199/4

1997. Human Inhalation of Halon 1301, HFC-134a and HFC-227ea for Collection of Pharmacokinetic Data.

Authors:
Vinegar A
Jepson GW
Cook RS
McCafferty JD
Caracci MC

Author Address: ManTech Environmental Technology, Inc., Dayton, OH.

Abstract:
TD3: International agreement and regulatory decisions have driven activities to replace ozone depleting chemicals (ODCs) in fire suppression and refrigeration applications. In order to validate a human physiologically based pharmacokinetic model designed for use in estimating chemical biodistribution and establishing egress times, human volunteers were exposed via inhalation to a series of chemicals relevant to ODC replacement activity. Seven male volunteers ranging from 21-49 years of age were selected to inhale bromotrifluoromethane (Halon 1301 0.5%), 1,1,1,2-tetrafluoroethane (HFC-134a, 0.4%) and 1,1,1,2,3,3,3-heptafluoropropane (HFC-227ea, 0.6%). Each inhalation exposure was to a single chemical and was scheduled to last 30 minutes. Inhaled concentration and end alveolar expired concentration of chemical were continuously measured throughout the procedure using a non-rebreathing valve inhalation apparatus and a mass spectrometer. Blood samples were drawn through an indwelling cannula at times 0, [abstract truncated]

NTIS/OTS0001295

EPA/OTS; Doc #FYI-OTS-0897-1295

1997. HUMAN INHALATION OF HALON 1301, HFC-134A AND HFC-227EA FOR COLLECTION OF PHARMACOKINETIC DATA WITH COVER LETTER DATED 08/27/1997 DEPT OF AIR FORCE
HALON 1301, HFC-134A, AND HFC-227EA
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
HUMANS
INHALATION

NTIS/OTS0557487

EPA/OTS; Doc #86940001897

1994. HFC 134A, 1,1,1,2-TETRAFLUOROETHANE: STUDY OF THE EFFECTS ON TESTICULAR ENDOCRINE FUNCTION AFTER INHALATION EXPOSURE IN RATS WITH COVER LETTER DATED 09/08/94

Corporate Name: INVERESK RESEARCH INTL

ALLIED SIGNAL INC
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY

NTIS/OTS0537653

EPA/OTS; Doc #86-930000210

1993. HFC 134A: 2 YEAR INHALATION TOXICITY STUDY IN THE RAT WITH COVER LETTER DATED 05/11/93

Corporate Name: ZENECA CENTRAL TOXICOLOGY LAB

DUPONT CHEMICALS
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0545647

EPA/OTS; Doc #88-930000312

1993. INITIAL SUBMISSION: HFC 134A: 2-YEAR INHALATION TOXICITY STUDY IN THE RAT WITH ATTACHMENTS AND COVER LETTER DATED 04/06/93

Corporate Name: ZENECA CENTRAL TOX LABS

ALLIED SIGNAL INC
ETHANE,1,1,1,2-TETRAFLUORO
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION
NTIS/OTS0570885

1992. INITIAL SUBMISSION: EMBRYOTOXICITY INHALATION STUDY IN THE RABBIT OF HFC 134A WITH COVER LETTER DATED 08/24/92

Corporate Name: ICI CENTRAL TOXICOL LAB

DUPONT CHEM
HFC 134A
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
INHALATION

NTIS/OTS0555269

EPA/OTS; Doc #88-920008952

1992. INITIAL SUBMISSION: TERATOGENICITY STUDY OF ARCTON 134A IN RATS WITH COVER LETTER DATED 08/24/92

Corporate Name: IMPERIAL CHEM INDUS LTD

E I DUPONT DE NEMOURS & CO
ARCTON 134A
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY

NTIS/OTS0555265

EPA/OTS; Doc #88-920008948

1992. INITIAL SUBMISSION: LETTER FROM E I DUPONT DE NEMOURS & CO TO USEPA SUBMITTING RESULTS OF MOUSE MICRONUCLEUS TEST OF CFC 134A INHALATION TOXICITY WITH COVER LETTER DATED 08/24/92 E I DUPONT DE NEMOURS & CO
CFC 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
MAMMALS
MICE
INHALATION
NEUROTOXICITY

NTIS/OTS0540599

EPA/OTS; Doc #88-920004251

1992. INITIAL SUBMISSION: CARDIAC SENSITIZATION STUDY WITH 1,1,1,2-TETRAFLUOROETHANE IN BEAGLE DOGS WITH COVER LETTER DATED 06/15/92 AND ATTACHMENTS

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
DOGS

NTIS/OTS0543258

EPA/OTS; Doc #88-920005407

1992. INITIAL SUBMISSION: LETTER FROM ALLIED-SIGNAL INC TO USEPA SUBMITTING INFORMATION ON 1,1,1,2-TETRAFLUOROETHANE 2-YEAR INHALATION TOXICITY/CARCINOGENICTY STUDY IN RATS ALLIED-SIGNAL INC
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0571901

EPA/OTS; Doc #88-920010755

1992. INITIAL SUBMISSION: TOXICITY TESTING SUMMARY FOR ALTERNATIVE FLUOROCARBONS WITH COVER LETTER DATED 08/24/92

Corporate Name: DUPONT CHEM

PHILLIPS PETROLEUM CO
FLUOROCARBONS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
CHRONIC TOXICITY
CARCINOGENICITY
DOGS
PRIMARY EYE IRRITATION
RABBITS
DERMAL
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION

CAS Registry Numbers:
75-10-5
75-37-6
75-43-4
75-45-6
75-68-3
75-88-7
306-83-2
593-70-4
811-97-2

2837-89-0

NTIS/OTS0536297

EPA/OTS; Doc #82-920000957

1992. HYDROFLUOROCARBON 134A: PHARMACOKINETICS & METABOLISM IN RATS FOLLOWING A SINGLE EXPOSURE BY INHALATION WITH COVER LETTER DATED 04/29/92

Corporate Name: ICI CENTRAL TOXICOLOGY LAB

ICI CHEMICALS & POLYMERS
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION

NTIS/OTS0535914

EPA/OTS; Doc #88-920001530

1992. INITIAL SUBMISSION: 1,1,1,2-TETRAFLUOROETHANE (FC-134A): EMBRYO-FETAL TOXICITY AND TERATOGENICITY STUDY BY INHALATION IN THE RAT (FINAL REPORT) W-ATTACHMENTS & LETTER DATED 03/27/92

Corporate Name: HASKELL LAB

Abstract: 1,1,1,2-Tetrafluoroethane (FC-134A; 811-97-2) was evaluated for developmental effects in groups of 7 female Crl:CD(SD)BR rats (14 control rats were used) administered the test substance by inhalation at concentrations of 0, 3, 10 and 30% for 6 hours/day on days 6 through 15 of gestation. Animals were sacrificed on day 21 of gestation. The group exposed to 30% concentration consumed significantly less feed and gained significantly less weight than the control group during exposure. The mean fetal weight at 30% was significantly less than that of the control group. The average percent of malformed fetuses per litter was not signi [abstract truncated]

E I DUPONT DE NEMOURS & CO

NTIS/OTS0000695

EPA/OTS; Doc #FYI-OTS-1091-0695

1991. SUPPLEMENTAL INFORMATION: HFC 134A: TWO-YEAR INHALATION TOXICITY STUDY IN THE RAT INTERIM REPORT AFTER 52 WEEKS (FINAL REPORT) WITH COVER LETTER DATED 09/30/91

Corporate Name: ICI CENTRAL TOXICOLOGY LAB


ALLIED-SIGNAL INC
HFC 134A
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION

Order Number: NTIS/OTS000069513

EPA/OTS; Doc #FYI-OTS-0991-0695

1991. SUPPLEMENTAL INFORMATION: LETTER SUBMITTING ONE ENCLOSED REVERSE MUTATION ASSAY AND ONE ENCLOSED CHROMOSOMAL ABERRATION TEST ON 1,1,1,2-TETRAFLUOROETHANE WITH ATTACHMENTS

Corporate Name: JAPAN BIOASSAY LAB

ALLIED-SIGNAL INC
1,1,1,2-TETRAFLUOROETHANE
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHROMOSOMAL EFFECTS
MAMMALS
HAMSTERS

NTIS/OTS0533521

EPA/OTS; Doc #86-920000302S

1991. LETTER TO USEPA REGARDING THE ENCLOSED HEALTH AND SAFETY STUDIES ON 2,2-DICHLORO-1,1,1-TRIFLUOROETHANE AND 1,1,1,2-TETRAFLUOROETHANE WITH ATTACHMENTS (SANITIZED)

CONFIDENTIAL
2,2-DICHLORO-1,1,1-TRIFLUOROETHANE (306-83-2)
ENVIRONMENTAL FATE

CAS Registry Numbers:
306-83-2
811-97-2

: NTIS/OTS0000695-7

EPA/OTS; Doc #FYI-OTS-0990-0695

1990.  HFC 134A: AN EVALUATION IN THE IN VITRO CYTOGENETIC ASSAY IN HUMAN LYMPHOCYTES (FINAL REPORT) WITH ATTACHMENTS AND COVER LETTER DATED 08-22-90

Corporate Name: ICI CENTRAL TOXICOLOGY LAB

ALLIED SIGNAL INC
HFC 134A
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
HUMANS
IN VITRO

NTIS/OTS0000695-7

EPA/OTS; Doc #FYI-OTS-0890-0695

1990.  HFC 134a: ASSESSMENT FOR THE INDUCTION OF UNSCHEDULED DNA SYNTHESIS IN RAT HEPATOCYTES IN VIVO (FINAL REPORT) WITH ATTACHMENTS AND COVER LETTER DATED 07/19/90

Corporate Name: ICI CENTRAL TOXICOLOGY LAB

Abstract: HFC 134a (1,1,2,2-tetrafluoroethane) was evaluated for genotoxicity in an in vivo unscheduled DNA synthesis assay in rat hepatocytes. Male rats were exposed to concentrations of 0, 10,000, 50,000, and 100,000 ppm for a single 6-hour period. Test results were clearly negative (the percentage of cells in repair were less than 20; mean net nuclear grain count was zero). HCFC 123 (1,1,1-trifluoro- 2,2-dichloroethane) was tested for subchronic inhalation toxicity in rats (10/sex/group) exposed to concentrations of 0, 300, 1,000, or 5,000 ppm for 6 hours/day, 5 days/week, for 90 days. A no- observable-effect-level was not identified. No compound-related mortality was observed. Increased hepatic peroxisomal beta- oxidation activity and decreased concentrations of serum triglyceride and glucose were observed at all doses in both sexes. No gross or microscopic morphological changes were observed in any tissue.

NTIS/OTS0530569

EPA/OTS; Doc #86-910000083S

1990.  EMBRYO-FETAL TOXICITY AND TERATOGENICITY STUDY OF 1,1,1,2-TETRAFLUOROETHANE BY INHALATION IN THE RAT WITH ATTACHMENTS AND COVER LETTER DATED 11/22/90 (SANITIZED)

Corporate Name: HASKELL LABORATORY


E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0530573

EPA/OTS; Doc #86-910000087S

1990. ACUTE INHALATION TOXICITY STUDY OF TETRAFLUOROETHANE IN RATS WITH COVER LETTER DATED 11/22/90 (SANITIZED)
Corporate Name: HASKELL LABORATORY
E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0530572

EPA/OTS; Doc #86-910000086S

1990. ACUTE INHALATION TOXICITY STUDY OF FREON 134a IN RATS WITH COVER LETTER DATED 112290 (SANITIZED)

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0000695-4

EPA/OTS; Doc #FYI-OTS-0490-0695
Keywords:

1990. HCFC 123: 28-DAY INHALATION STUDY TO ASSESS CHANGES IN RAT LIVER & PLASMA & HFC 134A - AN EVALUATION USING THE SALMONELLA MUTAGENICITY ASSAY WITH COVER LETTER DATED 03/29/90 ALLIED SIGNAL INC
HCFC 123
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION

NTIS/OTS0530568

EPA/OTS; Doc #86-910000082S

1990. STUDY OF CARDIAC SENSITIZATION POTENTIAL OF 1,1,1,2-TETRAFLUOROETHANE IN BEAGLE DOGS WITH COVER LETTER DATED 11/22/90 (SANITIZED)

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUOROETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION

NTIS/OTS0530570

EPA/OTS; Doc #86-910000084S

1990. MUTAGENIC ACTIVITY OF 1,1,1,2-TETRAFLUORO-ETHANE IN THE SALMONELLA/MICROSOME ASSAY WITH COVER LETTER DATED 11/22/90 (SANITIZED)

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO

NTIS/OTS0530571

EPA/OTS; Doc #86-910000085S

1990. SUBACUTE INHALATION TOXICITY OF 1,1,1,2-TETRAFLUOROETHANE IN RATS WITH ATTACHMENTS AND COVER LETTER DATED 11/22/90 (SANITIZED)

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0530572

EPA/OTS; Doc #86-910000086S

1990. ACUTE INHALATION TOXICITY STUDY OF FREON 134a IN RATS WITH COVER LETTER DATED 11/22/90 (SANITIZED)

Corporate Name: HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

NTIS/OTS0530617

EPA/OTS; Doc #86-910000461

1990. DEFLUORINATION OF 1,1,1,2-TETRAFLUOROETHANE (R-134a) BY RAT HEPATOCYTES WITH ENCLOSED LETTERS, ATTACHMENTS, AND COVER LETTER DATED 12/15/90

Corporate Name: GENERAL MOTORS RES LABS

GENERAL MOTORS CORP
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
IN VITRO

NTIS/OTS0530619

EPA/OTS; Doc #86-910000463

1990. DEFLUORINATION OF 1,1,1,2-TETRAFLUOROETHANE (R-134a) BY RAT HEPATOCYTES WITH ENCLOSED LETTER AND COVER LETTER DATED 12/15/90
Corporate Name: GENERAL MOTORS RES LABS
GENERAL MOTORS CORP
1,1,1,2-TETRAFLUORO-ETHANE (811-97-2)
HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
IN VITRO

NTIS/OTS0000695

EPA/OTS; Doc #FYI-OTS-0689-0695

1989.  ARCTON 134A DOMINANT LETHAL STUDY IN THE MOUSE, EXCRETION, TISSUE DISTRIBUTION AND METABOLISM IN RAT, TERATOGENICITY, CYTOGENTIC, AND SUB-ACUTE STUDIES IN RATS WITH LETTER 06/21/89

Corporate Name: IMPERIAL CHEM INUS LTD

ICI PRODUCTS LTD
ARCTON 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
CELL TRANSFORMATION
HAMSTERS
CHROMOSOMAL EFFECTS
INHALATION
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
SUBCHRONIC TOXICITY
MICE

CAS Registry Numbers:
75-45-6
75-88-7
420-46-2
593-70-4
811-97-2

 
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