“The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions in response to NaF at higher concentrations (>7.5 mM) compared with the corresponding blood vessels from age-matched control rats. This observation is consistent with the recent results reported by other investigators.”
SOURCE: Hattori Y, et al. (2000). Predominant contribution of the G protein-mediated mechanism to NaF-induced vascular contractions in diabetic rats: association with an increased level of G(qalpha) expression. J Pharmacol Exp Ther. 292(2):761-8.

“Pathological findings of the present study also indicate toxicological magnification by fluoride in diabetic rats. Both diabetes and fluorosis are major disorders which affect several organ systems. It may be concluded from the present study that toxicity by fluoride is greater in diabetes.”
SOURCE: Priya CA, et al. (1997). Toxicity of fluoride to diabetic rats. Fluoride 30(1): 51-58.

“The one histological variable on which fluoride did exert an effect in the diabetic animals was the width of the cortex in the tibia. Loss of bone mass and density are characteristic of both experimental and human diabetes and were evident in our diabetic animals in which the diaphyseal bone width was significantly less than in controls treated with 0, 5 or 15 parts/10^6 fluoride [ppm].”
SOURCE: Dunipace AJ, et al. (1996). Absence of detrimental effects of fluoride exposure in diabetic rats. Archives of Oral Biology 41(2): 191-203.

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